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MedGen UID:
Concept ID:
Neoplastic Process
Synonym: Fibromas
SNOMED CT: Fibroma (424568000)
HPO: HP:0010614
Monarch Initiative: MONDO:0005167


Benign tumors that are composed of fibrous or connective tissue. They can grow in all organs, arising from mesenchyme tissue. The term "fibroblastic" or "fibromatous" is used to describe tumors of the fibrous connective tissue. When the term fibroma is used without modifier, it is usually considered benign, with the term fibrosarcoma reserved for malignant tumors. [from HPO]

Conditions with this feature

Terminal osseous dysplasia-pigmentary defects syndrome
MedGen UID:
Concept ID:
Disease or Syndrome
Terminal osseous dysplasia is an X-linked dominant male-lethal disease characterized by skeletal dysplasia of the limbs, pigmentary defects of the skin, and recurrent digital fibroma during infancy (Sun et al., 2010).
Familial adenomatous polyposis 1
MedGen UID:
Concept ID:
Disease or Syndrome
APC-associated polyposis conditions include (classic or attenuated) familial adenomatous polyposis (FAP) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). FAP is a colorectal cancer (CRC) predisposition syndrome that can manifest in either classic or attenuated form. Classic FAP is characterized by hundreds to thousands of adenomatous colonic polyps, beginning on average at age 16 years (range 7-36 years). For those with the classic form of FAP, 95% of individuals have polyps by age 35 years; CRC is inevitable without colectomy. The mean age of CRC diagnosis in untreated individuals is 39 years (range 34-43 years). The attenuated form is characterized by multiple colonic polyps (average of 30), more proximally located polyps, and a diagnosis of CRC at a later age than in classic FAP. For those with an attenuated form, there is a 70% lifetime risk of CRC and the mean age of diagnosis is 50-55 years. Extracolonic manifestations are variably present and include polyps of the stomach and duodenum, osteomas, dental abnormalities, congenital hypertrophy of the retinal pigment epithelium (CHRPE), benign cutaneous lesions, desmoid tumors, adrenal masses, and other associated cancers. GAPPS is characterized by proximal gastric polyposis, increased risk of gastric adenocarcinoma, and no duodenal or colonic involvement in most individuals reported.
Myofibromatosis, infantile, 1
MedGen UID:
Concept ID:
Disease or Syndrome
A rare inherited form of myofibromatosis caused by autosomal dominant mutation(s) in the PDGFRB gene, encoding platelet-derived growth factor receptor beta. The condition is characterized by the onset of solitary or multicentric benign tumors in the skin, striated muscles, bones, and viscera. The lesions may be present at birth or become apparent in early infancy or even occasionally in adult life.
Immunodeficiency 94 with autoinflammation and dysmorphic facies
MedGen UID:
Concept ID:
Disease or Syndrome
Immunodeficiency-94 with autoinflammation and dysmorphic facies (IMD94) is a systemic immunologic disorder with onset in early infancy. Primary features include lymphadenopathy, autoinflammation, immunodeficiency with hypogammaglobulinemia, and dysmorphic facial features. Intellectual development is normal and serum IgE is not elevated. The disease results from constitutive activation of the IL6 signaling cascade, resulting in immune dysregulation and a hyperinflammatory state (summary by Materna-Kiryluk et al., 2021).

Professional guidelines


Martin JR, Auran RL, Duran MD, de Comas AM, Jacofsky DJ
J Knee Surg 2022 May;35(6):585-596. Epub 2022 Feb 18 doi: 10.1055/s-0042-1743221. PMID: 35181876
Koraitim M, Medra AM, Salloum AM, Shehata EA
J Craniofac Surg 2022 May 1;33(3):e265-e267. Epub 2021 Aug 13 doi: 10.1097/SCS.0000000000008085. PMID: 34387270
Goldstein JA, Cates JM
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Recent clinical studies


Shahrabi-Farahani S, Pencarinha DM, Anderson M
Head Neck Pathol 2022 Jun;16(2):339-343. Epub 2021 Jul 5 doi: 10.1007/s12105-021-01355-z. PMID: 34224081Free PMC Article
Hartmann W, Harder D, Baumhoer D
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Skeletal Radiol 2022 Mar;51(3):681-685. Epub 2021 Sep 23 doi: 10.1007/s00256-021-03912-7. PMID: 34554278Free PMC Article
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Surg Pathol Clin 2021 Dec;14(4):707-721. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.011. PMID: 34742489
Abramovitch K, Rice DD
Dent Clin North Am 2016 Jan;60(1):167-93. Epub 2015 Oct 21 doi: 10.1016/j.cden.2015.08.010. PMID: 26614954
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Dunlap CL
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Petris AO, Alexandrescu DM, Costache II
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Clinical prediction guides

Darling M, Li K, Burnside K, Smith N, Jackson-Boeters L, Hamilton D
Head Neck Pathol 2023 Jun;17(2):355-363. Epub 2022 Dec 6 doi: 10.1007/s12105-022-01493-y. PMID: 36472794Free PMC Article
Covington MK, Young PM, Bois MC, Maleszewski JJ, Anand V, Dearani JA, Klarich KW
Am J Cardiol 2022 Nov 1;182:95-103. Epub 2022 Aug 30 doi: 10.1016/j.amjcard.2022.06.062. PMID: 36055811
Shahrabi-Farahani S, Pencarinha DM, Anderson M
Head Neck Pathol 2022 Jun;16(2):339-343. Epub 2021 Jul 5 doi: 10.1007/s12105-021-01355-z. PMID: 34224081Free PMC Article
Humagain M , Dawadi A , Srii R , Poudel P
Kathmandu Univ Med J (KUMJ) 2017 Jul-Sept.;15(59):261-264. PMID: 30353905
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694

Recent systematic reviews

Sindoni A, Valeriani F, Protano C, Liguori G, Romano Spica V, Vitali M, Gallè F
Public Health 2022 Apr;205:202-215. Epub 2022 Mar 24 doi: 10.1016/j.puhe.2022.01.035. PMID: 35339940
Vázquez Fernández R, Maneiro Fernández JR, Cervantes Pérez EC, Mera Varela A
Ir J Med Sci 2021 Aug;190(3):1005-1014. Epub 2020 Oct 1 doi: 10.1007/s11845-020-02378-1. PMID: 33006046
Sarode SC, Sarode GS, Vaidya K
J Oral Pathol Med 2014 Mar;43(3):167-76. Epub 2013 May 13 doi: 10.1111/jop.12085. PMID: 23668324
Manes RP, Ryan MW, Batra PS, Mendelsohn D, Fang YV, Marple BF
Int Forum Allergy Rhinol 2013 Feb;3(2):161-8. Epub 2012 Jun 26 doi: 10.1002/alr.21067. PMID: 22736440
MacDonald-Jankowski DS
Dentomaxillofac Radiol 2009 Dec;38(8):495-513. doi: 10.1259/dmfr/70933621. PMID: 20026707

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