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Adverse Event by CTCAE v4 Severity Grade

MedGen UID:
415977
•Concept ID:
C2827351
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdverse Event by CTCAE v4 Severity Grade

Professional guidelines

PubMed

Impact of Breast Cancer Treatment on Employment: Results of a Multicenter Prospective Cohort Study (CANTO).
Dumas A, Vaz Luis I, Bovagnet T, El Mouhebb M, Di Meglio A, Pinto S, Charles C, Dauchy S, Delaloge S, Arveux P, Coutant C, Cottu P, Lesur A, Lerebours F, Tredan O, Vanlemmens L, Levy C, Lemonnier J, Mesleard C, Andre F, Menvielle G
J Clin Oncol 2020 Mar 1;38(7):734-743. Epub 2019 Dec 13 doi: 10.1200/JCO.19.01726. PMID: 31834818Free PMC Article
Outcomes of everolimus treatment for renal angiomyolipoma associated with tuberous sclerosis complex: A single institution experience in Japan.
Hatano T, Chikaraishi K, Inaba H, Endo K, Egawa S
Int J Urol 2016 Oct;23(10):833-838. Epub 2016 Aug 1 doi: 10.1111/iju.13168. PMID: 27480662

Recent clinical studies

Etiology

Extent of extravasation: Patients on parenteral plant alkaloids.
Somayaji S, Reddy SS, Murthy MK, Maka VV
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S841-S844. Epub 2023 Dec 15 doi: 10.4103/jcrt.JCRT_457_19. PMID: 38384064
Hand-foot syndrome induced by chemotherapy drug: Case series study and literature review.
Zaiem A, Hammamia SB, Aouinti I, Charfi O, Ladhari W, Kastalli S, Aidli SE, Lakhoua G
Indian J Pharmacol 2022 May-Jun;54(3):208-215. doi: 10.4103/ijp.ijp_175_21. PMID: 35848692Free PMC Article
Concordance of the WHO, RTOG, and CTCAE v4.0 grading scales for the evaluation of oral mucositis associated with chemoradiation therapy for the treatment of oral and oropharyngeal cancers.
Villa A, Vollemans M, De Moraes A, Sonis S
Support Care Cancer 2021 Oct;29(10):6061-6068. Epub 2021 Mar 31 doi: 10.1007/s00520-021-06177-x. PMID: 33788003
Real-world efficacy and safety of nivolumab in previously-treated metastatic renal cell carcinoma, and association between immune-related adverse events and survival: the Italian expanded access program.
Verzoni E, Cartenì G, Cortesi E, Giannarelli D, De Giglio A, Sabbatini R, Buti S, Rossetti S, Cognetti F, Rastelli F, Sobrero A, Turci D, Sternberg CN, Porta C, Cappuzzo F, Tortora G, Tassinari D, Panni S, Pazzola A, Surico G, Raimondi A, De Giorgi U, Procopio G; Italian Nivolumab Renal Cell Cancer Early Access Program group
J Immunother Cancer 2019 Apr 3;7(1):99. doi: 10.1186/s40425-019-0579-z. PMID: 30944023Free PMC Article
Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort.
Hudson MM, Ehrhardt MJ, Bhakta N, Baassiri M, Eissa H, Chemaitilly W, Green DM, Mulrooney DA, Armstrong GT, Brinkman TM, Klosky JL, Krull KR, Sabin ND, Wilson CL, Huang IC, Bass JK, Hale K, Kaste S, Khan RB, Srivastava DK, Yasui Y, Joshi VM, Srinivasan S, Stokes D, Hoehn ME, Wilson M, Ness KK, Robison LL
Cancer Epidemiol Biomarkers Prev 2017 May;26(5):666-674. Epub 2016 Dec 29 doi: 10.1158/1055-9965.EPI-16-0812. PMID: 28035022Free PMC Article

Diagnosis

Concordance of the WHO, RTOG, and CTCAE v4.0 grading scales for the evaluation of oral mucositis associated with chemoradiation therapy for the treatment of oral and oropharyngeal cancers.
Villa A, Vollemans M, De Moraes A, Sonis S
Support Care Cancer 2021 Oct;29(10):6061-6068. Epub 2021 Mar 31 doi: 10.1007/s00520-021-06177-x. PMID: 33788003
Impact of Breast Cancer Treatment on Employment: Results of a Multicenter Prospective Cohort Study (CANTO).
Dumas A, Vaz Luis I, Bovagnet T, El Mouhebb M, Di Meglio A, Pinto S, Charles C, Dauchy S, Delaloge S, Arveux P, Coutant C, Cottu P, Lesur A, Lerebours F, Tredan O, Vanlemmens L, Levy C, Lemonnier J, Mesleard C, Andre F, Menvielle G
J Clin Oncol 2020 Mar 1;38(7):734-743. Epub 2019 Dec 13 doi: 10.1200/JCO.19.01726. PMID: 31834818Free PMC Article
Real-world efficacy and safety of nivolumab in previously-treated metastatic renal cell carcinoma, and association between immune-related adverse events and survival: the Italian expanded access program.
Verzoni E, Cartenì G, Cortesi E, Giannarelli D, De Giglio A, Sabbatini R, Buti S, Rossetti S, Cognetti F, Rastelli F, Sobrero A, Turci D, Sternberg CN, Porta C, Cappuzzo F, Tortora G, Tassinari D, Panni S, Pazzola A, Surico G, Raimondi A, De Giorgi U, Procopio G; Italian Nivolumab Renal Cell Cancer Early Access Program group
J Immunother Cancer 2019 Apr 3;7(1):99. doi: 10.1186/s40425-019-0579-z. PMID: 30944023Free PMC Article
Evaluation of Bortezomib-Induced Neuropathy Using Total Neuropathy Score (Reduced and Clinical Versions) and NCI CTCAE v4.0 in Newly Diagnosed Patients With Multiple Myeloma Receiving Bortezomib-Based Induction.
Lakshman A, Modi M, Prakash G, Malhotra P, Khadwal A, Jain S, Kumari S, Varma N, Varma S
Clin Lymphoma Myeloma Leuk 2017 Aug;17(8):513-519.e1. Epub 2017 Jul 6 doi: 10.1016/j.clml.2017.06.035. PMID: 28842138
Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort.
Hudson MM, Ehrhardt MJ, Bhakta N, Baassiri M, Eissa H, Chemaitilly W, Green DM, Mulrooney DA, Armstrong GT, Brinkman TM, Klosky JL, Krull KR, Sabin ND, Wilson CL, Huang IC, Bass JK, Hale K, Kaste S, Khan RB, Srivastava DK, Yasui Y, Joshi VM, Srinivasan S, Stokes D, Hoehn ME, Wilson M, Ness KK, Robison LL
Cancer Epidemiol Biomarkers Prev 2017 May;26(5):666-674. Epub 2016 Dec 29 doi: 10.1158/1055-9965.EPI-16-0812. PMID: 28035022Free PMC Article

Therapy

Association between dermatologic adverse events and quality of life in lung cancer patients treated with epidermal growth factor receptor-tyrosine kinase inhibitors.
Hsu HT, Yu CC, Lee YH, Chan JC, Chu CY
Support Care Cancer 2022 Nov;30(11):9211-9219. Epub 2022 Sep 3 doi: 10.1007/s00520-022-07347-1. PMID: 36056941
Concordance of the WHO, RTOG, and CTCAE v4.0 grading scales for the evaluation of oral mucositis associated with chemoradiation therapy for the treatment of oral and oropharyngeal cancers.
Villa A, Vollemans M, De Moraes A, Sonis S
Support Care Cancer 2021 Oct;29(10):6061-6068. Epub 2021 Mar 31 doi: 10.1007/s00520-021-06177-x. PMID: 33788003
Taxane-induced peripheral neuropathy and quality of life in breast cancer patients.
Salehifar E, Janbabaei G, Alipour A, Tabrizi N, Avan R
J Oncol Pharm Pract 2020 Sep;26(6):1421-1428. Epub 2020 Jan 14 doi: 10.1177/1078155219898511. PMID: 31937190
Evaluation of Bortezomib-Induced Neuropathy Using Total Neuropathy Score (Reduced and Clinical Versions) and NCI CTCAE v4.0 in Newly Diagnosed Patients With Multiple Myeloma Receiving Bortezomib-Based Induction.
Lakshman A, Modi M, Prakash G, Malhotra P, Khadwal A, Jain S, Kumari S, Varma N, Varma S
Clin Lymphoma Myeloma Leuk 2017 Aug;17(8):513-519.e1. Epub 2017 Jul 6 doi: 10.1016/j.clml.2017.06.035. PMID: 28842138
Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort.
Hudson MM, Ehrhardt MJ, Bhakta N, Baassiri M, Eissa H, Chemaitilly W, Green DM, Mulrooney DA, Armstrong GT, Brinkman TM, Klosky JL, Krull KR, Sabin ND, Wilson CL, Huang IC, Bass JK, Hale K, Kaste S, Khan RB, Srivastava DK, Yasui Y, Joshi VM, Srinivasan S, Stokes D, Hoehn ME, Wilson M, Ness KK, Robison LL
Cancer Epidemiol Biomarkers Prev 2017 May;26(5):666-674. Epub 2016 Dec 29 doi: 10.1158/1055-9965.EPI-16-0812. PMID: 28035022Free PMC Article

Prognosis

Extent of extravasation: Patients on parenteral plant alkaloids.
Somayaji S, Reddy SS, Murthy MK, Maka VV
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S841-S844. Epub 2023 Dec 15 doi: 10.4103/jcrt.JCRT_457_19. PMID: 38384064
Hand-foot syndrome induced by chemotherapy drug: Case series study and literature review.
Zaiem A, Hammamia SB, Aouinti I, Charfi O, Ladhari W, Kastalli S, Aidli SE, Lakhoua G
Indian J Pharmacol 2022 May-Jun;54(3):208-215. doi: 10.4103/ijp.ijp_175_21. PMID: 35848692Free PMC Article
Taxane-induced peripheral neuropathy and quality of life in breast cancer patients.
Salehifar E, Janbabaei G, Alipour A, Tabrizi N, Avan R
J Oncol Pharm Pract 2020 Sep;26(6):1421-1428. Epub 2020 Jan 14 doi: 10.1177/1078155219898511. PMID: 31937190
Real-world efficacy and safety of nivolumab in previously-treated metastatic renal cell carcinoma, and association between immune-related adverse events and survival: the Italian expanded access program.
Verzoni E, Cartenì G, Cortesi E, Giannarelli D, De Giglio A, Sabbatini R, Buti S, Rossetti S, Cognetti F, Rastelli F, Sobrero A, Turci D, Sternberg CN, Porta C, Cappuzzo F, Tortora G, Tassinari D, Panni S, Pazzola A, Surico G, Raimondi A, De Giorgi U, Procopio G; Italian Nivolumab Renal Cell Cancer Early Access Program group
J Immunother Cancer 2019 Apr 3;7(1):99. doi: 10.1186/s40425-019-0579-z. PMID: 30944023Free PMC Article
Iodine-125 seed brachytherapy for early stage prostate cancer: a single-institution review.
Zuber S, Weiß S, Baaske D, Schöpe M, Stevens S, Bodis S, Zwahlen DR
Radiat Oncol 2015 Feb 22;10:49. doi: 10.1186/s13014-015-0349-0. PMID: 25880809Free PMC Article

Clinical prediction guides

Extent of extravasation: Patients on parenteral plant alkaloids.
Somayaji S, Reddy SS, Murthy MK, Maka VV
J Cancer Res Ther 2023 Jan 1;19(Suppl 2):S841-S844. Epub 2023 Dec 15 doi: 10.4103/jcrt.JCRT_457_19. PMID: 38384064
Intestinal Microbiome Associated With Immune-Related Adverse Events for Patients Treated With Anti-PD-1 Inhibitors, a Real-World Study.
Liu W, Ma F, Sun B, Liu Y, Tang H, Luo J, Chen H, Luo Z
Front Immunol 2021;12:756872. Epub 2021 Dec 16 doi: 10.3389/fimmu.2021.756872. PMID: 34975845Free PMC Article
Concordance of the WHO, RTOG, and CTCAE v4.0 grading scales for the evaluation of oral mucositis associated with chemoradiation therapy for the treatment of oral and oropharyngeal cancers.
Villa A, Vollemans M, De Moraes A, Sonis S
Support Care Cancer 2021 Oct;29(10):6061-6068. Epub 2021 Mar 31 doi: 10.1007/s00520-021-06177-x. PMID: 33788003
Immune effector cell-associated neurotoxicity syndrome after chimeric antigen receptor T-cell therapy for lymphoma: predictive biomarkers and clinical outcomes.
Holtzman NG, Xie H, Bentzen S, Kesari V, Bukhari A, El Chaer F, Lutfi F, Siglin J, Hutnick E, Gahres N, Ruehle K, Ahmad H, Shanholtz C, Kocoglu MH, Badros AZ, Yared JA, Hardy NM, Rapoport AP, Dahiya S
Neuro Oncol 2021 Jan 30;23(1):112-121. doi: 10.1093/neuonc/noaa183. PMID: 32750704Free PMC Article
Evaluation of Bortezomib-Induced Neuropathy Using Total Neuropathy Score (Reduced and Clinical Versions) and NCI CTCAE v4.0 in Newly Diagnosed Patients With Multiple Myeloma Receiving Bortezomib-Based Induction.
Lakshman A, Modi M, Prakash G, Malhotra P, Khadwal A, Jain S, Kumari S, Varma N, Varma S
Clin Lymphoma Myeloma Leuk 2017 Aug;17(8):513-519.e1. Epub 2017 Jul 6 doi: 10.1016/j.clml.2017.06.035. PMID: 28842138

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