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Childhood Malignant Liver Neoplasm

MedGen UID:: 424855
•Concept ID:: C2945767
•: Neoplastic Process

Synonyms:

Childhood Cancer of Liver; Childhood Cancer of the Liver; Childhood Liver Cancer; Childhood Malignant Liver Tumor; Pediatric Cancer of Liver; Pediatric Cancer of the Liver; Pediatric Liver Cancer

Definition

A malignant neoplasm of the liver developed in childhood. Representative examples include hepatoblastoma, undifferentiated (embryonal) sarcoma, and extrarenal rhabdoid tumor. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVChildhood Malignant Liver Neoplasm

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Childhood neoplasm
        Childhood Liver and Intrahepatic Bile Duct Neoplasm
        Childhood Malignant Liver Neoplasm
        Calcifying nested epithelial stromal tumor of the liver
        Extrarenal Rhabdoid Tumor of the Liver
        Hepatoblastoma
        Hepatoblastoma with Combined Fetal and Embryonal Epithelial Differentiation
        Hepatoblastoma with Pure Fetal Epithelial Differentiation
        Macrotrabecular hepatoblastoma
        Mixed hepatoblastoma
        Postsurgical Stage I Hepatoblastoma
        Postsurgical Stage II Hepatoblastoma
        Postsurgical Stage III Hepatoblastoma
        Postsurgical Stage IV Hepatoblastoma
        PRETEXT Stage 1 Hepatoblastoma
        PRETEXT Stage 2 Hepatoblastoma
        PRETEXT Stage 3 Hepatoblastoma
        PRETEXT Stage 4 Hepatoblastoma
        Recurrent Hepatoblastoma
        Refractory Hepatoblastoma
        Resectable Hepatoblastoma
        Small Cell Undifferentiated Hepatoblastoma
        Teratoid Hepatoblastoma
        Unresectable Hepatoblastoma
        Hepatocellular Malignant Neoplasm, Not Otherwise Specified
        Pediatric hepatocellular carcinoma
        Recurrent Childhood Hepatocellular Carcinoma
        Stage I Childhood Hepatocellular Carcinoma AJCC v6 and v7
        Stage II Childhood Hepatocellular Carcinoma AJCC v6 and v7
        Stage III Childhood Hepatocellular Carcinoma AJCC v7
        Stage IV Childhood Hepatocellular Carcinoma AJCC v7
        Recurrent Childhood Malignant Liver Neoplasm

Professional guidelines

PubMed

Treatment of hepatitis B virus infection in children and adolescents.

Stinco M, Rubino C, Trapani S, Indolfi G
World J Gastroenterol 2021 Sep 28;27(36):6053-6063. doi: 10.3748/wjg.v27.i36.6053. PMID: 34629819 Free PMC Article

SIDE EFFECTS OF PTU AND MMI IN THE TREATMENT OF HYPERTHYROIDISM: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Yu W, Wu N, Li L, Wang J, OuYang H, Shen H
Endocr Pract 2020 Feb;26(2):207-217. Epub 2019 Oct 25 doi: 10.4158/EP-2019-0221. PMID: 31652102

2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT).

Towbin AJ, Meyers RL, Woodley H, Miyazaki O, Weldon CB, Morland B, Hiyama E, Czauderna P, Roebuck DJ, Tiao GM
Pediatr Radiol 2018 Apr;48(4):536-554. Epub 2018 Feb 9 doi: 10.1007/s00247-018-4078-z. PMID: 29427028

See all (85)

Recent clinical studies

Etiology

Single-cell transcriptomics uncovers cellular architecture and developmental trajectories in hepatoblastoma.

Huang H, Wu L, Lu L, Zhang Z, Qiu B, Mo J, Luo Y, Xi Z, Feng M, Wan P, Zhu J, Yu D, Wu W, Tan K, Liu J, Sheng Q, Xu T, Huang J, Lv Z, Tang Y, Xia Q
Hepatology 2023 Jun 1;77(6):1911-1928. Epub 2023 Mar 29 doi: 10.1002/hep.32775. PMID: 36059151

Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.

Bendor CD, Bardugo A, Pinhas-Hamiel O, Afek A, Twig G
Cardiovasc Diabetol 2020 Jun 13;19(1):79. doi: 10.1186/s12933-020-01052-1. PMID: 32534575 Free PMC Article

Hepatoblastoma and Pediatric Hepatocellular Carcinoma: An Update.

Ranganathan S, Lopez-Terrada D, Alaggio R
Pediatr Dev Pathol 2020 Mar-Apr;23(2):79-95. Epub 2019 Sep 25 doi: 10.1177/1093526619875228. PMID: 31554479

2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT).

Coffee and cancer risk: a summary overview.

Alicandro G, Tavani A, La Vecchia C
Eur J Cancer Prev 2017 Sep;26(5):424-432. doi: 10.1097/CEJ.0000000000000341. PMID: 28288025

See all (534)

Diagnosis

Abdominal Tumors: Wilms, Neuroblastoma, Rhabdomyosarcoma, and Hepatoblastoma.

Castle JT, Levy BE, Rodeberg DA
Surg Clin North Am 2022 Oct;102(5):715-737. Epub 2022 Sep 7 doi: 10.1016/j.suc.2022.07.006. PMID: 36209742

Treatment of hepatitis B virus infection in children and adolescents.

Stinco M, Rubino C, Trapani S, Indolfi G
World J Gastroenterol 2021 Sep 28;27(36):6053-6063. doi: 10.3748/wjg.v27.i36.6053. PMID: 34629819 Free PMC Article

Hepatocellular carcinoma: old friends and new tricks.

Kim E, Viatour P
Exp Mol Med 2020 Dec;52(12):1898-1907. Epub 2020 Dec 2 doi: 10.1038/s12276-020-00527-1. PMID: 33268834 Free PMC Article

Hepatoblastoma and Pediatric Hepatocellular Carcinoma: An Update.

Ranganathan S, Lopez-Terrada D, Alaggio R
Pediatr Dev Pathol 2020 Mar-Apr;23(2):79-95. Epub 2019 Sep 25 doi: 10.1177/1093526619875228. PMID: 31554479

Hepatitis B virus infection in children and adolescents.

Indolfi G, Easterbrook P, Dusheiko G, Siberry G, Chang MH, Thorne C, Bulterys M, Chan PL, El-Sayed MH, Giaquinto C, Jonas MM, Meyers T, Walsh N, Wirth S, Penazzato M
Lancet Gastroenterol Hepatol 2019 Jun;4(6):466-476. Epub 2019 Apr 11 doi: 10.1016/S2468-1253(19)30042-1. PMID: 30982722

See all (584)

Therapy

Single-cell transcriptomics uncovers cellular architecture and developmental trajectories in hepatoblastoma.

Hepatitis B virus infection in children and adolescents.

2017 PRETEXT: radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT).

Coffee and cancer risk: a summary overview.

Alicandro G, Tavani A, La Vecchia C
Eur J Cancer Prev 2017 Sep;26(5):424-432. doi: 10.1097/CEJ.0000000000000341. PMID: 28288025

Hepatoblastoma.

Sharma D, Subbarao G, Saxena R
Semin Diagn Pathol 2017 Mar;34(2):192-200. Epub 2016 Dec 23 doi: 10.1053/j.semdp.2016.12.015. PMID: 28126357

See all (314)

Prognosis

Hepatocellular carcinoma: old friends and new tricks.

Kim E, Viatour P
Exp Mol Med 2020 Dec;52(12):1898-1907. Epub 2020 Dec 2 doi: 10.1038/s12276-020-00527-1. PMID: 33268834 Free PMC Article

Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.

Bendor CD, Bardugo A, Pinhas-Hamiel O, Afek A, Twig G
Cardiovasc Diabetol 2020 Jun 13;19(1):79. doi: 10.1186/s12933-020-01052-1. PMID: 32534575 Free PMC Article

Hepatoblastoma and Pediatric Hepatocellular Carcinoma: An Update.

Ranganathan S, Lopez-Terrada D, Alaggio R
Pediatr Dev Pathol 2020 Mar-Apr;23(2):79-95. Epub 2019 Sep 25 doi: 10.1177/1093526619875228. PMID: 31554479

Hepatoblastoma.

Sharma D, Subbarao G, Saxena R
Semin Diagn Pathol 2017 Mar;34(2):192-200. Epub 2016 Dec 23 doi: 10.1053/j.semdp.2016.12.015. PMID: 28126357

Kelsey MM, Zaepfel A, Bjornstad P, Nadeau KJ
Gerontology 2014;60(3):222-8. Epub 2014 Jan 9 doi: 10.1159/000356023. PMID: 24434909

See all (469)

Clinical prediction guides

Dyschromatosis universalis hereditaria.

Murthy AB, Palaniappan V, Karthikeyan K, Anbarasan V
Int J Dermatol 2023 Oct;62(10):1218-1227. Epub 2023 Aug 27 doi: 10.1111/ijd.16817. PMID: 37634201

Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.

Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, Geller J, Ranganathan S, Rangaswami AA, Woodfield SE, Goss JA, Vasudevan SA, Heczey A, Roy A, Fisher KE, Alaggio R, Patel KR, Finegold MJ, López-Terrada DH
J Hepatol 2022 Oct;77(4):1026-1037. Epub 2022 May 14 doi: 10.1016/j.jhep.2022.04.035. PMID: 35577029 Free PMC Article

Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: Implications for Liver Transplantation.

Younossi ZM, Marchesini G, Pinto-Cortez H, Petta S
Transplantation 2019 Jan;103(1):22-27. doi: 10.1097/TP.0000000000002484. PMID: 30335697

Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration.

Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, Schmid I, Watanabe K, Yoshimura K, Feng Y, Rinaldi E, Saraceno D, Derosa M, Czauderna P
Lancet Oncol 2017 Jan;18(1):122-131. Epub 2016 Nov 22 doi: 10.1016/S1470-2045(16)30598-8. PMID: 27884679 Free PMC Article

Kelsey MM, Zaepfel A, Bjornstad P, Nadeau KJ
Gerontology 2014;60(3):222-8. Epub 2014 Jan 9 doi: 10.1159/000356023. PMID: 24434909

See all (238)

Recent systematic reviews

Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.

Bendor CD, Bardugo A, Pinhas-Hamiel O, Afek A, Twig G
Cardiovasc Diabetol 2020 Jun 13;19(1):79. doi: 10.1186/s12933-020-01052-1. PMID: 32534575 Free PMC Article

Global trends in incidence rates of childhood liver cancers: A systematic review and meta-analysis.

Dasgupta P, Henshaw C, Youlden DR, Aitken JF, Sullivan A, Irving H, Baade PD
Paediatr Perinat Epidemiol 2020 Sep;34(5):609-617. Epub 2020 Apr 26 doi: 10.1111/ppe.12671. PMID: 32337759

SIDE EFFECTS OF PTU AND MMI IN THE TREATMENT OF HYPERTHYROIDISM: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Yu W, Wu N, Li L, Wang J, OuYang H, Shen H
Endocr Pract 2020 Feb;26(2):207-217. Epub 2019 Oct 25 doi: 10.4158/EP-2019-0221. PMID: 31652102

Hepatic late adverse effects after antineoplastic treatment for childhood cancer.

Mulder RL, van Dalen EC, Van den Hof M, Bresters D, Koot BG, Castellino SM, Loke Y, Leclercq E, Post PN, Caron HN, Postma A, Kremer LC
Cochrane Database Syst Rev 2011 Jul 6;2011(7):CD008205. doi: 10.1002/14651858.CD008205.pub2. PMID: 21735424 Free PMC Article

Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.

van Dalen EC, Raphaël MF, Caron HN, Kremer LC
Cochrane Database Syst Rev 2011 Jan 19;(1):CD006647. doi: 10.1002/14651858.CD006647.pub3. PMID: 21249679

See all (13)

MedGen

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Childhood Malignant Liver Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity