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Erysipelas

MedGen UID:
41855
Concept ID:
C0014733
Disease or Syndrome
Synonyms: erysipelas; Patch of erysipelas; St. Anthony's Fire
SNOMED CT: Erysipelas (44653001); Patch of erysipelas (44653001)
 
HPO: HP:0001055
Monarch Initiative: MONDO:0001266

Definition

Increased susceptibility to erysipelas, as manifested by a medical history of repeated episodes of erysipelas, which is a superficial infection of the skin, typically involving the lymphatic system. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErysipelas

Conditions with this feature

Familial Mediterranean fever
MedGen UID:
45811
Concept ID:
C0031069
Disease or Syndrome
Familial Mediterranean fever (FMF) is divided into two phenotypes: type 1 and type 2. FMF type 1 is characterized by recurrent short episodes of inflammation and serositis including fever, peritonitis, synovitis, pleuritis, and, rarely, pericarditis and meningitis. The symptoms and severity vary among affected individuals, sometimes even among members of the same family. Amyloidosis, which can lead to renal failure, is the most severe complication, if untreated. FMF type 2 is characterized by amyloidosis as the first clinical manifestation of FMF in an otherwise asymptomatic individual.
Cholestasis-edema syndrome, Norwegian type
MedGen UID:
78658
Concept ID:
C0268314
Disease or Syndrome
Cholestasis-lymphedema syndrome is a rare genetic disorder characterized by neonatal intrahepatic cholestasis, often lessening and becoming intermittent with age, and severe chronic lymphedema which mainly affects the lower limbs. Patients often present with fat malabsorption leading to failure to thrive, fat soluble vitamin deficiency with bleeding, rickets, and neuropathy. In 25% of cases, cirrhosis occurs during childhood or later in life.
TNF receptor-associated periodic fever syndrome (TRAPS)
MedGen UID:
226899
Concept ID:
C1275126
Disease or Syndrome
Familial periodic fever (FPF) is an autoinflammatory disorder characterized by recurrent fever with localized myalgia and painful erythema. Febrile attacks may last 1 or 2 days but often last longer than 1 week. Arthralgia of large joints, abdominal pain, conjunctivitis, and periorbital edema are common features. During attacks, painless cutaneous lesions may develop on the trunk or extremities and may migrate distally (review by Drenth and van der Meer, 2001).
Familial Mediterranean fever, autosomal dominant
MedGen UID:
341987
Concept ID:
C1851347
Disease or Syndrome
Familial Mediterranean fever (FMF) is divided into two phenotypes: type 1 and type 2. FMF type 1 is characterized by recurrent short episodes of inflammation and serositis including fever, peritonitis, synovitis, pleuritis, and, rarely, pericarditis and meningitis. The symptoms and severity vary among affected individuals, sometimes even among members of the same family. Amyloidosis, which can lead to renal failure, is the most severe complication, if untreated. FMF type 2 is characterized by amyloidosis as the first clinical manifestation of FMF in an otherwise asymptomatic individual.
Hereditary sclerosing poikiloderma with tendon and pulmonary involvement
MedGen UID:
816655
Concept ID:
C3810325
Disease or Syndrome
Hereditary fibrosing poikiloderma with tendon contractures, myopathy, and pulmonary fibrosis (POIKTMP) is characterized by the skin findings of poikiloderma (typically beginning in the first six months and mainly localized to the face), hypohidrosis with heat intolerance, mild lymphedema of the extremities, chronic erythematous and scaly skin lesions on the extremities, sclerosis of the digits, and mild palmoplantar keratoderma. Scalp hair, eyelashes, and/or eyebrows are typically sparse. Muscle contractures are usually seen in childhood and can be present as early as age two years. The majority of affected individuals develop progressive weakness of the proximal and distal muscles of all four limbs. Some adults develop progressive interstitial pulmonary fibrosis, which can be life threatening within three to four years after respiratory symptoms appear. Other features are exocrine pancreatic insufficiency, liver impairment, hematologic abnormalities, relative short stature, and cataract.
Hennekam lymphangiectasia-lymphedema syndrome 1
MedGen UID:
860487
Concept ID:
C4012050
Disease or Syndrome
Hennekam lymphangiectasia-lymphedema syndrome (HKLLS1) is an autosomal recessive disorder characterized by generalized lymphatic dysplasia affecting various organs, including the intestinal tract, pericardium, and limbs. Additional features of the disorder include facial dysmorphism and cognitive impairment (summary by Alders et al., 2014). Genetic Heterogeneity of Hennekam Lymphangiectasia-Lymphedema Syndrome See also HKLLS2 (616006), caused by mutation in the FAT4 gene (612411) on chromosome 4q28, and HKLLS3 (618154), caused by mutation in the ADAMTS3 gene (605011) on chromosome 4q13.

Professional guidelines

PubMed

Cross ELA, Jordan H, Godfrey R, Onakpoya IJ, Shears A, Fidler K, Peto TEA, Walker AS, Llewelyn MJ
J Infect 2020 Oct;81(4):521-531. Epub 2020 Jul 31 doi: 10.1016/j.jinf.2020.07.030. PMID: 32745638
Galli L, Venturini E, Bassi A, Gattinara GC, Chiappini E, Defilippi C, Diociaiuti A, Esposito S, Garazzino S, Giannattasio A, Krzysztofiak A, Latorre S, Lo Vecchio A, Marchisio P, Montagnani C, Nicolini G, Novelli A, Rossolini GM, Tersigni C, Villani A, El Hachem M, Neri I; Italian Pediatric Infectious Diseases Society; Italian Pediatric Dermatology Society
Clin Ther 2019 Mar;41(3):532-551.e17. Epub 2019 Feb 15 doi: 10.1016/j.clinthera.2019.01.010. PMID: 30777258
Ortiz-Lazo E, Arriagada-Egnen C, Poehls C, Concha-Rogazy M
Actas Dermosifiliogr (Engl Ed) 2019 Mar;110(2):124-130. Epub 2018 Oct 31 doi: 10.1016/j.ad.2018.07.010. PMID: 30390916

Recent clinical studies

Etiology

Borst C, Symmank D, Drach M, Weninger W
Ann Rheum Dis 2022 Apr;81(4):454-465. Epub 2022 Jan 17 doi: 10.1136/annrheumdis-2021-220977. PMID: 35039323
Bystritsky RJ
Infect Dis Clin North Am 2021 Mar;35(1):49-60. doi: 10.1016/j.idc.2020.10.002. PMID: 33494874
Cross ELA, Jordan H, Godfrey R, Onakpoya IJ, Shears A, Fidler K, Peto TEA, Walker AS, Llewelyn MJ
J Infect 2020 Oct;81(4):521-531. Epub 2020 Jul 31 doi: 10.1016/j.jinf.2020.07.030. PMID: 32745638
Galli L, Venturini E, Bassi A, Gattinara GC, Chiappini E, Defilippi C, Diociaiuti A, Esposito S, Garazzino S, Giannattasio A, Krzysztofiak A, Latorre S, Lo Vecchio A, Marchisio P, Montagnani C, Nicolini G, Novelli A, Rossolini GM, Tersigni C, Villani A, El Hachem M, Neri I; Italian Pediatric Infectious Diseases Society; Italian Pediatric Dermatology Society
Clin Ther 2019 Mar;41(3):532-551.e17. Epub 2019 Feb 15 doi: 10.1016/j.clinthera.2019.01.010. PMID: 30777258
Dalal A, Eskin-Schwartz M, Mimouni D, Ray S, Days W, Hodak E, Leibovici L, Paul M
Cochrane Database Syst Rev 2017 Jun 20;6(6):CD009758. doi: 10.1002/14651858.CD009758.pub2. PMID: 28631307Free PMC Article

Diagnosis

Bystritsky RJ
Infect Dis Clin North Am 2021 Mar;35(1):49-60. doi: 10.1016/j.idc.2020.10.002. PMID: 33494874
Gurel MS, Tekin B, Uzun S
Clin Dermatol 2020 Mar-Apr;38(2):140-151. Epub 2019 Oct 24 doi: 10.1016/j.clindermatol.2019.10.008. PMID: 32513395
Ortiz-Lazo E, Arriagada-Egnen C, Poehls C, Concha-Rogazy M
Actas Dermosifiliogr (Engl Ed) 2019 Mar;110(2):124-130. Epub 2018 Oct 31 doi: 10.1016/j.ad.2018.07.010. PMID: 30390916
Clebak KT, Malone MA
Prim Care 2018 Sep;45(3):433-454. doi: 10.1016/j.pop.2018.05.004. PMID: 30115333
Trieb K
Bone Joint J 2016 Sep;98-B(9):1155-9. doi: 10.1302/0301-620X.98B9.37038. PMID: 27587513

Therapy

De Vrieze T, Gebruers N, Nevelsteen I, Fieuws S, Thomis S, De Groef A, Tjalma WA, Belgrado JP, Vandermeeren L, Monten C, Hanssens M, Devoogdt N
J Physiother 2022 Apr;68(2):110-122. Epub 2022 Apr 12 doi: 10.1016/j.jphys.2022.03.010. PMID: 35428594
Bystritsky RJ
Infect Dis Clin North Am 2021 Mar;35(1):49-60. doi: 10.1016/j.idc.2020.10.002. PMID: 33494874
Cross ELA, Jordan H, Godfrey R, Onakpoya IJ, Shears A, Fidler K, Peto TEA, Walker AS, Llewelyn MJ
J Infect 2020 Oct;81(4):521-531. Epub 2020 Jul 31 doi: 10.1016/j.jinf.2020.07.030. PMID: 32745638
Galli L, Venturini E, Bassi A, Gattinara GC, Chiappini E, Defilippi C, Diociaiuti A, Esposito S, Garazzino S, Giannattasio A, Krzysztofiak A, Latorre S, Lo Vecchio A, Marchisio P, Montagnani C, Nicolini G, Novelli A, Rossolini GM, Tersigni C, Villani A, El Hachem M, Neri I; Italian Pediatric Infectious Diseases Society; Italian Pediatric Dermatology Society
Clin Ther 2019 Mar;41(3):532-551.e17. Epub 2019 Feb 15 doi: 10.1016/j.clinthera.2019.01.010. PMID: 30777258
Dalal A, Eskin-Schwartz M, Mimouni D, Ray S, Days W, Hodak E, Leibovici L, Paul M
Cochrane Database Syst Rev 2017 Jun 20;6(6):CD009758. doi: 10.1002/14651858.CD009758.pub2. PMID: 28631307Free PMC Article

Prognosis

Gurel MS, Tekin B, Uzun S
Clin Dermatol 2020 Mar-Apr;38(2):140-151. Epub 2019 Oct 24 doi: 10.1016/j.clindermatol.2019.10.008. PMID: 32513395
Weins AB, Biedermann T, Weiss T, Weiss JM
J Dtsch Dermatol Ges 2016 Oct;14(10):989-993. doi: 10.1111/ddg.13132. PMID: 27767278
Trieb K
Bone Joint J 2016 Sep;98-B(9):1155-9. doi: 10.1302/0301-620X.98B9.37038. PMID: 27587513
Wang Q, Chang BJ, Riley TV
Vet Microbiol 2010 Jan 27;140(3-4):405-17. Epub 2009 Aug 8 doi: 10.1016/j.vetmic.2009.08.012. PMID: 19733019
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Clinical prediction guides

Cross ELA, Jordan H, Godfrey R, Onakpoya IJ, Shears A, Fidler K, Peto TEA, Walker AS, Llewelyn MJ
J Infect 2020 Oct;81(4):521-531. Epub 2020 Jul 31 doi: 10.1016/j.jinf.2020.07.030. PMID: 32745638
Galli L, Venturini E, Bassi A, Gattinara GC, Chiappini E, Defilippi C, Diociaiuti A, Esposito S, Garazzino S, Giannattasio A, Krzysztofiak A, Latorre S, Lo Vecchio A, Marchisio P, Montagnani C, Nicolini G, Novelli A, Rossolini GM, Tersigni C, Villani A, El Hachem M, Neri I; Italian Pediatric Infectious Diseases Society; Italian Pediatric Dermatology Society
Clin Ther 2019 Mar;41(3):532-551.e17. Epub 2019 Feb 15 doi: 10.1016/j.clinthera.2019.01.010. PMID: 30777258
Weins AB, Biedermann T, Weiss T, Weiss JM
J Dtsch Dermatol Ges 2016 Oct;14(10):989-993. doi: 10.1111/ddg.13132. PMID: 27767278
Morris AD
BMJ Clin Evid 2008 Jan 2;2008 PMID: 19450336Free PMC Article
Van der Zee AG, Oonk MH, De Hullu JA, Ansink AC, Vergote I, Verheijen RH, Maggioni A, Gaarenstroom KN, Baldwin PJ, Van Dorst EB, Van der Velden J, Hermans RH, van der Putten H, Drouin P, Schneider A, Sluiter WJ
J Clin Oncol 2008 Feb 20;26(6):884-9. doi: 10.1200/JCO.2007.14.0566. PMID: 18281661

Recent systematic reviews

Nightingale R, Yadav K, Hamill L, Glasziou P, Scott AM, Clark J, Keijzers G
J Gen Intern Med 2023 Aug;38(10):2396-2404. Epub 2023 May 25 doi: 10.1007/s11606-023-08229-w. PMID: 37231210Free PMC Article
Cross ELA, Jordan H, Godfrey R, Onakpoya IJ, Shears A, Fidler K, Peto TEA, Walker AS, Llewelyn MJ
J Infect 2020 Oct;81(4):521-531. Epub 2020 Jul 31 doi: 10.1016/j.jinf.2020.07.030. PMID: 32745638
Dalal A, Eskin-Schwartz M, Mimouni D, Ray S, Days W, Hodak E, Leibovici L, Paul M
Cochrane Database Syst Rev 2017 Jun 20;6(6):CD009758. doi: 10.1002/14651858.CD009758.pub2. PMID: 28631307Free PMC Article
Gunderson CG, Martinello RA
J Infect 2012 Feb;64(2):148-55. Epub 2011 Nov 11 doi: 10.1016/j.jinf.2011.11.004. PMID: 22101078
Morris AD
BMJ Clin Evid 2008 Jan 2;2008 PMID: 19450336Free PMC Article

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