U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Juvenile Systemic Sclerosis

MedGen UID:
419841
•Concept ID:
C2931591
•
Disease or Syndrome
Synonym: Juvenile systemic scleroderma

Definition

Systemic sclerosis that is diagnosed in children. Juvenile systemic sclerosis is more likely to be of the overlap variant and presents with musculoskeletal involvement. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJuvenile Systemic Sclerosis

Professional guidelines

PubMed

Consensus-based recommendations for the management of juvenile systemic sclerosis.
Foeldvari I, Culpo R, Sperotto F, Anton J, Avcin T, Baildam E, Boros C, Chaitow J, Constantin T, Kasapcopur O, Knupp Feitosa de Oliveira S, Pilkington C, Toplak N, van Royen A, Saad Magalhaes C, Vastert SJ, Wulffraat N, Zulian F
Rheumatology (Oxford) 2021 Apr 6;60(4):1651-1658. doi: 10.1093/rheumatology/keaa584. PMID: 33147624
Treatment in Juvenile Scleroderma.
Zulian F, Tirelli F
Curr Rheumatol Rep 2020 Jun 26;22(8):45. doi: 10.1007/s11926-020-00910-x. PMID: 32591919
Recent advances in the management of juvenile systemic sclerosis.
Zulian F, Balzarin M, Birolo C
Expert Rev Clin Immunol 2017 Apr;13(4):361-369. Epub 2016 Oct 11 doi: 10.1080/1744666X.2017.1243467. PMID: 27690679

Recent clinical studies

Etiology

Childhood rheumatic diseases: bites not only the joint, but also the heart.
Thomas KN, Aggarwal A
Clin Rheumatol 2023 Oct;42(10):2703-2715. Epub 2023 May 9 doi: 10.1007/s10067-023-06621-9. PMID: 37160484Free PMC Article
Systemic sclerosis sine scleroderma in children.
Zulian F, Lanzoni G, Castaldi B, Meneghel A, Tirelli F, Zanatta E, Martini G
Rheumatology (Oxford) 2022 May 30;61(6):2555-2562. doi: 10.1093/rheumatology/keab738. PMID: 34605913Free PMC Article
DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma.
Coit P, Schollaert KL, Mirizio EM, Torok KS, Sawalha AH
Clin Immunol 2021 Jul;228:108756. Epub 2021 May 13 doi: 10.1016/j.clim.2021.108756. PMID: 33992755Free PMC Article
Treatment in Juvenile Scleroderma.
Zulian F, Tirelli F
Curr Rheumatol Rep 2020 Jun 26;22(8):45. doi: 10.1007/s11926-020-00910-x. PMID: 32591919
Scleroderma in Children and Adolescents: Localized Scleroderma and Systemic Sclerosis.
Li SC
Pediatr Clin North Am 2018 Aug;65(4):757-781. doi: 10.1016/j.pcl.2018.04.002. PMID: 30031497

Diagnosis

Juvenile Systemic Sclerosis: A Rare Phenomenon.
Zaki SA, Bade SR, Banur D
J Assoc Physicians India 2022 Dec;70(12):11-12. PMID: 37355978
Scleroderma in Children and Adolescents: Localized Scleroderma and Systemic Sclerosis.
Li SC
Pediatr Clin North Am 2018 Aug;65(4):757-781. doi: 10.1016/j.pcl.2018.04.002. PMID: 30031497
Scleroderma in children.
Zulian F
Best Pract Res Clin Rheumatol 2017 Aug;31(4):576-595. Epub 2018 Mar 27 doi: 10.1016/j.berh.2018.02.004. PMID: 29773274
Update on juvenile systemic sclerosis.
Foeldvari I
Curr Rheumatol Rep 2015 Mar;17(3):18. doi: 10.1007/s11926-014-0491-y. PMID: 25761925
Childhood systemic sclerosis.
Zulian F, Martini G
Curr Opin Rheumatol 2007 Nov;19(6):592-7. doi: 10.1097/BOR.0b013e3282f01625. PMID: 17917540

Therapy

Tocilizumab therapy in juvenile systemic sclerosis: a retrospective single centre pilot study.
Adrovic A, Yildiz M, Haslak F, Koker O, Aliyeva A, Sahin S, Barut K, Kasapcopur O
Rheumatol Int 2021 Jan;41(1):121-128. Epub 2020 Oct 27 doi: 10.1007/s00296-020-04732-z. PMID: 33108799
Treatment in Juvenile Scleroderma.
Zulian F, Tirelli F
Curr Rheumatol Rep 2020 Jun 26;22(8):45. doi: 10.1007/s11926-020-00910-x. PMID: 32591919
Scleroderma in Children and Adolescents: Localized Scleroderma and Systemic Sclerosis.
Li SC
Pediatr Clin North Am 2018 Aug;65(4):757-781. doi: 10.1016/j.pcl.2018.04.002. PMID: 30031497
Juvenile Scleroderma-What has Changed in the Meantime?
Adrovic A, Sahin S, Barut K, Kasapcopur O
Curr Rheumatol Rev 2018;14(3):219-225. doi: 10.2174/1573397114666180423105056. PMID: 29692255
Scleroderma in children.
Zulian F
Best Pract Res Clin Rheumatol 2017 Aug;31(4):576-595. Epub 2018 Mar 27 doi: 10.1016/j.berh.2018.02.004. PMID: 29773274

Prognosis

Systemic sclerosis sine scleroderma in children.
Zulian F, Lanzoni G, Castaldi B, Meneghel A, Tirelli F, Zanatta E, Martini G
Rheumatology (Oxford) 2022 May 30;61(6):2555-2562. doi: 10.1093/rheumatology/keab738. PMID: 34605913Free PMC Article
Rituximab for rapidly progressive juvenile systemic sclerosis.
Zulian F, Dal Pozzolo R, Meneghel A, Castaldi B, Marcolongo R, Caforio ALP, Martini G
Rheumatology (Oxford) 2020 Dec 1;59(12):3793-3797. doi: 10.1093/rheumatology/keaa193. PMID: 32442284
Scleroderma in Children and Adolescents: Localized Scleroderma and Systemic Sclerosis.
Li SC
Pediatr Clin North Am 2018 Aug;65(4):757-781. doi: 10.1016/j.pcl.2018.04.002. PMID: 30031497
Juvenile Scleroderma-What has Changed in the Meantime?
Adrovic A, Sahin S, Barut K, Kasapcopur O
Curr Rheumatol Rev 2018;14(3):219-225. doi: 10.2174/1573397114666180423105056. PMID: 29692255
Childhood systemic sclerosis.
Zulian F, Martini G
Curr Opin Rheumatol 2007 Nov;19(6):592-7. doi: 10.1097/BOR.0b013e3282f01625. PMID: 17917540

Clinical prediction guides

Treatment in Juvenile Scleroderma.
Zulian F, Tirelli F
Curr Rheumatol Rep 2020 Jun 26;22(8):45. doi: 10.1007/s11926-020-00910-x. PMID: 32591919
Scleroderma in children.
Zulian F
Best Pract Res Clin Rheumatol 2017 Aug;31(4):576-595. Epub 2018 Mar 27 doi: 10.1016/j.berh.2018.02.004. PMID: 29773274
Recent advances in the management of juvenile systemic sclerosis.
Zulian F, Balzarin M, Birolo C
Expert Rev Clin Immunol 2017 Apr;13(4):361-369. Epub 2016 Oct 11 doi: 10.1080/1744666X.2017.1243467. PMID: 27690679
Update on juvenile systemic sclerosis.
Foeldvari I
Curr Rheumatol Rep 2015 Mar;17(3):18. doi: 10.1007/s11926-014-0491-y. PMID: 25761925
Scleroderma in children: an update.
Zulian F, Cuffaro G, Sperotto F
Curr Opin Rheumatol 2013 Sep;25(5):643-50. doi: 10.1097/BOR.0b013e3283641f61. PMID: 23912318

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...