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Somnolence

MedGen UID:
417941
•Concept ID:
C2830004
•
Mental or Behavioral Dysfunction
Synonym: Sleepiness
SNOMED CT: Somnolence (79519003); Somnolence (271782001)

Definition

A sleep disorder characterized by excessive sleepiness and drowsiness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSomnolence

Professional guidelines

PubMed

Diagnosis and Management of Hyponatremia: A Review.
Adrogué HJ, Tucker BM, Madias NE
JAMA 2022 Jul 19;328(3):280-291. doi: 10.1001/jama.2022.11176. PMID: 35852524
Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials.
Onakpoya IJ, Thomas ET, Lee JJ, Goldacre B, Heneghan CJ
BMJ Open 2019 Jan 21;9(1):e023600. doi: 10.1136/bmjopen-2018-023600. PMID: 30670513Free PMC Article
The efficacy and safety of memantine for the treatment of Alzheimer's disease.
Matsunaga S, Kishi T, Nomura I, Sakuma K, Okuya M, Ikuta T, Iwata N
Expert Opin Drug Saf 2018 Oct;17(10):1053-1061. Epub 2018 Sep 26 doi: 10.1080/14740338.2018.1524870. PMID: 30222469

Recent clinical studies

Etiology

Understanding and approaching excessive daytime sleepiness.
Pérez-Carbonell L, Mignot E, Leschziner G, Dauvilliers Y
Lancet 2022 Sep 24;400(10357):1033-1046. Epub 2022 Sep 14 doi: 10.1016/S0140-6736(22)01018-2. PMID: 36115367
The efficacy and safety of dual orexin receptor antagonists in primary insomnia: A systematic review and network meta-analysis.
Xue T, Wu X, Chen S, Yang Y, Yan Z, Song Z, Zhang W, Zhang J, Chen Z, Wang Z
Sleep Med Rev 2022 Feb;61:101573. Epub 2021 Nov 26 doi: 10.1016/j.smrv.2021.101573. PMID: 34902823
Excessive Daytime Sleepiness: A Clinical Review.
Gandhi KD, Mansukhani MP, Silber MH, Kolla BP
Mayo Clin Proc 2021 May;96(5):1288-1301. Epub 2021 Apr 9 doi: 10.1016/j.mayocp.2020.08.033. PMID: 33840518
Excessive Daytime Sleepiness in Obstructive Sleep Apnea. Mechanisms and Clinical Management.
Lal C, Weaver TE, Bae CJ, Strohl KP
Ann Am Thorac Soc 2021 May;18(5):757-768. doi: 10.1513/AnnalsATS.202006-696FR. PMID: 33621163Free PMC Article
The adverse effects profile of levetiracetam in epilepsy: a more detailed look.
Mbizvo GK, Dixon P, Hutton JL, Marson AG
Int J Neurosci 2014 Sep;124(9):627-34. Epub 2013 Dec 18 doi: 10.3109/00207454.2013.866951. PMID: 24256446

Diagnosis

Precision Medicine for Idiopathic Hypersomnia.
Arnulf I, Leu-Semenescu S, Dodet P
Sleep Med Clin 2022 Sep;17(3):379-398. Epub 2022 Sep 8 doi: 10.1016/j.jsmc.2022.06.016. PMID: 36150801
Understanding and approaching excessive daytime sleepiness.
Pérez-Carbonell L, Mignot E, Leschziner G, Dauvilliers Y
Lancet 2022 Sep 24;400(10357):1033-1046. Epub 2022 Sep 14 doi: 10.1016/S0140-6736(22)01018-2. PMID: 36115367
Excessive Daytime Sleepiness: A Clinical Review.
Gandhi KD, Mansukhani MP, Silber MH, Kolla BP
Mayo Clin Proc 2021 May;96(5):1288-1301. Epub 2021 Apr 9 doi: 10.1016/j.mayocp.2020.08.033. PMID: 33840518
Pediatric angiostrongyliasis.
Lombard F, Basset D, Cambonie G, Bastien P, Jeziorski E
Med Sante Trop 2018 Feb 1;28(1):76-81. doi: 10.1684/mst.2018.0756. PMID: 29616650
Depression and Hypersomnia: A Complex Association.
Lopez R, Barateau L, Evangelista E, Dauvilliers Y
Sleep Med Clin 2017 Sep;12(3):395-405. Epub 2017 May 26 doi: 10.1016/j.jsmc.2017.03.016. PMID: 28778237

Therapy

Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia.
Mühlbauer V, Möhler R, Dichter MN, Zuidema SU, Köpke S, Luijendijk HJ
Cochrane Database Syst Rev 2021 Dec 17;12(12):CD013304. doi: 10.1002/14651858.CD013304.pub2. PMID: 34918337Free PMC Article
Pregabalin for neuropathic pain in adults.
Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA
Cochrane Database Syst Rev 2019 Jan 23;1(1):CD007076. doi: 10.1002/14651858.CD007076.pub3. PMID: 30673120Free PMC Article
Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials.
Onakpoya IJ, Thomas ET, Lee JJ, Goldacre B, Heneghan CJ
BMJ Open 2019 Jan 21;9(1):e023600. doi: 10.1136/bmjopen-2018-023600. PMID: 30670513Free PMC Article
Review of Safety and Efficacy of Sleep Medicines in Older Adults.
Schroeck JL, Ford J, Conway EL, Kurtzhalts KE, Gee ME, Vollmer KA, Mergenhagen KA
Clin Ther 2016 Nov;38(11):2340-2372. Epub 2016 Oct 15 doi: 10.1016/j.clinthera.2016.09.010. PMID: 27751669
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J
JAMA 2015 Jun 23-30;313(24):2456-73. doi: 10.1001/jama.2015.6358. PMID: 26103030

Prognosis

Sleep pattern, healthy lifestyle and colorectal cancer incidence.
Chen J, Chen N, Huang T, Huang N, Zhuang Z, Liang H
Sci Rep 2022 Oct 31;12(1):18317. doi: 10.1038/s41598-022-21879-w. PMID: 36316431Free PMC Article
Painful Sleep: Insomnia in Patients with Chronic Pain Syndrome and its Consequences.
Ostovar-Kermani T, Arnaud D, Almaguer A, Garcia I, Gonzalez S, Mendez Martinez YH, Surani S
Folia Med (Plovdiv) 2020 Dec 31;62(4):645-654. doi: 10.3897/folmed.62.e50705. PMID: 33415907
Mirogabalin for the treatment of diabetic peripheral neuropathic pain: A randomized, double-blind, placebo-controlled phase III study in Asian patients.
Baba M, Matsui N, Kuroha M, Wasaki Y, Ohwada S
J Diabetes Investig 2019 Sep;10(5):1299-1306. Epub 2019 Feb 28 doi: 10.1111/jdi.13013. PMID: 30672128Free PMC Article
Obstructive Sleep Apnea: Update and Future.
Lim DC, Pack AI
Annu Rev Med 2017 Jan 14;68:99-112. Epub 2016 Oct 5 doi: 10.1146/annurev-med-042915-102623. PMID: 27732789
Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies.
Cappuccio FP, D'Elia L, Strazzullo P, Miller MA
Sleep 2010 May;33(5):585-92. doi: 10.1093/sleep/33.5.585. PMID: 20469800Free PMC Article

Clinical prediction guides

Sleep pattern, healthy lifestyle and colorectal cancer incidence.
Chen J, Chen N, Huang T, Huang N, Zhuang Z, Liang H
Sci Rep 2022 Oct 31;12(1):18317. doi: 10.1038/s41598-022-21879-w. PMID: 36316431Free PMC Article
Sublingual Dexmedetomidine for the Treatment of Acute Agitation in Adults With Schizophrenia or Schizoaffective Disorder: A Randomized Placebo-Controlled Trial.
Citrome L, Preskorn SH, Lauriello J, Krystal JH, Kakar R, Finman J, De Vivo M, Yocca FD, Risinger R, Rajachandran L
J Clin Psychiatry 2022 Oct 3;83(6) doi: 10.4088/JCP.22m14447. PMID: 36198061
A Randomized, Double-Blind, Controlled Trial of Lithium Versus Quetiapine for the Treatment of Acute Mania in Youth with Early Course Bipolar Disorder.
Patino LR, Klein CC, Strawn JR, Blom TJ, Tallman MJ, Adler CM, Welge JA, DelBello MP
J Child Adolesc Psychopharmacol 2021 Sep;31(7):485-493. Epub 2021 Sep 14 doi: 10.1089/cap.2021.0039. PMID: 34520250Free PMC Article
Quetiapine for acute bipolar depression: a systematic review and meta-analysis.
Suttajit S, Srisurapanont M, Maneeton N, Maneeton B
Drug Des Devel Ther 2014;8:827-38. Epub 2014 Jun 25 doi: 10.2147/DDDT.S63779. PMID: 25028535Free PMC Article
A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
Johns MW
Sleep 1991 Dec;14(6):540-5. doi: 10.1093/sleep/14.6.540. PMID: 1798888

Recent systematic reviews

Sleep and physical activity in university students: A systematic review and meta-analysis.
Memon AR, Gupta CC, Crowther ME, Ferguson SA, Tuckwell GA, Vincent GE
Sleep Med Rev 2021 Aug;58:101482. Epub 2021 Mar 20 doi: 10.1016/j.smrv.2021.101482. PMID: 33864990
Pregabalin for neuropathic pain in adults.
Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA
Cochrane Database Syst Rev 2019 Jan 23;1(1):CD007076. doi: 10.1002/14651858.CD007076.pub3. PMID: 30673120Free PMC Article
Fatigue in Parkinson's disease: A systematic review and meta-analysis.
Siciliano M, Trojano L, Santangelo G, De Micco R, Tedeschi G, Tessitore A
Mov Disord 2018 Nov;33(11):1712-1723. Epub 2018 Sep 28 doi: 10.1002/mds.27461. PMID: 30264539
The efficacy and safety of memantine for the treatment of Alzheimer's disease.
Matsunaga S, Kishi T, Nomura I, Sakuma K, Okuya M, Ikuta T, Iwata N
Expert Opin Drug Saf 2018 Oct;17(10):1053-1061. Epub 2018 Sep 26 doi: 10.1080/14740338.2018.1524870. PMID: 30222469
Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.
Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J
JAMA 2015 Jun 23-30;313(24):2456-73. doi: 10.1001/jama.2015.6358. PMID: 26103030

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