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Zenker diverticulum

MedGen UID:
43132
•Concept ID:
C0085232
•
Disease or Syndrome
Synonyms: Diverticula, Esophago-Pharyngeal; Diverticula, Pharyngeal; Diverticula, Pharyngo-Esophageal; Diverticula, Pharyngoesophageal; Diverticula, Pharyngoesophageal Pulsion; Diverticula, Zenker's; Diverticulum, Esophago-Pharyngeal; Diverticulum, Esophagopharyngeal; Diverticulum, Pharyngeal; Diverticulum, Pharyngo-Esophageal; Diverticulum, Pharyngoesophageal; Diverticulum, Pharyngoesophageal Pulsion; Diverticulum, Zenker; Diverticulum, Zenker's; Esophago Pharyngeal Diverticula; Esophago Pharyngeal Diverticulum; Esophago-Pharyngeal Diverticula; Esophago-Pharyngeal Diverticulum; Esophagopharyngeal Diverticulum; Esophagopharyngeal Diverticulums; Pharyngeal Diverticula; Pharyngeal Diverticulum; Pharyngo Esophageal Diverticula; Pharyngo Esophageal Diverticulum; Pharyngo-Esophageal Diverticula; Pharyngo-Esophageal Diverticulum; Pharyngoesophageal Diverticula; Pharyngoesophageal Diverticulum; Pharyngoesophageal Pulsion Diverticula; Pharyngoesophageal Pulsion Diverticulum; Pulsion Diverticula, Pharyngoesophageal; Pulsion Diverticulum, Pharyngoesophageal; Zenker Diverticula; Zenker Diverticulum; Zenker's Diverticula; Zenker's Diverticulum; Zenkers Diverticula; Zenkers Diverticulum
SNOMED CT: Zenker's diverticulum (399291005); Zenker's hypopharyngeal diverticulum (399291005); Zenker diverticulum (399291005); Hypopharyngeal diverticulum (399291005); Acquired pharyngoesophageal diverticulum (399291005); Pharyngoesophageal diverticulum (399291005); Pharyngo-oesophageal diverticulum (399291005)

Definition

A diverticulum of the posterior pharyngeal wall opening, which is located just posterior the cricoid cartilage, between the inferior pharyngeal constrictor and the cricopharyngeus muscles. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVZenker diverticulum

Professional guidelines

PubMed

Epidemiology and Management of Zenker Diverticulum in a Low-Threshold Single-payer Health Care System.
Uoti S, Andersson SE, Robinson E, Räsänen J, Kytö V, Ilonen I
JAMA Otolaryngol Head Neck Surg 2022 Mar 1;148(3):235-242. doi: 10.1001/jamaoto.2021.3671. PMID: 34913965Free PMC Article
Zenker Diverticulum Treatment: Endoscopic or Surgical?
Ciuc D, Birlă R, Panaitescu E, Tanţău M, Constantinoiu S
Chirurgia (Bucur) 2018 Mar-Apr;113(2):234-243. doi: 10.21614/chirurgia.113.2.234. PMID: 29733017
Evaluation and management of diseases of the esophagus.
Meyer GW, Castell DO
Am J Otolaryngol 1981 Nov;2(4):336-44. doi: 10.1016/s0196-0709(81)80043-9. PMID: 7034570

Recent clinical studies

Etiology

Modern approaches to treating Zenker's diverticulum.
Fair L, Ward MA
Curr Opin Gastroenterol 2023 Jul 1;39(4):333-339. Epub 2023 Apr 25 doi: 10.1097/MOG.0000000000000941. PMID: 37278290
Zenker's Diverticulum: Readability and Quality of Online Written Education Materials.
Shneyderman M, Davis R, Snow G, Dhar S, Akst LM
Dysphagia 2022 Dec;37(6):1461-1467. Epub 2022 Jan 29 doi: 10.1007/s00455-022-10406-8. PMID: 35092487
Epidemiology and Management of Zenker Diverticulum in a Low-Threshold Single-payer Health Care System.
Uoti S, Andersson SE, Robinson E, Räsänen J, Kytö V, Ilonen I
JAMA Otolaryngol Head Neck Surg 2022 Mar 1;148(3):235-242. doi: 10.1001/jamaoto.2021.3671. PMID: 34913965Free PMC Article
New and emerging techniques for endoscopic treatment of Zenker's diverticulum: State-of-the-art review.
Ishaq S, Sultan H, Siau K, Kuwai T, Mulder CJ, Neumann H
Dig Endosc 2018 Jul;30(4):449-460. Epub 2018 Mar 7 doi: 10.1111/den.13035. PMID: 29423955
Efficacy and Safety of Flexible Endoscopic Management of Zenker's Diverticulum.
Jain D, Sharma A, Shah M, Patel U, Thosani N, Singhal S
J Clin Gastroenterol 2018 May/Jun;52(5):369-385. doi: 10.1097/MCG.0000000000000977. PMID: 29283905

Diagnosis

POEM, GPOEM, and ZPOEM.
Parsa N, Friedel D, Stavropoulos SN
Dig Dis Sci 2022 May;67(5):1500-1520. Epub 2022 Apr 2 doi: 10.1007/s10620-022-07398-8. PMID: 35366120
Upper Esophageal Dysphagia.
Chheda NN
Surg Clin North Am 2022 Apr;102(2):199-207. Epub 2022 Mar 4 doi: 10.1016/j.suc.2021.12.002. PMID: 35344692
Zenker's Diverticulum.
Law R, Katzka DA, Baron TH
Clin Gastroenterol Hepatol 2014 Nov;12(11):1773-82; quiz e111-2. Epub 2013 Sep 18 doi: 10.1016/j.cgh.2013.09.016. PMID: 24055983
Zenker diverticulum.
Prisman E, Genden EM
Otolaryngol Clin North Am 2013 Dec;46(6):1101-11. Epub 2013 Oct 10 doi: 10.1016/j.otc.2013.08.011. PMID: 24262962
Zenker's diverticulum: reappraisal.
Watemberg S, Landau O, Avrahami R
Am J Gastroenterol 1996 Aug;91(8):1494-8. PMID: 8759648

Therapy

Zenker's peroral endoscopic myotomy for management of large Zenker's diverticulum.
Zhang LY, Hernández Mondragón O, Pioche M, Steinway SN, Nieto J, Ujiki MB, VanDruff VN, Kim RE, Canakis A, Tantau M, Tantau A, Pop A, Jacques J, Lajin M, Desai P, Shrigiriwar A, Bejjani M, Kumta NA, Khashab MA
Endoscopy 2023 Jun;55(6):501-507. Epub 2023 Feb 24 doi: 10.1055/a-2025-0715. PMID: 36827992
Endoscopic stapler versus laser diverticulotomy for Zenker's diverticulum: a systematic review and meta-analysis.
Edwards D, Prades E, Thorne C, Harris A
J Laryngol Otol 2023 Jul;137(7):718-724. Epub 2022 Nov 16 doi: 10.1017/S0022215122002377. PMID: 36382425
Transcervical pharyngeal pouch stapling.
Brimioulle M, Corbridge R, Elsayed M
Eur Arch Otorhinolaryngol 2023 Jan;280(1):487-490. Epub 2022 Aug 30 doi: 10.1007/s00405-022-07603-4. PMID: 36040518
Efficacy and Safety of Flexible Endoscopic Management of Zenker's Diverticulum.
Jain D, Sharma A, Shah M, Patel U, Thosani N, Singhal S
J Clin Gastroenterol 2018 May/Jun;52(5):369-385. doi: 10.1097/MCG.0000000000000977. PMID: 29283905
Surgical treatment of Zenker's diverticulum.
Yuan Y, Zhao YF, Hu Y, Chen LQ
Dig Surg 2013;30(3):207-18. Epub 2013 Jul 6 doi: 10.1159/000351433. PMID: 23838812

Prognosis

Comparison of Zenker's per-oral endoscopic myotomy (Z-POEM) with standard flexible endoscopic septotomy for Zenker's diverticulum: a prospective study with 2-year follow-up.
Swei E, Pokala SK, Menard-Katcher P, Wagh MS
Surg Endosc 2023 Sep;37(9):6818-6823. Epub 2023 Jun 5 doi: 10.1007/s00464-023-10136-4. PMID: 37277515Free PMC Article
Natural History of Cricopharyngeus Muscle Dysfunction Symptomatology.
Randall DR, Chan R, Gomes D, Walker K
Dysphagia 2022 Aug;37(4):937-945. Epub 2021 Sep 8 doi: 10.1007/s00455-021-10355-8. PMID: 34495387
New and emerging techniques for endoscopic treatment of Zenker's diverticulum: State-of-the-art review.
Ishaq S, Sultan H, Siau K, Kuwai T, Mulder CJ, Neumann H
Dig Endosc 2018 Jul;30(4):449-460. Epub 2018 Mar 7 doi: 10.1111/den.13035. PMID: 29423955
Respiratory Symptoms and Complications of Zenker Diverticulum: Effect of Trans-Oral Septum Stapling.
Siboni S, Asti E, Sozzi M, Bonitta G, Melloni M, Bonavina L
J Gastrointest Surg 2017 Sep;21(9):1391-1395. Epub 2017 May 3 doi: 10.1007/s11605-017-3435-9. PMID: 28470561
Oesophageal diverticula.
Costantini M, Zaninotto G, Rizzetto C, Narne S, Ancona E
Best Pract Res Clin Gastroenterol 2004 Feb;18(1):3-17. doi: 10.1016/S1521-6918(03)00105-7. PMID: 15123081

Clinical prediction guides

Zenker's peroral endoscopic myotomy for management of large Zenker's diverticulum.
Zhang LY, Hernández Mondragón O, Pioche M, Steinway SN, Nieto J, Ujiki MB, VanDruff VN, Kim RE, Canakis A, Tantau M, Tantau A, Pop A, Jacques J, Lajin M, Desai P, Shrigiriwar A, Bejjani M, Kumta NA, Khashab MA
Endoscopy 2023 Jun;55(6):501-507. Epub 2023 Feb 24 doi: 10.1055/a-2025-0715. PMID: 36827992
Upper Esophageal Dysphagia.
Chheda NN
Surg Clin North Am 2022 Apr;102(2):199-207. Epub 2022 Mar 4 doi: 10.1016/j.suc.2021.12.002. PMID: 35344692
Zenker's Diverticulum: Readability and Quality of Online Written Education Materials.
Shneyderman M, Davis R, Snow G, Dhar S, Akst LM
Dysphagia 2022 Dec;37(6):1461-1467. Epub 2022 Jan 29 doi: 10.1007/s00455-022-10406-8. PMID: 35092487
Endoscopic septotomy of Zenker's diverticulum with Stag-Beetle Knife™: A descriptive observational study and literature review.
Toro-Ortiz JP, Fernández-García F, Pinazo-Bandera J, Alcaín Martínez GJ, Lavín Castejón I
Gastroenterol Hepatol 2022 Jun-Jul;45(6):432-439. Epub 2021 Jun 12 doi: 10.1016/j.gastrohep.2021.06.001. PMID: 34129902
Efficacy and Safety of Flexible Endoscopic Management of Zenker's Diverticulum.
Jain D, Sharma A, Shah M, Patel U, Thosani N, Singhal S
J Clin Gastroenterol 2018 May/Jun;52(5):369-385. doi: 10.1097/MCG.0000000000000977. PMID: 29283905

Recent systematic reviews

Endoscopic stapler versus laser diverticulotomy for Zenker's diverticulum: a systematic review and meta-analysis.
Edwards D, Prades E, Thorne C, Harris A
J Laryngol Otol 2023 Jul;137(7):718-724. Epub 2022 Nov 16 doi: 10.1017/S0022215122002377. PMID: 36382425
The role of peroral endoscopic myotomy for Zenker's diverticulum: a systematic review and meta-analysis.
Zhang H, Huang S, Xia H, Shi L, Zeng X, Jiang J, Ren W, Peng Y, Lü M, Tang X
Surg Endosc 2022 May;36(5):2749-2759. Epub 2022 Jan 12 doi: 10.1007/s00464-022-09021-3. PMID: 35020054
Endoscopic needle-knife treatment for symptomatic esophageal Zenker's diverticulum: A meta-analysis and systematic review.
Li LY, Yang YT, Qu CM, Liang SW, Zhong CQ, Wang XY, Chen Y, Spandorfer RM, Christofaro S, Cai Q
J Dig Dis 2018 Apr;19(4):204-214. Epub 2018 Apr 19 doi: 10.1111/1751-2980.12588. PMID: 29675866
Flexible endoscopic treatment for Zenker's diverticulum: a systematic review and meta-analysis.
Ishaq S, Hassan C, Antonello A, Tanner K, Bellisario C, Battaglia G, Anderloni A, Correale L, Sharma P, Baron TH, Repici A
Gastrointest Endosc 2016 Jun;83(6):1076-1089.e5. Epub 2016 Jan 21 doi: 10.1016/j.gie.2016.01.039. PMID: 26802196
Surgical treatment of Zenker's diverticulum.
Yuan Y, Zhao YF, Hu Y, Chen LQ
Dig Surg 2013;30(3):207-18. Epub 2013 Jul 6 doi: 10.1159/000351433. PMID: 23838812

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