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Oropharyngeal Human Papillomavirus-Positive Squamous Cell Carcinoma

MedGen UID:
415751
Concept ID:
C2828150
Neoplastic Process
Synonyms: HPV-Associated Oropharyngeal Squamous Cell Carcinoma; HPV-Positive Oropharyngeal Squamous Cell Carcinoma; Human Papilloma Virus Associated Oropharyngeal Squamous Cell Carcinoma; Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma; Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma; Oropharyngeal HPV-Positive Squamous Cell Carcinoma; Oropharyngeal Human Papillomavirus Positive Squamous Cell Carcinoma

Definition

A squamous cell carcinoma that arises from the oropharynx and is associated with human papillomavirus type 16 infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOropharyngeal Human Papillomavirus-Positive Squamous Cell Carcinoma

Professional guidelines

PubMed

Zhan KY, Puram SV, Li MM, Silverman DA, Agrawal AA, Ozer E, Old MO, Carrau RL, Rocco JW, Higgins KM, Enepekides DJ, Husain Z, Kang SY, Eskander A
Cancer 2020 Mar 15;126(6):1295-1305. Epub 2019 Dec 11 doi: 10.1002/cncr.32654. PMID: 31825543
Stock GT, Bonadio RRCC, de Castro G Junior
Curr Opin Oncol 2018 May;30(3):146-151. doi: 10.1097/CCO.0000000000000441. PMID: 29474271
Walvik L, Svensson AB, Friborg J, Lajer CB
Oral Oncol 2016 Dec;63:61-65. Epub 2016 Nov 16 doi: 10.1016/j.oraloncology.2016.11.003. PMID: 27939001

Recent clinical studies

Etiology

Lim YX, Mierzwa ML, Sartor MA, D'Silva NJ
Oncogene 2023 Sep;42(40):2939-2955. Epub 2023 Sep 4 doi: 10.1038/s41388-023-02819-y. PMID: 37666939Free PMC Article
Caprini E, D'Agnese G, Brennan PA, Rahimi S
J Oral Pathol Med 2023 Apr;52(4):300-304. Epub 2023 Mar 13 doi: 10.1111/jop.13419. PMID: 36847112
Gillison ML, Trotti AM, Harris J, Eisbruch A, Harari PM, Adelstein DJ, Jordan RCK, Zhao W, Sturgis EM, Burtness B, Ridge JA, Ringash J, Galvin J, Yao M, Koyfman SA, Blakaj DM, Razaq MA, Colevas AD, Beitler JJ, Jones CU, Dunlap NE, Seaward SA, Spencer S, Galloway TJ, Phan J, Dignam JJ, Le QT
Lancet 2019 Jan 5;393(10166):40-50. Epub 2018 Nov 15 doi: 10.1016/S0140-6736(18)32779-X. PMID: 30449625Free PMC Article
Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, Dalby M, Mistry P, Sen M, O'Toole L, Al Booz H, Dyker K, Moleron R, Whitaker S, Brennan S, Cook A, Griffin M, Aynsley E, Rolles M, De Winton E, Chan A, Srinivasan D, Nixon I, Grumett J, Leemans CR, Buter J, Henderson J, Harrington K, McConkey C, Gray A, Dunn J; De-ESCALaTE HPV Trial Group
Lancet 2019 Jan 5;393(10166):51-60. Epub 2018 Nov 15 doi: 10.1016/S0140-6736(18)32752-1. PMID: 30449623Free PMC Article
Albergotti WG, Davis KS, Abberbock S, Bauman JE, Ohr J, Clump DA, Heron DE, Duvvuri U, Kim S, Johnson JT, Ferris RL
Oral Oncol 2016 Sep;60:55-60. Epub 2016 Jul 7 doi: 10.1016/j.oraloncology.2016.07.003. PMID: 27531873Free PMC Article

Diagnosis

Allevato MM, Smith JD, Brenner MJ, Chinn SB
Cancer J 2023 Jul-Aug 01;29(4):230-237. doi: 10.1097/PPO.0000000000000671. PMID: 37471614Free PMC Article
Caprini E, D'Agnese G, Brennan PA, Rahimi S
J Oral Pathol Med 2023 Apr;52(4):300-304. Epub 2023 Mar 13 doi: 10.1111/jop.13419. PMID: 36847112
Ferris RL, Westra W
Annu Rev Pathol 2023 Jan 24;18:515-535. doi: 10.1146/annurev-pathmechdis-031521-041424. PMID: 36693202
Madrigal E, Bishop JA, Faquin WC
Surg Pathol Clin 2018 Sep;11(3):501-514. doi: 10.1016/j.path.2018.04.002. PMID: 30190137
Anayannis NV, Schlecht NF, Belbin TJ
Arch Pathol Lab Med 2015 Nov;139(11):1373-8. Epub 2015 May 15 doi: 10.5858/arpa.2014-0554-RA. PMID: 25978766

Therapy

Quan DL, Grauer JS, Sunkara PR, Cramer JD
Cancer 2023 Feb 1;129(3):376-384. Epub 2022 Nov 19 doi: 10.1002/cncr.34562. PMID: 36401615
Näsman A, Holzhauser S, Kostopoulou ON, Zupancic M, Ährlund-Richter A, Du J, Dalianis T
Viruses 2021 May 14;13(5) doi: 10.3390/v13050910. PMID: 34069114Free PMC Article
Gillison ML, Trotti AM, Harris J, Eisbruch A, Harari PM, Adelstein DJ, Jordan RCK, Zhao W, Sturgis EM, Burtness B, Ridge JA, Ringash J, Galvin J, Yao M, Koyfman SA, Blakaj DM, Razaq MA, Colevas AD, Beitler JJ, Jones CU, Dunlap NE, Seaward SA, Spencer S, Galloway TJ, Phan J, Dignam JJ, Le QT
Lancet 2019 Jan 5;393(10166):40-50. Epub 2018 Nov 15 doi: 10.1016/S0140-6736(18)32779-X. PMID: 30449625Free PMC Article
Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, Dalby M, Mistry P, Sen M, O'Toole L, Al Booz H, Dyker K, Moleron R, Whitaker S, Brennan S, Cook A, Griffin M, Aynsley E, Rolles M, De Winton E, Chan A, Srinivasan D, Nixon I, Grumett J, Leemans CR, Buter J, Henderson J, Harrington K, McConkey C, Gray A, Dunn J; De-ESCALaTE HPV Trial Group
Lancet 2019 Jan 5;393(10166):51-60. Epub 2018 Nov 15 doi: 10.1016/S0140-6736(18)32752-1. PMID: 30449623Free PMC Article
Stock GT, Bonadio RRCC, de Castro G Junior
Curr Opin Oncol 2018 May;30(3):146-151. doi: 10.1097/CCO.0000000000000441. PMID: 29474271

Prognosis

Allevato MM, Smith JD, Brenner MJ, Chinn SB
Cancer J 2023 Jul-Aug 01;29(4):230-237. doi: 10.1097/PPO.0000000000000671. PMID: 37471614Free PMC Article
Caprini E, D'Agnese G, Brennan PA, Rahimi S
J Oral Pathol Med 2023 Apr;52(4):300-304. Epub 2023 Mar 13 doi: 10.1111/jop.13419. PMID: 36847112
Ferris RL, Westra W
Annu Rev Pathol 2023 Jan 24;18:515-535. doi: 10.1146/annurev-pathmechdis-031521-041424. PMID: 36693202
Albergotti WG, Davis KS, Abberbock S, Bauman JE, Ohr J, Clump DA, Heron DE, Duvvuri U, Kim S, Johnson JT, Ferris RL
Oral Oncol 2016 Sep;60:55-60. Epub 2016 Jul 7 doi: 10.1016/j.oraloncology.2016.07.003. PMID: 27531873Free PMC Article
Wang MB, Liu IY, Gornbein JA, Nguyen CT
Otolaryngol Head Neck Surg 2015 Nov;153(5):758-69. Epub 2015 Jun 29 doi: 10.1177/0194599815592157. PMID: 26124261

Clinical prediction guides

Allevato MM, Smith JD, Brenner MJ, Chinn SB
Cancer J 2023 Jul-Aug 01;29(4):230-237. doi: 10.1097/PPO.0000000000000671. PMID: 37471614Free PMC Article
Badaoui JN, Yin LX, Sauer AB, Moore EJ, Lohse CM, Price DL, Kasperbauer JL, Noel DB, Olsen KD, Van Abel KM
Otolaryngol Head Neck Surg 2022 Sep;167(3):509-516. Epub 2022 Jan 18 doi: 10.1177/01945998211071000. PMID: 35041566
Zhan KY, Puram SV, Li MM, Silverman DA, Agrawal AA, Ozer E, Old MO, Carrau RL, Rocco JW, Higgins KM, Enepekides DJ, Husain Z, Kang SY, Eskander A
Cancer 2020 Mar 15;126(6):1295-1305. Epub 2019 Dec 11 doi: 10.1002/cncr.32654. PMID: 31825543
Walvik L, Svensson AB, Friborg J, Lajer CB
Oral Oncol 2016 Dec;63:61-65. Epub 2016 Nov 16 doi: 10.1016/j.oraloncology.2016.11.003. PMID: 27939001
Wang MB, Liu IY, Gornbein JA, Nguyen CT
Otolaryngol Head Neck Surg 2015 Nov;153(5):758-69. Epub 2015 Jun 29 doi: 10.1177/0194599815592157. PMID: 26124261

Recent systematic reviews

Morey T, Hodge JC, Stern C, Krishnan S, Foreman A
Head Neck 2022 Dec;44(12):2875-2885. Epub 2022 Sep 7 doi: 10.1002/hed.27183. PMID: 36071683Free PMC Article
Bollig CA, Lee DS, Mazul AL, Stepan K, Puram SV, Massa ST, Zenga J, Faden DL, Doering MM, Jackson RS, Pipkorn P
Otolaryngol Head Neck Surg 2021 Apr;164(4):733-740. Epub 2020 Sep 15 doi: 10.1177/0194599820951175. PMID: 32928026
Tiedemann D, Jakobsen KK, von Buchwald C, Grønhøj C
Head Neck 2019 Mar;41(3):793-798. Epub 2018 Dec 23 doi: 10.1002/hed.25458. PMID: 30582231
Wang MB, Liu IY, Gornbein JA, Nguyen CT
Otolaryngol Head Neck Surg 2015 Nov;153(5):758-69. Epub 2015 Jun 29 doi: 10.1177/0194599815592157. PMID: 26124261
Petrelli F, Sarti E, Barni S
Head Neck 2014 May;36(5):750-9. Epub 2013 Oct 7 doi: 10.1002/hed.23351. PMID: 23606404

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