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Plasma cell granuloma

MedGen UID:
42293
•Concept ID:
C0018199
•
Pathologic Function
Synonyms: Granuloma, Plasma Cell; Granulomas, Plasma Cell; Plasma Cell Granuloma; Plasma Cell Granulomas
SNOMED CT: Plasma cell granuloma (21971004); Plasma cell pseudotumor (21971004)

Definition

An inflammatory lesion of the lungs comprised of plasma cells and fibrous tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlasma cell granuloma

Professional guidelines

PubMed

Management Strategies of Plasma Cell Granuloma Involving the Central Nervous System: A Systematic Review of the Literature.
Sreenivasan S, Agarwal N, Bharath Raju, Kandregula S, Narayan V, Chen CC, Sharma M
World Neurosurg 2023 Dec;180:194-202.e11. Epub 2023 Sep 13 doi: 10.1016/j.wneu.2023.09.026. PMID: 37708970

Recent clinical studies

Etiology

Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions.
Hassaf-Arreola AG, Caro-Sánchez CH, Domínguez-Malagón H, Irigoyen-Camacho ME, Almeida OP, Sánchez-Romero C, Mosqueda-Taylor A
Med Oral Patol Oral Cir Bucal 2022 Nov 1;27(6):e497-e506. doi: 10.4317/medoral.25326. PMID: 36243994Free PMC Article
Plasma Cell Granuloma of the Thyroid: Review of an Uncommon Entity.
Patil PA, DeLellis RA
Arch Pathol Lab Med 2018 Aug;142(8):998-1005. doi: 10.5858/arpa.2017-0068-RS. PMID: 30040458
Benign esophageal tumors.
Ha C, Regan J, Cetindag IB, Ali A, Mellinger JD
Surg Clin North Am 2015 Jun;95(3):491-514. Epub 2015 Mar 21 doi: 10.1016/j.suc.2015.02.005. PMID: 25965126
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132

Diagnosis

Management Strategies of Plasma Cell Granuloma Involving the Central Nervous System: A Systematic Review of the Literature.
Sreenivasan S, Agarwal N, Bharath Raju, Kandregula S, Narayan V, Chen CC, Sharma M
World Neurosurg 2023 Dec;180:194-202.e11. Epub 2023 Sep 13 doi: 10.1016/j.wneu.2023.09.026. PMID: 37708970
Plasma cell granuloma of the conjunctiva in a young female.
Alam MS, Vijay V, Barh A, Subramanian K
Orbit 2021 Feb;40(1):69-72. Epub 2020 Mar 1 doi: 10.1080/01676830.2020.1727538. PMID: 32116097
Plasma Cell Granuloma of the Thyroid: Review of an Uncommon Entity.
Patil PA, DeLellis RA
Arch Pathol Lab Med 2018 Aug;142(8):998-1005. doi: 10.5858/arpa.2017-0068-RS. PMID: 30040458
Radiographic and Pathologic Manifestations of Uncommon and Rare Pulmonary Lesions.
Pfeifer K, Mian A, Adebowale A, Alomari A, Kalra V, Krejci E, Shin MS
Can Assoc Radiol J 2016 May;67(2):179-89. Epub 2015 Dec 11 doi: 10.1016/j.carj.2015.07.004. PMID: 26690551
Inflammatory pseudotumor.
Narla LD, Newman B, Spottswood SS, Narla S, Kolli R
Radiographics 2003 May-Jun;23(3):719-29. doi: 10.1148/rg.233025073. PMID: 12740472

Therapy

Supraglottic immunoglobulin-G4 related plasma cell granuloma: case report and literature review.
Khoo JF, Batt M, Stimpson P, Safdar A
Head Neck 2014 Jun;36(6):E57-9. Epub 2014 Jan 22 doi: 10.1002/hed.23519. PMID: 24115385
Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
Tothova Z, Wagner AJ
Curr Opin Oncol 2012 Jul;24(4):409-13. doi: 10.1097/CCO.0b013e328354c155. PMID: 22664824
IgG4-related sclerosing disease.
Kamisawa T, Okamoto A
World J Gastroenterol 2008 Jul 7;14(25):3948-55. doi: 10.3748/wjg.14.3948. PMID: 18609677Free PMC Article
Cryptococcal inflammatory pseudotumors.
Sing Y, Ramdial PK
Am J Surg Pathol 2007 Oct;31(10):1521-7. doi: 10.1097/PAS.0b013e318040ad0a. PMID: 17895752
Medical cure of plasma cell granuloma of the thyroid associated with Hashimoto's thyroiditis: a case report and review.
Laurent S, Mouthon L, Longchampt E, Roudaire M, Franc S, Krivitzky A, Cohen R
J Clin Endocrinol Metab 2004 Apr;89(4):1534-7. doi: 10.1210/jc.2003-031355. PMID: 15070909

Prognosis

Inflammatory myofibroblastic tumor of the thyroid gland.
Zhang Y, Liu J
Front Endocrinol (Lausanne) 2023;14:1156117. Epub 2023 May 15 doi: 10.3389/fendo.2023.1156117. PMID: 37255972Free PMC Article
Uterine inflammatory myofibroblastic tumor.
Karpathiou G, Devouassoux-Shisheboran M, Stolnicu S, Chauleur C, Péoc'h M
Pathol Res Pract 2023 Feb;242:154335. Epub 2023 Jan 23 doi: 10.1016/j.prp.2023.154335. PMID: 36706588
Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions.
Hassaf-Arreola AG, Caro-Sánchez CH, Domínguez-Malagón H, Irigoyen-Camacho ME, Almeida OP, Sánchez-Romero C, Mosqueda-Taylor A
Med Oral Patol Oral Cir Bucal 2022 Nov 1;27(6):e497-e506. doi: 10.4317/medoral.25326. PMID: 36243994Free PMC Article
Plasma Cell Granuloma of the Thyroid: Review of an Uncommon Entity.
Patil PA, DeLellis RA
Arch Pathol Lab Med 2018 Aug;142(8):998-1005. doi: 10.5858/arpa.2017-0068-RS. PMID: 30040458
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468

Clinical prediction guides

Role of myofibroblasts in oral plasma cell granuloma: Immunohistochemical evaluation of α-SMA and ALK in a retrospective study of 30 cases.
Ibrahim MMA
J Stomatol Oral Maxillofac Surg 2023 Dec;124(6S):101595. Epub 2023 Aug 11 doi: 10.1016/j.jormas.2023.101595. PMID: 37573967
Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions.
Hassaf-Arreola AG, Caro-Sánchez CH, Domínguez-Malagón H, Irigoyen-Camacho ME, Almeida OP, Sánchez-Romero C, Mosqueda-Taylor A
Med Oral Patol Oral Cir Bucal 2022 Nov 1;27(6):e497-e506. doi: 10.4317/medoral.25326. PMID: 36243994Free PMC Article
Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Chiba K, Iwasaki S, Endo Y, Kuwata G, Koizumi K, Shimosegawa T, Okazaki K, Chiba T
World J Gastroenterol 2013 Sep 21;19(35):5769-74. doi: 10.3748/wjg.v19.i35.5769. PMID: 24124321Free PMC Article
Cardiovascular pseudoneoplasms.
Miller DV, Tazelaar HD
Arch Pathol Lab Med 2010 Mar;134(3):362-8. doi: 10.5858/134.3.362. PMID: 20196664
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468

Recent systematic reviews

Management Strategies of Plasma Cell Granuloma Involving the Central Nervous System: A Systematic Review of the Literature.
Sreenivasan S, Agarwal N, Bharath Raju, Kandregula S, Narayan V, Chen CC, Sharma M
World Neurosurg 2023 Dec;180:194-202.e11. Epub 2023 Sep 13 doi: 10.1016/j.wneu.2023.09.026. PMID: 37708970
What do we know about inflammatory myofibroblastic tumors? - A systematic review.
Siemion K, Reszec-Gielazyn J, Kisluk J, Roszkowiak L, Zak J, Korzynska A
Adv Med Sci 2022 Mar;67(1):129-138. Epub 2022 Feb 23 doi: 10.1016/j.advms.2022.02.002. PMID: 35219201
Imaging features, therapies, and outcomes of fibrosing inflammatory pseudotumor of the nasopharynx: A systematic review.
Mishra S, Suh CH, Bergmark RW, Jo VY, Miyawaki EK, Schoenfeld JD, Uppaluri R, Guenette JP
J Neuroimaging 2022 Mar;32(2):223-229. Epub 2021 Dec 8 doi: 10.1111/jon.12953. PMID: 34879175
Lateral skull base Inflammatory pseudotumor: A systematic review.
Spinazzi EF, Desai SV, Fang CH, Jyung RW, Liu JK, Baredes S, Eloy JA
Laryngoscope 2015 Nov;125(11):2593-600. Epub 2015 Apr 17 doi: 10.1002/lary.25308. PMID: 25892586
Sinonasal and ventral skull base inflammatory pseudotumor: a systematic review.
Desai SV, Spinazzi EF, Fang CH, Huang G, Tomovic S, Liu JK, Baredes S, Eloy JA
Laryngoscope 2015 Apr;125(4):813-21. Epub 2014 Nov 6 doi: 10.1002/lary.24993. PMID: 25376630

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