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Erythema induratum

MedGen UID:
41857
Concept ID:
C0014741
Disease or Syndrome
Synonyms: Bazin Disease; Bazin's Disease; Bazins Disease; Disease, Bazin; Disease, Bazin's; Erythema Induratum; Tuberculosis Cutis Indurativa
SNOMED CT: Tuberculosis cutis indurativa (11354005); Tuberculous erythema induratum (11354005); Tuberculous Bazin's disease (11354005); Bazin's disease (11354005); Erythema induratum (2028007)

Definition

A type of panniculitis characterized histologically by the presence of granulomas, vasculitis, and necrosis. It is traditionally considered to be the tuberculous counterpart of nodular vasculitis, but is now known to occur without tuberculous precedent. It is seen most commonly in adolescent and menopausal women, is initiated or exacerbated by cold weather, and typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves. The nodules may progress to form indurations, ulcerations, and scars. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythema induratum

Professional guidelines

PubMed

Kaul S, Jakhar D, Mehta S, Singal A
J Am Acad Dermatol 2023 Dec;89(6):1107-1119. Epub 2022 Feb 8 doi: 10.1016/j.jaad.2021.12.064. PMID: 35149148
Gilchrist H, Patterson JW
Dermatol Ther 2010 Jul-Aug;23(4):320-7. doi: 10.1111/j.1529-8019.2010.01332.x. PMID: 20666819
Barbagallo J, Tager P, Ingleton R, Hirsch RJ, Weinberg JM
Am J Clin Dermatol 2002;3(5):319-28. doi: 10.2165/00128071-200203050-00004. PMID: 12069638

Recent clinical studies

Etiology

Llamas-Velasco M, Fraga J, Sánchez-Schmidt JM, Fernández-Figueras M, Gallardo F, Rütten A, Kempf W
Am J Dermatopathol 2020 Oct;42(10):717-730. doi: 10.1097/DAD.0000000000001597. PMID: 32956080
Morita TCAB, Trés GFS, García MSC, Halpern I, Criado PR, de Carvalho JF
Adv Rheumatol 2019 Aug 1;59(1):35. doi: 10.1186/s42358-019-0077-5. PMID: 31370889
Ferrara G, Stefanato CM, Gianotti R, Kubba A, Annessi G
G Ital Dermatol Venereol 2013 Aug;148(4):387-94. PMID: 23900160
Sethuraman G, Ramesh V
Pediatr Dermatol 2013 Jan-Feb;30(1):7-16. Epub 2012 Nov 22 doi: 10.1111/j.1525-1470.2012.01794.x. PMID: 23173930
White WL, Wieselthier JS, Hitchcock MG
Semin Cutan Med Surg 1996 Dec;15(4):278-99. doi: 10.1016/s1085-5629(96)80042-3. PMID: 9069596

Diagnosis

Kaul S, Kaur I, Mehta S, Singal A
J Am Acad Dermatol 2023 Dec;89(6):1091-1103. Epub 2022 Feb 8 doi: 10.1016/j.jaad.2021.12.063. PMID: 35149149
Chen Q, Chen W, Hao F
Clin Dermatol 2019 May-Jun;37(3):192-199. Epub 2019 Jan 11 doi: 10.1016/j.clindermatol.2019.01.008. PMID: 31178102
Wick MR
Semin Diagn Pathol 2017 May;34(3):261-272. Epub 2016 Dec 27 doi: 10.1053/j.semdp.2016.12.004. PMID: 28129926
Ferrara G, Stefanato CM, Gianotti R, Kubba A, Annessi G
G Ital Dermatol Venereol 2013 Aug;148(4):387-94. PMID: 23900160
Requena L, Requena C
Dermatol Online J 2002 Jun;8(1):4. PMID: 12165214

Therapy

Fernandes NC, Hortêncio AP
Rev Soc Bras Med Trop 2023;56:e0465. Epub 2023 Feb 20 doi: 10.1590/0037-8682-0465-2022. PMID: 36820661Free PMC Article
Llamas-Velasco M, Fraga J, Sánchez-Schmidt JM, Fernández-Figueras M, Gallardo F, Rütten A, Kempf W
Am J Dermatopathol 2020 Oct;42(10):717-730. doi: 10.1097/DAD.0000000000001597. PMID: 32956080
Chen Q, Chen W, Hao F
Clin Dermatol 2019 May-Jun;37(3):192-199. Epub 2019 Jan 11 doi: 10.1016/j.clindermatol.2019.01.008. PMID: 31178102
Gilchrist H, Patterson JW
Dermatol Ther 2010 Jul-Aug;23(4):320-7. doi: 10.1111/j.1529-8019.2010.01332.x. PMID: 20666819
Mascaró JM Jr, Baselga E
Dermatol Clin 2008 Oct;26(4):439-45, v. doi: 10.1016/j.det.2008.05.007. PMID: 18793975

Prognosis

Connors WJ, Fisher DA, Kunimoto DY, Jarand JM
BMC Infect Dis 2019 Jan 29;19(1):97. doi: 10.1186/s12879-019-3737-5. PMID: 30696400Free PMC Article
Sethuraman G, Ramesh V
Pediatr Dermatol 2013 Jan-Feb;30(1):7-16. Epub 2012 Nov 22 doi: 10.1111/j.1525-1470.2012.01794.x. PMID: 23173930
Motswaledi HM, Schulz EJ
Int J Dermatol 2006 Nov;45(11):1337-40. doi: 10.1111/j.1365-4632.2006.02763.x. PMID: 17076720
Requena L, Requena C
Dermatol Online J 2002 Jun;8(1):4. PMID: 12165214
Barbagallo J, Tager P, Ingleton R, Hirsch RJ, Weinberg JM
Am J Clin Dermatol 2002;3(5):319-28. doi: 10.2165/00128071-200203050-00004. PMID: 12069638

Clinical prediction guides

Kara Polat A, Gore Karaali M, Esra Koku Aksu A, Asli Turgut Erdemir V, Leblebici C, Salih Gurel M
Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):123-128. PMID: 32975298
Llamas-Velasco M, Fraga J, Sánchez-Schmidt JM, Fernández-Figueras M, Gallardo F, Rütten A, Kempf W
Am J Dermatopathol 2020 Oct;42(10):717-730. doi: 10.1097/DAD.0000000000001597. PMID: 32956080
Sethuraman G, Ramesh V
Pediatr Dermatol 2013 Jan-Feb;30(1):7-16. Epub 2012 Nov 22 doi: 10.1111/j.1525-1470.2012.01794.x. PMID: 23173930
Handa R, Ramam M, Verma KK, Singh MK, Kumar U, Aggarwal P, Wali JP
J Assoc Physicians India 2002 Aug;50:1008-12. PMID: 12421020
White WL, Wieselthier JS, Hitchcock MG
Semin Cutan Med Surg 1996 Dec;15(4):278-99. doi: 10.1016/s1085-5629(96)80042-3. PMID: 9069596

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