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Giant cell epulis

MedGen UID:
41844
•Concept ID:
C0014647
•
Disease or Syndrome
Synonyms: Epulides, Giant Cell; Epulis, Giant Cell; Giant Cell Epulides; Giant Cell Epulis; Peripheral Giant Cell Granuloma
SNOMED CT: Giant cell epulis (89722009); Peripheral giant cell granuloma (89722009); PGCG - Peripheral giant cell granuloma (89722009); Giant cell peripheral granuloma (89722009)

Definition

A reactive localized proliferation of mononuclear cells and osteoclast-type giant cells in a vascular stroma outside bone. It occurs in the gingiva or alveolar mucosa. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant cell epulis

Professional guidelines

PubMed

Pediatric Aggressive Benign Mandibular Tumors: Clinical Features and Management.
Koraitim M, Medra AM, Salloum AM, Shehata EA
J Craniofac Surg 2022 May 1;33(3):e265-e267. Epub 2021 Aug 13 doi: 10.1097/SCS.0000000000008085. PMID: 34387270
Pharmacological Therapy for Treatment of Recurrent Central Giant Cell Lesion in a Child.
Fernandes Gonçalves IM, Barbosa Luna AH, de Melo DP, Weege Nonaka CF, Alves PM
J Dent Child (Chic) 2019 May 15;86(2):113-117. PMID: 31395117
Current understanding and management of giant cell arteritis and polymyalgia rheumatica.
Ghosh P, Borg FA, Dasgupta B
Expert Rev Clin Immunol 2010 Nov;6(6):913-28. doi: 10.1586/eci.10.59. PMID: 20979556

Recent clinical studies

Etiology

Peripheral giant cell granuloma (giant cell epulis) in two dogs.
Valentine BA, Eckhaus MA
Vet Pathol 1986 May;23(3):340-1. doi: 10.1177/030098588602300321. PMID: 3727322
Enzyme patterns in human endocytotic multinucleate giant cells--a histochemical study.
Elleder M
Acta Histochem 1986;79(1):1-10. doi: 10.1016/S0065-1281(86)80091-5. PMID: 2874682
Hyperplastic lesions of the gingiva and alveolar mucosa. A study of 175 cases.
Anneroth G, Sigurdson A
Acta Odontol Scand 1983;41(2):75-86. doi: 10.3109/00016358309162306. PMID: 6576600

Diagnosis

Giant cell epulis.
Tchernev G, Kandathil LJ, Oliveira N
Wien Med Wochenschr 2023 Sep;173(11-12):249-250. Epub 2021 Nov 4 doi: 10.1007/s10354-021-00894-y. PMID: 34735668
Reparative giant cell granuloma in a pediatric patient.
Duarte Ruiz B, Riba García Fde A, Navarro Cuéllar C, Bucci T, Cuesta Gil M, Navarro Vila C
Med Oral Patol Oral Cir Bucal 2007 Aug 1;12(4):E331-5. PMID: 17664921
Peripheral giant-cell granuloma. Review of 13 cases.
Gandara-Rey JM, Pacheco Martins Carneiro JL, Gandara-Vila P, Blanco-Carrion A, García-García A, Madriñán-Graña P, Martín MS
Med Oral 2002 Jul-Oct;7(4):254-9. PMID: 12134126
Giant cell epulis with unusual clinical and radiological features--a diagnostic pitfall in FNAC material. Report of a case with differential diagnosis.
Ryska A, Jirousek Z
Cesk Patol 1997 Nov;33(4):118-22. PMID: 9501648
Hyperplastic lesions of the gingiva and alveolar mucosa. A study of 175 cases.
Anneroth G, Sigurdson A
Acta Odontol Scand 1983;41(2):75-86. doi: 10.3109/00016358309162306. PMID: 6576600

Therapy

Central giant cell granulomas of the jaws regress with calcitonin therapy.
Harris M
Br J Oral Maxillofac Surg 1993 Apr;31(2):89-94. doi: 10.1016/0266-4356(93)90168-v. PMID: 8471587

Prognosis

Peripheral giant-cell granuloma. Review of 13 cases.
Gandara-Rey JM, Pacheco Martins Carneiro JL, Gandara-Vila P, Blanco-Carrion A, García-García A, Madriñán-Graña P, Martín MS
Med Oral 2002 Jul-Oct;7(4):254-9. PMID: 12134126
Enzyme patterns in human endocytotic multinucleate giant cells--a histochemical study.
Elleder M
Acta Histochem 1986;79(1):1-10. doi: 10.1016/S0065-1281(86)80091-5. PMID: 2874682

Clinical prediction guides

S100, bcl2 and myeloperoxid protein expirations during periodontal inflammation.
Kuzenko Y, Romanyuk A, Politun A, Karpenko L
BMC Oral Health 2015 Aug 7;15:93. doi: 10.1186/s12903-015-0077-8. PMID: 26251029Free PMC Article

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