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VIPoma

MedGen UID:
41532
Concept ID:
C0011993
Neoplastic Process
Synonyms: Pancreatic VIPoma; Vasoactive intestinal peptide (VIP) tumor; Vasoactive intestinal peptide-producing tumor
SNOMED CT: VIP-oma - Vasoactive intestinal peptide-secreting tumor (253005002); Vasoactive intestinal peptide-secreting tumor (253005002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019960
Orphanet: ORPHA97282

Definition

VIPoma is an extremely rare type of pancreatic neuroendocrine tumor (see this term) that secretes vasoactive intestinal polypeptide (VIP) leading to the manifestations of watery diarrhea, hypokalemia and achlorhydia or hypochhlorhydia (known as WDHA syndrome). [from ORDO]

Professional guidelines

PubMed

Azizian A, König A, Ghadimi M
Langenbecks Arch Surg 2022 Nov;407(7):2629-2636. Epub 2022 Aug 5 doi: 10.1007/s00423-022-02620-7. PMID: 35931878Free PMC Article
Ito T, Jensen RT
Expert Opin Pharmacother 2021 Apr;22(6):685-693. Epub 2020 Nov 11 doi: 10.1080/14656566.2020.1845651. PMID: 33131345Free PMC Article
Parbhu SK, Adler DG
Hosp Pract (1995) 2016 Aug;44(3):109-19. Epub 2016 Jul 18 doi: 10.1080/21548331.2016.1210474. PMID: 27404266

Recent clinical studies

Etiology

Damaskos C, Dimitroulis D, Garmpi A, Antoniou EA, Kouraklis G, Psilopatis I, Mavri M, Diamantis E, Marinos G, Kyriakos G, Farmaki P, Patsouras A, Kontzoglou K, Garmpis N
In Vivo 2023 Nov-Dec;37(6):2402-2408. doi: 10.21873/invivo.13345. PMID: 37905620Free PMC Article
Azizian A, König A, Ghadimi M
Langenbecks Arch Surg 2022 Nov;407(7):2629-2636. Epub 2022 Aug 5 doi: 10.1007/s00423-022-02620-7. PMID: 35931878Free PMC Article
Brugel M, Walter T, Goichot B, Smith D, Lepage C, Do Cao C, Hautefeuille V, Rebours V, Cadiot G, de Mestier L; Groupe d’Étude des Tumeurs Endocrines (GTE)
Pancreatology 2021 Dec;21(8):1531-1539. Epub 2021 Aug 5 doi: 10.1016/j.pan.2021.08.001. PMID: 34404601
Siddappa PK, Vege SS
Pancreas 2019 Oct;48(9):1119-1125. doi: 10.1097/MPA.0000000000001402. PMID: 31609932
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article

Diagnosis

Hofland J, Falconi M, Christ E, Castaño JP, Faggiano A, Lamarca A, Perren A, Petrucci S, Prasad V, Ruszniewski P, Thirlwell C, Vullierme MP, Welin S, Bartsch DK
J Neuroendocrinol 2023 Aug;35(8):e13318. Epub 2023 Aug 14 doi: 10.1111/jne.13318. PMID: 37578384
Ito T, Jensen RT
Expert Opin Pharmacother 2021 Apr;22(6):685-693. Epub 2020 Nov 11 doi: 10.1080/14656566.2020.1845651. PMID: 33131345Free PMC Article
Belei OA, Heredea ER, Boeriu E, Marcovici TM, Cerbu S, Mărginean O, Iacob ER, Iacob D, Motoc AGM, Boia ES
Rom J Morphol Embryol 2017;58(2):371-376. PMID: 28730220
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Batcher E, Madaj P, Gianoukakis AG
Endocr Res 2011;36(1):35-43. doi: 10.3109/07435800.2010.525085. PMID: 21226566

Therapy

Azizian A, König A, Ghadimi M
Langenbecks Arch Surg 2022 Nov;407(7):2629-2636. Epub 2022 Aug 5 doi: 10.1007/s00423-022-02620-7. PMID: 35931878Free PMC Article
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Desai KK, Khan MS, Toumpanakis C, Caplin ME
Minerva Gastroenterol Dietol 2009 Dec;55(4):425-43. PMID: 19942827
Udelsman R, Yeo CJ, Hruban RH, Pitt HA, Niederhuber JE, Coleman J, Cameron JL
Surg Gynecol Obstet 1993 Sep;177(3):269-78. PMID: 8102815
Harris AG
Metabolism 1990 Sep;39(9 Suppl 2):180-5. doi: 10.1016/0026-0495(90)90241-4. PMID: 2205787

Prognosis

Damaskos C, Dimitroulis D, Garmpi A, Antoniou EA, Kouraklis G, Psilopatis I, Mavri M, Diamantis E, Marinos G, Kyriakos G, Farmaki P, Patsouras A, Kontzoglou K, Garmpis N
In Vivo 2023 Nov-Dec;37(6):2402-2408. doi: 10.21873/invivo.13345. PMID: 37905620Free PMC Article
Lam AK, Ishida H
Histol Histopathol 2021 Apr;36(4):367-382. Epub 2020 Dec 11 doi: 10.14670/HH-18-288. PMID: 33305819
Ro C, Chai W, Yu VE, Yu R
Chin J Cancer 2013 Jun;32(6):312-24. Epub 2012 Dec 14 doi: 10.5732/cjc.012.10295. PMID: 23237225Free PMC Article
Morgan KA, Adams DB
Surg Clin North Am 2010 Apr;90(2):287-307. doi: 10.1016/j.suc.2009.12.009. PMID: 20362787
Lips CJ, Vasen HF, Lamers CB
Crit Rev Oncol Hematol 1984;2(2):117-84. doi: 10.1016/s1040-8428(84)80017-7. PMID: 6152202

Clinical prediction guides

Murakami M, Fujimori N, Matsumoto K, Ohno A, Teramatsu K, Takamatsu Y, Takeno A, Ueda K, Oono T, Ito T, Ogawa Y
Endocr J 2022 Oct 28;69(10):1201-1209. Epub 2022 May 27 doi: 10.1507/endocrj.EJ22-0111. PMID: 35644576
de Mestier L, Walter T, Brixi H, Lombard-Bohas C, Cadiot G
Eur J Endocrinol 2015 Jan;172(1):K1-3. Epub 2014 Oct 10 doi: 10.1530/EJE-14-0682. PMID: 25305306
Kanakis G, Kaltsas G
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):791-802. doi: 10.1016/j.bpg.2012.12.006. PMID: 23582919
de Graaf JH, Tamminga RY, Kamps WA
Eur J Pediatr 1994 Nov;153(11):784-91. doi: 10.1007/BF01972883. PMID: 7843190
Krejs GJ
Am J Med 1987 May 29;82(5B):37-48. doi: 10.1016/0002-9343(87)90425-6. PMID: 3035922

Recent systematic reviews

Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985

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