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Trisomy 19

MedGen UID:
417669
Concept ID:
C2827366
Cell or Molecular Dysfunction

Definition

A chromosomal abnormality consisting of the presence of a third copy of chromosome 19 in somatic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrisomy 19

Professional guidelines

PubMed

Zhang Y, Zhong M, Zheng D
J Cell Mol Med 2021 Jan;25(1):358-366. Epub 2020 Nov 17 doi: 10.1111/jcmm.16080. PMID: 33201576Free PMC Article

Recent clinical studies

Etiology

van Weelderen RE, Harrison CJ, Klein K, Jiang Y, Abrahamsson J, Alonzo T, Aplenc R, Arad-Cohen N, Bart-Delabesse E, Buldini B, De Moerloose B, Dworzak MN, Elitzur S, Fernández Navarro JM, Gamis A, Gerbing RB, Goemans BF, de Groot-Kruseman HA, Guest E, Ha SY, Hasle H, Kelaidi C, Lapillonne H, Leverger G, Locatelli F, Miyamura T, Norén-Nyström U, Polychronopoulou S, Rasche M, Rubnitz JE, Stary J, Tierens A, Tomizawa D, Zwaan CM, Kaspers GJL
Blood Adv 2024 Jun 25;8(12):3200-3213. doi: 10.1182/bloodadvances.2023011771. PMID: 38621200Free PMC Article
Kayser S, Martínez-Cuadrón D, Rodriguez-Veiga R, Hänel M, Tormo M, Schäfer-Eckart K, Botella C, Stölzel F, Del Castillo TB, Keller U, Rodriguez-Medina C, Held G, Amigo ML, Schliemann C, Colorado M, Kaufmann M, Garcia MB, Krause SW, Görner M, Jost E, Steffen B, Zukunft S, Platzbecker U, Ho AD, Baldus CD, Serve H, Müller-Tidow C, Thiede C, Bornhäuser M, Montesinos P, Röllig C, Schlenk RF
Haematologica 2023 Aug 1;108(8):2059-2066. doi: 10.3324/haematol.2022.282127. PMID: 36815361Free PMC Article
Zhou Q, Zhao D, Eladl E, Capo-Chichi JM, Kim DDH, Chang H
Leuk Res 2023 Jan;124:107002. Epub 2022 Dec 16 doi: 10.1016/j.leukres.2022.107002. PMID: 36563650
Sareen D, McMillan E, Ebert AD, Shelley BC, Johnson JA, Meisner LF, Svendsen CN
PLoS One 2009 Oct 29;4(10):e7630. doi: 10.1371/journal.pone.0007630. PMID: 19898616Free PMC Article
Mitelman F
Leuk Lymphoma 1993;11 Suppl 1:11-5. doi: 10.3109/10428199309047856. PMID: 8251885

Diagnosis

Kayser S, Martínez-Cuadrón D, Rodriguez-Veiga R, Hänel M, Tormo M, Schäfer-Eckart K, Botella C, Stölzel F, Del Castillo TB, Keller U, Rodriguez-Medina C, Held G, Amigo ML, Schliemann C, Colorado M, Kaufmann M, Garcia MB, Krause SW, Görner M, Jost E, Steffen B, Zukunft S, Platzbecker U, Ho AD, Baldus CD, Serve H, Müller-Tidow C, Thiede C, Bornhäuser M, Montesinos P, Röllig C, Schlenk RF
Haematologica 2023 Aug 1;108(8):2059-2066. doi: 10.3324/haematol.2022.282127. PMID: 36815361Free PMC Article
Zhang Y, Zhong M, Zheng D
J Cell Mol Med 2021 Jan;25(1):358-366. Epub 2020 Nov 17 doi: 10.1111/jcmm.16080. PMID: 33201576Free PMC Article
Abrams ZB, Li S, Zhang L, Coombes CE, Payne PRO, Heerema NA, Abruzzo LV, Coombes KR
Cancer Genet 2020 Oct;248-249:34-38. Epub 2020 Oct 2 doi: 10.1016/j.cancergen.2020.09.005. PMID: 33059160Free PMC Article
Maarouf N, Mahmoud S, Khedr R, Lehmann L, Shaaban K, Ibrahim S, Fahmy S, Hassanain O, Nader N, Elhaddad A
Clin Lymphoma Myeloma Leuk 2019 Mar;19(3):e142-e152. Epub 2018 Dec 20 doi: 10.1016/j.clml.2018.12.011. PMID: 30686774
Espersen ADL, Noren-Nyström U, Abrahamsson J, Ha SY, Pronk CJ, Jahnukainen K, Jónsson ÓG, Lausen B, Palle J, Zeller B, Palmqvist L, Hasle H
Genes Chromosomes Cancer 2018 Jul;57(7):359-365. Epub 2018 Apr 30 doi: 10.1002/gcc.22538. PMID: 29569294

Therapy

Crisan AM, Coriu D, Arion C, Colita A, Jardan C
J Med Life 2015 Oct-Dec;8(4):502-8. PMID: 26664479Free PMC Article
Fabarius A, Leitner A, Hochhaus A, Müller MC, Hanfstein B, Haferlach C, Göhring G, Schlegelberger B, Jotterand M, Reiter A, Jung-Munkwitz S, Proetel U, Schwaab J, Hofmann WK, Schubert J, Einsele H, Ho AD, Falge C, Kanz L, Neubauer A, Kneba M, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Baerlocher GM, Lauseker M, Pfirrmann M, Hasford J, Saussele S, Hehlmann R; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group
Blood 2011 Dec 22;118(26):6760-8. Epub 2011 Oct 28 doi: 10.1182/blood-2011-08-373902. PMID: 22039253
Daskalakis M, Mauritzson N, Johansson B, Bouabdallah K, Onida F, Kunzmann R, Müller-Berndorff H, Schmitt-Gräff A, Lübbert M
Leuk Res 2006 Aug;30(8):1043-7. Epub 2006 Feb 7 doi: 10.1016/j.leukres.2006.01.003. PMID: 16464494
Jacob RT, Gayathri K, Surath A, Rao DR
Indian J Cancer 2002 Jun;39(2):61-5. PMID: 12789726

Prognosis

van Weelderen RE, Harrison CJ, Klein K, Jiang Y, Abrahamsson J, Alonzo T, Aplenc R, Arad-Cohen N, Bart-Delabesse E, Buldini B, De Moerloose B, Dworzak MN, Elitzur S, Fernández Navarro JM, Gamis A, Gerbing RB, Goemans BF, de Groot-Kruseman HA, Guest E, Ha SY, Hasle H, Kelaidi C, Lapillonne H, Leverger G, Locatelli F, Miyamura T, Norén-Nyström U, Polychronopoulou S, Rasche M, Rubnitz JE, Stary J, Tierens A, Tomizawa D, Zwaan CM, Kaspers GJL
Blood Adv 2024 Jun 25;8(12):3200-3213. doi: 10.1182/bloodadvances.2023011771. PMID: 38621200Free PMC Article
Zhou Q, Zhao D, Eladl E, Capo-Chichi JM, Kim DDH, Chang H
Leuk Res 2023 Jan;124:107002. Epub 2022 Dec 16 doi: 10.1016/j.leukres.2022.107002. PMID: 36563650
Abrams ZB, Li S, Zhang L, Coombes CE, Payne PRO, Heerema NA, Abruzzo LV, Coombes KR
Cancer Genet 2020 Oct;248-249:34-38. Epub 2020 Oct 2 doi: 10.1016/j.cancergen.2020.09.005. PMID: 33059160Free PMC Article
Espersen ADL, Noren-Nyström U, Abrahamsson J, Ha SY, Pronk CJ, Jahnukainen K, Jónsson ÓG, Lausen B, Palle J, Zeller B, Palmqvist L, Hasle H
Genes Chromosomes Cancer 2018 Jul;57(7):359-365. Epub 2018 Apr 30 doi: 10.1002/gcc.22538. PMID: 29569294
Mitelman F
Leuk Lymphoma 1993;11 Suppl 1:11-5. doi: 10.3109/10428199309047856. PMID: 8251885

Clinical prediction guides

Zhang Y, Zhong M, Zheng D
J Cell Mol Med 2021 Jan;25(1):358-366. Epub 2020 Nov 17 doi: 10.1111/jcmm.16080. PMID: 33201576Free PMC Article
Yang N, Huh J, Chung WS, Cho MS, Ryu KH, Chung HS
Cancer Genet 2015 Sep;208(9):464-7. Epub 2015 May 6 doi: 10.1016/j.cancergen.2015.04.011. PMID: 26164398
Seidel MG, Duerr C, Woutsas S, Schwerin-Nagel A, Sadeghi K, Neesen J, Uhrig S, Santos-Valente E, Pickl WF, Schwinger W, Urban C, Boztug K, Förster-Waldl E
J Med Genet 2014 Apr;51(4):254-63. Epub 2014 Jan 15 doi: 10.1136/jmedgenet-2013-102122. PMID: 24431329Free PMC Article
Fabarius A, Leitner A, Hochhaus A, Müller MC, Hanfstein B, Haferlach C, Göhring G, Schlegelberger B, Jotterand M, Reiter A, Jung-Munkwitz S, Proetel U, Schwaab J, Hofmann WK, Schubert J, Einsele H, Ho AD, Falge C, Kanz L, Neubauer A, Kneba M, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Baerlocher GM, Lauseker M, Pfirrmann M, Hasford J, Saussele S, Hehlmann R; Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung (SAKK) and the German CML Study Group
Blood 2011 Dec 22;118(26):6760-8. Epub 2011 Oct 28 doi: 10.1182/blood-2011-08-373902. PMID: 22039253
Sareen D, McMillan E, Ebert AD, Shelley BC, Johnson JA, Meisner LF, Svendsen CN
PLoS One 2009 Oct 29;4(10):e7630. doi: 10.1371/journal.pone.0007630. PMID: 19898616Free PMC Article

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