U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant Epithelioid Cell Type Gastrointestinal Stromal Tumor

MedGen UID:
415168
•Concept ID:
C2825773
•
Neoplastic Process

Definition

An epithelioid cell type gastrointestinal stromal tumor with an aggressive clinical course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Epithelioid Cell Type Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

Epithelioid Leiomyosarcoma of the Uterus: Modern Outcome-based Appraisal of Diagnostic Criteria in a Large Institutional Series.
Chapel DB, Nucci MR, Quade BJ, Parra-Herran C
Am J Surg Pathol 2022 Apr 1;46(4):464-475. doi: 10.1097/PAS.0000000000001795. PMID: 34419987
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188
Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis.
Miettinen M, Lasota J
Virchows Arch 2001 Jan;438(1):1-12. doi: 10.1007/s004280000338. PMID: 11213830

Recent clinical studies

Etiology

Leiomyoma with nuclear atypia: Rare diseases that present a common diagnostic problem.
Wei JJ
Semin Diagn Pathol 2022 May;39(3):187-200. Epub 2022 Feb 2 doi: 10.1053/j.semdp.2022.01.006. PMID: 35144823Free PMC Article
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Inflammatory Myofibroblastic Tumor in Female Genital Tract.
Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784
Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis.
Jumniensuk C, Charoenpitakchai M
World J Surg Oncol 2018 Dec 3;16(1):231. doi: 10.1186/s12957-018-1532-1. PMID: 30509310Free PMC Article
Gastrointestinal stromal tumours.
Miettinen M, Sarlomo-Rikala M, Lasota J
Ann Chir Gynaecol 1998;87(4):278-81. PMID: 9891765

Diagnosis

Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Smooth Muscle Tumors of the Female Genital Tract.
Devereaux KA, Schoolmeester JK
Surg Pathol Clin 2019 Jun;12(2):397-455. doi: 10.1016/j.path.2019.02.004. PMID: 31097110
Inflammatory Myofibroblastic Tumor in Female Genital Tract.
Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784
Review of the pathophysiology, diagnosis, and therapy of vulvar leiomyoma, a rare gynecological tumor.
Sun C, Zou J, Wang Q, Wang Q, Han L, Batchu N, Ulain Q, Du J, Lv S, Song Q, Li Q
J Int Med Res 2018 Feb;46(2):663-674. Epub 2017 Sep 6 doi: 10.1177/0300060517721796. PMID: 28875758Free PMC Article
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Therapy

Recurrent vaginal epithelioid leiomyosarcoma; a case report from Botswana and review of the literature.
Benti TM, Mercy N, Eshetu AB, Iwuh IE, Kassa MW
Afr J Reprod Health 2021 Feb;25(1):161-168. doi: 10.29063/ajrh2021/v25i1.17. PMID: 34077121
Gastrointestinal stromal tumors: what do we know now?
Corless CL
Mod Pathol 2014 Jan;27 Suppl 1:S1-16. doi: 10.1038/modpathol.2013.173. PMID: 24384849
Rhabdomyosarcomatous differentiation in gastrointestinal stromal tumors after tyrosine kinase inhibitor therapy: a novel form of tumor progression.
Liegl B, Hornick JL, Antonescu CR, Corless CL, Fletcher CD
Am J Surg Pathol 2009 Feb;33(2):218-26. doi: 10.1097/PAS.0b013e31817ec2e6. PMID: 18830121
Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature.
Prakash S, Sarran L, Socci N, DeMatteo RP, Eisenstat J, Greco AM, Maki RG, Wexler LH, LaQuaglia MP, Besmer P, Antonescu CR
J Pediatr Hematol Oncol 2005 Apr;27(4):179-87. doi: 10.1097/01.mph.0000157790.81329.47. PMID: 15838387
Pleomorphic liposarcoma of the uterus: case report and literature review.
Levine PH, Wei XJ, Gagner JP, Flax H, Mittal K, Blank SV
Int J Gynecol Pathol 2003 Oct;22(4):407-11. doi: 10.1097/01.pgp.0000092156.33490.89. PMID: 14501826

Prognosis

Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Smooth Muscle Tumors of the Female Genital Tract.
Devereaux KA, Schoolmeester JK
Surg Pathol Clin 2019 Jun;12(2):397-455. doi: 10.1016/j.path.2019.02.004. PMID: 31097110
Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis.
Jumniensuk C, Charoenpitakchai M
World J Surg Oncol 2018 Dec 3;16(1):231. doi: 10.1186/s12957-018-1532-1. PMID: 30509310Free PMC Article
Mesenchymal tumours of the bladder and prostate: an update.
Tavora F, Kryvenko ON, Epstein JI
Pathology 2013 Feb;45(2):104-15. doi: 10.1097/PAT.0b013e32835c768b. PMID: 23250042
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Clinical prediction guides

PDGFRA Immunohistochemistry Predicts PDGFRA Mutations in Gastrointestinal Stromal Tumors.
Papke DJ Jr, Forgó E, Charville GW, Hornick JL
Am J Surg Pathol 2022 Jan 1;46(1):3-10. doi: 10.1097/PAS.0000000000001720. PMID: 33859072
Uterine angiomyolipoma: a clinical analysis of 8 cases and literature review.
Wang J, Yang Q, Zhang N, Wang D
Arch Gynecol Obstet 2021 Jul;304(1):171-177. Epub 2021 Feb 10 doi: 10.1007/s00404-021-05992-1. PMID: 33569612
Gastrointestinal stromal tumors: what do we know now?
Corless CL
Mod Pathol 2014 Jan;27 Suppl 1:S1-16. doi: 10.1038/modpathol.2013.173. PMID: 24384849
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188
Gastrointestinal stromal tumors. A review of characteristics morphologic, immunohistochemical, and molecular genetic features.
Goldblum JR
Am J Clin Pathol 2002 Jun;117 Suppl:S49-61. doi: 10.1309/7EWE-PF04-VWJR-G4WQ. PMID: 14569802

Recent systematic reviews

The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343
Uterine lesions with sex cord-like architectures: a systematic review.
Jia M, Sun PL, Gao H
Diagn Pathol 2019 Nov 18;14(1):129. doi: 10.1186/s13000-019-0909-y. PMID: 31739799Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...