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Fetal death

MedGen UID:
42004
Concept ID:
C0015927
Pathologic Function
Synonyms: Death, Fetal; Deaths, Fetal; Demise, Fetal; Fetal Death; Fetal Deaths; Fetal Demise
SNOMED CT: Fetal death (276507005)

Definition

Death of a fetus after 10 weeks gestation. [from NCI]

Professional guidelines

PubMed

Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Auriti C, De Rose DU, Santisi A, Martini L, Piersigilli F, Bersani I, Ronchetti MP, Caforio L
Biochim Biophys Acta Mol Basis Dis 2021 Oct 1;1867(10):166198. Epub 2021 Jun 10 doi: 10.1016/j.bbadis.2021.166198. PMID: 34118406Free PMC Article
Obstet Gynecol 2021 Jun 1;137(6):e116-e127. doi: 10.1097/AOG.0000000000004410. PMID: 34011889

Recent clinical studies

Etiology

Page JM, Blue NR, Silver RM
Obstet Gynecol Clin North Am 2021 Jun;48(2):297-310. doi: 10.1016/j.ogc.2021.03.001. PMID: 33972067
Page JM, Silver RM
Obstet Gynecol Clin North Am 2020 Sep;47(3):439-451. doi: 10.1016/j.ogc.2020.04.008. PMID: 32762929
Pathak B, Sheibani L, Lee RH
Obstet Gynecol Clin North Am 2010 Jun;37(2):269-82. doi: 10.1016/j.ogc.2010.02.011. PMID: 20685553
Silver RM
Obstet Gynecol 2007 Jan;109(1):153-67. doi: 10.1097/01.AOG.0000248537.89739.96. PMID: 17197601
Divon MY, Barnhard Y
J Assoc Acad Minor Phys 1994;5(3):126-31. PMID: 7949825

Diagnosis

Costescu D, Mui C
Best Pract Res Clin Obstet Gynaecol 2022 Mar;79:81-94. Epub 2021 Nov 17 doi: 10.1016/j.bpobgyn.2021.11.001. PMID: 35000810
Pathak B, Sheibani L, Lee RH
Obstet Gynecol Clin North Am 2010 Jun;37(2):269-82. doi: 10.1016/j.ogc.2010.02.011. PMID: 20685553
Frøen JF, Heazell AE, Tveit JV, Saastad E, Fretts RC, Flenady V
Semin Perinatol 2008 Aug;32(4):243-6. doi: 10.1053/j.semperi.2008.04.004. PMID: 18652921
Miller DA
Clin Obstet Gynecol 1998 Sep;41(3):647-53. doi: 10.1097/00003081-199809000-00019. PMID: 9742361
Divon MY, Barnhard Y
J Assoc Acad Minor Phys 1994;5(3):126-31. PMID: 7949825

Therapy

Hoffman MK, Clifton RG, Biggio JR, Saade GR, Ugwu LG, Longo M, Bousleiman SZ, Clark K, Grobman WA, Frey HA, Chauhan SP, Dugoff L, Manuck TA, Chien EK, Rouse DJ, Simhan HN, Esplin MS, Macones GA; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network
JAMA 2023 Jul 25;330(4):340-348. doi: 10.1001/jama.2023.10812. PMID: 37490086Free PMC Article
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Ota E, da Silva Lopes K, Middleton P, Flenady V, Wariki WM, Rahman MO, Tobe-Gai R, Mori R
Cochrane Database Syst Rev 2020 Dec 18;12(12):CD009599. doi: 10.1002/14651858.CD009599.pub2. PMID: 33336827Free PMC Article
Middleton P, Gomersall JC, Gould JF, Shepherd E, Olsen SF, Makrides M
Cochrane Database Syst Rev 2018 Nov 15;11(11):CD003402. doi: 10.1002/14651858.CD003402.pub3. PMID: 30480773Free PMC Article
Adzick NS, Thom EA, Spong CY, Brock JW 3rd, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D'Alton ME, Farmer DL; MOMS Investigators
N Engl J Med 2011 Mar 17;364(11):993-1004. Epub 2011 Feb 9 doi: 10.1056/NEJMoa1014379. PMID: 21306277Free PMC Article

Prognosis

Page JM, Silver RM
Obstet Gynecol Clin North Am 2020 Sep;47(3):439-451. doi: 10.1016/j.ogc.2020.04.008. PMID: 32762929
Buyon JP, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, Sammaritano L, Branch DW, Porter TF, Sawitzke A, Merrill JT, Stephenson MD, Cohn E, Garabet L, Salmon JE
Ann Intern Med 2015 Aug 4;163(3):153-63. doi: 10.7326/M14-2235. PMID: 26098843Free PMC Article
Fell DB, Platt RW, Lanes A, Wilson K, Kaufman JS, Basso O, Buckeridge D
BJOG 2015 Jan;122(1):17-26. Epub 2014 Jul 10 doi: 10.1111/1471-0528.12977. PMID: 25040307
Lisonkova S, Joseph KS
Am J Obstet Gynecol 2013 Dec;209(6):544.e1-544.e12. Epub 2013 Aug 22 doi: 10.1016/j.ajog.2013.08.019. PMID: 23973398
Harrison KA
Lancet 1979 Dec 8;2(8154):1229-32. doi: 10.1016/s0140-6736(79)92344-4. PMID: 92632

Clinical prediction guides

Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
Baschat AA, Galan HL, Lee W, DeVore GR, Mari G, Hobbins J, Vintzileos A, Platt LD, Manning FA
Am J Obstet Gynecol 2022 Apr;226(4):475-486. doi: 10.1016/j.ajog.2022.01.020. PMID: 35369904
Pacora P, Romero R, Jung E, Gudicha DW, Hernandez-Andrade E, Musilova I, Kacerovsky M, Jaiman S, Erez O, Hsu CD, Tarca AL
Ultrasound Obstet Gynecol 2021 Jun;57(6):942-952. doi: 10.1002/uog.23111. PMID: 32936481Free PMC Article
Fell DB, Platt RW, Lanes A, Wilson K, Kaufman JS, Basso O, Buckeridge D
BJOG 2015 Jan;122(1):17-26. Epub 2014 Jul 10 doi: 10.1111/1471-0528.12977. PMID: 25040307
Miller DA
Clin Obstet Gynecol 1998 Sep;41(3):647-53. doi: 10.1097/00003081-199809000-00019. PMID: 9742361

Recent systematic reviews

Teede HJ, Bailey C, Moran LJ, Bahri Khomami M, Enticott J, Ranasinha S, Rogozinska E, Skouteris H, Boyle JA, Thangaratinam S, Harrison CL
JAMA Intern Med 2022 Feb 1;182(2):106-114. doi: 10.1001/jamainternmed.2021.6373. PMID: 34928300Free PMC Article
Ciapponi A, Klein K, Colaci D, Althabe F, Belizán JM, Deegan A, Veroniki AA, Florez ID
Am J Obstet Gynecol MFM 2021 May;3(3):100312. Epub 2021 Jan 20 doi: 10.1016/j.ajogmf.2021.100312. PMID: 33482400
Ota E, da Silva Lopes K, Middleton P, Flenady V, Wariki WM, Rahman MO, Tobe-Gai R, Mori R
Cochrane Database Syst Rev 2020 Dec 18;12(12):CD009599. doi: 10.1002/14651858.CD009599.pub2. PMID: 33336827Free PMC Article
Middleton P, Gomersall JC, Gould JF, Shepherd E, Olsen SF, Makrides M
Cochrane Database Syst Rev 2018 Nov 15;11(11):CD003402. doi: 10.1002/14651858.CD003402.pub3. PMID: 30480773Free PMC Article
Viale L, Allotey J, Cheong-See F, Arroyo-Manzano D, Mccorry D, Bagary M, Mignini L, Khan KS, Zamora J, Thangaratinam S; EBM CONNECT Collaboration
Lancet 2015 Nov 7;386(10006):1845-52. Epub 2015 Aug 25 doi: 10.1016/S0140-6736(15)00045-8. PMID: 26318519

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