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Hemobilia

MedGen UID:
42393
•Concept ID:
C0018994
•
Disease or Syndrome
Synonyms: Biliary Tract Hemorrhage; Biliary Tract Hemorrhages; Hemobilias; Hemorrhage, Biliary Tract
SNOMED CT: Hemobilia (66556007); Hemorrhage in bile (66556007); Hematobilia (66556007)
 
HPO: HP:0100762

Definition

Bleeding into the biliary tree. [from HPO]

Professional guidelines

PubMed

Challenges in Diagnosis and Management of Hemobilia.
Parvinian A, Fletcher JG, Storm AC, Venkatesh SK, Fidler JL, Khandelwal AR
Radiographics 2021 May-Jun;41(3):802-813. doi: 10.1148/rg.2021200192. PMID: 33939540
Diagnosis and Management of Complications from Percutaneous Biliary Tract Interventions.
Venkatanarasimha N, Damodharan K, Gogna A, Leong S, Too CW, Patel A, Tay KH, Tan BS, Lo R, Irani F
Radiographics 2017 Mar-Apr;37(2):665-680. doi: 10.1148/rg.2017160159. PMID: 28287940
Endoscopic ultrasound in the diagnosis and treatment of upper digestive bleeding: a useful tool.
Seicean A
J Gastrointestin Liver Dis 2013 Dec;22(4):465-9. PMID: 24369332

Recent clinical studies

Etiology

Transcatheter arterial embolization for massive hemobilia with N-butyl cyanoacrylate (NBCA) Glubran 2.
Shi Y, Chen L, Zhao B, Huang H, Lu Z, Su H
Acta Radiol 2022 Mar;63(3):360-367. Epub 2021 Feb 9 doi: 10.1177/0284185121992971. PMID: 33562997
Hemobilia: An Uncommon But Notable Cause of Upper Gastrointestinal Bleeding.
Cathcart S, Birk JW, Tadros M, Schuster M
J Clin Gastroenterol 2017 Oct;51(9):796-804. doi: 10.1097/MCG.0000000000000876. PMID: 28644311
Haemobilia.
Green MH, Duell RM, Johnson CD, Jamieson NV
Br J Surg 2001 Jun;88(6):773-86. doi: 10.1046/j.1365-2168.2001.01756.x. PMID: 11412246
Hepatic trauma.
Sheldon GF, Rutledge R
Adv Surg 1989;22:179-93. PMID: 2645745
Iatrogenic hemobilia.
Sandblom P
Am J Surg 1986 Jun;151(6):754-8. doi: 10.1016/0002-9610(86)90059-0. PMID: 3521357

Diagnosis

Imaging of benign biliary pathologies.
Sundaram KM, Morgan MA, Itani M, Thompson W
Abdom Radiol (NY) 2023 Jan;48(1):106-126. Epub 2022 Feb 24 doi: 10.1007/s00261-022-03440-5. PMID: 35201397
Upper gastrointestinal bleeding.
Feinman M, Haut ER
Surg Clin North Am 2014 Feb;94(1):43-53. doi: 10.1016/j.suc.2013.10.004. PMID: 24267496
Hemobilia.
Chin MW, Enns R
Curr Gastroenterol Rep 2010 Apr;12(2):121-9. doi: 10.1007/s11894-010-0092-5. PMID: 20424984
Haemobilia.
Green MH, Duell RM, Johnson CD, Jamieson NV
Br J Surg 2001 Jun;88(6):773-86. doi: 10.1046/j.1365-2168.2001.01756.x. PMID: 11412246
Hemobilia.
Goodnight JE Jr, Blaisdell FW
Surg Clin North Am 1981 Aug;61(4):973-9. doi: 10.1016/s0039-6109(16)42493-x. PMID: 7025304

Therapy

Radiologic findings of biliary complications post liver transplantation.
Khot R, Morgan MA, Nair RT, Ludwig DR, Arif-Tiwari H, Bhati CS, Itani M
Abdom Radiol (NY) 2023 Jan;48(1):166-185. Epub 2022 Oct 26 doi: 10.1007/s00261-022-03714-y. PMID: 36289069
Drug-eluting/biodegradable stents.
ASGE Technology Committee, Tokar JL, Banerjee S, Barth BA, Desilets DJ, Kaul V, Kethi SR, Pedrosa MC, Pfau PR, Pleskow DK, Varadarajulu S, Wang A, Song LM, Rodriguez SA
Gastrointest Endosc 2011 Nov;74(5):954-8. Epub 2011 Sep 23 doi: 10.1016/j.gie.2011.07.028. PMID: 21944310
Iatrogenic hemobilia.
Sandblom P
Am J Surg 1986 Jun;151(6):754-8. doi: 10.1016/0002-9610(86)90059-0. PMID: 3521357
Hemobilia.
Bismuth H
N Engl J Med 1973 Mar 22;288(12):617-9. doi: 10.1056/NEJM197303222881207. PMID: 4346967
Hemobilia.
Sandblom P
Surg Clin North Am 1973 Oct;53(5):1191-201. doi: 10.1016/s0039-6109(16)40146-5. PMID: 4205165

Prognosis

Imaging of benign biliary pathologies.
Sundaram KM, Morgan MA, Itani M, Thompson W
Abdom Radiol (NY) 2023 Jan;48(1):106-126. Epub 2022 Feb 24 doi: 10.1007/s00261-022-03440-5. PMID: 35201397
Hemobilia: An Uncommon But Notable Cause of Upper Gastrointestinal Bleeding.
Cathcart S, Birk JW, Tadros M, Schuster M
J Clin Gastroenterol 2017 Oct;51(9):796-804. doi: 10.1097/MCG.0000000000000876. PMID: 28644311
Management of paediatric liver trauma.
van As AB, Millar AJ
Pediatr Surg Int 2017 Apr;33(4):445-453. Epub 2016 Dec 27 doi: 10.1007/s00383-016-4046-3. PMID: 28028561
Hemobilia.
Chin MW, Enns R
Curr Gastroenterol Rep 2010 Apr;12(2):121-9. doi: 10.1007/s11894-010-0092-5. PMID: 20424984
Hemobilia.
Goodnight JE Jr, Blaisdell FW
Surg Clin North Am 1981 Aug;61(4):973-9. doi: 10.1016/s0039-6109(16)42493-x. PMID: 7025304

Clinical prediction guides

Hemobilia: An Uncommon But Notable Cause of Upper Gastrointestinal Bleeding.
Cathcart S, Birk JW, Tadros M, Schuster M
J Clin Gastroenterol 2017 Oct;51(9):796-804. doi: 10.1097/MCG.0000000000000876. PMID: 28644311
Hemobilia following laparoscopic cholecystectomy: computed tomography findings and clinical outcome of transcatheter arterial embolization.
Feng W, Yue D, ZaiMing L, ZhaoYu L, Wei L, Qiyong G
Acta Radiol 2017 Jan;58(1):46-52. Epub 2016 Mar 16 doi: 10.1177/0284185116638570. PMID: 26987672
Biliary tract complications after liver transplantation: a review.
Wojcicki M, Milkiewicz P, Silva M
Dig Surg 2008;25(4):245-57. Epub 2008 Jul 15 doi: 10.1159/000144653. PMID: 18628624
Hemobilia.
Goodnight JE Jr, Blaisdell FW
Surg Clin North Am 1981 Aug;61(4):973-9. doi: 10.1016/s0039-6109(16)42493-x. PMID: 7025304
Minor hemobilia. Clinical significance and pathophysiological background.
Sandblom P, Mirkovitch V
Ann Surg 1979 Aug;190(2):254-64. doi: 10.1097/00000658-197908000-00020. PMID: 464695Free PMC Article

Recent systematic reviews

Comparison of Efficacy and Safety of Laparoscopic Holmium laser Lithotripsy and Laparoscopic Bile Duct Exploration for Bile Duct Stones: A Systematic Review and Meta-Analysis.
Liu B, Fu L, Lu T, Zhang G, Dong X, Zhao Q, Yu M, Ma H, Yang K, Cai H
World J Surg 2023 Jul;47(7):1809-1820. Epub 2023 Apr 11 doi: 10.1007/s00268-023-06995-6. PMID: 37041308
Procedure-related risk factors for bleeding after percutaneous transhepatic biliary drainage: A systematic review and meta-analysis.
Lee YT, Yen KC, Liang PC, Wu CH
J Formos Med Assoc 2022 Sep;121(9):1680-1688. Epub 2021 Dec 10 doi: 10.1016/j.jfma.2021.11.013. PMID: 34903432
Efficacy and safety of laparoscopic holmium laser lithotripsy in the treatment of complicated biliary calculus: A PRISMA-compliant systematic reviews and meta-analysis.
Jin P, Jing W, Zhan W, Han C, Si M, Yang J, Li Y, Gu Y, Ma Y, Guo T
Medicine (Baltimore) 2019 Jan;98(4):e14286. doi: 10.1097/MD.0000000000014286. PMID: 30681633Free PMC Article
Radiofrequency ablation combined with biliary stent placement versus stent placement alone for malignant biliary strictures: a systematic review and meta-analysis.
Sofi AA, Khan MA, Das A, Sachdev M, Khuder S, Nawras A, Lee W
Gastrointest Endosc 2018 Apr;87(4):944-951.e1. Epub 2017 Nov 3 doi: 10.1016/j.gie.2017.10.029. PMID: 29108980
Endoscopic radiofrequency ablation may be preferable in the management of malignant biliary obstruction: A systematic review and meta-analysis.
Zheng X, Bo ZY, Wan W, Wu YC, Wang TT, Wu J, Gao DJ, Hu B
J Dig Dis 2016 Nov;17(11):716-724. doi: 10.1111/1751-2980.12429. PMID: 27768835

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