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Neglected Diseases

MedGen UID:
424704
•Concept ID:
C2936328
•
Disease or Syndrome
Synonyms: Disease, Neglected; Neglected Disease

Definition

Diseases that are underfunded and have low name recognition but are major burdens in less developed countries. Neglected diseases include many tropical infectious diseases, e.g., HELMINTHIASIS; LEPROSY; LYMPHATIC FILARIASIS; ONCHOCERCIASIS; SCHISTOSOMIASIS; and TRACHOMA. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeglected Diseases

Professional guidelines

PubMed

Trypanocidal treatment of Chagas disease.
Pérez-Molina JA, Crespillo-Andújar C, Bosch-Nicolau P, Molina I
Enferm Infecc Microbiol Clin (Engl Ed) 2021 Nov;39(9):458-470. doi: 10.1016/j.eimce.2020.04.012. PMID: 34736749
Recent Advancement in the Diagnosis and Treatment of Leprosy.
Aamir M, Sadaf A, Khan S, Perveen S, Khan A
Curr Top Med Chem 2018;18(18):1550-1558. doi: 10.2174/1568026618666181025100434. PMID: 30360715
Diagnosis and Management of Endomyocardial Fibrosis.
Beaton A, Mocumbi AO
Cardiol Clin 2017 Feb;35(1):87-98. doi: 10.1016/j.ccl.2016.08.005. PMID: 27886792

Recent clinical studies

Etiology

Leishmaniasis and Heart.
Farina JM, García-Martínez CE, Saldarriaga C, Pérez GE, Melo MB, Wyss F, Sosa-Liprandi A, Ortiz-Lopez HI, Gupta S, López-Santi R, Mendoza I, Baranchuk A
Arch Cardiol Mex 2022;92(1):85-93. doi: 10.24875/ACM.20000508. PMID: 34987235Free PMC Article
Leptospirosis: a neglected tropical zoonotic infection of public health importance-an updated review.
Karpagam KB, Ganesh B
Eur J Clin Microbiol Infect Dis 2020 May;39(5):835-846. Epub 2020 Jan 2 doi: 10.1007/s10096-019-03797-4. PMID: 31898795
Scabies: A Neglected Global Disease.
Leung AKC, Lam JM, Leong KF
Curr Pediatr Rev 2020;16(1):33-42. doi: 10.2174/1573396315666190717114131. PMID: 31544694
Human African trypanosomiasis.
Büscher P, Cecchi G, Jamonneau V, Priotto G
Lancet 2017 Nov 25;390(10110):2397-2409. Epub 2017 Jun 30 doi: 10.1016/S0140-6736(17)31510-6. PMID: 28673422
Chromoblastomycosis.
Queiroz-Telles F, de Hoog S, Santos DW, Salgado CG, Vicente VA, Bonifaz A, Roilides E, Xi L, Azevedo CM, da Silva MB, Pana ZD, Colombo AL, Walsh TJ
Clin Microbiol Rev 2017 Jan;30(1):233-276. doi: 10.1128/CMR.00032-16. PMID: 27856522Free PMC Article

Diagnosis

Scabies: A Neglected Global Disease.
Leung AKC, Lam JM, Leong KF
Curr Pediatr Rev 2020;16(1):33-42. doi: 10.2174/1573396315666190717114131. PMID: 31544694
Ectoparasites: Scabies.
Thomas C, Coates SJ, Engelman D, Chosidow O, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):533-548. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.109. PMID: 31310840
Climate Change and the Neglected Tropical Diseases.
Booth M
Adv Parasitol 2018;100:39-126. Epub 2018 Mar 28 doi: 10.1016/bs.apar.2018.02.001. PMID: 29753342Free PMC Article
Emerging and Neglected Infectious Diseases: Insights, Advances, and Challenges.
Nii-Trebi NI
Biomed Res Int 2017;2017:5245021. Epub 2017 Feb 13 doi: 10.1155/2017/5245021. PMID: 28286767Free PMC Article
Cystic Echinococcosis.
Agudelo Higuita NI, Brunetti E, McCloskey C
J Clin Microbiol 2016 Mar;54(3):518-23. Epub 2015 Dec 16 doi: 10.1128/JCM.02420-15. PMID: 26677245Free PMC Article

Therapy

Scabies: A Neglected Global Disease.
Leung AKC, Lam JM, Leong KF
Curr Pediatr Rev 2020;16(1):33-42. doi: 10.2174/1573396315666190717114131. PMID: 31544694
Ectoparasites: Scabies.
Thomas C, Coates SJ, Engelman D, Chosidow O, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):533-548. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.109. PMID: 31310840
Drug Design and Development for Neglected Diseases.
Ferreira EI
Curr Med Chem 2019;26(23):4298-4300. doi: 10.2174/092986732623190927101548. PMID: 31618168
Strongyloidiasis: A Neglected Tropical Disease.
Krolewiecki A, Nutman TB
Infect Dis Clin North Am 2019 Mar;33(1):135-151. doi: 10.1016/j.idc.2018.10.006. PMID: 30712758Free PMC Article
Chromoblastomycosis.
Queiroz-Telles F, de Hoog S, Santos DW, Salgado CG, Vicente VA, Bonifaz A, Roilides E, Xi L, Azevedo CM, da Silva MB, Pana ZD, Colombo AL, Walsh TJ
Clin Microbiol Rev 2017 Jan;30(1):233-276. doi: 10.1128/CMR.00032-16. PMID: 27856522Free PMC Article

Prognosis

Global burden and trends of neglected tropical diseases from 1990 to 2019.
Lin Y, Fang K, Zheng Y, Wang HL, Wu J
J Travel Med 2022 May 31;29(3) doi: 10.1093/jtm/taac031. PMID: 35238925
Scabies: A Neglected Global Disease.
Leung AKC, Lam JM, Leong KF
Curr Pediatr Rev 2020;16(1):33-42. doi: 10.2174/1573396315666190717114131. PMID: 31544694
Human African trypanosomiasis.
Büscher P, Cecchi G, Jamonneau V, Priotto G
Lancet 2017 Nov 25;390(10110):2397-2409. Epub 2017 Jun 30 doi: 10.1016/S0140-6736(17)31510-6. PMID: 28673422
Global Morbidity and Mortality of Leptospirosis: A Systematic Review.
Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI
PLoS Negl Trop Dis 2015;9(9):e0003898. Epub 2015 Sep 17 doi: 10.1371/journal.pntd.0003898. PMID: 26379143Free PMC Article
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Global Burden of Disease Study 2013 Collaborators
Lancet 2015 Aug 22;386(9995):743-800. Epub 2015 Jun 7 doi: 10.1016/S0140-6736(15)60692-4. PMID: 26063472Free PMC Article

Clinical prediction guides

Mycetoma and the environment.
Fahal AH, Bakhiet SM
PLoS Negl Trop Dis 2023 Nov;17(11):e0011736. Epub 2023 Nov 16 doi: 10.1371/journal.pntd.0011736. PMID: 37971968Free PMC Article
Neuroimmunology of rabies: New insights into an ancient disease.
Bastos V, Pacheco V, Rodrigues ÉDL, Moraes CNS, Nóbile AL, Fonseca DLM, Souza KBS, do Vale FYN, Filgueiras IS, Schimke LF, Giil LM, Moll G, Cabral-Miranda G, Ochs HD, Vasconcelos PFDC, de Melo GD, Bourhy H, Casseb LMN, Cabral-Marques O
J Med Virol 2023 Oct;95(10):e29042. doi: 10.1002/jmv.29042. PMID: 37885152
Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study.
Tarín-Vicente EJ, Alemany A, Agud-Dios M, Ubals M, Suñer C, Antón A, Arando M, Arroyo-Andrés J, Calderón-Lozano L, Casañ C, Cabrera JM, Coll P, Descalzo V, Folgueira MD, García-Pérez JN, Gil-Cruz E, González-Rodríguez B, Gutiérrez-Collar C, Hernández-Rodríguez Á, López-Roa P, de Los Ángeles Meléndez M, Montero-Menárguez J, Muñoz-Gallego I, Palencia-Pérez SI, Paredes R, Pérez-Rivilla A, Piñana M, Prat N, Ramirez A, Rivero Á, Rubio-Muñiz CA, Vall M, Acosta-Velásquez KS, Wang A, Galván-Casas C, Marks M, Ortiz-Romero PL, Mitjà O
Lancet 2022 Aug 27;400(10353):661-669. Epub 2022 Aug 8 doi: 10.1016/S0140-6736(22)01436-2. PMID: 35952705Free PMC Article
Scabies: A Neglected Global Disease.
Leung AKC, Lam JM, Leong KF
Curr Pediatr Rev 2020;16(1):33-42. doi: 10.2174/1573396315666190717114131. PMID: 31544694
Global Morbidity and Mortality of Leptospirosis: A Systematic Review.
Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI
PLoS Negl Trop Dis 2015;9(9):e0003898. Epub 2015 Sep 17 doi: 10.1371/journal.pntd.0003898. PMID: 26379143Free PMC Article

Recent systematic reviews

A systematic review of neglected tropical diseases (NTDs) in Myanmar.
Swe MMM, Phyo AP, Cooper BS, White NJ, Smithuis F, Ashley EA
PLoS Negl Trop Dis 2023 Nov;17(11):e0011706. Epub 2023 Nov 1 doi: 10.1371/journal.pntd.0011706. PMID: 37910592Free PMC Article
Burden of neglected tropical diseases and access to medicine and diagnostics in Ethiopia: a scoping review.
Semahegn A, Manyazewal T, Getachew E, Fekadu B, Assefa E, Kassa M, Davey G, Hopkins M, Araya M, Woldehanna T, Hanlon C, Fekadu A
Syst Rev 2023 Aug 14;12(1):140. doi: 10.1186/s13643-023-02302-5. PMID: 37580784Free PMC Article
Dengue and the heart.
Araiza-Garaygordobil D, García-Martínez CE, Burgos LM, Saldarriaga C, Liblik K, Mendoza I, Martinez-Selles M, Scatularo CE, Farina JM, Baranchuk A; Neglected Tropical Diseases and other Infectious Diseases affecting the Heart (the NET‐Heart) project
Cardiovasc J Afr 2021 Sep-Oct 23;32(5):276-283. Epub 2021 Jul 20 doi: 10.5830/CVJA-2021-033. PMID: 34292294Free PMC Article
Social stigma towards neglected tropical diseases: a systematic review.
Hofstraat K, van Brakel WH
Int Health 2016 Mar;8 Suppl 1:i53-70. doi: 10.1093/inthealth/ihv071. PMID: 26940310
Global Morbidity and Mortality of Leptospirosis: A Systematic Review.
Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI
PLoS Negl Trop Dis 2015;9(9):e0003898. Epub 2015 Sep 17 doi: 10.1371/journal.pntd.0003898. PMID: 26379143Free PMC Article

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