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Metastatic Clear Cell Renal Cell Carcinoma

MedGen UID:
419920
Concept ID:
C2931852
Neoplastic Process
Synonym: Clear-cell metastatic renal cell carcinoma
SNOMED CT: Metastatic clear cell renal cell carcinoma (1187285005)

Definition

A clear cell renal cell carcinoma that has spread from its original site of growth to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Clear Cell Renal Cell Carcinoma

Professional guidelines

PubMed

Simonaggio A, Auvray-Kuentz M, Rochand A, Thibault C, Gervais C, Oudard S, Vano YA
Bull Cancer 2022 May;109(2S):2S47-2S58. doi: 10.1016/S0007-4551(22)00238-7. PMID: 35760471
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Schmidt A, Azad A, Goh J, Harris C, Joshua AM, Weickhardt A, Krieger L
Asia Pac J Clin Oncol 2019 Nov;15 Suppl 10:3-10. doi: 10.1111/ajco.13289. PMID: 31762165

Recent clinical studies

Etiology

Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Motzer RJ, Powles T, Burotto M, Escudier B, Bourlon MT, Shah AY, Suárez C, Hamzaj A, Porta C, Hocking CM, Kessler ER, Gurney H, Tomita Y, Bedke J, Zhang J, Simsek B, Scheffold C, Apolo AB, Choueiri TK
Lancet Oncol 2022 Jul;23(7):888-898. Epub 2022 Jun 7 doi: 10.1016/S1470-2045(22)00290-X. PMID: 35688173Free PMC Article
Au L, Hatipoglu E, Robert de Massy M, Litchfield K, Beattie G, Rowan A, Schnidrig D, Thompson R, Byrne F, Horswell S, Fotiadis N, Hazell S, Nicol D, Shepherd STC, Fendler A, Mason R, Del Rosario L, Edmonds K, Lingard K, Sarker S, Mangwende M, Carlyle E, Attig J, Joshi K, Uddin I, Becker PD, Sunderland MW, Akarca A, Puccio I, Yang WW, Lund T, Dhillon K, Vasquez MD, Ghorani E, Xu H, Spencer C, López JI, Green A, Mahadeva U, Borg E, Mitchison M, Moore DA, Proctor I, Falzon M, Pickering L, Furness AJS, Reading JL, Salgado R, Marafioti T, Jamal-Hanjani M; PEACE Consortium, Kassiotis G, Chain B, Larkin J, Swanton C, Quezada SA, Turajlic S; TRACERx Renal Consortium
Cancer Cell 2021 Nov 8;39(11):1497-1518.e11. Epub 2021 Oct 28 doi: 10.1016/j.ccell.2021.10.001. PMID: 34715028Free PMC Article
Méjean A, Ravaud A, Thezenas S, Colas S, Beauval JB, Bensalah K, Geoffrois L, Thiery-Vuillemin A, Cormier L, Lang H, Guy L, Gravis G, Rolland F, Linassier C, Lechevallier E, Beisland C, Aitchison M, Oudard S, Patard JJ, Theodore C, Chevreau C, Laguerre B, Hubert J, Gross-Goupil M, Bernhard JC, Albiges L, Timsit MO, Lebret T, Escudier B
N Engl J Med 2018 Aug 2;379(5):417-427. Epub 2018 Jun 3 doi: 10.1056/NEJMoa1803675. PMID: 29860937
Motzer RJ, Hutson TE, Glen H, Michaelson MD, Molina A, Eisen T, Jassem J, Zolnierek J, Maroto JP, Mellado B, Melichar B, Tomasek J, Kremer A, Kim HJ, Wood K, Dutcus C, Larkin J
Lancet Oncol 2015 Nov;16(15):1473-1482. Epub 2015 Oct 22 doi: 10.1016/S1470-2045(15)00290-9. PMID: 26482279

Diagnosis

Sellner F, Compérat E, Klimpfinger M
Int J Mol Sci 2023 Nov 14;24(22) doi: 10.3390/ijms242216292. PMID: 38003482Free PMC Article
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Velez Torres JM, Briski LM, Martinez Duarte E, Sadow PM, Kerr DA, Kryvenko ON
Int J Surg Pathol 2022 Oct;30(7):743-752. Epub 2022 Mar 7 doi: 10.1177/10668969221081729. PMID: 35253524Free PMC Article
Zhang T, Zhu J, George DJ, Nixon AB
Urol Oncol 2016 Nov;34(11):510-518. Epub 2016 Aug 4 doi: 10.1016/j.urolonc.2016.06.020. PMID: 27498927
Sangoi AR, Karamchandani J, Kim J, Pai RK, McKenney JK
Adv Anat Pathol 2010 Nov;17(6):377-93. doi: 10.1097/PAP.0b013e3181f89400. PMID: 20966644

Therapy

Davidson G, Helleux A, Vano YA, Lindner V, Fattori A, Cerciat M, Elaidi RT, Verkarre V, Sun CM, Chevreau C, Bennamoun M, Lang H, Tricard T, Fridman WH, Sautes-Fridman C, Su X, Plassard D, Keime C, Thibault-Carpentier C, Barthelemy P, Oudard SM, Davidson I, Malouf GG
Cancer Res 2023 Sep 1;83(17):2952-2969. doi: 10.1158/0008-5472.CAN-22-3034. PMID: 37335139
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Motzer RJ, Powles T, Burotto M, Escudier B, Bourlon MT, Shah AY, Suárez C, Hamzaj A, Porta C, Hocking CM, Kessler ER, Gurney H, Tomita Y, Bedke J, Zhang J, Simsek B, Scheffold C, Apolo AB, Choueiri TK
Lancet Oncol 2022 Jul;23(7):888-898. Epub 2022 Jun 7 doi: 10.1016/S1470-2045(22)00290-X. PMID: 35688173Free PMC Article
Au L, Hatipoglu E, Robert de Massy M, Litchfield K, Beattie G, Rowan A, Schnidrig D, Thompson R, Byrne F, Horswell S, Fotiadis N, Hazell S, Nicol D, Shepherd STC, Fendler A, Mason R, Del Rosario L, Edmonds K, Lingard K, Sarker S, Mangwende M, Carlyle E, Attig J, Joshi K, Uddin I, Becker PD, Sunderland MW, Akarca A, Puccio I, Yang WW, Lund T, Dhillon K, Vasquez MD, Ghorani E, Xu H, Spencer C, López JI, Green A, Mahadeva U, Borg E, Mitchison M, Moore DA, Proctor I, Falzon M, Pickering L, Furness AJS, Reading JL, Salgado R, Marafioti T, Jamal-Hanjani M; PEACE Consortium, Kassiotis G, Chain B, Larkin J, Swanton C, Quezada SA, Turajlic S; TRACERx Renal Consortium
Cancer Cell 2021 Nov 8;39(11):1497-1518.e11. Epub 2021 Oct 28 doi: 10.1016/j.ccell.2021.10.001. PMID: 34715028Free PMC Article
Méjean A, Ravaud A, Thezenas S, Colas S, Beauval JB, Bensalah K, Geoffrois L, Thiery-Vuillemin A, Cormier L, Lang H, Guy L, Gravis G, Rolland F, Linassier C, Lechevallier E, Beisland C, Aitchison M, Oudard S, Patard JJ, Theodore C, Chevreau C, Laguerre B, Hubert J, Gross-Goupil M, Bernhard JC, Albiges L, Timsit MO, Lebret T, Escudier B
N Engl J Med 2018 Aug 2;379(5):417-427. Epub 2018 Jun 3 doi: 10.1056/NEJMoa1803675. PMID: 29860937

Prognosis

Davidson G, Helleux A, Vano YA, Lindner V, Fattori A, Cerciat M, Elaidi RT, Verkarre V, Sun CM, Chevreau C, Bennamoun M, Lang H, Tricard T, Fridman WH, Sautes-Fridman C, Su X, Plassard D, Keime C, Thibault-Carpentier C, Barthelemy P, Oudard SM, Davidson I, Malouf GG
Cancer Res 2023 Sep 1;83(17):2952-2969. doi: 10.1158/0008-5472.CAN-22-3034. PMID: 37335139
Motzer RJ, Powles T, Burotto M, Escudier B, Bourlon MT, Shah AY, Suárez C, Hamzaj A, Porta C, Hocking CM, Kessler ER, Gurney H, Tomita Y, Bedke J, Zhang J, Simsek B, Scheffold C, Apolo AB, Choueiri TK
Lancet Oncol 2022 Jul;23(7):888-898. Epub 2022 Jun 7 doi: 10.1016/S1470-2045(22)00290-X. PMID: 35688173Free PMC Article
Au L, Hatipoglu E, Robert de Massy M, Litchfield K, Beattie G, Rowan A, Schnidrig D, Thompson R, Byrne F, Horswell S, Fotiadis N, Hazell S, Nicol D, Shepherd STC, Fendler A, Mason R, Del Rosario L, Edmonds K, Lingard K, Sarker S, Mangwende M, Carlyle E, Attig J, Joshi K, Uddin I, Becker PD, Sunderland MW, Akarca A, Puccio I, Yang WW, Lund T, Dhillon K, Vasquez MD, Ghorani E, Xu H, Spencer C, López JI, Green A, Mahadeva U, Borg E, Mitchison M, Moore DA, Proctor I, Falzon M, Pickering L, Furness AJS, Reading JL, Salgado R, Marafioti T, Jamal-Hanjani M; PEACE Consortium, Kassiotis G, Chain B, Larkin J, Swanton C, Quezada SA, Turajlic S; TRACERx Renal Consortium
Cancer Cell 2021 Nov 8;39(11):1497-1518.e11. Epub 2021 Oct 28 doi: 10.1016/j.ccell.2021.10.001. PMID: 34715028Free PMC Article
Méjean A, Ravaud A, Thezenas S, Colas S, Beauval JB, Bensalah K, Geoffrois L, Thiery-Vuillemin A, Cormier L, Lang H, Guy L, Gravis G, Rolland F, Linassier C, Lechevallier E, Beisland C, Aitchison M, Oudard S, Patard JJ, Theodore C, Chevreau C, Laguerre B, Hubert J, Gross-Goupil M, Bernhard JC, Albiges L, Timsit MO, Lebret T, Escudier B
N Engl J Med 2018 Aug 2;379(5):417-427. Epub 2018 Jun 3 doi: 10.1056/NEJMoa1803675. PMID: 29860937
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544

Clinical prediction guides

Davidson G, Helleux A, Vano YA, Lindner V, Fattori A, Cerciat M, Elaidi RT, Verkarre V, Sun CM, Chevreau C, Bennamoun M, Lang H, Tricard T, Fridman WH, Sautes-Fridman C, Su X, Plassard D, Keime C, Thibault-Carpentier C, Barthelemy P, Oudard SM, Davidson I, Malouf GG
Cancer Res 2023 Sep 1;83(17):2952-2969. doi: 10.1158/0008-5472.CAN-22-3034. PMID: 37335139
Choueiri TK, McDermott DF, Merchan J, Bauer TM, Figlin R, Heath EI, Michaelson MD, Arrowsmith E, D'Souza A, Zhao S, Roy A, Perini R, Vickery D, Tykodi SS
Lancet Oncol 2023 May;24(5):553-562. Epub 2023 Mar 31 doi: 10.1016/S1470-2045(23)00097-9. PMID: 37011650
Au L, Hatipoglu E, Robert de Massy M, Litchfield K, Beattie G, Rowan A, Schnidrig D, Thompson R, Byrne F, Horswell S, Fotiadis N, Hazell S, Nicol D, Shepherd STC, Fendler A, Mason R, Del Rosario L, Edmonds K, Lingard K, Sarker S, Mangwende M, Carlyle E, Attig J, Joshi K, Uddin I, Becker PD, Sunderland MW, Akarca A, Puccio I, Yang WW, Lund T, Dhillon K, Vasquez MD, Ghorani E, Xu H, Spencer C, López JI, Green A, Mahadeva U, Borg E, Mitchison M, Moore DA, Proctor I, Falzon M, Pickering L, Furness AJS, Reading JL, Salgado R, Marafioti T, Jamal-Hanjani M; PEACE Consortium, Kassiotis G, Chain B, Larkin J, Swanton C, Quezada SA, Turajlic S; TRACERx Renal Consortium
Cancer Cell 2021 Nov 8;39(11):1497-1518.e11. Epub 2021 Oct 28 doi: 10.1016/j.ccell.2021.10.001. PMID: 34715028Free PMC Article
de Vries-Brilland M, McDermott DF, Suárez C, Powles T, Gross-Goupil M, Ravaud A, Flippot R, Escudier B, Albigès L
Cancer Treat Rev 2021 Sep;99:102228. Epub 2021 May 20 doi: 10.1016/j.ctrv.2021.102228. PMID: 34111642
Méjean A, Ravaud A, Thezenas S, Colas S, Beauval JB, Bensalah K, Geoffrois L, Thiery-Vuillemin A, Cormier L, Lang H, Guy L, Gravis G, Rolland F, Linassier C, Lechevallier E, Beisland C, Aitchison M, Oudard S, Patard JJ, Theodore C, Chevreau C, Laguerre B, Hubert J, Gross-Goupil M, Bernhard JC, Albiges L, Timsit MO, Lebret T, Escudier B
N Engl J Med 2018 Aug 2;379(5):417-427. Epub 2018 Jun 3 doi: 10.1056/NEJMoa1803675. PMID: 29860937

Recent systematic reviews

Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Sati N, Boyne DJ, Cheung WY, Cash SB, Arora P
JAMA Netw Open 2021 Jan 4;4(1):e2034201. doi: 10.1001/jamanetworkopen.2020.34201. PMID: 33496794Free PMC Article
Buti S, Petrelli F, Ghidini A, Vavassori I, Maestroni U, Bersanelli M
Clin Transl Oncol 2020 Sep;22(9):1657-1663. Epub 2020 Jan 19 doi: 10.1007/s12094-020-02292-z. PMID: 31956940
Malouf GG, Flippot R, Khayat D
J Oncol Pract 2016 May;12(5):412-20. doi: 10.1200/JOP.2016.011809. PMID: 27170687
Minardi D, Quaresima L, Santoni M, Bianconi M, Scartozzi M, Cascinu S, Muzzonigro G
Curr Urol Rep 2015 Feb;16(2):3. doi: 10.1007/s11934-014-0478-2. PMID: 25627021

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