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St. Louis encephalitis

MedGen UID:
41773
Concept ID:
C0014060
Disease or Syndrome
Synonyms: Encephalitis, Saint Louis; Encephalitis, St. Louis; Encephalitis, Viral, St. Louis; Lethargic Encephalitis, Type C; Saint Louis Encephalitis; St. Louis Encephalitis; St. Louis Viral Encephalitis; Type C Lethargic Encephalitis
SNOMED CT: St. Louis encephalitis virus infection (417192005); St. Louis encephalitis virus neuroinvasive disease (417607009); St. Louis viral disease (417192005); Neuroinvasive St. Louis encephalitis virus infection (417607009); SLE - Saint Louis encephalitis (417607009); Saint Louis encephalitis (417607009); St. Louis encephalitis (417607009); Type C lethargic encephalitis (417607009); Neuroinvasive Saint Louis encephalitis virus infection (417607009); Encephalitis, St-Louis (417607009); Saint Louis encephalitis virus infection (417192005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0005969
Orphanet: ORPHA83484

Definition

An acute arboviral infection caused by a virus of the <i>Flaviviridae</i> family transmitted by an infected mosquito, and characterized by the onset of flulike symptoms such as fever, malaise, headache, cough, and sore throat that can progress to meningitis or encephalitis with symptoms like nausea, vomiting, confusion, stiff neck, disorientation, irritability, tremors, and convulsions. Photophobia, cranial nerve palsies, and even coma may occur. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSt. Louis encephalitis
Follow this link to review classifications for St. Louis encephalitis in Orphanet.

Professional guidelines

PubMed

Beranek M, Torres C, Laurito M, Farías A, Contigiani M, Almirón W, Diaz A
Acta Trop 2024 Feb;250:107088. Epub 2023 Dec 1 doi: 10.1016/j.actatropica.2023.107088. PMID: 38043673
Brook I
Int J Pediatr Otorhinolaryngol 2003 May;67(5):447-51. doi: 10.1016/s0165-5876(03)00010-7. PMID: 12697345
Leyssen P, De Clercq E, Neyts J
Clin Microbiol Rev 2000 Jan;13(1):67-82, table of contents. doi: 10.1128/CMR.13.1.67. PMID: 10627492Free PMC Article

Recent clinical studies

Etiology

Moraes MM, Kubiszeski JR, Vieira CJDSP, Gusmao AF, Pratis TS, Colombo TE, Thies SF, do Carmo Araujo F, Zanelli CF, Milhim BHGA, da Silva GCD, Nogueira ML, Pacca CC, Bronzoni RVM, Mondini A
J Med Virol 2022 Feb;94(2):776-781. Epub 2021 Nov 1 doi: 10.1002/jmv.27402. PMID: 34664719
Barbosa Costa G, Marinho PES, Vilela APP, Saraiva-Silva AT, Crispim APC, Borges IA, Dutra AGS, Lobato ZIP, Dos Reis JKP, de Oliveira DB, Drumond BP, Kroon EG, Trindade GS
Viruses 2019 Nov 5;11(11) doi: 10.3390/v11111029. PMID: 31694207Free PMC Article
Reisen WK
Adv Virus Res 2003;61:139-83. doi: 10.1016/s0065-3527(03)61004-3. PMID: 14714432
Day JF
Annu Rev Entomol 2001;46:111-38. doi: 10.1146/annurev.ento.46.1.111. PMID: 11112165
LENNETTE EH, LONGSHORE WA
Calif Med 1951 Sep;75(3):189-95. PMID: 14870034Free PMC Article

Diagnosis

Danforth ME, Snyder RE, Feiszli T, Bullick T, Messenger S, Hanson C, Padgett K, Coffey LL, Barker CM, Reisen WK, Kramer VL
PLoS Negl Trop Dis 2022 Aug;16(8):e0010664. Epub 2022 Aug 8 doi: 10.1371/journal.pntd.0010664. PMID: 35939506Free PMC Article
Barbosa Costa G, Marinho PES, Vilela APP, Saraiva-Silva AT, Crispim APC, Borges IA, Dutra AGS, Lobato ZIP, Dos Reis JKP, de Oliveira DB, Drumond BP, Kroon EG, Trindade GS
Viruses 2019 Nov 5;11(11) doi: 10.3390/v11111029. PMID: 31694207Free PMC Article
Figueiredo LT
Rev Soc Bras Med Trop 2014 Sep-Oct;47(5):541-2. doi: 10.1590/0037-8682-0197-2014. PMID: 25467251
Day JF
Annu Rev Entomol 2001;46:111-38. doi: 10.1146/annurev.ento.46.1.111. PMID: 11112165
Monath TP, Tsai TF
Am J Trop Med Hyg 1987 Nov;37(3 Suppl):40S-59S. doi: 10.4269/ajtmh.1987.37.40s. PMID: 3318523

Therapy

Venkat H, Adams L, Sunenshine R, Krow-Lucal E, Levy C, Kafenbaum T, Sylvester T, Smith K, Townsend J, Dosmann M, Kamel H, Patron R, Kuehnert M, Annambhotla P, Basavaraju SV, Rabe IB; SLEV Transmission Investigation Team
Transfusion 2017 Dec;57(12):2987-2994. Epub 2017 Sep 14 doi: 10.1111/trf.14314. PMID: 28905395Free PMC Article
Hartmann CA, Vikram HR, Seville MT, Orenstein R, Kusne S, Blair JE, Grys TE, Patron RL
Am J Transplant 2017 Aug;17(8):2200-2206. Epub 2017 May 27 doi: 10.1111/ajt.14336. PMID: 28452107
Pupo-Antúnez M, Vázquez S, Sosa AL, Caballero Y, Vásquez Y, Morier L, Álvarez M, Guzmán MG
J Virol Methods 2015 Jun 15;218:14-8. Epub 2015 Mar 3 doi: 10.1016/j.jviromet.2015.01.004. PMID: 25744380
Rios J, Hacker CS, Hailey CA, Parsons RE
J Am Mosq Control Assoc 2006 Jun;22(2):254-63. doi: 10.2987/8756-971X(2006)22[254:DASAOW]2.0.CO;2. PMID: 17019771
Rahal JJ, Anderson J, Rosenberg C, Reagan T, Thompson LL
J Infect Dis 2004 Sep 15;190(6):1084-7. Epub 2004 Aug 10 doi: 10.1086/423325. PMID: 15319857

Prognosis

Curren EJ, Lindsey NP, Fischer M, Hills SL
Am J Trop Med Hyg 2018 Oct;99(4):1074-1079. doi: 10.4269/ajtmh.18-0420. PMID: 30182919Free PMC Article
Ortiz-Martínez Y, Vega-Useche L, Villamil-Gómez WE, Rodriguez-Morales AJ
Infez Med 2017 Mar 1;25(1):77-79. PMID: 28353461
Day JF
Annu Rev Entomol 2001;46:111-38. doi: 10.1146/annurev.ento.46.1.111. PMID: 11112165
Monath TP, Tsai TF
Am J Trop Med Hyg 1987 Nov;37(3 Suppl):40S-59S. doi: 10.4269/ajtmh.1987.37.40s. PMID: 3318523
Brinker KR, Paulson G, Monath TP, Wise G, Fass RJ
Arch Intern Med 1979 May;139(5):561-6. PMID: 443951

Clinical prediction guides

Hartmann CA, Vikram HR, Seville MT, Orenstein R, Kusne S, Blair JE, Grys TE, Patron RL
Am J Transplant 2017 Aug;17(8):2200-2206. Epub 2017 May 27 doi: 10.1111/ajt.14336. PMID: 28452107
Roberson JA, Crill WD, Chang GJ
J Clin Microbiol 2007 Oct;45(10):3167-74. Epub 2007 Aug 22 doi: 10.1128/JCM.01143-07. PMID: 17715375Free PMC Article
Rios J, Hacker CS, Hailey CA, Parsons RE
J Am Mosq Control Assoc 2006 Jun;22(2):254-63. doi: 10.2987/8756-971X(2006)22[254:DASAOW]2.0.CO;2. PMID: 17019771
Day JF
Annu Rev Entomol 2001;46:111-38. doi: 10.1146/annurev.ento.46.1.111. PMID: 11112165
Monath TP, Tsai TF
Am J Trop Med Hyg 1987 Nov;37(3 Suppl):40S-59S. doi: 10.4269/ajtmh.1987.37.40s. PMID: 3318523

Supplemental Content

Table of contents

    Clinical resources

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