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Heart block

MedGen UID:
42363
•Concept ID:
C0018794
•
Disease or Syndrome; Finding
Synonyms: Block, Heart; Blocks, Heart; Heart Block; Heart Blocks
SNOMED CT: Heart block (233916004); HB - Heart block (233916004)
 
HPO: HP:0012722

Definition

Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeart block

Conditions with this feature

Meier-Gorlin syndrome 7
MedGen UID:
934705
•Concept ID:
C4310738
•
Disease or Syndrome
Any Meier-Gorlin syndrome in which the cause of the disease is a mutation in the CDC45 gene.
See: Condition Record
Meier-Gorlin syndrome 7

Professional guidelines

PubMed

Fetal Arrhythmia Diagnosis and Pharmacologic Management.
Strasburger JF, Eckstein G, Butler M, Noffke P, Wacker-Gussmann A
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S53-S66. doi: 10.1002/jcph.2129. PMID: 36106782Free PMC Article
Management of Patients With Giant Cell Myocarditis: JACC Review Topic of the Week.
Bang V, Ganatra S, Shah SP, Dani SS, Neilan TG, Thavendiranathan P, Resnic FS, Piemonte TC, Barac A, Patel R, Sharma A, Parikh R, Chaudhry GM, Vesely M, Hayek SS, Leja M, Venesy D, Patten R, Lenihan D, Nohria A, Cooper LT
J Am Coll Cardiol 2021 Mar 2;77(8):1122-1134. doi: 10.1016/j.jacc.2020.11.074. PMID: 33632487
2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society.
Kusumoto FM, Schoenfeld MH, Barrett C, Edgerton JR, Ellenbogen KA, Gold MR, Goldschlager NF, Hamilton RM, Joglar JA, Kim RJ, Lee R, Marine JE, McLeod CJ, Oken KR, Patton KK, Pellegrini CN, Selzman KA, Thompson A, Varosy PD
Circulation 2019 Aug 20;140(8):e382-e482. Epub 2018 Nov 6 doi: 10.1161/CIR.0000000000000628. PMID: 30586772

Recent clinical studies

Etiology

Congenital Heart Block.
Steinberg L
Cardiol Clin 2023 Aug;41(3):399-410. doi: 10.1016/j.ccl.2023.03.002. PMID: 37321690
Congenital Heart Block.
Steinberg L
Card Electrophysiol Clin 2021 Dec;13(4):691-702. doi: 10.1016/j.ccep.2021.07.006. PMID: 34689896
Prenatal diagnosis and management of congenital complete heart block.
Pruetz JD, Miller JC, Loeb GE, Silka MJ, Bar-Cohen Y, Chmait RH
Birth Defects Res 2019 May 1;111(8):380-388. Epub 2019 Mar 1 doi: 10.1002/bdr2.1459. PMID: 30821931Free PMC Article
Fetal dysrhythmias.
Carvalho JS
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:28-41. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.002. PMID: 30738635
Cardiac manifestations of systemic lupus erythematosus.
Miner JJ, Kim AH
Rheum Dis Clin North Am 2014 Feb;40(1):51-60. doi: 10.1016/j.rdc.2013.10.003. PMID: 24268009

Diagnosis

Congenital Heart Block.
Steinberg L
Cardiol Clin 2023 Aug;41(3):399-410. doi: 10.1016/j.ccl.2023.03.002. PMID: 37321690
Identifying Congenital Heart Block in Primary Care.
Flowers ME, Garber K, Temples HS
J Pediatr Health Care 2023 Sep-Oct;37(5):478-483. Epub 2023 Apr 6 doi: 10.1016/j.pedhc.2023.03.001. PMID: 37031100
Reversal of Fetal Heart Block in Antibody-Positive Mother After Hydroxychloroquine and Dexamethasone.
Hoda M, Scott W, Sharma K, Duryea E, Ikemba C
Pediatr Cardiol 2023 Mar;44(3):727-731. Epub 2022 Jun 14 doi: 10.1007/s00246-022-02945-6. PMID: 35699754
Congenital Heart Block.
Steinberg L
Card Electrophysiol Clin 2021 Dec;13(4):691-702. doi: 10.1016/j.ccep.2021.07.006. PMID: 34689896
Neonatal congenital heart block.
Yildirim A, Tunaoolu FS, Karaaoac AT
Indian Pediatr 2013 May 8;50(5):483-8. doi: 10.1007/s13312-013-0156-3. PMID: 23778728

Therapy

Beta-blockers for congestive heart failure in children.
Alabed S, Sabouni A, Al Dakhoul S, Bdaiwi Y
Cochrane Database Syst Rev 2020 Jul 23;7(7):CD007037. doi: 10.1002/14651858.CD007037.pub4. PMID: 32700759Free PMC Article
Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers.
Izmirly P, Kim M, Friedman DM, Costedoat-Chalumeau N, Clancy R, Copel JA, Phoon CKL, Cuneo BF, Cohen RE, Robins K, Masson M, Wainwright BJ, Zahr N, Saxena A, Buyon JP
J Am Coll Cardiol 2020 Jul 21;76(3):292-302. doi: 10.1016/j.jacc.2020.05.045. PMID: 32674792Free PMC Article
Dysrhythmias and heart failure complicating acute myocardial infarction: An emergency medicine review.
Davis WT, Montrief T, Koyfman A, Long B
Am J Emerg Med 2019 Aug;37(8):1554-1561. Epub 2019 Apr 27 doi: 10.1016/j.ajem.2019.04.047. PMID: 31060863
Fetal dysrhythmias.
Carvalho JS
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:28-41. Epub 2019 Jan 9 doi: 10.1016/j.bpobgyn.2019.01.002. PMID: 30738635
Beta-blockers for congestive heart failure in children.
Alabed S, Sabouni A, Al Dakhoul S, Bdaiwi Y, Frobel-Mercier AK
Cochrane Database Syst Rev 2016 Jan 28;(1):CD007037. doi: 10.1002/14651858.CD007037.pub3. PMID: 26820557

Prognosis

Incidence and recovery of post-surgical heart block in children following cardiac surgery.
Madani R, Aronoff E, Posey J, Basu M, Zinyandu T, Chai P, Whitehill R, Maher KO, Beshish AG
Cardiol Young 2023 Jul;33(7):1150-1156. Epub 2022 Jul 29 doi: 10.1017/S1047951122002025. PMID: 35903026
Transcatheter aortic valve replacement and cardiac conduction.
Shreenivas S, Schloss E, Choo J, Sarembock I, Lilly S, Kereiakes D
Expert Rev Cardiovasc Ther 2019 Apr;17(4):293-304. doi: 10.1080/14779072.2019.1598264. PMID: 30912984
Congenitally corrected transposition.
Wallis GA, Debich-Spicer D, Anderson RH
Orphanet J Rare Dis 2011 May 14;6:22. doi: 10.1186/1750-1172-6-22. PMID: 21569592Free PMC Article
Pacemaker therapies in cardiology.
Toogood G
Aust Fam Physician 2007 Jul;36(7):518-9, 521-4. PMID: 17619666
Postoperative arrhythmia.
Lan YT, Lee JC, Wetzel G
Curr Opin Cardiol 2003 Mar;18(2):73-8. doi: 10.1097/00001573-200303000-00001. PMID: 12652209

Clinical prediction guides

Autoimmune-mediated congenital heart block.
Wainwright B, Bhan R, Trad C, Cohen R, Saxena A, Buyon J, Izmirly P
Best Pract Res Clin Obstet Gynaecol 2020 Apr;64:41-51. Epub 2019 Oct 8 doi: 10.1016/j.bpobgyn.2019.09.001. PMID: 31685414
Congenital heart block: Pace earlier (Childhood) than later (Adulthood).
Manolis AA, Manolis TA, Melita H, Manolis AS
Trends Cardiovasc Med 2020 Jul;30(5):275-286. Epub 2019 Jun 20 doi: 10.1016/j.tcm.2019.06.006. PMID: 31262557
Cardiac manifestations of systemic lupus erythematosus.
Miner JJ, Kim AH
Rheum Dis Clin North Am 2014 Feb;40(1):51-60. doi: 10.1016/j.rdc.2013.10.003. PMID: 24268009
Syncope diagnostic scores.
Sheldon R
Prog Cardiovasc Dis 2013 Jan-Feb;55(4):390-5. doi: 10.1016/j.pcad.2012.10.011. PMID: 23472776
Pregnancy in lupus.
Meng C, Lockshin M
Curr Opin Rheumatol 1999 Sep;11(5):348-51. doi: 10.1097/00002281-199909000-00004. PMID: 10503653

Recent systematic reviews

Maternal and infant outcomes of pregnancy associated with anti-SSA/RO antibodies: a systematic review and meta-analysis.
Sheng X, Song X, Xiong Y, Ren T, Chang X, Wu J, Cao J, Cheng T, Wang M
Pediatr Rheumatol Online J 2023 Mar 4;21(1):22. doi: 10.1186/s12969-023-00803-0. PMID: 36870970Free PMC Article
BRASH Syndrome: A Systematic Review of Reported Cases.
Majeed H, Khan U, Khan AM, Khalid SN, Farook S, Gangu K, Sagheer S, Sheikh AB
Curr Probl Cardiol 2023 Jun;48(6):101663. Epub 2023 Feb 24 doi: 10.1016/j.cpcardiol.2023.101663. PMID: 36842470
Characteristics of bradyarrhythmia in patients with COVID-19: Systematic scoping review.
Nagamine T, Randhawa S, Nishimura Y, Huang R, Leesutipornchai T, Benavente K, Yoshimura S, Zhang J, Kanitsorphan C
Pacing Clin Electrophysiol 2022 Apr;45(4):556-566. Epub 2022 Mar 3 doi: 10.1111/pace.14466. PMID: 35182433Free PMC Article
Beta-blockers for congestive heart failure in children.
Alabed S, Sabouni A, Al Dakhoul S, Bdaiwi Y
Cochrane Database Syst Rev 2020 Jul 23;7(7):CD007037. doi: 10.1002/14651858.CD007037.pub4. PMID: 32700759Free PMC Article
Clinical and electrocardiographic features of complete heart block after blunt cardiac injury: A systematic review of the literature.
Ali H, Furlanello F, Lupo P, Foresti S, De Ambroggi G, Epicoco G, Semprini L, Fundaliotis A, Cappato R
Heart Rhythm 2017 Oct;14(10):1561-1569. Epub 2017 Jun 3 doi: 10.1016/j.hrthm.2017.05.040. PMID: 28583850

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