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Nasal cavity and paranasal sinus lethal midline granuloma

MedGen UID:
42292
•Concept ID:
C0018197
•
Neoplastic Process
Synonyms: Granuloma, Lethal Midline; Granulomas, Lethal Midline; Lethal Midline Granuloma; Lethal Midline Granulomas; Midline Granuloma, Lethal; Midline Granulomas, Lethal
SNOMED CT: Lethal midline granuloma (58961005); Malignant granuloma of face (58961005); Lethal midline granuloma of face (58961005)
 
Monarch Initiative: MONDO:0006828

Definition

An aggressive, progressive, and destructive lesion affecting the nasal cavities, paranasal sinuses, and the palate. The vast majority of cases are malignant lymphoproliferations affecting the midline of the face in patients with nasal type extranodal NK/T-cell lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasal cavity and paranasal sinus lethal midline granuloma

Professional guidelines

PubMed

Midline destructive lesions of the sinonasal tract: simplified terminology based on histopathologic criteria.
Borges A, Fink J, Villablanca P, Eversole R, Lufkin R
AJNR Am J Neuroradiol 2000 Feb;21(2):331-6. PMID: 10696019Free PMC Article
Natural killer cell lymphoma/leukemia: pathology and treatment.
Kwong YL, Chan AC, Liang RH
Hematol Oncol 1997 May;15(2):71-9. doi: 10.1002/(sici)1099-1069(199705)15:2<71::aid-hon601>3.0.co;2-u. PMID: 9375032
Sinonasal T-cell lymphoma in the differential diagnosis of lethal midline granuloma using in situ hybridization for Epstein-Barr virus RNA.
Dictor M, Cervin A, Kalm O, Rambech E
Mod Pathol 1996 Jan;9(1):7-14. PMID: 8821949

Recent clinical studies

Etiology

Nasal and nasal-type natural killer (NK)/T-cell lymphoma: immunophenotype and Epstein-Barr virus (EBV) association.
Peh SC, Quen QW
Med J Malaysia 2003 Jun;58(2):196-204. PMID: 14569739
Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis.
Jaffe ES
Mod Pathol 2002 Mar;15(3):255-63. doi: 10.1038/modpathol.3880521. PMID: 11904341
Nasal peripheral T-cell lymphoma: a 20-year review of cases treated in Scotland.
Senan S, Symonds RP, Brown IL
Clin Oncol (R Coll Radiol) 1992 Mar;4(2):96-100. doi: 10.1016/s0936-6555(05)80974-4. PMID: 1554633
Midfacial necrotizing lesions.
Batsakis JG, Luna MA
Semin Diagn Pathol 1987 May;4(2):90-116. PMID: 3313603
Wegener's granulomatosis.
McDonald TJ, DeRemee RA
Laryngoscope 1983 Feb;93(2):220-31. doi: 10.1288/00005537-198302000-00020. PMID: 6823195

Diagnosis

Sinonasal lymphomas.
Cleary KR, Batsakis JG
Ann Otol Rhinol Laryngol 1994 Nov;103(11):911-4. doi: 10.1177/000348949410301116. PMID: 7979008
Wegener's granulomatosis.
McDonald TJ, DeRemee RA
Laryngoscope 1983 Feb;93(2):220-31. doi: 10.1288/00005537-198302000-00020. PMID: 6823195
Midline granuloma.
Lober CW, Kaplan RJ, West WH
Arch Dermatol 1982 Jan;118(1):52-4. PMID: 7059202
Idiopathic midface lesions.
Wetmore SJ, Platz CE
Ann Otol Rhinol Laryngol 1978 Jan-Feb;87(1 Pt 1):60-9. doi: 10.1177/000348947808700112. PMID: 623422
WEGENER'S GRANULOMATOSIS.
MILLS CP
Br J Dermatol 1965 Apr;77:203-6. doi: 10.1111/j.1365-2133.1965.tb14631.x. PMID: 14278793

Therapy

Mucor irregularis infection and lethal midline granuloma: a case report and review of published literature.
Li DM, Lun LD
Mycopathologia 2012 Dec;174(5-6):429-39. Epub 2012 Jun 29 doi: 10.1007/s11046-012-9559-2. PMID: 22744721
Wegener's granulomatosis.
McDonald TJ, DeRemee RA
Laryngoscope 1983 Feb;93(2):220-31. doi: 10.1288/00005537-198302000-00020. PMID: 6823195
Wegener's granulomatosis.
Lancet 1972 Sep 9;2(7776):519-21. PMID: 4115575
Malignant pyodermas.
Perry HO, Winkelmann RK, Muller SA, Kierland RR
Arch Dermatol 1968 Dec;98(6):561-76. PMID: 5697229
MIDLINE LETHAL GRANULOMA.
VONLEDEN H
Trans Am Acad Ophthalmol Otolaryngol 1964 Jul-Aug;68:620-4. PMID: 14195980

Prognosis

Deceptive nasal NK/T-cell lymphoma.
Thakur JS, Mahajan A, Saluja M, Mohindroo NK
Trop Doct 2017 Jul;47(3):268-271. Epub 2016 Dec 20 doi: 10.1177/0049475516684088. PMID: 28689491
Epidemiology and pathogenesis of nasal NK/T-cell lymphoma: a mini-review.
Aozasa K, Zaki MA
ScientificWorldJournal 2011 Feb 14;11:422-8. doi: 10.1100/tsw.2011.41. PMID: 21336457Free PMC Article
Lethal midline granuloma-nasal natural killer/T-cell lymphoma.
Mendenhall WM, Olivier KR, Lynch JW Jr, Mendenhall NP
Am J Clin Oncol 2006 Apr;29(2):202-6. doi: 10.1097/01.coc.0000198738.61238.eb. PMID: 16601443
Midline "nonhealing" granuloma.
Nelson JF, Finkelstein MW, Acevedo A, Gonzales GM
Oral Surg Oral Med Oral Pathol 1984 Nov;58(5):554-60. doi: 10.1016/0030-4220(84)90079-3. PMID: 6595616
Wegener's granulomatosis.
McDonald TJ, DeRemee RA
Laryngoscope 1983 Feb;93(2):220-31. doi: 10.1288/00005537-198302000-00020. PMID: 6823195

Clinical prediction guides

Nasal cocaine abuse presenting as a central facial destructive granuloma.
Sittel C, Eckel HE
Eur Arch Otorhinolaryngol 1998;255(9):446-7. doi: 10.1007/s004050050096. PMID: 9833211
Natural killer cell lymphoma/leukemia: pathology and treatment.
Kwong YL, Chan AC, Liang RH
Hematol Oncol 1997 May;15(2):71-9. doi: 10.1002/(sici)1099-1069(199705)15:2<71::aid-hon601>3.0.co;2-u. PMID: 9375032
Nasal T-cell lymphoma as a type of so-called "lethal midline granuloma".
Ishii Y, Yamanaka N, Ogawa K, Yoshida Y, Takami T, Matsuura A, Isago H, Kataura A, Kikuchi K
Cancer 1982 Dec 1;50(11):2336-44. doi: 10.1002/1097-0142(19821201)50:11<2336::aid-cncr2820501120>3.0.co;2-c. PMID: 6754065
Malignant histiocytosis presenting as lethal midline granuloma.
Aozasa K, Watanabe Y, Ikeda H
Pathol Res Pract 1981 May;171(3-4):314-24. doi: 10.1016/S0344-0338(81)80104-5. PMID: 7279783
Laryngeal tuberculosis.
Lindell MM Jr, Jing BS, Wallace S
AJR Am J Roentgenol 1977 Oct;129(4):677-80. doi: 10.2214/ajr.129.4.677. PMID: 409242

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