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Hemorrhagic disease of the newborn due to vitamin K deficiency

MedGen UID:
42406
•Concept ID:
C0019088
•
Disease or Syndrome
Synonyms: Hemorrhagic Disease of Newborn; Newborn Hemorrhagic Disease; Newborn Hemorrhagic Diseases
SNOMED CT: HDN - Hemorrhagic disease of newborn (12546009); Hemorrhagic disease of the newborn (12546009); Vitamin K deficiency of the newborn (12546009); Hemorrhagic disease of the newborn due to vitamin K deficiency (12546009); Hemorrhagic diathesis of newborn (12546009); Vitamin K deficiency of newborn (12546009); Neonatal vitamin K deficiency (12546009)

Definition

A condition characterized as a coagulation disturbance in newborns due to vitamin K deficiency resulting in impaired production of coagulation factors II, VII, IX, and X, and proteins C and S by the liver. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemorrhagic disease of the newborn due to vitamin K deficiency

Professional guidelines

PubMed

Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant.
Fiesack S, Smits A, Rayyan M, Allegaert K, Alliet P, Arts W, Bael A, Cornette L, De Guchtenaere A, De Mulder N, George I, Henrion E, Keiren K, Kreins N, Raes M, Philippet P, Van Overmeire B, Van Winckel M, Vlieghe V, Vandenplas Y, On Behalf Of The Groups
Nutrients 2021 Nov 16;13(11) doi: 10.3390/nu13114109. PMID: 34836364Free PMC Article
Position Statement: Guidelines for vitamin K prophylaxis in newborns: A joint statement of the Canadian Paediatric Society and the College of Family Physicians of Canada.
Ng E, Loewy AD
Can Fam Physician 2018 Oct;64(10):736-739. PMID: 30315016Free PMC Article
Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition.
Mihatsch WA, Braegger C, Bronsky J, Campoy C, Domellöf M, Fewtrell M, Mis NF, Hojsak I, Hulst J, Indrio F, Lapillonne A, Mlgaard C, Embleton N, van Goudoever J; ESPGHAN Committee on Nutrition
J Pediatr Gastroenterol Nutr 2016 Jul;63(1):123-9. doi: 10.1097/MPG.0000000000001232. PMID: 27050049

Recent clinical studies

Etiology

Take the Shot: A Review of Vitamin K Deficiency.
Shaw MA, Liu A
Pediatr Ann 2023 Feb;52(2):e42-e45. Epub 2023 Feb 1 doi: 10.3928/19382359-20230102-02. PMID: 36779880
Laboratory assessment of vitamin K status.
Card DJ, Gorska R, Harrington DJ
J Clin Pathol 2020 Feb;73(2):70-75. Epub 2019 Dec 20 doi: 10.1136/jclinpath-2019-205997. PMID: 31862867
Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates.
Ardell S, Offringa M, Ovelman C, Soll R
Cochrane Database Syst Rev 2018 Feb 5;2(2):CD008342. doi: 10.1002/14651858.CD008342.pub2. PMID: 29401369Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Vitamins.
Lauer B, Spector N
Pediatr Rev 2012 Aug;33(8):339-51; quiz 351-2. doi: 10.1542/pir.33-8-339. PMID: 22855926

Diagnosis

Take the Shot: A Review of Vitamin K Deficiency.
Shaw MA, Liu A
Pediatr Ann 2023 Feb;52(2):e42-e45. Epub 2023 Feb 1 doi: 10.3928/19382359-20230102-02. PMID: 36779880
Laboratory assessment of vitamin K status.
Card DJ, Gorska R, Harrington DJ
J Clin Pathol 2020 Feb;73(2):70-75. Epub 2019 Dec 20 doi: 10.1136/jclinpath-2019-205997. PMID: 31862867
Vitamins.
Lauer B, Spector N
Pediatr Rev 2012 Aug;33(8):339-51; quiz 351-2. doi: 10.1542/pir.33-8-339. PMID: 22855926
Haemophilia and the newborn.
Chalmers EA
Blood Rev 2004 Jun;18(2):85-92. doi: 10.1016/S0268-960X(03)00062-6. PMID: 15010147
Acquired coagulation disorders.
Prentice CR
Clin Haematol 1985 Jun;14(2):413-42. PMID: 3899441

Therapy

Vitamin K prophylaxis in newborns.
Jullien S
BMC Pediatr 2021 Sep 8;21(Suppl 1):350. doi: 10.1186/s12887-021-02701-4. PMID: 34496783Free PMC Article
Vitamin K Deficiency Bleeding in Infancy.
Araki S, Shirahata A
Nutrients 2020 Mar 16;12(3) doi: 10.3390/nu12030780. PMID: 32187975Free PMC Article
Vitamin K deficiency: a case report and review of current guidelines.
Marchili MR, Santoro E, Marchesi A, Bianchi S, Rotondi Aufiero L, Villani A
Ital J Pediatr 2018 Mar 14;44(1):36. doi: 10.1186/s13052-018-0474-0. PMID: 29540231Free PMC Article
Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates.
Ardell S, Offringa M, Ovelman C, Soll R
Cochrane Database Syst Rev 2018 Feb 5;2(2):CD008342. doi: 10.1002/14651858.CD008342.pub2. PMID: 29401369Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article

Prognosis

Vitamin K and the Newborn Infant.
Hand I, Noble L, Abrams SA
Pediatrics 2022 Mar 1;149(3) doi: 10.1542/peds.2021-056036. PMID: 35190810
Refusal of Intramuscular Vitamin K by Parents of Newborns: A Review.
Loyal J, Shapiro ED
Hosp Pediatr 2020 Mar;10(3):286-294. Epub 2020 Feb 4 doi: 10.1542/hpeds.2019-0228. PMID: 32019806Free PMC Article
Laboratory assessment of vitamin K status.
Card DJ, Gorska R, Harrington DJ
J Clin Pathol 2020 Feb;73(2):70-75. Epub 2019 Dec 20 doi: 10.1136/jclinpath-2019-205997. PMID: 31862867
Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates.
Ardell S, Offringa M, Ovelman C, Soll R
Cochrane Database Syst Rev 2018 Feb 5;2(2):CD008342. doi: 10.1002/14651858.CD008342.pub2. PMID: 29401369Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article

Clinical prediction guides

Pediatric Emergency Medicine Simulation Curriculum: Vitamin K Deficiency in the Newborn.
Sanseau E, Carr LH, Case J, Tay KY, Ades A, Yang K, Huang H, Bustin A, Good G, Gaines S, Augenstein J, Ciener D, Pearce J, Reid J, Stone K, Burns R, Thomas A
MedEdPORTAL 2021 Jan 25;17:11078. doi: 10.15766/mep_2374-8265.11078. PMID: 33511273Free PMC Article
Late vitamin K deficiency bleeding in infants: five-year prospective study.
Al-Zuhairy SH
J Pediatr (Rio J) 2021 Sep-Oct;97(5):514-519. Epub 2020 Oct 13 doi: 10.1016/j.jped.2020.09.003. PMID: 33064995Free PMC Article
Laboratory assessment of vitamin K status.
Card DJ, Gorska R, Harrington DJ
J Clin Pathol 2020 Feb;73(2):70-75. Epub 2019 Dec 20 doi: 10.1136/jclinpath-2019-205997. PMID: 31862867
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Haemophilia and the newborn.
Chalmers EA
Blood Rev 2004 Jun;18(2):85-92. doi: 10.1016/S0268-960X(03)00062-6. PMID: 15010147

Recent systematic reviews

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates.
Ardell S, Offringa M, Ovelman C, Soll R
Cochrane Database Syst Rev 2018 Feb 5;2(2):CD008342. doi: 10.1002/14651858.CD008342.pub2. PMID: 29401369Free PMC Article
Effectiveness of prothrombin complex concentrate (PCC) in neonates and infants with bleeding or risk of bleeding: a systematic review and meta-analysis.
Zeng L, Choonara I, Zhang L, Li Y, Shi J
Eur J Pediatr 2017 May;176(5):581-589. Epub 2017 Mar 9 doi: 10.1007/s00431-017-2877-0. PMID: 28281092
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Prophylactic vitamin K for vitamin K deficiency bleeding in neonates.
Puckett RM, Offringa M
Cochrane Database Syst Rev 2000;2000(4):CD002776. doi: 10.1002/14651858.CD002776. PMID: 11034761Free PMC Article

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