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Granuloma inguinale

MedGen UID:
42291
•Concept ID:
C0018190
•
Disease or Syndrome
Synonym: Donovanosis
SNOMED CT: Granuloma inguinale (28867007); Granuloma venereum (28867007); Donovanosis (28867007); Ulcerating granuloma pudendi (28867007); Infection due to Calymmatobacterium granulomatis (28867007); Infection due to Donovania granulomatis (28867007); Pudendal ulcer (28867007); Granuloma Donovani (28867007); GI - Granuloma inguinale (28867007)
 
Monarch Initiative: MONDO:0005777

Definition

A condition resulting from infection by Klebsiella granulomati, which is characterized by ulcerative lesions of the genitalia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGranuloma inguinale

Professional guidelines

PubMed

Diagnosis and management of genital ulcers.
Roett MA, Mayor MT, Uduhiri KA
Am Fam Physician 2012 Feb 1;85(3):254-62. PMID: 22335265
The diagnosis and treatment of donovanosis (granuloma inguinale).
Richens J
Genitourin Med 1991 Dec;67(6):441-52. doi: 10.1136/sti.67.6.441. PMID: 1774048Free PMC Article
The treatment of gonorrhea, syphilis, chancroid, lymphogranuloma venereum, and granuloma inguinale.
Spence MR
Clin Obstet Gynecol 1988 Jun;31(2):453-65. doi: 10.1097/00003081-198806000-00019. PMID: 3042224

Recent clinical studies

Etiology

Granulomatous & histiocytic dermatitides.
Wick MR
Semin Diagn Pathol 2017 May;34(3):301-311. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.003. PMID: 28094163
Sexually transmitted diseases.
Markle W, Conti T, Kad M
Prim Care 2013 Sep;40(3):557-87. Epub 2013 Jun 29 doi: 10.1016/j.pop.2013.05.001. PMID: 23958358
Donovanosis: an update.
O'Farrell N
Int J STD AIDS 2001 Jul;12(7):423-7. doi: 10.1258/0956462011923435. PMID: 11394976
Sexually transmitted arthritis syndromes.
Keat A
Med Clin North Am 1990 Nov;74(6):1617-31. doi: 10.1016/s0025-7125(16)30498-9. PMID: 2246956
Granuloma inguinale.
Rosen T, Tschen JA, Ramsdell W, Moore J, Markham B
J Am Acad Dermatol 1984 Sep;11(3):433-7. doi: 10.1016/s0190-9622(84)70186-1. PMID: 6384290

Diagnosis

Donovanosis.
Belda Junior W
An Bras Dermatol 2020 Nov-Dec;95(6):675-683. Epub 2020 Sep 17 doi: 10.1016/j.abd.2020.07.002. PMID: 33069513Free PMC Article
Sexually Transmitted Infections.
Smith L, Angarone MP
Urol Clin North Am 2015 Nov;42(4):507-18. doi: 10.1016/j.ucl.2015.06.004. PMID: 26475947
Sexually transmitted infections.
Fuchs W, Brockmeyer NH
J Dtsch Dermatol Ges 2014 Jun;12(6):451-63. doi: 10.1111/ddg.12310. PMID: 24889293
Sexually transmitted diseases.
Markle W, Conti T, Kad M
Prim Care 2013 Sep;40(3):557-87. Epub 2013 Jun 29 doi: 10.1016/j.pop.2013.05.001. PMID: 23958358
Donovanosis.
Velho PE, Souza EM, Belda Junior W
Braz J Infect Dis 2008 Dec;12(6):521-5. doi: 10.1590/s1413-86702008000600015. PMID: 19287842

Therapy

Sexually Transmitted Infections.
Smith L, Angarone MP
Urol Clin North Am 2015 Nov;42(4):507-18. doi: 10.1016/j.ucl.2015.06.004. PMID: 26475947
Sexually transmitted infections.
Fuchs W, Brockmeyer NH
J Dtsch Dermatol Ges 2014 Jun;12(6):451-63. doi: 10.1111/ddg.12310. PMID: 24889293
Sexually transmitted diseases.
Markle W, Conti T, Kad M
Prim Care 2013 Sep;40(3):557-87. Epub 2013 Jun 29 doi: 10.1016/j.pop.2013.05.001. PMID: 23958358
Sexually transmitted diseases.
Kalter DC, Rosen T
Emerg Med Clin North Am 1985 Nov;3(4):693-716. PMID: 3902459
Granuloma inguinale.
Rosen T, Tschen JA, Ramsdell W, Moore J, Markham B
J Am Acad Dermatol 1984 Sep;11(3):433-7. doi: 10.1016/s0190-9622(84)70186-1. PMID: 6384290

Prognosis

Sexually transmitted diseases.
Markle W, Conti T, Kad M
Prim Care 2013 Sep;40(3):557-87. Epub 2013 Jun 29 doi: 10.1016/j.pop.2013.05.001. PMID: 23958358
Genital elephantiasis and sexually transmitted infections - revisited.
Gupta S, Ajith C, Kanwar AJ, Sehgal VN, Kumar B, Mete U
Int J STD AIDS 2006 Mar;17(3):157-65; quiz 166. doi: 10.1258/095646206775809150. PMID: 16510000
An overview of sexually transmitted diseases. Part III. Sexually transmitted diseases in HIV-infected patients.
Czelusta A, Yen-Moore A, Van der Straten M, Carrasco D, Tyring SK
J Am Acad Dermatol 2000 Sep;43(3):409-32; quiz 433-6. doi: 10.1067/mjd.2000.105158. PMID: 10954653
Cancer complicating chronic ulcerative and scarifying mucocutaneous disorders.
Kaplan RP
Adv Dermatol 1987;2:19-46. PMID: 3079255
Granuloma inguinale.
Rosen T, Tschen JA, Ramsdell W, Moore J, Markham B
J Am Acad Dermatol 1984 Sep;11(3):433-7. doi: 10.1016/s0190-9622(84)70186-1. PMID: 6384290

Clinical prediction guides

Facial and oral aspects of some venereal and tropical diseases.
Ramos-E-Silva M
Acta Dermatovenerol Croat 2004;12(3):173-80. PMID: 15369643
Clinico-epidemiologic features of granuloma inguinale in the era of acquired immune deficiency syndrome.
Jamkhedkar PP, Hira SK, Shroff HJ, Lanjewar DN
Sex Transm Dis 1998 Apr;25(4):196-200. doi: 10.1097/00007435-199804000-00004. PMID: 9564722
Genital ulcer disease: accuracy of clinical diagnosis and strategies to improve control in Durban, South Africa.
O'Farrell N, Hoosen AA, Coetzee KD, van den Ende J
Genitourin Med 1994 Feb;70(1):7-11. doi: 10.1136/sti.70.1.7. PMID: 8300105Free PMC Article
Sexually transmitted diseases in adolescents: update 1991.
Rosenfeld WD
Pediatr Ann 1991 Jun;20(6):303-12. doi: 10.3928/0090-4481-19910601-07. PMID: 1861893
Etiology of nonvesicular genital ulcers in Winnipeg.
Diaz-Mitoma F, Benningen G, Slutchuk M, Ronald AR, Brunham RC
Sex Transm Dis 1987 Jan-Mar;14(1):33-6. doi: 10.1097/00007435-198701000-00007. PMID: 3494322

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