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Hidradenitis

MedGen UID:
43115
•Concept ID:
C0085160
•
Disease or Syndrome
Synonyms: Hidradenitides; Hidrosadenitides; Hidrosadenitis; Hydradenitides; Hydradenitis
SNOMED CT: Hidradenitis (69741000)
 
Monarch Initiative: MONDO:0002260

Definition

Inflammation of the apocrine sweat glands, characterized by redness, itching, pain or swelling of the sweat glands, usually in the axillae or groin. [from NCI]

Professional guidelines

PubMed

Comorbidity screening in hidradenitis suppurativa: Evidence-based recommendations from the US and Canadian Hidradenitis Suppurativa Foundations.
Garg A, Malviya N, Strunk A, Wright S, Alavi A, Alhusayen R, Alikhan A, Daveluy SD, Delorme I, Goldfarb N, Gulliver W, Hamzavi I, Jaleel T, Kimball AB, Kirby JS, Kirchhof MG, Lester J, Lev-Tov H, Lowes MA, Micheletti R, Orenstein LA, Piguet V, Sayed C, Tan J, Naik HB
J Am Acad Dermatol 2022 May;86(5):1092-1101. Epub 2021 Jan 23 doi: 10.1016/j.jaad.2021.01.059. PMID: 33493574Free PMC Article
North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part I: Diagnosis, evaluation, and the use of complementary and procedural management.
Alikhan A, Sayed C, Alavi A, Alhusayen R, Brassard A, Burkhart C, Crowell K, Eisen DB, Gottlieb AB, Hamzavi I, Hazen PG, Jaleel T, Kimball AB, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y
J Am Acad Dermatol 2019 Jul;81(1):76-90. Epub 2019 Mar 11 doi: 10.1016/j.jaad.2019.02.067. PMID: 30872156Free PMC Article
Hidradenitis Suppurativa: Advances in Diagnosis and Treatment.
Saunte DML, Jemec GBE
JAMA 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691. PMID: 29183082

Recent clinical studies

Etiology

Hidradenitis suppurativa.
Sabat R, Jemec GBE, Matusiak Ł, Kimball AB, Prens E, Wolk K
Nat Rev Dis Primers 2020 Mar 12;6(1):18. doi: 10.1038/s41572-020-0149-1. PMID: 32165620
Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis.
Goldburg SR, Strober BE, Payette MJ
J Am Acad Dermatol 2020 May;82(5):1045-1058. Epub 2019 Oct 9 doi: 10.1016/j.jaad.2019.08.090. PMID: 31604104
Hidradenitis suppurativa: Current and emerging treatments.
Goldburg SR, Strober BE, Payette MJ
J Am Acad Dermatol 2020 May;82(5):1061-1082. Epub 2019 Oct 9 doi: 10.1016/j.jaad.2019.08.089. PMID: 31604100
North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part I: Diagnosis, evaluation, and the use of complementary and procedural management.
Alikhan A, Sayed C, Alavi A, Alhusayen R, Brassard A, Burkhart C, Crowell K, Eisen DB, Gottlieb AB, Hamzavi I, Hazen PG, Jaleel T, Kimball AB, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y
J Am Acad Dermatol 2019 Jul;81(1):76-90. Epub 2019 Mar 11 doi: 10.1016/j.jaad.2019.02.067. PMID: 30872156Free PMC Article
North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part II: Topical, intralesional, and systemic medical management.
Alikhan A, Sayed C, Alavi A, Alhusayen R, Brassard A, Burkhart C, Crowell K, Eisen DB, Gottlieb AB, Hamzavi I, Hazen PG, Jaleel T, Kimball AB, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y
J Am Acad Dermatol 2019 Jul;81(1):91-101. Epub 2019 Mar 11 doi: 10.1016/j.jaad.2019.02.068. PMID: 30872149Free PMC Article

Diagnosis

Hidradenitis Suppurativa: Where We Are and Where We Are Going.
Scala E, Cacciapuoti S, Garzorz-Stark N, Megna M, Marasca C, Seiringer P, Volz T, Eyerich K, Fabbrocini G
Cells 2021 Aug 15;10(8) doi: 10.3390/cells10082094. PMID: 34440863Free PMC Article
Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis.
Goldburg SR, Strober BE, Payette MJ
J Am Acad Dermatol 2020 May;82(5):1045-1058. Epub 2019 Oct 9 doi: 10.1016/j.jaad.2019.08.090. PMID: 31604104
Hidradenitis suppurativa: Current and emerging treatments.
Goldburg SR, Strober BE, Payette MJ
J Am Acad Dermatol 2020 May;82(5):1061-1082. Epub 2019 Oct 9 doi: 10.1016/j.jaad.2019.08.089. PMID: 31604100
Hidradenitis Suppurativa: Advances in Diagnosis and Treatment.
Saunte DML, Jemec GBE
JAMA 2017 Nov 28;318(20):2019-2032. doi: 10.1001/jama.2017.16691. PMID: 29183082
What is hidradenitis suppurativa?
Lee EY, Alhusayen R, Lansang P, Shear N, Yeung J
Can Fam Physician 2017 Feb;63(2):114-120. PMID: 28209676Free PMC Article

Therapy

Secukinumab in moderate-to-severe hidradenitis suppurativa (SUNSHINE and SUNRISE): week 16 and week 52 results of two identical, multicentre, randomised, placebo-controlled, double-blind phase 3 trials.
Kimball AB, Jemec GBE, Alavi A, Reguiai Z, Gottlieb AB, Bechara FG, Paul C, Giamarellos Bourboulis EJ, Villani AP, Schwinn A, Ruëff F, Pillay Ramaya L, Reich A, Lobo I, Sinclair R, Passeron T, Martorell A, Mendes-Bastos P, Kokolakis G, Becherel PA, Wozniak MB, Martinez AL, Wei X, Uhlmann L, Passera A, Keefe D, Martin R, Field C, Chen L, Vandemeulebroecke M, Ravichandran S, Muscianisi E
Lancet 2023 Mar 4;401(10378):747-761. Epub 2023 Feb 3 doi: 10.1016/S0140-6736(23)00022-3. PMID: 36746171
Zinc in dermatology.
Searle T, Ali FR, Al-Niaimi F
J Dermatolog Treat 2022 Aug;33(5):2455-2458. Epub 2022 Apr 18 doi: 10.1080/09546634.2022.2062282. PMID: 35437093
Hidradenitis Suppurativa: Where We Are and Where We Are Going.
Scala E, Cacciapuoti S, Garzorz-Stark N, Megna M, Marasca C, Seiringer P, Volz T, Eyerich K, Fabbrocini G
Cells 2021 Aug 15;10(8) doi: 10.3390/cells10082094. PMID: 34440863Free PMC Article
Hidradenitis suppurativa: Current and emerging treatments.
Goldburg SR, Strober BE, Payette MJ
J Am Acad Dermatol 2020 May;82(5):1061-1082. Epub 2019 Oct 9 doi: 10.1016/j.jaad.2019.08.089. PMID: 31604100
North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part I: Diagnosis, evaluation, and the use of complementary and procedural management.
Alikhan A, Sayed C, Alavi A, Alhusayen R, Brassard A, Burkhart C, Crowell K, Eisen DB, Gottlieb AB, Hamzavi I, Hazen PG, Jaleel T, Kimball AB, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y
J Am Acad Dermatol 2019 Jul;81(1):76-90. Epub 2019 Mar 11 doi: 10.1016/j.jaad.2019.02.067. PMID: 30872156Free PMC Article

Prognosis

Practical Guidelines for Managing Patients With Hidradenitis Suppurativa: An Update.
Johnston LA, Alhusayen R, Bourcier M, Delorme I, George R, O'Brien E, Wong SM, Poelman SM
J Cutan Med Surg 2022 Sep-Oct;26(2_suppl):2S-24S. Epub 2022 Aug 24 doi: 10.1177/12034754221116115. PMID: 36000460
The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review.
Diotallevi F, Campanati A, Martina E, Radi G, Paolinelli M, Marani A, Molinelli E, Candelora M, Taus M, Galeazzi T, Nicolai A, Offidani A
Nutrients 2022 Jan 29;14(3) doi: 10.3390/nu14030591. PMID: 35276950Free PMC Article
Prevalence of Hidradenitis Suppurativa: A Systematic Review and Meta-regression Analysis.
Jfri A, Nassim D, O'Brien E, Gulliver W, Nikolakis G, Zouboulis CC
JAMA Dermatol 2021 Aug 1;157(8):924-931. doi: 10.1001/jamadermatol.2021.1677. PMID: 34037678Free PMC Article
Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis.
Goldburg SR, Strober BE, Payette MJ
J Am Acad Dermatol 2020 May;82(5):1045-1058. Epub 2019 Oct 9 doi: 10.1016/j.jaad.2019.08.090. PMID: 31604104
North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part II: Topical, intralesional, and systemic medical management.
Alikhan A, Sayed C, Alavi A, Alhusayen R, Brassard A, Burkhart C, Crowell K, Eisen DB, Gottlieb AB, Hamzavi I, Hazen PG, Jaleel T, Kimball AB, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y
J Am Acad Dermatol 2019 Jul;81(1):91-101. Epub 2019 Mar 11 doi: 10.1016/j.jaad.2019.02.068. PMID: 30872149Free PMC Article

Clinical prediction guides

Off-label dermatologic uses of IL-17 inhibitors.
Wu KK, Dao H Jr
J Dermatolog Treat 2022 Feb;33(1):41-47. Epub 2020 Mar 9 doi: 10.1080/09546634.2020.1737638. PMID: 32116066
Efficacy and Safety of Bimekizumab in Moderate to Severe Hidradenitis Suppurativa: A Phase 2, Double-blind, Placebo-Controlled Randomized Clinical Trial.
Glatt S, Jemec GBE, Forman S, Sayed C, Schmieder G, Weisman J, Rolleri R, Seegobin S, Baeten D, Ionescu L, Zouboulis CC, Shaw S
JAMA Dermatol 2021 Nov 1;157(11):1279-1288. doi: 10.1001/jamadermatol.2021.2905. PMID: 34406364Free PMC Article
Hidradenitis suppurativa: an update on epidemiology, phenotypes, diagnosis, pathogenesis, comorbidities and quality of life.
Nguyen TV, Damiani G, Orenstein LAV, Hamzavi I, Jemec GB
J Eur Acad Dermatol Venereol 2021 Jan;35(1):50-61. Epub 2020 Jul 16 doi: 10.1111/jdv.16677. PMID: 32460374
Hidradenitis Suppurativa: A Systematic Review and Meta-analysis of Therapeutic Interventions.
Tchero H, Herlin C, Bekara F, Fluieraru S, Teot L
Indian J Dermatol Venereol Leprol 2019 May-Jun;85(3):248-257. doi: 10.4103/ijdvl.IJDVL_69_18. PMID: 30924446
Two Phase 3 Trials of Adalimumab for Hidradenitis Suppurativa.
Kimball AB, Okun MM, Williams DA, Gottlieb AB, Papp KA, Zouboulis CC, Armstrong AW, Kerdel F, Gold MH, Forman SB, Korman NJ, Giamarellos-Bourboulis EJ, Crowley JJ, Lynde C, Reguiai Z, Prens EP, Alwawi E, Mostafa NM, Pinsky B, Sundaram M, Gu Y, Carlson DM, Jemec GB
N Engl J Med 2016 Aug 4;375(5):422-34. doi: 10.1056/NEJMoa1504370. PMID: 27518661

Recent systematic reviews

Infliximab in hidradenitis suppurativa: A systematic review and meta-analysis.
Shih T, Lee K, Grogan T, De DR, Shi VY, Hsiao JL
Dermatol Ther 2022 Sep;35(9):e15691. Epub 2022 Jul 18 doi: 10.1111/dth.15691. PMID: 35790062Free PMC Article
Prevalence of Hidradenitis Suppurativa: A Systematic Review and Meta-regression Analysis.
Jfri A, Nassim D, O'Brien E, Gulliver W, Nikolakis G, Zouboulis CC
JAMA Dermatol 2021 Aug 1;157(8):924-931. doi: 10.1001/jamadermatol.2021.1677. PMID: 34037678Free PMC Article
Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis.
Yee BE, Richards P, Sui JY, Marsch AF
Dermatol Ther 2020 Nov;33(6):e14252. Epub 2020 Sep 15 doi: 10.1111/dth.14252. PMID: 32860489
Hidradenitis Suppurativa: A Systematic Review and Meta-analysis of Therapeutic Interventions.
Tchero H, Herlin C, Bekara F, Fluieraru S, Teot L
Indian J Dermatol Venereol Leprol 2019 May-Jun;85(3):248-257. doi: 10.4103/ijdvl.IJDVL_69_18. PMID: 30924446
Hidradenitis suppurativa/acne inversa: a practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group.
Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horváth B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE
J Eur Acad Dermatol Venereol 2019 Jan;33(1):19-31. Epub 2018 Oct 23 doi: 10.1111/jdv.15233. PMID: 30176066Free PMC Article

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