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Plasma cell granuloma

MedGen UID:
42293
•Concept ID:
C0018199
•
Pathologic Function
Synonyms: Granuloma, Plasma Cell; Granulomas, Plasma Cell; Plasma Cell Granuloma; Plasma Cell Granulomas
SNOMED CT: Plasma cell granuloma (21971004); Plasma cell pseudotumor (21971004)

Definition

An inflammatory lesion of the lungs comprised of plasma cells and fibrous tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlasma cell granuloma

Professional guidelines

PubMed

Inflammatory pseudotumor and myofibroblastic inflammatory tumor. Diagnostic criteria and prognostic differences.
Carrasco Rodríguez R, García Fontán EM, Blanco Ramos M, Magdalena Benavides LJ, Otero Lozano D, Moldes Rodriguez M, Cañizares Carretero MA
Cir Esp (Engl Ed) 2022 Jun;100(6):329-335. Epub 2022 May 13 doi: 10.1016/j.cireng.2022.05.012. PMID: 35577280
Diagnosis and management of solid benign liver lesions.
Belghiti J, Cauchy F, Paradis V, Vilgrain V
Nat Rev Gastroenterol Hepatol 2014 Dec;11(12):737-49. Epub 2014 Sep 2 doi: 10.1038/nrgastro.2014.151. PMID: 25178878
Gallbladder tumor and pseudotumor: Diagnosis and management.
Zemour J, Marty M, Lapuyade B, Collet D, Chiche L
J Visc Surg 2014 Sep;151(4):289-300. Epub 2014 Jun 12 doi: 10.1016/j.jviscsurg.2014.05.003. PMID: 24930718

Recent clinical studies

Etiology

Plasma Cell Granuloma of the Thyroid: Review of an Uncommon Entity.
Patil PA, DeLellis RA
Arch Pathol Lab Med 2018 Aug;142(8):998-1005. doi: 10.5858/arpa.2017-0068-RS. PMID: 30040458
A Case of Plasma Cell Granuloma Located on the Gingiva.
Akdoğan N, Yalçın B, Gür Aksoy G, Tuna EE, Ünal DT
Am J Dermatopathol 2017 May;39(5):393-396. doi: 10.1097/DAD.0000000000000779. PMID: 27759699
Uncommon liver tumors: Case report and literature review.
Wu CH, Chiu NC, Yeh YC, Kuo Y, Yu SS, Weng CY, Liu CA, Chou YH, Chiou YY
Medicine (Baltimore) 2016 Sep;95(39):e4952. doi: 10.1097/MD.0000000000004952. PMID: 27684838Free PMC Article
Benign esophageal tumors.
Ha C, Regan J, Cetindag IB, Ali A, Mellinger JD
Surg Clin North Am 2015 Jun;95(3):491-514. Epub 2015 Mar 21 doi: 10.1016/j.suc.2015.02.005. PMID: 25965126
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132

Diagnosis

Plasma Cell Granuloma of the Thyroid: Review of an Uncommon Entity.
Patil PA, DeLellis RA
Arch Pathol Lab Med 2018 Aug;142(8):998-1005. doi: 10.5858/arpa.2017-0068-RS. PMID: 30040458
Radiographic and Pathologic Manifestations of Uncommon and Rare Pulmonary Lesions.
Pfeifer K, Mian A, Adebowale A, Alomari A, Kalra V, Krejci E, Shin MS
Can Assoc Radiol J 2016 May;67(2):179-89. Epub 2015 Dec 11 doi: 10.1016/j.carj.2015.07.004. PMID: 26690551
Supraglottic immunoglobulin-G4 related plasma cell granuloma: case report and literature review.
Khoo JF, Batt M, Stimpson P, Safdar A
Head Neck 2014 Jun;36(6):E57-9. Epub 2014 Jan 22 doi: 10.1002/hed.23519. PMID: 24115385
Gingival plasma cell granuloma.
Phadnaik MB, Attar N
Indian J Dent Res 2010 Jul-Sep;21(3):460-2. doi: 10.4103/0970-9290.70788. PMID: 20930366
Inflammatory pseudotumor.
Narla LD, Newman B, Spottswood SS, Narla S, Kolli R
Radiographics 2003 May-Jun;23(3):719-29. doi: 10.1148/rg.233025073. PMID: 12740472

Therapy

Supraglottic immunoglobulin-G4 related plasma cell granuloma: case report and literature review.
Khoo JF, Batt M, Stimpson P, Safdar A
Head Neck 2014 Jun;36(6):E57-9. Epub 2014 Jan 22 doi: 10.1002/hed.23519. PMID: 24115385
Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
Tothova Z, Wagner AJ
Curr Opin Oncol 2012 Jul;24(4):409-13. doi: 10.1097/CCO.0b013e328354c155. PMID: 22664824
IgG4-related sclerosing disease.
Kamisawa T, Okamoto A
World J Gastroenterol 2008 Jul 7;14(25):3948-55. doi: 10.3748/wjg.14.3948. PMID: 18609677Free PMC Article
Cryptococcal inflammatory pseudotumors.
Sing Y, Ramdial PK
Am J Surg Pathol 2007 Oct;31(10):1521-7. doi: 10.1097/PAS.0b013e318040ad0a. PMID: 17895752
Medical cure of plasma cell granuloma of the thyroid associated with Hashimoto's thyroiditis: a case report and review.
Laurent S, Mouthon L, Longchampt E, Roudaire M, Franc S, Krivitzky A, Cohen R
J Clin Endocrinol Metab 2004 Apr;89(4):1534-7. doi: 10.1210/jc.2003-031355. PMID: 15070909

Prognosis

Uterine inflammatory myofibroblastic tumor.
Karpathiou G, Devouassoux-Shisheboran M, Stolnicu S, Chauleur C, Péoc'h M
Pathol Res Pract 2023 Feb;242:154335. Epub 2023 Jan 23 doi: 10.1016/j.prp.2023.154335. PMID: 36706588
Plasma Cell Granuloma of the Thyroid: Review of an Uncommon Entity.
Patil PA, DeLellis RA
Arch Pathol Lab Med 2018 Aug;142(8):998-1005. doi: 10.5858/arpa.2017-0068-RS. PMID: 30040458
A Case of Plasma Cell Granuloma Located on the Gingiva.
Akdoğan N, Yalçın B, Gür Aksoy G, Tuna EE, Ünal DT
Am J Dermatopathol 2017 May;39(5):393-396. doi: 10.1097/DAD.0000000000000779. PMID: 27759699
Head and neck inflammatory pseudotumor: Case series and review of the literature.
Kansara S, Bell D, Johnson J, Zafereo M
Neuroradiol J 2016 Dec;29(6):440-446. Epub 2016 Sep 20 doi: 10.1177/1971400916665377. PMID: 27650653Free PMC Article
Plasma cell granuloma of the lung: difficulties in diagnosis and prognosis.
Copin MC, Gosselin BH, Ribet ME
Ann Thorac Surg 1996 May;61(5):1477-82. doi: 10.1016/0003-4975(96)00081-1. PMID: 8633962

Clinical prediction guides

Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions.
Hassaf-Arreola AG, Caro-Sánchez CH, Domínguez-Malagón H, Irigoyen-Camacho ME, Almeida OP, Sánchez-Romero C, Mosqueda-Taylor A
Med Oral Patol Oral Cir Bucal 2022 Nov 1;27(6):e497-e506. doi: 10.4317/medoral.25326. PMID: 36243994Free PMC Article
Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Chiba K, Iwasaki S, Endo Y, Kuwata G, Koizumi K, Shimosegawa T, Okazaki K, Chiba T
World J Gastroenterol 2013 Sep 21;19(35):5769-74. doi: 10.3748/wjg.v19.i35.5769. PMID: 24124321Free PMC Article
Cardiovascular pseudoneoplasms.
Miller DV, Tazelaar HD
Arch Pathol Lab Med 2010 Mar;134(3):362-8. doi: 10.5858/134.3.362. PMID: 20196664
Plasma cell granuloma of the thyroid: report of case and review of literature.
Fontenot JW, Levine SN, Adegboyega PA, Cotelingam JD
Endocr Pract 2008 Jul-Aug;14(5):611-7. doi: 10.4158/EP.14.5.611. PMID: 18753107
Inflammatory myofibroblastic tumors.
Kovach SJ, Fischer AC, Katzman PJ, Salloum RM, Ettinghausen SE, Madeb R, Koniaris LG
J Surg Oncol 2006 Oct 1;94(5):385-91. doi: 10.1002/jso.20516. PMID: 16967468

Recent systematic reviews

What do we know about inflammatory myofibroblastic tumors? - A systematic review.
Siemion K, Reszec-Gielazyn J, Kisluk J, Roszkowiak L, Zak J, Korzynska A
Adv Med Sci 2022 Mar;67(1):129-138. Epub 2022 Feb 23 doi: 10.1016/j.advms.2022.02.002. PMID: 35219201
Imaging features, therapies, and outcomes of fibrosing inflammatory pseudotumor of the nasopharynx: A systematic review.
Mishra S, Suh CH, Bergmark RW, Jo VY, Miyawaki EK, Schoenfeld JD, Uppaluri R, Guenette JP
J Neuroimaging 2022 Mar;32(2):223-229. Epub 2021 Dec 8 doi: 10.1111/jon.12953. PMID: 34879175
Lateral skull base Inflammatory pseudotumor: A systematic review.
Spinazzi EF, Desai SV, Fang CH, Jyung RW, Liu JK, Baredes S, Eloy JA
Laryngoscope 2015 Nov;125(11):2593-600. Epub 2015 Apr 17 doi: 10.1002/lary.25308. PMID: 25892586
Sinonasal and ventral skull base inflammatory pseudotumor: a systematic review.
Desai SV, Spinazzi EF, Fang CH, Huang G, Tomovic S, Liu JK, Baredes S, Eloy JA
Laryngoscope 2015 Apr;125(4):813-21. Epub 2014 Nov 6 doi: 10.1002/lary.24993. PMID: 25376630
Parenchymal pseudotumoral tuberculosis: case series and systematic review of literature.
Agarwal R, Srinivas R, Aggarwal AN
Respir Med 2008 Mar;102(3):382-9. Epub 2007 Dec 3 doi: 10.1016/j.rmed.2007.10.017. PMID: 18060757

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