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Euthyroid sick syndrome

MedGen UID:
41908
•Concept ID:
C0015190
•
Disease or Syndrome
Synonyms: Euthyroid Sick Syndrome; Euthyroid Sick Syndromes; Non Thyroidal Illness Syndrome; Non-Thyroidal Illness Syndrome; Sick Euthyroid Syndrome; Syndrome, Non-Thyroidal Illness; Syndrome, Sick Euthyroid; Syndromes, Non-Thyroidal Illness
SNOMED CT: Sick euthyroid syndrome (237542005); Sick-euthyroid syndrome (237542005)
 
Monarch Initiative: MONDO:0006755

Definition

Abnormal thyroid function tests, low triiodothyronine with elevated reverse triiodothyronine, in the setting of non-thyroidal illness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEuthyroid sick syndrome

Professional guidelines

PubMed

Thyroid dysfunction during treatment with systemic antineoplastic therapy for childhood cancer: A systematic review.
van der Leij S, Lebbink CA, Lentjes EG, Tissing WJ, Stuart AV, van den Heuvel-Eibrink MM, van Santen HM, van Dalen EC
Crit Rev Oncol Hematol 2023 Apr;184:103958. Epub 2023 Mar 11 doi: 10.1016/j.critrevonc.2023.103958. PMID: 36907363
Emerging pharmacotherapy for treatment of traumatic brain injury: targeting hypopituitarism and inflammation.
Paterniti I, Cordaro M, Navarra M, Esposito E, Cuzzocrea S
Expert Opin Emerg Drugs 2015;20(4):583-96. Epub 2015 Jun 18 doi: 10.1517/14728214.2015.1058358. PMID: 26087316
The euthyroid sick syndrome: is there a physiologic rationale for thyroid hormone treatment?
Stathatos N, Wartofsky L
J Endocrinol Invest 2003 Dec;26(12):1174-9. doi: 10.1007/BF03349153. PMID: 15055468

Recent clinical studies

Etiology

Euthyroid sick syndrome and its association with complications of type 1 diabetes mellitus onset.
Marzuillo P, Iafusco D, Guarino S, Di Sessa A, Zanfardino A, Piscopo A, Luongo C, Capalbo D, Verde M, Aiello F, Festa A, Miraglia Del Giudice E, Grandone A
Pediatr Res 2023 Aug;94(2):632-642. Epub 2023 Jan 31 doi: 10.1038/s41390-023-02494-5. PMID: 36721033Free PMC Article
Biochemical indicators of euthyroid sick syndrome in critically ill children.
Besci T, Besci Ö, Arslan G, Ilgaz H, Prencuva P, Özdemir G, Abacı A, Demir K
J Pediatr Endocrinol Metab 2022 Oct 26;35(10):1285-1292. Epub 2022 Sep 16 doi: 10.1515/jpem-2022-0232. PMID: 36106490
Euthyroid Sick Syndrome in Patients With COVID-19.
Zou R, Wu C, Zhang S, Wang G, Zhang Q, Yu B, Wu Y, Dong H, Wu G, Wu S, Zhong Y
Front Endocrinol (Lausanne) 2020;11:566439. Epub 2020 Oct 7 doi: 10.3389/fendo.2020.566439. PMID: 33117282Free PMC Article
Euthyroid sick syndrome in hip fractures: Evaluation of postoperative anemia.
M C, R V, C P, M C, G S, N P, E P, Ziranu A, G M
Injury 2020 Aug;51 Suppl 3:S9-S12. Epub 2020 Jul 3 doi: 10.1016/j.injury.2020.07.006. PMID: 32669206
Investigation of the Oxidative Stress and DIO1 Expression in CRF Patients Accompanied With and Without Euthyroid Sick Syndrome.
Shu-Lan Q, Chun-Yan H, Qi H, Juan C, Cheng-Fang J, Aimee YC, Xia S, Zhi-Hong L, Long-Xin X
Kidney Blood Press Res 2018;43(3):924-930. Epub 2018 Jun 7 doi: 10.1159/000490471. PMID: 29894998

Diagnosis

Biochemical indicators of euthyroid sick syndrome in critically ill children.
Besci T, Besci Ö, Arslan G, Ilgaz H, Prencuva P, Özdemir G, Abacı A, Demir K
J Pediatr Endocrinol Metab 2022 Oct 26;35(10):1285-1292. Epub 2022 Sep 16 doi: 10.1515/jpem-2022-0232. PMID: 36106490
Euthyroid Sick Syndrome in Patients With COVID-19.
Zou R, Wu C, Zhang S, Wang G, Zhang Q, Yu B, Wu Y, Dong H, Wu G, Wu S, Zhong Y
Front Endocrinol (Lausanne) 2020;11:566439. Epub 2020 Oct 7 doi: 10.3389/fendo.2020.566439. PMID: 33117282Free PMC Article
Euthyroid sick syndrome in hip fractures: Evaluation of postoperative anemia.
M C, R V, C P, M C, G S, N P, E P, Ziranu A, G M
Injury 2020 Aug;51 Suppl 3:S9-S12. Epub 2020 Jul 3 doi: 10.1016/j.injury.2020.07.006. PMID: 32669206
Euthyroid sick syndrome.
Umpierrez GE
South Med J 2002 May;95(5):506-13. PMID: 12005007
Euthyroid sick syndrome.
Zaloga GP, O'Brian JT
Am Fam Physician 1985 Feb;31(2):236-50. PMID: 3919544

Therapy

Euthyroid sick syndrome in paediatric and adult patients requiring extracorporeal circulatory support and the role of thyroid hormone supplementation: a review.
Nistal-Nuño B
Perfusion 2021 Jan;36(1):21-33. Epub 2020 May 19 doi: 10.1177/0267659120914136. PMID: 32423366
Euthyroid sick syndrome in hip fractures: Evaluation of postoperative anemia.
M C, R V, C P, M C, G S, N P, E P, Ziranu A, G M
Injury 2020 Aug;51 Suppl 3:S9-S12. Epub 2020 Jul 3 doi: 10.1016/j.injury.2020.07.006. PMID: 32669206
The Role of Thyroid Hormones in Heart Failure.
Vale C, Neves JS, von Hafe M, Borges-Canha M, Leite-Moreira A
Cardiovasc Drugs Ther 2019 Apr;33(2):179-188. doi: 10.1007/s10557-019-06870-4. PMID: 30847626
Euthyroid Sick Syndrome.
Lee S, Farwell AP
Compr Physiol 2016 Mar 15;6(2):1071-80. doi: 10.1002/cphy.c150017. PMID: 27065175
Euthyroid sick syndrome.
Umpierrez GE
South Med J 2002 May;95(5):506-13. PMID: 12005007

Prognosis

Euthyroid sick syndrome and its association with complications of type 1 diabetes mellitus onset.
Marzuillo P, Iafusco D, Guarino S, Di Sessa A, Zanfardino A, Piscopo A, Luongo C, Capalbo D, Verde M, Aiello F, Festa A, Miraglia Del Giudice E, Grandone A
Pediatr Res 2023 Aug;94(2):632-642. Epub 2023 Jan 31 doi: 10.1038/s41390-023-02494-5. PMID: 36721033Free PMC Article
Biochemical indicators of euthyroid sick syndrome in critically ill children.
Besci T, Besci Ö, Arslan G, Ilgaz H, Prencuva P, Özdemir G, Abacı A, Demir K
J Pediatr Endocrinol Metab 2022 Oct 26;35(10):1285-1292. Epub 2022 Sep 16 doi: 10.1515/jpem-2022-0232. PMID: 36106490
Euthyroid Sick Syndrome in Patients With COVID-19.
Zou R, Wu C, Zhang S, Wang G, Zhang Q, Yu B, Wu Y, Dong H, Wu G, Wu S, Zhong Y
Front Endocrinol (Lausanne) 2020;11:566439. Epub 2020 Oct 7 doi: 10.3389/fendo.2020.566439. PMID: 33117282Free PMC Article
Euthyroid sick syndrome in hip fractures: Evaluation of postoperative anemia.
M C, R V, C P, M C, G S, N P, E P, Ziranu A, G M
Injury 2020 Aug;51 Suppl 3:S9-S12. Epub 2020 Jul 3 doi: 10.1016/j.injury.2020.07.006. PMID: 32669206
Euthyroid Sick Syndrome.
Lee S, Farwell AP
Compr Physiol 2016 Mar 15;6(2):1071-80. doi: 10.1002/cphy.c150017. PMID: 27065175

Clinical prediction guides

Biochemical indicators of euthyroid sick syndrome in critically ill children.
Besci T, Besci Ö, Arslan G, Ilgaz H, Prencuva P, Özdemir G, Abacı A, Demir K
J Pediatr Endocrinol Metab 2022 Oct 26;35(10):1285-1292. Epub 2022 Sep 16 doi: 10.1515/jpem-2022-0232. PMID: 36106490
The Association Between FT3 With the Outcome and Inflammation/Coagulopathy/Fibrinolysis of COVID-19.
Deng J, Zhang S, Peng F, Zhang Q, Li Y, Zhong Y
Front Endocrinol (Lausanne) 2022;13:877010. Epub 2022 Jun 3 doi: 10.3389/fendo.2022.877010. PMID: 35721727Free PMC Article
Euthyroid Sick Syndrome in Patients With COVID-19.
Zou R, Wu C, Zhang S, Wang G, Zhang Q, Yu B, Wu Y, Dong H, Wu G, Wu S, Zhong Y
Front Endocrinol (Lausanne) 2020;11:566439. Epub 2020 Oct 7 doi: 10.3389/fendo.2020.566439. PMID: 33117282Free PMC Article
Euthyroid sick syndrome in hip fractures: Evaluation of postoperative anemia.
M C, R V, C P, M C, G S, N P, E P, Ziranu A, G M
Injury 2020 Aug;51 Suppl 3:S9-S12. Epub 2020 Jul 3 doi: 10.1016/j.injury.2020.07.006. PMID: 32669206
Euthyroid sick syndrome in hip fractures: Valuation of vitamin D and parathyroid hormone axis.
Vitiello R, Perisano C, Covino M, Perna A, Bianchi A, Oliva MS, Greco T, Sirgiovanni M, Maccauro G
Injury 2020 Aug;51 Suppl 3:S13-S16. Epub 2020 Jan 9 doi: 10.1016/j.injury.2020.01.013. PMID: 31983423

Recent systematic reviews

Thyroid dysfunction during treatment with systemic antineoplastic therapy for childhood cancer: A systematic review.
van der Leij S, Lebbink CA, Lentjes EG, Tissing WJ, Stuart AV, van den Heuvel-Eibrink MM, van Santen HM, van Dalen EC
Crit Rev Oncol Hematol 2023 Apr;184:103958. Epub 2023 Mar 11 doi: 10.1016/j.critrevonc.2023.103958. PMID: 36907363
Low free-T3 serum levels and prognosis of COVID-19: systematic review and meta-analysis.
Llamas M, Garo ML, Giovanella L
Clin Chem Lab Med 2021 Nov 25;59(12):1906-1913. Epub 2021 Aug 11 doi: 10.1515/cclm-2021-0805. PMID: 34380183
Thyroid Hormone (Triiodothyronine) Therapy in Children After Congenital Heart Surgery: A Meta-Analysis.
Flores S, Loomba RS, Checchia PA, Graham EM, Bronicki RA
Semin Thorac Cardiovasc Surg 2020 Spring;32(1):87-95. Epub 2019 May 22 doi: 10.1053/j.semtcvs.2019.05.020. PMID: 31128253

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