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Vertebral artery syndrome

MedGen UID:
419936
Concept ID:
C2931914
Disease or Syndrome
Synonym: PICA syndrome
SNOMED CT: Vertebral artery syndrome (34781003)

Definition

A syndrome which occurs as a result of the occlusion of one of the vertebral arteries. It may be caused by atherosclerosis, embolism or hemorrhage. Collateral circulation through the circle of Willis is usually comprised as well. Clinical signs may include vertigo, nystagmus, dysarthria, ataxia and sensorimotor deficits. Clinical course may lead to persistence of neurologic deficits. Prognosis is variable with a substantial risk for recurrent infarction. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Kim JS, Newman-Toker DE, Kerber KA, Jahn K, Bertholon P, Waterston J, Lee H, Bisdorff A, Strupp M
J Vestib Res 2022;32(3):205-222. doi: 10.3233/VES-210169. PMID: 35367974Free PMC Article

Recent clinical studies

Etiology

Ndongo Sonfack DJ, Bojanowski MW, Tarabay B, Gennari A, Shédid D, Yuh SJ
Neurochirurgie 2024 May;70(3):101525. Epub 2024 Jan 29 doi: 10.1016/j.neuchi.2023.101525. PMID: 38277863
Vilimas A, Gaigalaitė V, Urbonas M, Jatužis D
Medicina (Kaunas) 2022 Aug 31;58(9) doi: 10.3390/medicina58091189. PMID: 36143866Free PMC Article
Qashqari H, Bhathal I, Pulcine E, Muthusami P, Moharir M, MacGregor D, Kulkarni A, Dlamini N
J Clin Neurosci 2020 Aug;78:418-419. Epub 2020 Jun 7 doi: 10.1016/j.jocn.2020.04.110. PMID: 32522486
Schelfaut S, Verhasselt S, Carpentier K, Moke L
J Spinal Disord Tech 2015 Mar;28(2):66-70. doi: 10.1097/BSD.0b013e3182886fbf. PMID: 23429312
Sarkar J, Wolfe SQ, Ching BH, Kellicut DC
Ann Vasc Surg 2014 May;28(4):1032.e1-1032.e10. Epub 2013 Nov 1 doi: 10.1016/j.avsg.2013.06.038. PMID: 24184499

Diagnosis

Ndongo Sonfack DJ, Bojanowski MW, Tarabay B, Gennari A, Shédid D, Yuh SJ
Neurochirurgie 2024 May;70(3):101525. Epub 2024 Jan 29 doi: 10.1016/j.neuchi.2023.101525. PMID: 38277863
Qashqari H, Bhathal I, Pulcine E, Muthusami P, Moharir M, MacGregor D, Kulkarni A, Dlamini N
J Clin Neurosci 2020 Aug;78:418-419. Epub 2020 Jun 7 doi: 10.1016/j.jocn.2020.04.110. PMID: 32522486
Hain TC
Curr Opin Neurol 2015 Feb;28(1):69-73. doi: 10.1097/WCO.0000000000000161. PMID: 25502050
Sarkar J, Wolfe SQ, Ching BH, Kellicut DC
Ann Vasc Surg 2014 May;28(4):1032.e1-1032.e10. Epub 2013 Nov 1 doi: 10.1016/j.avsg.2013.06.038. PMID: 24184499
Marti S, Hegemann S, von Büdingen HC, Baumgartner RW, Straumann D
J Neurol 2008 May;255(5):663-7. Epub 2008 Feb 18 doi: 10.1007/s00415-008-0773-2. PMID: 18274804

Therapy

Renthlei L, Mariappan R, Raju K, Joseph J
BMJ Case Rep 2023 May 2;16(5) doi: 10.1136/bcr-2022-253834. PMID: 37130633Free PMC Article
Vilimas A, Gaigalaitė V, Urbonas M, Jatužis D
Medicina (Kaunas) 2022 Aug 31;58(9) doi: 10.3390/medicina58091189. PMID: 36143866Free PMC Article
Qashqari H, Bhathal I, Pulcine E, Muthusami P, Moharir M, MacGregor D, Kulkarni A, Dlamini N
J Clin Neurosci 2020 Aug;78:418-419. Epub 2020 Jun 7 doi: 10.1016/j.jocn.2020.04.110. PMID: 32522486
Marti S, Hegemann S, von Büdingen HC, Baumgartner RW, Straumann D
J Neurol 2008 May;255(5):663-7. Epub 2008 Feb 18 doi: 10.1007/s00415-008-0773-2. PMID: 18274804
Choi KD, Shin HY, Kim JS, Kim SH, Kwon OK, Koo JW, Park SH, Yoon BW, Roh JK
Neurology 2005 Oct 25;65(8):1287-90. doi: 10.1212/01.wnl.0000180405.00560.51. PMID: 16247059

Prognosis

Sarkar J, Wolfe SQ, Ching BH, Kellicut DC
Ann Vasc Surg 2014 May;28(4):1032.e1-1032.e10. Epub 2013 Nov 1 doi: 10.1016/j.avsg.2013.06.038. PMID: 24184499

Clinical prediction guides

Ndongo Sonfack DJ, Bojanowski MW, Tarabay B, Gennari A, Shédid D, Yuh SJ
Neurochirurgie 2024 May;70(3):101525. Epub 2024 Jan 29 doi: 10.1016/j.neuchi.2023.101525. PMID: 38277863
Sarkar J, Wolfe SQ, Ching BH, Kellicut DC
Ann Vasc Surg 2014 May;28(4):1032.e1-1032.e10. Epub 2013 Nov 1 doi: 10.1016/j.avsg.2013.06.038. PMID: 24184499
Kim HA, Yi HA, Lee CY, Lee H
Neurol Sci 2011 Dec;32(6):1203-7. Epub 2011 Jun 28 doi: 10.1007/s10072-011-0667-4. PMID: 21710126
Noh Y, Kwon OK, Kim HJ, Kim JS
J Neurol 2011 Oct;258(10):1775-80. Epub 2011 Mar 17 doi: 10.1007/s00415-011-6005-1. PMID: 21416208
Lu DC, Zador Z, Mummaneni PV, Lawton MT
Neurosurgery 2010 Oct;67(4):1066-72; discussion 1072. doi: 10.1227/NEU.0b013e3181ee36db. PMID: 20881570

Recent systematic reviews

Ndongo Sonfack DJ, Bojanowski MW, Tarabay B, Gennari A, Shédid D, Yuh SJ
Neurochirurgie 2024 May;70(3):101525. Epub 2024 Jan 29 doi: 10.1016/j.neuchi.2023.101525. PMID: 38277863

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