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Pseudoangiomatous stromal hyperplasia

MedGen UID:
418966
Concept ID:
C2931031
Disease or Syndrome
Synonyms: Mammary pseudoangiomatous stromal hyperplasia; Pseudoangiomatous stromal hyperplasia of the breast
SNOMED CT: Pseudoangiomatous stromal hyperplasia (705153001)

Definition

A benign proliferation of the stromal cells in the breast. It is classified as simple, when associated with the presence of slit-like spaces without erythrocytes and as fascicular/proliferative, when spindle cell proliferation without atypia is present. It is often seen in breast tissue specimens as small foci associated with benign epithelial lesions. Pseudoangiomatous stromal hyperplasia presenting as a well-circumscribed palpable mass is rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudoangiomatous stromal hyperplasia

Professional guidelines

PubMed

Karamchandani MM, De La Cruz Ku G, Sokol BL, Chatterjee A, Homsy C
Surg Clin North Am 2022 Dec;102(6):989-1005. doi: 10.1016/j.suc.2022.06.003. PMID: 36335933
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

Recent clinical studies

Etiology

Esmer AC, Tazeoglu D, Dag A
Breast Dis 2023;42(1):115-119. doi: 10.3233/BD-220070. PMID: 37066901
Ni Y, Tse GM
Arch Pathol Lab Med 2023 Jan 1;147(1):30-37. doi: 10.5858/arpa.2022-0048-RA. PMID: 35976671
Alran L, Chamming's F, Auriol-Leizagoyen S, Velasco V, Deleau F, Brouste V, Bonhomme B, Ben Rejeb H, Marty M, MacGrogan G
Histopathology 2022 Jan;80(2):304-313. Epub 2021 Sep 22 doi: 10.1111/his.14544. PMID: 34403159
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875
Celliers L, Wong DD, Bourke A
Clin Radiol 2010 Feb;65(2):145-9. Epub 2009 Dec 14 doi: 10.1016/j.crad.2009.10.003. PMID: 20103437

Diagnosis

Karamchandani MM, De La Cruz Ku G, Sokol BL, Chatterjee A, Homsy C
Surg Clin North Am 2022 Dec;102(6):989-1005. doi: 10.1016/j.suc.2022.06.003. PMID: 36335933
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Valeur NS, Rahbar H, Chapman T
Pediatr Radiol 2015 Oct;45(11):1584-99; quiz 1581-3. Epub 2015 Jul 12 doi: 10.1007/s00247-015-3402-0. PMID: 26164440
Gresik CM, Godellas C, Aranha GV, Rajan P, Shoup M
Surgery 2010 Oct;148(4):752-7; discussion 757-8. Epub 2010 Aug 14 doi: 10.1016/j.surg.2010.07.020. PMID: 20708765

Therapy

Hunt KN, Conners AL, Gray L, Hruska CB, O'Connor MK
Radiol Imaging Cancer 2024 Jun;6(4):e230186. doi: 10.1148/rycan.230186. PMID: 38847615
Kikuchi DS, Mustin DE, Ghanouni A, Walsh MD
J Plast Reconstr Aesthet Surg 2023 Feb;77:209-217. Epub 2022 Dec 19 doi: 10.1016/j.bjps.2022.12.003. PMID: 36587475
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Alran L, Chamming's F, Auriol-Leizagoyen S, Velasco V, Deleau F, Brouste V, Bonhomme B, Ben Rejeb H, Marty M, MacGrogan G
Histopathology 2022 Jan;80(2):304-313. Epub 2021 Sep 22 doi: 10.1111/his.14544. PMID: 34403159
Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016Free PMC Article

Prognosis

Patel G, Bipte S, Narurkar S
J Cancer Res Ther 2023 Oct 1;19(7):1714-1720. Epub 2023 Jan 3 doi: 10.4103/jcrt.jcrt_127_22. PMID: 38376269
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640
Hoda SA, Rosen PP
Breast J 2004 Nov-Dec;10(6):522-7. doi: 10.1111/j.1075-122X.2004.21412.x. PMID: 15569209

Clinical prediction guides

Jorns JM, Farooq A, Puzyrenko A, Jarzembowski J, Thike AA, Nasir NDM, Ng CCY, Liu W, Lee JY, Lim AH, Guan P, Teh BT, Tan PH
Histopathology 2023 Sep;83(3):357-365. Epub 2023 May 4 doi: 10.1111/his.14935. PMID: 37140543
Esmer AC, Tazeoglu D, Dag A
Breast Dis 2023;42(1):115-119. doi: 10.3233/BD-220070. PMID: 37066901
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Sevim Y, Kocaay AF, Eker T, Celasin H, Karabork A, Erden E, Genc V
Clinics (Sao Paulo) 2014 Aug;69(8):515-23. doi: 10.6061/clinics/2014(08)03. PMID: 25141109Free PMC Article

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