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Central Nervous System Signs and Symptoms

MedGen UID:
416166
•Concept ID:
C2828177
•
Sign or Symptom

Definition

Signs and symptoms associated with disturbances within the central nervous system, which includes the brain, spinal cord and meninges. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Signs and Symptoms

Professional guidelines

PubMed

The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy.
Wenning GK, Stankovic I, Vignatelli L, Fanciulli A, Calandra-Buonaura G, Seppi K, Palma JA, Meissner WG, Krismer F, Berg D, Cortelli P, Freeman R, Halliday G, Höglinger G, Lang A, Ling H, Litvan I, Low P, Miki Y, Panicker J, Pellecchia MT, Quinn N, Sakakibara R, Stamelou M, Tolosa E, Tsuji S, Warner T, Poewe W, Kaufmann H
Mov Disord 2022 Jun;37(6):1131-1148. Epub 2022 Apr 21 doi: 10.1002/mds.29005. PMID: 35445419Free PMC Article
Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update).
Bhattacharyya N, Gubbels SP, Schwartz SR, Edlow JA, El-Kashlan H, Fife T, Holmberg JM, Mahoney K, Hollingsworth DB, Roberts R, Seidman MD, Steiner RW, Do BT, Voelker CC, Waguespack RW, Corrigan MD
Otolaryngol Head Neck Surg 2017 Mar;156(3_suppl):S1-S47. doi: 10.1177/0194599816689667. PMID: 28248609

Recent clinical studies

Etiology

Brain-First versus Gut-First Parkinson's Disease: A Hypothesis.
Borghammer P, Van Den Berge N
J Parkinsons Dis 2019;9(s2):S281-S295. doi: 10.3233/JPD-191721. PMID: 31498132Free PMC Article
Inflammation in the pathophysiology of neuropathic pain.
Sommer C, Leinders M, Üçeyler N
Pain 2018 Mar;159(3):595-602. doi: 10.1097/j.pain.0000000000001122. PMID: 29447138
Symptoms of menopause - global prevalence, physiology and implications.
Monteleone P, Mascagni G, Giannini A, Genazzani AR, Simoncini T
Nat Rev Endocrinol 2018 Apr;14(4):199-215. Epub 2018 Feb 2 doi: 10.1038/nrendo.2017.180. PMID: 29393299
Central sensitization in chronic low back pain: A narrative review.
Sanzarello I, Merlini L, Rosa MA, Perrone M, Frugiuele J, Borghi R, Faldini C
J Back Musculoskelet Rehabil 2016 Nov 21;29(4):625-633. doi: 10.3233/BMR-160685. PMID: 27062464
Outpatient management of alcohol withdrawal syndrome.
Muncie HL Jr, Yasinian Y, Oge' L
Am Fam Physician 2013 Nov 1;88(9):589-95. PMID: 24364635

Diagnosis

Paraneoplastic motor disorders.
Younger DS
Handb Clin Neurol 2023;196:231-250. doi: 10.1016/B978-0-323-98817-9.00018-1. PMID: 37620071
Chronic Pain in the Elderly: Mechanisms and Distinctive Features.
Tinnirello A, Mazzoleni S, Santi C
Biomolecules 2021 Aug 23;11(8) doi: 10.3390/biom11081256. PMID: 34439922Free PMC Article
Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Central Sensitization in Musculoskeletal Pain: Lost in Translation?
van Griensven H, Schmid A, Trendafilova T, Low M
J Orthop Sports Phys Ther 2020 Nov;50(11):592-596. doi: 10.2519/jospt.2020.0610. PMID: 33131390
Neuropathic Pain: Central vs. Peripheral Mechanisms.
Meacham K, Shepherd A, Mohapatra DP, Haroutounian S
Curr Pain Headache Rep 2017 Jun;21(6):28. doi: 10.1007/s11916-017-0629-5. PMID: 28432601

Therapy

Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Advances in Understanding, Diagnosis, and Treatment of Tinnitus.
Tang D, Li H, Chen L
Adv Exp Med Biol 2019;1130:109-128. doi: 10.1007/978-981-13-6123-4_7. PMID: 30915704
Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation.
Sluka KA, Frey-Law L, Hoeger Bement M
Pain 2018 Sep;159 Suppl 1(Suppl 1):S91-S97. doi: 10.1097/j.pain.0000000000001235. PMID: 30113953Free PMC Article
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain.
Ji RR, Nackley A, Huh Y, Terrando N, Maixner W
Anesthesiology 2018 Aug;129(2):343-366. doi: 10.1097/ALN.0000000000002130. PMID: 29462012Free PMC Article
Inflammation in the pathophysiology of neuropathic pain.
Sommer C, Leinders M, Üçeyler N
Pain 2018 Mar;159(3):595-602. doi: 10.1097/j.pain.0000000000001122. PMID: 29447138

Prognosis

Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Transition from Acute to Chronic Pain: Evaluating Risk for Chronic Postsurgical Pain.
Fregoso G, Wang A, Tseng K, Wang J
Pain Physician 2019 Sep;22(5):479-488. PMID: 31561647
Chronic whiplash pain.
Seroussi R, Singh V, Fry A
Phys Med Rehabil Clin N Am 2015 May;26(2):359-73. Epub 2015 Mar 7 doi: 10.1016/j.pmr.2015.01.003. PMID: 25952070
Febrile seizures.
Patterson JL, Carapetian SA, Hageman JR, Kelley KR
Pediatr Ann 2013 Dec;42(12):249-54. doi: 10.3928/00904481-20131122-09. PMID: 24295158
Chronic meningitis.
Helbok R, Broessner G, Pfausler B, Schmutzhard E
J Neurol 2009 Feb;256(2):168-75. Epub 2009 Feb 17 doi: 10.1007/s00415-009-0122-0. PMID: 19224317

Clinical prediction guides

Diagnosis and Treatment of Multiple Sclerosis: A Review.
McGinley MP, Goldschmidt CH, Rae-Grant AD
JAMA 2021 Feb 23;325(8):765-779. doi: 10.1001/jama.2020.26858. PMID: 33620411
Sleep Disorders in Hereditary Ataxias.
Huebra L, Coelho FM, Filho FMR, Barsottini OG, Pedroso JL
Curr Neurol Neurosci Rep 2019 Jul 25;19(8):59. doi: 10.1007/s11910-019-0968-1. PMID: 31342187
Symptoms of menopause - global prevalence, physiology and implications.
Monteleone P, Mascagni G, Giannini A, Genazzani AR, Simoncini T
Nat Rev Endocrinol 2018 Apr;14(4):199-215. Epub 2018 Feb 2 doi: 10.1038/nrendo.2017.180. PMID: 29393299
Clinical indicators of 'nociceptive', 'peripheral neuropathic' and 'central' mechanisms of musculoskeletal pain. A Delphi survey of expert clinicians.
Smart KM, Blake C, Staines A, Doody C
Man Ther 2010 Feb;15(1):80-7. Epub 2009 Aug 12 doi: 10.1016/j.math.2009.07.005. PMID: 19679504
Validation of a new coma scale: The FOUR score.
Wijdicks EF, Bamlet WR, Maramattom BV, Manno EM, McClelland RL
Ann Neurol 2005 Oct;58(4):585-93. doi: 10.1002/ana.20611. PMID: 16178024

Recent systematic reviews

Deep brain stimulation targets in epilepsy: Systematic review and meta-analysis of anterior and centromedian thalamic nuclei and hippocampus.
Vetkas A, Fomenko A, Germann J, Sarica C, Iorio-Morin C, Samuel N, Yamamoto K, Milano V, Cheyuo C, Zemmar A, Elias G, Boutet A, Loh A, Santyr B, Gwun D, Tasserie J, Kalia SK, Lozano AM
Epilepsia 2022 Mar;63(3):513-524. Epub 2022 Jan 3 doi: 10.1111/epi.17157. PMID: 34981509
Sleep, cerebrospinal fluid, and the glymphatic system: A systematic review.
Chong PLH, Garic D, Shen MD, Lundgaard I, Schwichtenberg AJ
Sleep Med Rev 2022 Feb;61:101572. Epub 2021 Nov 18 doi: 10.1016/j.smrv.2021.101572. PMID: 34902819Free PMC Article
Congenital Zika syndrome: A systematic review.
Freitas DA, Souza-Santos R, Carvalho LMA, Barros WB, Neves LM, Brasil P, Wakimoto MD
PLoS One 2020;15(12):e0242367. Epub 2020 Dec 15 doi: 10.1371/journal.pone.0242367. PMID: 33320867Free PMC Article
Migraine and sleep disorders: a systematic review.
Tiseo C, Vacca A, Felbush A, Filimonova T, Gai A, Glazyrina T, Hubalek IA, Marchenko Y, Overeem LH, Piroso S, Tkachev A, Martelletti P, Sacco S; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2020 Oct 27;21(1):126. doi: 10.1186/s10194-020-01192-5. PMID: 33109076Free PMC Article
Recommendation for a definition of acute symptomatic seizure.
Beghi E, Carpio A, Forsgren L, Hesdorffer DC, Malmgren K, Sander JW, Tomson T, Hauser WA
Epilepsia 2010 Apr;51(4):671-5. Epub 2009 Sep 3 doi: 10.1111/j.1528-1167.2009.02285.x. PMID: 19732133

Supplemental Content

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