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Nasal cavity and paranasal sinus lethal midline granuloma

MedGen UID:
42292
Concept ID:
C0018197
Neoplastic Process
Synonyms: Granuloma, Lethal Midline; Granulomas, Lethal Midline; Lethal Midline Granuloma; Lethal Midline Granulomas; Midline Granuloma, Lethal; Midline Granulomas, Lethal
SNOMED CT: Lethal midline granuloma (58961005); Malignant granuloma of face (58961005); Lethal midline granuloma of face (58961005)
 
Monarch Initiative: MONDO:0006828

Definition

An aggressive, progressive, and destructive lesion affecting the nasal cavities, paranasal sinuses, and the palate. The vast majority of cases are malignant lymphoproliferations affecting the midline of the face in patients with nasal type extranodal NK/T-cell lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasal cavity and paranasal sinus lethal midline granuloma

Professional guidelines

PubMed

Borges A, Fink J, Villablanca P, Eversole R, Lufkin R
AJNR Am J Neuroradiol 2000 Feb;21(2):331-6. PMID: 10696019Free PMC Article
Kwong YL, Chan AC, Liang RH
Hematol Oncol 1997 May;15(2):71-9. doi: 10.1002/(sici)1099-1069(199705)15:2<71::aid-hon601>3.0.co;2-u. PMID: 9375032
Dictor M, Cervin A, Kalm O, Rambech E
Mod Pathol 1996 Jan;9(1):7-14. PMID: 8821949

Recent clinical studies

Etiology

Rodrigo JP, Suárez C, Rinaldo A, Devaney KO, Carbone A, Barnes L, Heffner DK, Ferlito A
Oral Oncol 2005 Apr;41(4):340-8. doi: 10.1016/j.oraloncology.2004.10.007. PMID: 15792605
Peh SC, Quen QW
Med J Malaysia 2003 Jun;58(2):196-204. PMID: 14569739
Jaffe ES
Mod Pathol 2002 Mar;15(3):255-63. doi: 10.1038/modpathol.3880521. PMID: 11904341
Sakata K, Hareyama M, Ohuchi A, Sido M, Nagakura H, Morita K, Harabuchi Y, Kataura A
Acta Oncol 1997;36(3):307-11. doi: 10.3109/02841869709001268. PMID: 9208902
Senan S, Symonds RP, Brown IL
Clin Oncol (R Coll Radiol) 1992 Mar;4(2):96-100. doi: 10.1016/s0936-6555(05)80974-4. PMID: 1554633

Diagnosis

Thakur JS, Mahajan A, Saluja M, Mohindroo NK
Trop Doct 2017 Jul;47(3):268-271. Epub 2016 Dec 20 doi: 10.1177/0049475516684088. PMID: 28689491
Mendenhall WM, Olivier KR, Lynch JW Jr, Mendenhall NP
Am J Clin Oncol 2006 Apr;29(2):202-6. doi: 10.1097/01.coc.0000198738.61238.eb. PMID: 16601443
Cleary KR, Batsakis JG
Ann Otol Rhinol Laryngol 1994 Nov;103(11):911-4. doi: 10.1177/000348949410301116. PMID: 7979008
Lober CW, Kaplan RJ, West WH
Arch Dermatol 1982 Jan;118(1):52-4. PMID: 7059202
Lancet 1977 Jun 18;1(8025):1296-7. PMID: 68391

Therapy

Li DM, Lun LD
Mycopathologia 2012 Dec;174(5-6):429-39. Epub 2012 Jun 29 doi: 10.1007/s11046-012-9559-2. PMID: 22744721
O'Devaney K, Ferlito A, Hunter BC, Devaney SL, Rinaldo A
Ann Otol Rhinol Laryngol 1998 May;107(5 Pt 1):439-45. doi: 10.1177/000348949810700515. PMID: 9596226
Kassel SH, Echevarria RA, Guzzo FP
Cancer 1969 Apr;23(4):920-35. doi: 10.1002/1097-0142(196904)23:4<920::aid-cncr2820230430>3.0.co;2-m. PMID: 5818523
Perry HO, Winkelmann RK, Muller SA, Kierland RR
Arch Dermatol 1968 Dec;98(6):561-76. PMID: 5697229
VONLEDEN H
Trans Am Acad Ophthalmol Otolaryngol 1964 Jul-Aug;68:620-4. PMID: 14195980

Prognosis

Agrawal M, Champaka G, Amirtham U, Jacob LA, Premalata CS
J Cancer Res Ther 2022 Jul-Sep;18(4):1137-1143. doi: 10.4103/jcrt.JCRT_226_20. PMID: 36149173
Thakur JS, Mahajan A, Saluja M, Mohindroo NK
Trop Doct 2017 Jul;47(3):268-271. Epub 2016 Dec 20 doi: 10.1177/0049475516684088. PMID: 28689491
Li DM, Lun LD
Mycopathologia 2012 Dec;174(5-6):429-39. Epub 2012 Jun 29 doi: 10.1007/s11046-012-9559-2. PMID: 22744721
Aozasa K, Zaki MA
ScientificWorldJournal 2011 Feb 14;11:422-8. doi: 10.1100/tsw.2011.41. PMID: 21336457Free PMC Article
Mendenhall WM, Olivier KR, Lynch JW Jr, Mendenhall NP
Am J Clin Oncol 2006 Apr;29(2):202-6. doi: 10.1097/01.coc.0000198738.61238.eb. PMID: 16601443

Clinical prediction guides

Sittel C, Eckel HE
Eur Arch Otorhinolaryngol 1998;255(9):446-7. doi: 10.1007/s004050050096. PMID: 9833211
Kwong YL, Chan AC, Liang RH
Hematol Oncol 1997 May;15(2):71-9. doi: 10.1002/(sici)1099-1069(199705)15:2<71::aid-hon601>3.0.co;2-u. PMID: 9375032
Aozasa K
J Clin Pathol 1982 Jun;35(6):599-605. doi: 10.1136/jcp.35.6.599. PMID: 7085910Free PMC Article
Ishii Y, Yamanaka N, Ogawa K, Yoshida Y, Takami T, Matsuura A, Isago H, Kataura A, Kikuchi K
Cancer 1982 Dec 1;50(11):2336-44. doi: 10.1002/1097-0142(19821201)50:11<2336::aid-cncr2820501120>3.0.co;2-c. PMID: 6754065
Lindell MM Jr, Jing BS, Wallace S
AJR Am J Roentgenol 1977 Oct;129(4):677-80. doi: 10.2214/ajr.129.4.677. PMID: 409242

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