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Hemorrhagic disease of newborn

MedGen UID:
42406
•Concept ID:
C0019088
•
Disease or Syndrome
Synonyms: Hemorrhagic Disease of Newborn; Newborn Hemorrhagic Disease; Newborn Hemorrhagic Diseases
SNOMED CT: HDN - Hemorrhagic disease of newborn (12546009); Hemorrhagic disease of the newborn (12546009); Vitamin K deficiency of the newborn (12546009); Hemorrhagic disease of the newborn due to vitamin K deficiency (12546009); Hemorrhagic diathesis of newborn (12546009); Vitamin K deficiency of newborn (12546009); Neonatal vitamin K deficiency (12546009)
 
Monarch Initiative: MONDO:0006784

Definition

A condition characterized as a coagulation disturbance in newborns due to vitamin K deficiency resulting in impaired production of coagulation factors II, VII, IX, and X, and proteins C and S by the liver. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemorrhagic disease of newborn

Professional guidelines

PubMed

THE DIAGNOSIS AND MANAGEMENT OF BLEEDING DISORDERS.
HOAK JC, CONNOR WE, WARNER ED
J Iowa Med Soc 1964 Jul;54:331-41. PMID: 14157038

Recent clinical studies

Etiology

Prevalence of retinal hemorrhages in critically ill children.
Agrawal S, Peters MJ, Adams GG, Pierce CM
Pediatrics 2012 Jun;129(6):e1388-96. Epub 2012 May 21 doi: 10.1542/peds.2011-2772. PMID: 22614777
The impact of national and international guidelines on newborn care in the nurseries of Piedmont and Aosta Valley, Italy.
Guala A, Guarino R, Zaffaroni M, Martano C, Fabris C, Pastore G, Bona G; Neonatal Piedmont Group
BMC Pediatr 2005 Dec 5;5:45. doi: 10.1186/1471-2431-5-45. PMID: 16329760Free PMC Article
Pattern of admissions to neonatal unit.
Parkash J, Das N
J Coll Physicians Surg Pak 2005 Jun;15(6):341-4. PMID: 15924838
Comparative study of oral versus injectable vitamin K in neonates.
Malik S, Udani RH, Bichile SK, Agrawal RM, Bahrainwala AT, Tilaye S
Indian Pediatr 1992 Jul;29(7):857-9. PMID: 1428134

Diagnosis

Prevalence of retinal hemorrhages in critically ill children.
Agrawal S, Peters MJ, Adams GG, Pierce CM
Pediatrics 2012 Jun;129(6):e1388-96. Epub 2012 May 21 doi: 10.1542/peds.2011-2772. PMID: 22614777
Late hemorrhagic disease of newborn.
D'Souza IE, Rao SD
Indian Pediatr 2003 Mar;40(3):226-9. PMID: 12657755
HEMORRHAGE IN THE NEWBORN.
QUICK AJ
J Lancet 1965 Jan;85:222-4. PMID: 14291655
THE DIAGNOSIS AND MANAGEMENT OF BLEEDING DISORDERS.
HOAK JC, CONNOR WE, WARNER ED
J Iowa Med Soc 1964 Jul;54:331-41. PMID: 14157038
DIAGNOSTIC AND THERAPEUTIC ADVANCES IN HAEMORRHAGIC DISORDERS OF CHILDHOOD.
VAN CREVELD
Ceylon Med J 1962 Sep-Dec;7:139-52. PMID: 14073586

Therapy

The impact of national and international guidelines on newborn care in the nurseries of Piedmont and Aosta Valley, Italy.
Guala A, Guarino R, Zaffaroni M, Martano C, Fabris C, Pastore G, Bona G; Neonatal Piedmont Group
BMC Pediatr 2005 Dec 5;5:45. doi: 10.1186/1471-2431-5-45. PMID: 16329760Free PMC Article
Comparative study of oral versus injectable vitamin K in neonates.
Malik S, Udani RH, Bichile SK, Agrawal RM, Bahrainwala AT, Tilaye S
Indian Pediatr 1992 Jul;29(7):857-9. PMID: 1428134
Hemorrhagic disease of the newborn: a report of seven cases in a two year period, recommendations for prevention particularly with reference to infants delivered by midwives of South Carolina.
BEACH MW, PAUL JR Jr, AYCOCK EK
J S C Med Assoc 1957 Dec;53(12):455-8. PMID: 13482012

Prognosis

Pattern of admissions to neonatal unit.
Parkash J, Das N
J Coll Physicians Surg Pak 2005 Jun;15(6):341-4. PMID: 15924838

Clinical prediction guides

Prevalence of retinal hemorrhages in critically ill children.
Agrawal S, Peters MJ, Adams GG, Pierce CM
Pediatrics 2012 Jun;129(6):e1388-96. Epub 2012 May 21 doi: 10.1542/peds.2011-2772. PMID: 22614777
The impact of national and international guidelines on newborn care in the nurseries of Piedmont and Aosta Valley, Italy.
Guala A, Guarino R, Zaffaroni M, Martano C, Fabris C, Pastore G, Bona G; Neonatal Piedmont Group
BMC Pediatr 2005 Dec 5;5:45. doi: 10.1186/1471-2431-5-45. PMID: 16329760Free PMC Article
The pathogenesis of haemorrhages in newborn babies. Experimental observations of the platelet serotonin.
GRASSO E, BIANCHI P, CROSTI PF, ERMACORA E
Panminerva Med 1961 Feb;3:49-50. PMID: 13707954
Observations on the prophylactic use of vitamin Kin the newborn infant.
VIETTI TJ, MURPHY TP, JAMES JA, PRITCHARD JA
J Pediatr 1960 Mar;56:343-6. doi: 10.1016/s0022-3476(60)80185-0. PMID: 13842162

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