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Yang deficiency

MedGen UID:
43139
•Concept ID:
C0085258
•
Pathologic Function
Synonyms: Deficiency, Yang; Hsu, Yang; Xu, Yang; Yang Deficiency; Yang Hsu; Yang Xu; Yangxu
SNOMED CT: Yang deficiency (370534002)

Definition

In the YIN-YANG system of philosophy and medicine, a lack of vital energy (called yangxu in Chinese). It manifests itself in various systemic and organic diseases. (The Pinyin Chinese-English Dictionary, 1979) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVYang deficiency

Professional guidelines

PubMed

Study on the substance basis of the efficacy of eucommiae cortex before and after salt processing for the treatment of kidney-yang deficiency syndrome based on the spectrum-effect relationship.
Wu H, Lv Y, Zhao M, Tang R, Li Y, Fang K, Wei F, Ge W, Du W, Li C, Zhang Y
J Ethnopharmacol 2024 Jan 10;318(Pt A):116926. Epub 2023 Jul 20 doi: 10.1016/j.jep.2023.116926. PMID: 37479066
Diagnostic and Categorization Criteria for Palpitations Below the Heart in Traditional Chinese Medicine: A Delphi Consensus Study.
Song C, Ye X, Fu H, Lin L, Jin Y, Liu F, Zhu W
Altern Ther Health Med 2021 Sep;27(5):68-72. PMID: 33128537
Clinical trials of traditional Chinese medicine in the treatment of diabetic nephropathy--a systematic review based on a subgroup analysis.
Liu X, Liu L, Chen P, Zhou L, Zhang Y, Wu Y, Jiang L, Cheng D, Huang W, Yi D
J Ethnopharmacol 2014 Feb 3;151(2):810-9. Epub 2013 Dec 1 doi: 10.1016/j.jep.2013.11.028. PMID: 24296085

Recent clinical studies

Etiology

Dose-effect of long-snake-like moxibustion for chronic fatigue syndrome: a randomized controlled trial.
Luo H, Gong R, Zheng R, Tan J, Chen R, Wu J, Ma T
J Transl Med 2023 Jul 3;21(1):430. doi: 10.1186/s12967-023-04250-z. PMID: 37400824Free PMC Article
The Effectiveness of a Traditional Chinese Medicine-Based Mobile Health App for Individuals With Prediabetes: Randomized Controlled Trial.
Chung HW, Tai CJ, Chang P, Su WL, Chien LY
JMIR Mhealth Uhealth 2023 Jun 20;11:e41099. doi: 10.2196/41099. PMID: 37338977Free PMC Article
The characteristics of intestinal flora of IBS-D with different syndromes.
Chao G, Zhang S
Immun Inflamm Dis 2020 Dec;8(4):615-628. Epub 2020 Sep 17 doi: 10.1002/iid3.348. PMID: 32940426Free PMC Article
A multi-center, randomized, double-blind, placebo-parallel controlled trial for the efficacy and safety of shenfuqiangxin pills in the treatment of chronic heart failure (Heart-Kidney yang deficiency syndrome).
Guo L, Yuan H, Zhang D, Zhang J, Hua Q, Ma X, Chen K
Medicine (Baltimore) 2020 May 22;99(21):e20271. doi: 10.1097/MD.0000000000020271. PMID: 32481305Free PMC Article
Chinese herbal medicines for hypothyroidism.
Ke LQ, Hu Y, Yang K, Tong N
Cochrane Database Syst Rev 2015 Feb 12;(2):CD008779. doi: 10.1002/14651858.CD008779.pub2. PMID: 25914906Free PMC Article

Diagnosis

Efficacy of thunder-fire moxibustion in treating ankylosing spondylitis of kidney deficiency and governor meridian cold and its influence on TNF-α and RANKL: study protocol for a prospective, nonblinded, single-center, randomized controlled trial.
Liu Y, Wang P, Sun YY, Qu J, Li M
Trials 2022 Apr 23;23(1):344. doi: 10.1186/s13063-022-06227-7. PMID: 35461283Free PMC Article
Study of Differential Serum Metabolites in Patients with Adenomatous Polyps of Colon and Yang-Deficiency Constitution Based on Ultra-Performance Liquid Chromatography-Mass Spectrometry.
Du WZ, Zhang AH, Ren JL, Lyu K, Tuo LY, Xu W
Chin J Integr Med 2022 May;28(5):403-409. Epub 2019 Nov 29 doi: 10.1007/s11655-019-3181-9. PMID: 31784934
End-to-End syndrome differentiation of Yin deficiency and Yang deficiency in traditional Chinese medicine.
Hu Q, Yu T, Li J, Yu Q, Zhu L, Gu Y
Comput Methods Programs Biomed 2019 Jun;174:9-15. Epub 2018 Oct 16 doi: 10.1016/j.cmpb.2018.10.011. PMID: 30376987
Integrative metabolic and microbial profiling on patients with Spleen-yang-deficiency syndrome.
Lin Z, Ye W, Zu X, Xie H, Li H, Li Y, Zhang W
Sci Rep 2018 Apr 26;8(1):6619. doi: 10.1038/s41598-018-24130-7. PMID: 29700349Free PMC Article
Chinese herbal medicines for hypothyroidism.
Ke LQ, Hu Y, Yang K, Tong N
Cochrane Database Syst Rev 2015 Feb 12;(2):CD008779. doi: 10.1002/14651858.CD008779.pub2. PMID: 25914906Free PMC Article

Therapy

Dose-effect of long-snake-like moxibustion for chronic fatigue syndrome: a randomized controlled trial.
Luo H, Gong R, Zheng R, Tan J, Chen R, Wu J, Ma T
J Transl Med 2023 Jul 3;21(1):430. doi: 10.1186/s12967-023-04250-z. PMID: 37400824Free PMC Article
The Effectiveness of a Traditional Chinese Medicine-Based Mobile Health App for Individuals With Prediabetes: Randomized Controlled Trial.
Chung HW, Tai CJ, Chang P, Su WL, Chien LY
JMIR Mhealth Uhealth 2023 Jun 20;11:e41099. doi: 10.2196/41099. PMID: 37338977Free PMC Article
Clinical research linking Traditional Chinese Medicine constitution types with diseases: a literature review of 1639 observational studies.
Liang X, Wang Q, Jiang Z, Li Z, Zhang M, Yang P, Wang X, Wang Y, Qin Y, Li T, Zhang T, Wang Y, Sun J, Li Y, Luo H, Li L
J Tradit Chin Med 2020 Aug;40(4):690-702. doi: 10.19852/j.cnki.jtcm.2020.04.019. PMID: 32744037
Chinese herbal medicines for hypothyroidism.
Ke LQ, Hu Y, Yang K, Tong N
Cochrane Database Syst Rev 2015 Feb 12;(2):CD008779. doi: 10.1002/14651858.CD008779.pub2. PMID: 25914906Free PMC Article
Yang-tonifying traditional Chinese medicinal plants and their potential phytoandrogenic activity.
Edouard MJ, Miao L, Fan GW, Ojong BB, Zhen H, Zhang J, Gao XM, Zhu Y
Chin J Nat Med 2014 May;12(5):321-34. doi: 10.1016/S1875-5364(14)60040-6. PMID: 24856755

Prognosis

Dose-effect of long-snake-like moxibustion for chronic fatigue syndrome: a randomized controlled trial.
Luo H, Gong R, Zheng R, Tan J, Chen R, Wu J, Ma T
J Transl Med 2023 Jul 3;21(1):430. doi: 10.1186/s12967-023-04250-z. PMID: 37400824Free PMC Article
Correlation between TCM Constitutional Types and Lung Carcinoma in Various Geographical Areas: A Systematic Review and Meta-Analysis.
Yu X, Yan L, Lan Q, Wan L, Xiong J, Zhang L, Nie H, Ding Z
Contrast Media Mol Imaging 2022;2022:5660231. Epub 2022 Aug 17 doi: 10.1155/2022/5660231. PMID: 36072639Free PMC Article
A multi-center, randomized, double-blind, placebo-parallel controlled trial for the efficacy and safety of shenfuqiangxin pills in the treatment of chronic heart failure (Heart-Kidney yang deficiency syndrome).
Guo L, Yuan H, Zhang D, Zhang J, Hua Q, Ma X, Chen K
Medicine (Baltimore) 2020 May 22;99(21):e20271. doi: 10.1097/MD.0000000000020271. PMID: 32481305Free PMC Article
miRNA Expression Profile of Saliva in Subjects of Yang Deficiency Constitution and Yin Deficiency Constitution.
Chen Y, Wu Y, Yao H, Luo H, Lin B, Zhang X, Liang X, Sun R, Zhao S, Li Y, Zheng Y, Li L, Wang Q
Cell Physiol Biochem 2018;49(5):2088-2098. Epub 2018 Sep 24 doi: 10.1159/000493769. PMID: 30248664
Effects of symptoms and complementary and alternative medicine use on the yang deficiency pattern among breast cancer patients receiving chemotherapy.
Huang SM, Chien LY, Tai CJ, Chen PH, Lien PJ, Tai CJ
Complement Ther Med 2015 Apr;23(2):233-41. Epub 2015 Jan 12 doi: 10.1016/j.ctim.2015.01.004. PMID: 25847561

Clinical prediction guides

Dose-effect of long-snake-like moxibustion for chronic fatigue syndrome: a randomized controlled trial.
Luo H, Gong R, Zheng R, Tan J, Chen R, Wu J, Ma T
J Transl Med 2023 Jul 3;21(1):430. doi: 10.1186/s12967-023-04250-z. PMID: 37400824Free PMC Article
The Effectiveness of a Traditional Chinese Medicine-Based Mobile Health App for Individuals With Prediabetes: Randomized Controlled Trial.
Chung HW, Tai CJ, Chang P, Su WL, Chien LY
JMIR Mhealth Uhealth 2023 Jun 20;11:e41099. doi: 10.2196/41099. PMID: 37338977Free PMC Article
Clinical research linking Traditional Chinese Medicine constitution types with diseases: a literature review of 1639 observational studies.
Liang X, Wang Q, Jiang Z, Li Z, Zhang M, Yang P, Wang X, Wang Y, Qin Y, Li T, Zhang T, Wang Y, Sun J, Li Y, Luo H, Li L
J Tradit Chin Med 2020 Aug;40(4):690-702. doi: 10.19852/j.cnki.jtcm.2020.04.019. PMID: 32744037
A multi-center, randomized, double-blind, placebo-parallel controlled trial for the efficacy and safety of shenfuqiangxin pills in the treatment of chronic heart failure (Heart-Kidney yang deficiency syndrome).
Guo L, Yuan H, Zhang D, Zhang J, Hua Q, Ma X, Chen K
Medicine (Baltimore) 2020 May 22;99(21):e20271. doi: 10.1097/MD.0000000000020271. PMID: 32481305Free PMC Article
End-to-End syndrome differentiation of Yin deficiency and Yang deficiency in traditional Chinese medicine.
Hu Q, Yu T, Li J, Yu Q, Zhu L, Gu Y
Comput Methods Programs Biomed 2019 Jun;174:9-15. Epub 2018 Oct 16 doi: 10.1016/j.cmpb.2018.10.011. PMID: 30376987

Recent systematic reviews

A systematic review of traditional uses, phytochemistry, pharmacology and toxicity of Epimedium koreanum Nakai.
Qian HQ, Wu DC, Li CY, Liu XR, Han XK, Peng Y, Zhang H, Zhao BY, Zhao Y
J Ethnopharmacol 2024 Jan 10;318(Pt B):116957. Epub 2023 Aug 6 doi: 10.1016/j.jep.2023.116957. PMID: 37544344
Correlation between TCM Constitutional Types and Lung Carcinoma in Various Geographical Areas: A Systematic Review and Meta-Analysis.
Yu X, Yan L, Lan Q, Wan L, Xiong J, Zhang L, Nie H, Ding Z
Contrast Media Mol Imaging 2022;2022:5660231. Epub 2022 Aug 17 doi: 10.1155/2022/5660231. PMID: 36072639Free PMC Article
Chinese herbal medicines for hypothyroidism.
Ke LQ, Hu Y, Yang K, Tong N
Cochrane Database Syst Rev 2015 Feb 12;(2):CD008779. doi: 10.1002/14651858.CD008779.pub2. PMID: 25914906Free PMC Article
The association between blood lipid and phlegm turbidity syndrome of angina pectoris: a systematic review and meta-analysis.
Kong D, Wang Y, Liu Y, Zhang Z, Liu G, Qi W, Xiao L, Yuan D, Yang G
Complement Ther Med 2014 Aug;22(4):801-13. Epub 2014 May 27 doi: 10.1016/j.ctim.2014.05.008. PMID: 25146084
Traditional Chinese medicine syndrome distribution in chronic hepatitis B populations: a systematic review.
Zeng XX, Bian ZX, Wu TX, Fu SF, Ziea E, Woon WT
Am J Chin Med 2011;39(6):1061-74. doi: 10.1142/S0192415X11009408. PMID: 22083981

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