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Yin deficiency

MedGen UID:
43138
•Concept ID:
C0085257
•
Pathologic Function
Synonyms: Deficiency, Yin; Hsu, Yin; Xu, Yin; Yin Deficiencies; Yin Deficiency; Yin Hsu; Yin Xu; Yinxu
SNOMED CT: Yin deficiency (370538004)

Definition

In the YIN-YANG system of philosophy and medicine, an insufficiency of body fluid (called yinxu), manifesting often as irritability, thirst, constipation, etc. (The Pinyin Chinese-English Dictionary, 1979). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVYin deficiency

Professional guidelines

PubMed

Meta-Analysis Study on Treatment of Children's Attention Deficit Disorder with Hyperactivity.
Xue J, Hao Y, Li X, Guan R, Wang Y, Li Y, Tian H
J Healthc Eng 2021;2021:8229039. Epub 2021 Oct 22 doi: 10.1155/2021/8229039. PMID: 34721828Free PMC Article
From the perspective of Traditional Chinese Medicine: Treatment of mental disorders in COVID-19 survivors.
Ma K, Wang X, Feng S, Xia X, Zhang H, Rahaman A, Dong Z, Lu Y, Li X, Zhou X, Zhao H, Wang Y, Wang S, Baloch Z
Biomed Pharmacother 2020 Dec;132:110810. Epub 2020 Sep 30 doi: 10.1016/j.biopha.2020.110810. PMID: 33053508Free PMC Article
Exploring the mechanism of TCM formulae in the treatment of different types of coronary heart disease by network pharmacology and machining learning.
Yang J, Tian S, Zhao J, Zhang W
Pharmacol Res 2020 Sep;159:105034. Epub 2020 Jun 18 doi: 10.1016/j.phrs.2020.105034. PMID: 32565312

Recent clinical studies

Etiology

Visual analysis and evaluation of clinical research on Traditional Chinese medicine compounds in treating insomnia of Yin deficiency syndrome.
Wu Q, Chen X, Gan G, Zhang Q, Yu L, Li C, Zhang Y, Ao M
J Ethnopharmacol 2022 Nov 15;298:115669. Epub 2022 Aug 27 doi: 10.1016/j.jep.2022.115669. PMID: 36031101
Exploring the mechanism of TCM formulae in the treatment of different types of coronary heart disease by network pharmacology and machining learning.
Yang J, Tian S, Zhao J, Zhang W
Pharmacol Res 2020 Sep;159:105034. Epub 2020 Jun 18 doi: 10.1016/j.phrs.2020.105034. PMID: 32565312
Gene Expression Profiles of HIV/AIDS Patients with Qi-Yin Deficiency and Dampness-Heat Retention.
Liu S, Chen Y, Xie S, Xu Q, Chen J, Wang C, Wang Z, Ma S, Wu X, Zhang N
J Altern Complement Med 2016 Nov;22(11):865-879. Epub 2016 Oct 19 doi: 10.1089/acm.2015.0350. PMID: 27759429Free PMC Article
Development and validation of Yin-Deficiency Questionnaire.
Lee S, Park J, Lee H, Kim K
Am J Chin Med 2007;35(1):11-20. doi: 10.1142/S0192415X07004576. PMID: 17265546
The liver in traditional Chinese medicine.
Chen TS, Chen PS
J Gastroenterol Hepatol 1998 Apr;13(4):437-42. doi: 10.1111/j.1440-1746.1998.tb00662.x. PMID: 9641312

Diagnosis

Visual analysis and evaluation of clinical research on Traditional Chinese medicine compounds in treating insomnia of Yin deficiency syndrome.
Wu Q, Chen X, Gan G, Zhang Q, Yu L, Li C, Zhang Y, Ao M
J Ethnopharmacol 2022 Nov 15;298:115669. Epub 2022 Aug 27 doi: 10.1016/j.jep.2022.115669. PMID: 36031101
Analysis of Traditional Chinese Medicine Diagnosis and Treatment Strategies for COVID-19 Based on "The Diagnosis and Treatment Program for Coronavirus Disease-2019" from Chinese Authority.
Zhao ZH, Zhou Y, Li WH, Huang QS, Tang ZH, Li H
Am J Chin Med 2020;48(5):1035-1049. doi: 10.1142/S0192415X20500500. PMID: 32668970
End-to-End syndrome differentiation of Yin deficiency and Yang deficiency in traditional Chinese medicine.
Hu Q, Yu T, Li J, Yu Q, Zhu L, Gu Y
Comput Methods Programs Biomed 2019 Jun;174:9-15. Epub 2018 Oct 16 doi: 10.1016/j.cmpb.2018.10.011. PMID: 30376987
Development and validation of the Yin deficiency scale.
Park YJ, Cho SW, Lee BH, Park YB
J Altern Complement Med 2013 Jan;19(1):50-6. Epub 2012 Sep 5 doi: 10.1089/acm.2011.0677. PMID: 22950657
Development and validation of Yin-Deficiency Questionnaire.
Lee S, Park J, Lee H, Kim K
Am J Chin Med 2007;35(1):11-20. doi: 10.1142/S0192415X07004576. PMID: 17265546

Therapy

Visual analysis and evaluation of clinical research on Traditional Chinese medicine compounds in treating insomnia of Yin deficiency syndrome.
Wu Q, Chen X, Gan G, Zhang Q, Yu L, Li C, Zhang Y, Ao M
J Ethnopharmacol 2022 Nov 15;298:115669. Epub 2022 Aug 27 doi: 10.1016/j.jep.2022.115669. PMID: 36031101
Clinical research linking Traditional Chinese Medicine constitution types with diseases: a literature review of 1639 observational studies.
Liang X, Wang Q, Jiang Z, Li Z, Zhang M, Yang P, Wang X, Wang Y, Qin Y, Li T, Zhang T, Wang Y, Sun J, Li Y, Luo H, Li L
J Tradit Chin Med 2020 Aug;40(4):690-702. doi: 10.19852/j.cnki.jtcm.2020.04.019. PMID: 32744037
Exploring the mechanism of TCM formulae in the treatment of different types of coronary heart disease by network pharmacology and machining learning.
Yang J, Tian S, Zhao J, Zhang W
Pharmacol Res 2020 Sep;159:105034. Epub 2020 Jun 18 doi: 10.1016/j.phrs.2020.105034. PMID: 32565312
Characteristics of the traditional Liu-Wei-Di-Huang prescription reassessed in modern pharmacology.
Cheng XR, Qi CH, Wang TX, Zhou WX, Zhang YX
Chin J Nat Med 2019 Feb;17(2):103-121. doi: 10.1016/S1875-5364(19)30013-5. PMID: 30797417
Development and validation of Yin-Deficiency Questionnaire.
Lee S, Park J, Lee H, Kim K
Am J Chin Med 2007;35(1):11-20. doi: 10.1142/S0192415X07004576. PMID: 17265546

Prognosis

Study on the differences of gut microbiota composition between phlegm-dampness syndrome and qi-yin deficiency syndrome in patients with metabolic syndrome.
Shang H, Zhang L, Xiao T, Zhang L, Ruan J, Zhang Q, Liu K, Yu Z, Ni Y, Wang B
Front Endocrinol (Lausanne) 2022;13:1063579. Epub 2022 Nov 9 doi: 10.3389/fendo.2022.1063579. PMID: 36440222Free PMC Article
miRNA Expression Profile of Saliva in Subjects of Yang Deficiency Constitution and Yin Deficiency Constitution.
Chen Y, Wu Y, Yao H, Luo H, Lin B, Zhang X, Liang X, Sun R, Zhao S, Li Y, Zheng Y, Li L, Wang Q
Cell Physiol Biochem 2018;49(5):2088-2098. Epub 2018 Sep 24 doi: 10.1159/000493769. PMID: 30248664
Relationships between pathological patterns and vocal qualities estimated by acoustic parameters.
Park YJ, Park YB
Chin J Integr Med 2015 May;21(5):346-54. Epub 2015 May 3 doi: 10.1007/s11655-015-2171-9. PMID: 25935142
Fire-heat and Qi deficiency syndromes as predictors of short-term prognosis of acute ischemic stroke.
Cheng SC, Lin CH, Chang YJ, Lee TH, Ryu SJ, Chen CH, Chang HK, Chang CJ, Hu WL, Hung YC
J Altern Complement Med 2013 Aug;19(8):721-8. Epub 2013 Apr 19 doi: 10.1089/acm.2012.0546. PMID: 23600945Free PMC Article
The distribution of Yin-Deficient symptoms and their relationship on survival rate in cancer patients with Yin-Deficiency.
Lin SC, Chen MF, Li TC, Hsieh YH, Liu SJ
Am J Chin Med 2008;36(4):655-63. doi: 10.1142/S0192415X08006120. PMID: 18711763

Clinical prediction guides

Meta-Analysis Study on Treatment of Children's Attention Deficit Disorder with Hyperactivity.
Xue J, Hao Y, Li X, Guan R, Wang Y, Li Y, Tian H
J Healthc Eng 2021;2021:8229039. Epub 2021 Oct 22 doi: 10.1155/2021/8229039. PMID: 34721828Free PMC Article
From the perspective of Traditional Chinese Medicine: Treatment of mental disorders in COVID-19 survivors.
Ma K, Wang X, Feng S, Xia X, Zhang H, Rahaman A, Dong Z, Lu Y, Li X, Zhou X, Zhao H, Wang Y, Wang S, Baloch Z
Biomed Pharmacother 2020 Dec;132:110810. Epub 2020 Sep 30 doi: 10.1016/j.biopha.2020.110810. PMID: 33053508Free PMC Article
Clinical research linking Traditional Chinese Medicine constitution types with diseases: a literature review of 1639 observational studies.
Liang X, Wang Q, Jiang Z, Li Z, Zhang M, Yang P, Wang X, Wang Y, Qin Y, Li T, Zhang T, Wang Y, Sun J, Li Y, Luo H, Li L
J Tradit Chin Med 2020 Aug;40(4):690-702. doi: 10.19852/j.cnki.jtcm.2020.04.019. PMID: 32744037
End-to-End syndrome differentiation of Yin deficiency and Yang deficiency in traditional Chinese medicine.
Hu Q, Yu T, Li J, Yu Q, Zhu L, Gu Y
Comput Methods Programs Biomed 2019 Jun;174:9-15. Epub 2018 Oct 16 doi: 10.1016/j.cmpb.2018.10.011. PMID: 30376987
Development and validation of the Yin deficiency scale.
Park YJ, Cho SW, Lee BH, Park YB
J Altern Complement Med 2013 Jan;19(1):50-6. Epub 2012 Sep 5 doi: 10.1089/acm.2011.0677. PMID: 22950657

Recent systematic reviews

Correlation between TCM Constitutional Types and Lung Carcinoma in Various Geographical Areas: A Systematic Review and Meta-Analysis.
Yu X, Yan L, Lan Q, Wan L, Xiong J, Zhang L, Nie H, Ding Z
Contrast Media Mol Imaging 2022;2022:5660231. Epub 2022 Aug 17 doi: 10.1155/2022/5660231. PMID: 36072639Free PMC Article
Chinese Medicine Syndromes and Stages of Early Breast Cancer: Hierarchical Cluster Analysis and Implication for Clinical Practice.
Guo Q, Chen Q, Xue CC, Zhang AL, Coyle ME
J Altern Complement Med 2021 Nov;27(11):904-914. Epub 2021 Jun 1 doi: 10.1089/acm.2021.0055. PMID: 34076505
The association between blood lipid and phlegm turbidity syndrome of angina pectoris: a systematic review and meta-analysis.
Kong D, Wang Y, Liu Y, Zhang Z, Liu G, Qi W, Xiao L, Yuan D, Yang G
Complement Ther Med 2014 Aug;22(4):801-13. Epub 2014 May 27 doi: 10.1016/j.ctim.2014.05.008. PMID: 25146084
Clinical trials of traditional Chinese medicine in the treatment of diabetic nephropathy--a systematic review based on a subgroup analysis.
Liu X, Liu L, Chen P, Zhou L, Zhang Y, Wu Y, Jiang L, Cheng D, Huang W, Yi D
J Ethnopharmacol 2014 Feb 3;151(2):810-9. Epub 2013 Dec 1 doi: 10.1016/j.jep.2013.11.028. PMID: 24296085
Traditional Chinese medicine syndrome distribution in chronic hepatitis B populations: a systematic review.
Zeng XX, Bian ZX, Wu TX, Fu SF, Ziea E, Woon WT
Am J Chin Med 2011;39(6):1061-74. doi: 10.1142/S0192415X11009408. PMID: 22083981

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