del(12p13)

MedGen UID:: 419167
•Concept ID:: C2931806
•: Cell or Molecular Dysfunction

Synonyms:

Deletion 12p13; Monosomy 12p13

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVdel(12p13)

Molecular Abnormality
- Cytogenetic Abnormality
  - Chromosomal Rearrangement
    - Chromosomal Deletion
      - del(12p13)

Recent clinical studies

Therapy

Heterogeneous chromosome 12p deletion is an independent adverse prognostic factor and resistant to bortezomib-based therapy in multiple myeloma.

Li F, Xu Y, Deng P, Yang Y, Sui W, Jin F, Hao M, Li Z, Zang M, Zhou D, Gu Z, Ru K, Wang J, Cheng T, Qiu L
Oncotarget 2015 Apr 20;6(11):9434-44. doi: 10.18632/oncotarget.3319. PMID: 25831238 Free PMC Article

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Prognosis

Heterogeneous chromosome 12p deletion is an independent adverse prognostic factor and resistant to bortezomib-based therapy in multiple myeloma.

Prognostic significance of copy-number alterations in multiple myeloma.

Avet-Loiseau H, Li C, Magrangeas F, Gouraud W, Charbonnel C, Harousseau JL, Attal M, Marit G, Mathiot C, Facon T, Moreau P, Anderson KC, Campion L, Munshi NC, Minvielle S
J Clin Oncol 2009 Sep 20;27(27):4585-90. Epub 2009 Aug 17 doi: 10.1200/JCO.2008.20.6136. PMID: 19687334 Free PMC Article

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Clinical prediction guides

Prognostic significance of copy-number alterations in multiple myeloma.

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MedGen

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del(12p13)

Term Hierarchy

Recent clinical studies

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

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