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Implant Capsular Contracture

MedGen UID:
422322
•Concept ID:
C2936274
•
Pathologic Function
Synonyms: Capsular Contracture, Implant; Contracture, Implant Capsular

Definition

The shrinkage of the foreign body encapsulation scar tissue that forms around artificial implants imbedded in body tissues. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImplant Capsular Contracture

Professional guidelines

PubMed

Surgical Treatment of Capsular Contracture (CC): Literature Review and Outcomes Utilizing Implants in Revisionary Surgery.
Zingaretti N, Vittorini P, Savino V, Vittorini JC, De Francesco F, Riccio M, Parodi PC
Aesthetic Plast Surg 2021 Oct;45(5):2036-2047. Epub 2021 Feb 4 doi: 10.1007/s00266-021-02148-z. PMID: 33543344
Round Form-Stable Breast Implants: Diagnosis and Management of Complications.
Nahabedian MY
Plast Reconstr Surg 2019 Jul;144(1S Utilizing a Spectrum of Cohesive Implants in Aesthetic and Reconstructive Breast Surgery):73S-81S. doi: 10.1097/PRS.0000000000005953. PMID: 31246764
Surgeons' Dilemma: Treatment of Implant-Associated Infection in the Cosmetic Breast Augmentation Patient.
Vasilakis V, Yamin F, Reish RG
Aesthetic Plast Surg 2019 Aug;43(4):905-909. Epub 2019 Apr 3 doi: 10.1007/s00266-019-01369-7. PMID: 30944965

Recent clinical studies

Etiology

The Keller Funnel, Capsular Contracture, and Conflict of Interest: A Review.
Swanson E
Ann Plast Surg 2023 Aug 1;91(2):301-306. Epub 2023 Jun 1 doi: 10.1097/SAP.0000000000003549. PMID: 37347153Free PMC Article
Incision and Capsular Contracture Risk: Is There a Relationship in Breast Augmentation and Augmentation/Mastopexy?
Swanson E
Ann Plast Surg 2023 Apr 1;90(4):389-391. Epub 2023 Feb 15 doi: 10.1097/SAP.0000000000003437. PMID: 37093773Free PMC Article
Histological Analyses of Capsular Contracture and Associated Risk Factors: A Systematic Review.
Larsen A, Rasmussen LE, Rasmussen LF, Weltz TK, Hemmingsen MN, Poulsen SS, Jacobsen JCB, Vester-Glowinski P, Herly M
Aesthetic Plast Surg 2021 Dec;45(6):2714-2728. Epub 2021 Jul 26 doi: 10.1007/s00266-021-02473-3. PMID: 34312696
Postirradiation Capsular Contracture in Implant-Based Breast Reconstruction: Management and Outcome.
Haran O, Bracha G, Tiosano A, Menes T, Madah E, Gur E, Barnea Y, Arad E
Plast Reconstr Surg 2021 Jan 1;147(1):11-19. doi: 10.1097/PRS.0000000000007453. PMID: 33002986
Capsular contracture in patients with prior breast augmentation undergoing breast conserving therapy and irradiation.
Serritzlev MS, Lorentzen AK, Matthiessen LW, Hölmich LR
J Plast Surg Hand Surg 2020 Aug;54(4):225-232. Epub 2020 May 7 doi: 10.1080/2000656X.2020.1755299. PMID: 32375532

Diagnosis

Exhaustive diagnosis of breast implants with capsular contracture: The microbiology laboratory as a major support.
Castellano M, Marín M, Alcalá L, Cunnas I, Rodríguez B, Ruíz MJ, Lasso J, Pérez-Cano R, Bouza E, Muñoz P, Guembe M
J Plast Reconstr Aesthet Surg 2022 Sep;75(9):3085-3093. Epub 2022 Jun 17 doi: 10.1016/j.bjps.2022.06.014. PMID: 35872019
Round Form-Stable Breast Implants: Diagnosis and Management of Complications.
Nahabedian MY
Plast Reconstr Surg 2019 Jul;144(1S Utilizing a Spectrum of Cohesive Implants in Aesthetic and Reconstructive Breast Surgery):73S-81S. doi: 10.1097/PRS.0000000000005953. PMID: 31246764
Surgeons' Dilemma: Treatment of Implant-Associated Infection in the Cosmetic Breast Augmentation Patient.
Vasilakis V, Yamin F, Reish RG
Aesthetic Plast Surg 2019 Aug;43(4):905-909. Epub 2019 Apr 3 doi: 10.1007/s00266-019-01369-7. PMID: 30944965
Capsular Contracture Rate After Breast Augmentation with Periareolar Versus Other Two (Inframammary and Transaxillary) Incisions: A Meta-Analysis.
Li S, Chen L, Liu W, Mu D, Luan J
Aesthetic Plast Surg 2018 Feb;42(1):32-37. Epub 2017 Sep 15 doi: 10.1007/s00266-017-0965-1. PMID: 28916908
The Relationship of Bacterial Biofilms and Capsular Contracture in Breast Implants.
Ajdic D, Zoghbi Y, Gerth D, Panthaki ZJ, Thaller S
Aesthet Surg J 2016 Mar;36(3):297-309. Epub 2016 Feb 2 doi: 10.1093/asj/sjv177. PMID: 26843099Free PMC Article

Therapy

The Keller Funnel, Capsular Contracture, and Conflict of Interest: A Review.
Swanson E
Ann Plast Surg 2023 Aug 1;91(2):301-306. Epub 2023 Jun 1 doi: 10.1097/SAP.0000000000003549. PMID: 37347153Free PMC Article
Incision and Capsular Contracture Risk: Is There a Relationship in Breast Augmentation and Augmentation/Mastopexy?
Swanson E
Ann Plast Surg 2023 Apr 1;90(4):389-391. Epub 2023 Feb 15 doi: 10.1097/SAP.0000000000003437. PMID: 37093773Free PMC Article
Pharmacological Approaches for the Prevention of Breast Implant Capsular Contracture.
Guimier E, Carson L, David B, Lambert JM, Heery E, Malcolm RK
J Surg Res 2022 Dec;280:129-150. Epub 2022 Aug 12 doi: 10.1016/j.jss.2022.06.073. PMID: 35969932
Capsular contracture in patients with prior breast augmentation undergoing breast conserving therapy and irradiation.
Serritzlev MS, Lorentzen AK, Matthiessen LW, Hölmich LR
J Plast Surg Hand Surg 2020 Aug;54(4):225-232. Epub 2020 May 7 doi: 10.1080/2000656X.2020.1755299. PMID: 32375532
Breast augmentation.
Hidalgo DA, Spector JA
Plast Reconstr Surg 2014 Apr;133(4):567e-583e. doi: 10.1097/PRS.0000000000000033. PMID: 24675209

Prognosis

Use of Antimicrobial Irrigation and Incidence of Capsular Contracture in Breast Augmentation and Immediate Implant-Based Breast Reconstruction.
Federica G, Tommaso F, Alessia C, Agostino C, Florian B, Antonio G, Domenico Nicola M, Abdallah R, Carmela S, Lorenzo S, Sergio B
Aesthetic Plast Surg 2023 Dec;47(6):2345-2350. Epub 2023 Jul 6 doi: 10.1007/s00266-023-03453-5. PMID: 37410129Free PMC Article
Postirradiation Capsular Contracture in Implant-Based Breast Reconstruction: Management and Outcome.
Haran O, Bracha G, Tiosano A, Menes T, Madah E, Gur E, Barnea Y, Arad E
Plast Reconstr Surg 2021 Jan 1;147(1):11-19. doi: 10.1097/PRS.0000000000007453. PMID: 33002986
Epidemiology and Prevention of Breast Prosthesis Capsular Contracture Recurrence.
Ganon S, Morinet S, Serror K, Mimoun M, Chaouat M, Boccara D
Aesthetic Plast Surg 2021 Feb;45(1):15-23. Epub 2020 Jul 21 doi: 10.1007/s00266-020-01876-y. PMID: 32696162
Capsular contracture in patients with prior breast augmentation undergoing breast conserving therapy and irradiation.
Serritzlev MS, Lorentzen AK, Matthiessen LW, Hölmich LR
J Plast Surg Hand Surg 2020 Aug;54(4):225-232. Epub 2020 May 7 doi: 10.1080/2000656X.2020.1755299. PMID: 32375532
Betadine and Breast Implants.
Jewell ML, Adams WP Jr
Aesthet Surg J 2018 May 15;38(6):623-626. doi: 10.1093/asj/sjy044. PMID: 29452341

Clinical prediction guides

Identification of Drug Compounds for Capsular Contracture Based on Text Mining and Deep Learning.
Lu Y, Chen Z, Pan Y, Qi F
Plast Reconstr Surg 2023 Nov 1;152(5):779e-790e. Epub 2023 Mar 3 doi: 10.1097/PRS.0000000000010350. PMID: 36862957
Reduced capsular contracture with smooth and textured breast implants following submuscular mammoplasty: systematic literature review.
Zhu L, Zhu J, Qian Y, Jiang H
Future Oncol 2021 Dec;17(36):5177-5187. Epub 2021 Nov 3 doi: 10.2217/fon-2021-0510. PMID: 34730405
Autologous Fat Grafting and the Occurrence of Radiation-Induced Capsular Contracture.
Martin S, Cai L, Beniwal A, Tevlin R, Lee G, Nazerali RS
Ann Plast Surg 2021 May 1;86(5S Suppl 3):S414-S417. doi: 10.1097/SAP.0000000000002817. PMID: 33833172
Capsular contracture in patients with prior breast augmentation undergoing breast conserving therapy and irradiation.
Serritzlev MS, Lorentzen AK, Matthiessen LW, Hölmich LR
J Plast Surg Hand Surg 2020 Aug;54(4):225-232. Epub 2020 May 7 doi: 10.1080/2000656X.2020.1755299. PMID: 32375532
A meta-analysis of implant-based breast reconstruction and timing of adjuvant radiation therapy.
Ricci JA, Epstein S, Momoh AO, Lin SJ, Singhal D, Lee BT
J Surg Res 2017 Oct;218:108-116. Epub 2017 Jun 15 doi: 10.1016/j.jss.2017.05.072. PMID: 28985836

Recent systematic reviews

Histological Analyses of Capsular Contracture and Associated Risk Factors: A Systematic Review.
Larsen A, Rasmussen LE, Rasmussen LF, Weltz TK, Hemmingsen MN, Poulsen SS, Jacobsen JCB, Vester-Glowinski P, Herly M
Aesthetic Plast Surg 2021 Dec;45(6):2714-2728. Epub 2021 Jul 26 doi: 10.1007/s00266-021-02473-3. PMID: 34312696
The aetiopathogenesis of capsular contracture: A systematic review of the literature.
Bachour Y, Verweij SP, Gibbs S, Ket JCF, Ritt MJPF, Niessen FB, Mullender MG
J Plast Reconstr Aesthet Surg 2018 Mar;71(3):307-317. Epub 2017 Dec 11 doi: 10.1016/j.bjps.2017.12.002. PMID: 29301730
A meta-analysis of implant-based breast reconstruction and timing of adjuvant radiation therapy.
Ricci JA, Epstein S, Momoh AO, Lin SJ, Singhal D, Lee BT
J Surg Res 2017 Oct;218:108-116. Epub 2017 Jun 15 doi: 10.1016/j.jss.2017.05.072. PMID: 28985836
Examining the Role of Antimicrobial Irrigation and Capsular Contracture: A Systematic Review and Meta-analysis.
Drinane JJ, Chowdhry T, Pham TH, Ritter E
Ann Plast Surg 2017 Jul;79(1):107-114. doi: 10.1097/SAP.0000000000001134. PMID: 28542075
Revisiting the Management of Capsular Contracture in Breast Augmentation: A Systematic Review.
Wan D, Rohrich RJ
Plast Reconstr Surg 2016 Mar;137(3):826-841. doi: 10.1097/01.prs.0000480095.23356.ae. PMID: 26910663

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