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Glioblastoma

MedGen UID:
42228
Concept ID:
C0017636
Neoplastic Process
Synonyms: Giant cell glioblastoma (histologic variant); Gliosarcoma (histologic variant)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018177
Orphanet: ORPHA360

Definition

Glioblastomas are malignant astrocytic tumors (grade IV according to the WHO classification). [from ORDO]

Professional guidelines

PubMed

McKinnon C, Nandhabalan M, Murray SA, Plaha P
BMJ 2021 Jul 14;374:n1560. doi: 10.1136/bmj.n1560. PMID: 34261630
Tan AC, Ashley DM, López GY, Malinzak M, Friedman HS, Khasraw M
CA Cancer J Clin 2020 Jul;70(4):299-312. Epub 2020 Jun 1 doi: 10.3322/caac.21613. PMID: 32478924
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Central Nervous System Cancers, 2023

Recent clinical studies

Etiology

Le Rhun E, Preusser M, Roth P, Reardon DA, van den Bent M, Wen P, Reifenberger G, Weller M
Cancer Treat Rev 2019 Nov;80:101896. Epub 2019 Sep 11 doi: 10.1016/j.ctrv.2019.101896. PMID: 31541850
McFaline-Figueroa JR, Lee EQ
Am J Med 2018 Aug;131(8):874-882. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2017.12.039. PMID: 29371158
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Wirsching HG, Galanis E, Weller M
Handb Clin Neurol 2016;134:381-97. doi: 10.1016/B978-0-12-802997-8.00023-2. PMID: 26948367
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082

Diagnosis

McKinnon C, Nandhabalan M, Murray SA, Plaha P
BMJ 2021 Jul 14;374:n1560. doi: 10.1136/bmj.n1560. PMID: 34261630
Alexander BM, Cloughesy TF
J Clin Oncol 2017 Jul 20;35(21):2402-2409. Epub 2017 Jun 22 doi: 10.1200/JCO.2017.73.0119. PMID: 28640706
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article
Campos B, Olsen LR, Urup T, Poulsen HS
Oncogene 2016 Nov 10;35(45):5819-5825. Epub 2016 Apr 4 doi: 10.1038/onc.2016.85. PMID: 27041580
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082

Therapy

Rominiyi O, Vanderlinden A, Clenton SJ, Bridgewater C, Al-Tamimi Y, Collis SJ
Br J Cancer 2021 Feb;124(4):697-709. Epub 2020 Nov 4 doi: 10.1038/s41416-020-01136-5. PMID: 33144698Free PMC Article
Garcia J, Hurwitz HI, Sandler AB, Miles D, Coleman RL, Deurloo R, Chinot OL
Cancer Treat Rev 2020 Jun;86:102017. Epub 2020 Mar 26 doi: 10.1016/j.ctrv.2020.102017. PMID: 32335505
Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, Horbinski C, Huang RY, Lassman AB, Le Rhun E, Lim M, Mehta MP, Mellinghoff IK, Minniti G, Nathanson D, Platten M, Preusser M, Roth P, Sanson M, Schiff D, Short SC, Taphoorn MJB, Tonn JC, Tsang J, Verhaak RGW, von Deimling A, Wick W, Zadeh G, Reardon DA, Aldape KD, van den Bent MJ
Neuro Oncol 2020 Aug 17;22(8):1073-1113. doi: 10.1093/neuonc/noaa106. PMID: 32328653Free PMC Article
Le Rhun E, Preusser M, Roth P, Reardon DA, van den Bent M, Wen P, Reifenberger G, Weller M
Cancer Treat Rev 2019 Nov;80:101896. Epub 2019 Sep 11 doi: 10.1016/j.ctrv.2019.101896. PMID: 31541850
Mun EJ, Babiker HM, Weinberg U, Kirson ED, Von Hoff DD
Clin Cancer Res 2018 Jan 15;24(2):266-275. Epub 2017 Aug 1 doi: 10.1158/1078-0432.CCR-17-1117. PMID: 28765323

Prognosis

Butler M, Prasad S, Srivastava SK
Adv Exp Med Biol 2020;1296:1-9. doi: 10.1007/978-3-030-59038-3_1. PMID: 34185283
Tan AC, Ashley DM, López GY, Malinzak M, Friedman HS, Khasraw M
CA Cancer J Clin 2020 Jul;70(4):299-312. Epub 2020 Jun 1 doi: 10.3322/caac.21613. PMID: 32478924
Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C, Barnholtz-Sloan JS
Neuro Oncol 2019 Nov 1;21(Suppl 5):v1-v100. doi: 10.1093/neuonc/noz150. PMID: 31675094Free PMC Article
Witthayanuwat S, Pesee M, Supaadirek C, Supakalin N, Thamronganantasakul K, Krusun S
Asian Pac J Cancer Prev 2018 Sep 26;19(9):2613-2617. doi: 10.22034/APJCP.2018.19.9.2613. PMID: 30256068Free PMC Article
Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG, Mirimanoff RO; European Organisation for Research and Treatment of Cancer Brain Tumour and Radiation Oncology Groups; National Cancer Institute of Canada Clinical Trials Group
Lancet Oncol 2009 May;10(5):459-66. Epub 2009 Mar 9 doi: 10.1016/S1470-2045(09)70025-7. PMID: 19269895

Clinical prediction guides

Zhao S, Chi H, Yang Q, Chen S, Wu C, Lai G, Xu K, Su K, Luo H, Peng G, Xia Z, Cheng C, Lu P
Front Immunol 2023;14:1090040. Epub 2023 Feb 7 doi: 10.3389/fimmu.2023.1090040. PMID: 36825022Free PMC Article
Sun Z, Zhao Y, Wei Y, Ding X, Tan C, Wang C
Front Immunol 2022;13:939523. Epub 2022 Aug 25 doi: 10.3389/fimmu.2022.939523. PMID: 36091049Free PMC Article
Wang Z, Dai Z, Zheng L, Xu B, Zhang H, Fan F, Zhang X, Liang X, Liu Z, Yang K, Cheng Q
Front Immunol 2021;12:747408. Epub 2022 Jan 19 doi: 10.3389/fimmu.2021.747408. PMID: 35126346Free PMC Article
Butler M, Pongor L, Su YT, Xi L, Raffeld M, Quezado M, Trepel J, Aldape K, Pommier Y, Wu J
Trends Cancer 2020 May;6(5):380-391. Epub 2020 Mar 27 doi: 10.1016/j.trecan.2020.02.010. PMID: 32348734Free PMC Article
Senders JT, Staples P, Mehrtash A, Cote DJ, Taphoorn MJB, Reardon DA, Gormley WB, Smith TR, Broekman ML, Arnaout O
Neurosurgery 2020 Feb 1;86(2):E184-E192. doi: 10.1093/neuros/nyz403. PMID: 31586211Free PMC Article

Recent systematic reviews

Sareen H, Ma Y, Becker TM, Roberts TL, de Souza P, Powter B
Int J Mol Sci 2022 Aug 9;23(16) doi: 10.3390/ijms23168835. PMID: 36012105Free PMC Article
Banik K, Khatoon E, Harsha C, Rana V, Parama D, Thakur KK, Bishayee A, Kunnumakkara AB
Phytother Res 2022 May;36(5):1854-1883. Epub 2022 Jan 31 doi: 10.1002/ptr.7386. PMID: 35102626
McBain C, Lawrie TA, Rogozińska E, Kernohan A, Robinson T, Jefferies S
Cochrane Database Syst Rev 2021 May 4;5(1):CD013579. doi: 10.1002/14651858.CD013579.pub2. PMID: 34559423Free PMC Article
Wu W, Klockow JL, Zhang M, Lafortune F, Chang E, Jin L, Wu Y, Daldrup-Link HE
Pharmacol Res 2021 Sep;171:105780. Epub 2021 Jul 21 doi: 10.1016/j.phrs.2021.105780. PMID: 34302977Free PMC Article
Brown TJ, Brennan MC, Li M, Church EW, Brandmeir NJ, Rakszawski KL, Patel AS, Rizk EB, Suki D, Sawaya R, Glantz M
JAMA Oncol 2016 Nov 1;2(11):1460-1469. doi: 10.1001/jamaoncol.2016.1373. PMID: 27310651Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Central Nervous System Cancers, 2023

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