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Pseudoangiomatous stromal hyperplasia

MedGen UID:
418966
•Concept ID:
C2931031
•
Disease or Syndrome
Synonyms: Mammary pseudoangiomatous stromal hyperplasia; Pseudoangiomatous stromal hyperplasia of the breast
SNOMED CT: Pseudoangiomatous stromal hyperplasia (705153001)

Definition

A benign proliferation of the stromal cells in the breast. It is classified as simple, when associated with the presence of slit-like spaces without erythrocytes and as fascicular/proliferative, when spindle cell proliferation without atypia is present. It is often seen in breast tissue specimens as small foci associated with benign epithelial lesions. Pseudoangiomatous stromal hyperplasia presenting as a well-circumscribed palpable mass is rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudoangiomatous stromal hyperplasia

Professional guidelines

PubMed

Management of Gynecomastia and Male Benign Diseases.
Karamchandani MM, De La Cruz Ku G, Sokol BL, Chatterjee A, Homsy C
Surg Clin North Am 2022 Dec;102(6):989-1005. doi: 10.1016/j.suc.2022.06.003. PMID: 36335933
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

Recent clinical studies

Etiology

Pseudoangiomatous stromal hyperplasia of the breast: Clinical evaluation.
Esmer AC, Tazeoglu D, Dag A
Breast Dis 2023;42(1):115-119. doi: 10.3233/BD-220070. PMID: 37066901
MRI features of pseudoangiomatous stromal hyperplasia with histopathological correlation.
Nia ES, Adrada BE, Whitman GJ, Candelaria RP, Krishnamurthy S, Bassett RL, M Arribas E
Breast J 2021 Mar;27(3):242-247. Epub 2021 Jan 4 doi: 10.1111/tbj.14154. PMID: 33393706
Pseudoangiomatous Stromal Hyperplasia in Core Needle Biopsies of Breast Specimens.
Kelten Talu C, Boyaci C, Leblebici C, Hacihasanoglu E, Bozkurt ER
Int J Surg Pathol 2017 Feb;25(1):26-30. Epub 2016 Jul 28 doi: 10.1177/1066896916660763. PMID: 27450985
Pseudoangiomatous Stromal Hyperplasia of the Breast: Multimodality Review With Pathologic Correlation.
Raj SD, Sahani VG, Adrada BE, Scoggins ME, Albarracin CT, Woodtichartpreecha P, Posleman Monetto FE, Whitman GJ
Curr Probl Diagn Radiol 2017 Mar-Apr;46(2):130-135. Epub 2016 Feb 2 doi: 10.1067/j.cpradiol.2016.01.005. PMID: 26949063
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640

Diagnosis

Management of Gynecomastia and Male Benign Diseases.
Karamchandani MM, De La Cruz Ku G, Sokol BL, Chatterjee A, Homsy C
Surg Clin North Am 2022 Dec;102(6):989-1005. doi: 10.1016/j.suc.2022.06.003. PMID: 36335933
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Bilateral Diffuse Pseudoangiomatous Stromal Hyperplasia Necessitating Mastectomy.
Jones VM, Cairns A, Miller-Ocuin J, Steele T, Aguila-Seara G, Ghandili M, LeRoy Coldren D, Marks MW, Howard-McNatt M, Chiba A
Am Surg 2022 Aug;88(8):1919-1921. Epub 2022 Apr 17 doi: 10.1177/00031348221086811. PMID: 35435015
Mesenchymal breast lesions.
Schickman R, Leibman AJ, Handa P, Kornmehl A, Abadi M
Clin Radiol 2015 Jun;70(6):567-75. Epub 2015 Jan 29 doi: 10.1016/j.crad.2014.12.015. PMID: 25638601
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640

Therapy

A review of pediatric macromastia etiology and indications for reduction mammaplasty.
Kikuchi DS, Mustin DE, Ghanouni A, Walsh MD
J Plast Reconstr Aesthet Surg 2023 Feb;77:209-217. Epub 2022 Dec 19 doi: 10.1016/j.bjps.2022.12.003. PMID: 36587475
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Breast hamartoma: reassessment of an under-recognised breast lesion.
Alran L, Chamming's F, Auriol-Leizagoyen S, Velasco V, Deleau F, Brouste V, Bonhomme B, Ben Rejeb H, Marty M, MacGrogan G
Histopathology 2022 Jan;80(2):304-313. Epub 2021 Sep 22 doi: 10.1111/his.14544. PMID: 34403159
Pseudoangiomatous stromal hyperplasia (PASH) presenting as axillary lump: case report and review of the literature.
Canu GL, Medas F, Ravarino A, Furcas S, Loi G, Cerrone G, Rossi C, Erdas E, Calò P G
G Chir 2018 Nov-Dec;39(6):378-382. PMID: 30563602
Pseudoangiomatous stromal hyperplasia of the breast.
AbdullGaffar B
Arch Pathol Lab Med 2009 Aug;133(8):1335-8. doi: 10.5858/133.8.1335. PMID: 19653734

Prognosis

Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Optimal treatment of pseudoangiomatous stromal hyperplasia of the breast.
Yoon KH, Koo B, Lee KB, Lee H, Lee J, Kim JY, Park HS, Park S, Kim SI, Cho YU, Park BW
Asian J Surg 2020 Jul;43(7):735-741. Epub 2019 Oct 26 doi: 10.1016/j.asjsur.2019.09.008. PMID: 31669037
Unilateral gynecomastia and pseudoangiomatous stromal hyperplasia in neurofibromatosis: case report and review of the literature.
Kimura S, Tanimoto A, Shimajiri S, Sasaguri T, Yamada S, Wang KY, Guo X, Sasaguri Y
Pathol Res Pract 2012 May 15;208(5):318-22. Epub 2012 Apr 19 doi: 10.1016/j.prp.2012.03.003. PMID: 22520406
Pseudoangiomatous stromal hyperplasia: an overview.
Virk RK, Khan A
Arch Pathol Lab Med 2010 Jul;134(7):1070-4. doi: 10.5858/2008-0686-RS.1. PMID: 20586640
Pseudoangiomatous stromal hyperplasia of the breast.
AbdullGaffar B
Arch Pathol Lab Med 2009 Aug;133(8):1335-8. doi: 10.5858/133.8.1335. PMID: 19653734

Clinical prediction guides

Pseudoangiomatous stromal hyperplasia of the breast: Clinical evaluation.
Esmer AC, Tazeoglu D, Dag A
Breast Dis 2023;42(1):115-119. doi: 10.3233/BD-220070. PMID: 37066901
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Myofibroblastic, fibroblastic and myoid lesions of the breast.
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Pseudoangiomatous stromal hyperplasia of the breast: a contemporary approach to its clinical and radiologic features and ideal management.
Gresik CM, Godellas C, Aranha GV, Rajan P, Shoup M
Surgery 2010 Oct;148(4):752-7; discussion 757-8. Epub 2010 Aug 14 doi: 10.1016/j.surg.2010.07.020. PMID: 20708765
Pseudoangiomatous stromal hyperplasia and breast cancer risk.
Degnim AC, Frost MH, Radisky DC, Anderson SS, Vierkant RA, Boughey JC, Pankratz VS, Ghosh K, Hartmann LC, Visscher DW
Ann Surg Oncol 2010 Dec;17(12):3269-77. Epub 2010 Jun 22 doi: 10.1245/s10434-010-1170-5. PMID: 20567920Free PMC Article

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