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Dientamoebiasis

MedGen UID:
41551
•Concept ID:
C0012147
•
Disease or Syndrome
Synonym: Dientamoebiases
 
Monarch Initiative: MONDO:0024608

Definition

Gastrointestinal infection with organisms of the genus dientamoeba. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDientamoebiasis

Professional guidelines

PubMed

Dientamoeba fragilis in children: a systematic review on diagnostic considerations and efficacy of treatment.
van Kalleveen MW, van Gool T, Klarenbeek N, Benninga MA, Savelkoul PHM, de Meij T, Plötz FB
Expert Rev Gastroenterol Hepatol 2020 Apr;14(4):231-242. Epub 2020 Mar 21 doi: 10.1080/17474124.2020.1739520. PMID: 32155096

Recent clinical studies

Etiology

Dientamoeba fragilis - the most common intestinal protozoan in the Helsinki Metropolitan Area, Finland, 2007 to 2017.
Pietilä JP, Meri T, Siikamäki H, Tyyni E, Kerttula AM, Pakarinen L, Jokiranta TS, Kantele A
Euro Surveill 2019 Jul;24(29) doi: 10.2807/1560-7917.ES.2019.24.29.1800546. PMID: 31339096Free PMC Article
Dientamoeba fragilis, One of the Neglected Intestinal Protozoa.
Garcia LS
J Clin Microbiol 2016 Sep;54(9):2243-50. Epub 2016 Apr 6 doi: 10.1128/JCM.00400-16. PMID: 27053676Free PMC Article
Metronidazole therapy for treating dientamoebiasis in children is not associated with better clinical outcomes: a randomized, double-blinded and placebo-controlled clinical trial.
Röser D, Simonsen J, Stensvold CR, Olsen KE, Bytzer P, Nielsen HV, Mølbak K
Clin Infect Dis 2014 Jun;58(12):1692-9. Epub 2014 Mar 18 doi: 10.1093/cid/ciu188. PMID: 24647023
A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis.
Kurt O, Girginkardeşler N, Balcioğlu IC, Ozbilgin A, Ok UZ
Clin Microbiol Infect 2008 Jun;14(6):601-4. Epub 2008 Apr 5 doi: 10.1111/j.1469-0691.2008.02002.x. PMID: 18397330
Clinical and microbiological features of dientamoebiasis in patients suspected of suffering from a parasitic gastrointestinal illness: a comparison of Dientamoeba fragilis and Giardia lamblia infections.
Vandenberg O, Peek R, Souayah H, Dediste A, Buset M, Scheen R, Retore P, Zissis G, van Gool T
Int J Infect Dis 2006 May;10(3):255-61. Epub 2006 Feb 15 doi: 10.1016/j.ijid.2005.05.011. PMID: 16469517

Diagnosis

Dientamoeba fragilis - the most common intestinal protozoan in the Helsinki Metropolitan Area, Finland, 2007 to 2017.
Pietilä JP, Meri T, Siikamäki H, Tyyni E, Kerttula AM, Pakarinen L, Jokiranta TS, Kantele A
Euro Surveill 2019 Jul;24(29) doi: 10.2807/1560-7917.ES.2019.24.29.1800546. PMID: 31339096Free PMC Article
A clinical guideline on Dientamoeba fragilis infections.
van Gestel RS, Kusters JG, Monkelbaan JF
Parasitology 2019 Aug;146(9):1131-1139. Epub 2018 Aug 31 doi: 10.1017/S0031182018001385. PMID: 30165915
Molecular epidemiology of Dientamoeba fragilis.
Cacciò SM
Acta Trop 2018 Aug;184:73-77. Epub 2017 Jul 8 doi: 10.1016/j.actatropica.2017.06.029. PMID: 28697994
Dientamoeba fragilis, the Neglected Trichomonad of the Human Bowel.
Stark D, Barratt J, Chan D, Ellis JT
Clin Microbiol Rev 2016 Jul;29(3):553-80. doi: 10.1128/CMR.00076-15. PMID: 27170141Free PMC Article
Dientamoebiasis: clinical importance and recent advances.
Stark DJ, Beebe N, Marriott D, Ellis JT, Harkness J
Trends Parasitol 2006 Feb;22(2):92-6. Epub 2005 Dec 27 doi: 10.1016/j.pt.2005.12.001. PMID: 16380293

Therapy

A clinical guideline on Dientamoeba fragilis infections.
van Gestel RS, Kusters JG, Monkelbaan JF
Parasitology 2019 Aug;146(9):1131-1139. Epub 2018 Aug 31 doi: 10.1017/S0031182018001385. PMID: 30165915
Dientamoeba fragilis, One of the Neglected Intestinal Protozoa.
Garcia LS
J Clin Microbiol 2016 Sep;54(9):2243-50. Epub 2016 Apr 6 doi: 10.1128/JCM.00400-16. PMID: 27053676Free PMC Article
Metronidazole therapy for treating dientamoebiasis in children is not associated with better clinical outcomes: a randomized, double-blinded and placebo-controlled clinical trial.
Röser D, Simonsen J, Stensvold CR, Olsen KE, Bytzer P, Nielsen HV, Mølbak K
Clin Infect Dis 2014 Jun;58(12):1692-9. Epub 2014 Mar 18 doi: 10.1093/cid/ciu188. PMID: 24647023
A review of the clinical presentation of dientamoebiasis.
Stark D, Barratt J, Roberts T, Marriott D, Harkness J, Ellis J
Am J Trop Med Hyg 2010 Apr;82(4):614-9. doi: 10.4269/ajtmh.2010.09-0478. PMID: 20348509Free PMC Article
A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis.
Kurt O, Girginkardeşler N, Balcioğlu IC, Ozbilgin A, Ok UZ
Clin Microbiol Infect 2008 Jun;14(6):601-4. Epub 2008 Apr 5 doi: 10.1111/j.1469-0691.2008.02002.x. PMID: 18397330

Prognosis

Fecal calprotectin as a factor that supports the pathogenicity of Dientamoeba fragilis.
Aykur M, Armagan G, Vardar R, Dagci H
Microb Pathog 2020 Feb;139:103868. Epub 2019 Nov 12 doi: 10.1016/j.micpath.2019.103868. PMID: 31730996
Dientamoeba fragilis, One of the Neglected Intestinal Protozoa.
Garcia LS
J Clin Microbiol 2016 Sep;54(9):2243-50. Epub 2016 Apr 6 doi: 10.1128/JCM.00400-16. PMID: 27053676Free PMC Article
Metronidazole therapy for treating dientamoebiasis in children is not associated with better clinical outcomes: a randomized, double-blinded and placebo-controlled clinical trial.
Röser D, Simonsen J, Stensvold CR, Olsen KE, Bytzer P, Nielsen HV, Mølbak K
Clin Infect Dis 2014 Jun;58(12):1692-9. Epub 2014 Mar 18 doi: 10.1093/cid/ciu188. PMID: 24647023
Transmission of Dientamoeba fragilis: pinworm or cysts?
Clark CG, Röser D, Stensvold CR
Trends Parasitol 2014 Mar;30(3):136-40. Epub 2014 Jan 31 doi: 10.1016/j.pt.2014.01.005. PMID: 24492020
A case-controlled study of Dientamoeba fragilis infections in children.
Banik GR, Barratt JL, Marriott D, Harkness J, Ellis JT, Stark D
Parasitology 2011 Jun;138(7):819-23. Epub 2011 Apr 27 doi: 10.1017/S0031182011000448. PMID: 21524324

Clinical prediction guides

A Cross-Sectional Study on the Occurrence of the Intestinal Protist, Dientamoeba fragilis, in the Gut-Healthy Volunteers and Their Animals.
Jirků M, Kašparová A, Lhotská Z, Oborník M, Brožová K, Petrželková KJ, Samaš P, Kadlecová O, Stensvold CR, Jirků K
Int J Mol Sci 2022 Dec 6;23(23) doi: 10.3390/ijms232315407. PMID: 36499734Free PMC Article
Prevalence and genetic characterization of Dientamoeba fragilis in asymptomatic children attending daycare centers.
Oliveira-Arbex AP, David ÉB, Cacciò SM, Fonseca CRBD, Martin JG, Kurokawa CS, Tosini F, Souza Neto JA, Guimarães S
Rev Inst Med Trop Sao Paulo 2021;63:e39. Epub 2021 May 7 doi: 10.1590/S1678-9946202163039. PMID: 33978095Free PMC Article
Clinical and Epidemiological Characteristics of Patients with Dientamoeba fragilis Infection.
Miguel L, Salvador F, Sulleiro E, Sánchez-Montalvá A, Molina-Morant D, López I, Molina I
Am J Trop Med Hyg 2018 Nov;99(5):1170-1173. doi: 10.4269/ajtmh.18-0433. PMID: 30328410Free PMC Article
The role of Blastocystis sp. and Dientamoeba fragilis in irritable bowel syndrome: a systematic review and meta-analysis.
Rostami A, Riahi SM, Haghighi A, Saber V, Armon B, Seyyedtabaei SJ
Parasitol Res 2017 Sep;116(9):2361-2371. Epub 2017 Jul 1 doi: 10.1007/s00436-017-5535-6. PMID: 28668983
Transmission of Dientamoeba fragilis: pinworm or cysts?
Clark CG, Röser D, Stensvold CR
Trends Parasitol 2014 Mar;30(3):136-40. Epub 2014 Jan 31 doi: 10.1016/j.pt.2014.01.005. PMID: 24492020

Recent systematic reviews

Dientamoeba fragilis in children: a systematic review on diagnostic considerations and efficacy of treatment.
van Kalleveen MW, van Gool T, Klarenbeek N, Benninga MA, Savelkoul PHM, de Meij T, Plötz FB
Expert Rev Gastroenterol Hepatol 2020 Apr;14(4):231-242. Epub 2020 Mar 21 doi: 10.1080/17474124.2020.1739520. PMID: 32155096
Does Dientamoeba fragilis cause diarrhea? A systematic review.
Wong ZW, Faulder K, Robinson JL
Parasitol Res 2018 Apr;117(4):971-980. Epub 2018 Feb 5 doi: 10.1007/s00436-018-5771-4. PMID: 29404747
The role of Blastocystis sp. and Dientamoeba fragilis in irritable bowel syndrome: a systematic review and meta-analysis.
Rostami A, Riahi SM, Haghighi A, Saber V, Armon B, Seyyedtabaei SJ
Parasitol Res 2017 Sep;116(9):2361-2371. Epub 2017 Jul 1 doi: 10.1007/s00436-017-5535-6. PMID: 28668983

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