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Erythema infectiosum

MedGen UID:
43142
Concept ID:
C0085273
Disease or Syndrome
Synonym: Human parvovirus B19 infection
SNOMED CT: Primate erythroparvovirus 1 infection (34730008); Parvovirus B19 infection (34730008); Slapped cheek syndrome (34730008); Erythema infectiosum (34730008); Fifth disease (34730008); Erythema contagiosum (34730008)
 
Monarch Initiative: MONDO:0006544

Definition

A self-limited viral infectious disorder caused by the human parvovirus B19. It affects predominantly children and is characterized by the development of a bright red skin eruption in the cheeks. It is followed by a maculopapular skin eruption in the extremities which eventually fades into a lacey pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythema infectiosum

Professional guidelines

PubMed

Attwood LO, Holmes NE, Hui L
Prenat Diagn 2020 Dec;40(13):1722-1731. Epub 2020 Sep 30 doi: 10.1002/pd.5819. PMID: 32860469
Aravindh R, Saikia UN, Mishra B, Kumari V, Sarkar S, Sharma M, Ratho RK, Joshi K
Arch Virol 2014 Sep;159(9):2371-6. Epub 2014 Apr 30 doi: 10.1007/s00705-014-2065-8. PMID: 24777824Free PMC Article
Crane J; Society of Obstetricians and Gynaecologists of Canada
J Obstet Gynaecol Can 2002 Sep;24(9):727-43; quiz 744-6. PMID: 12360369

Recent clinical studies

Etiology

Boissiere J, Watkins V, Kuller JA, Dotters-Katz SK
Obstet Gynecol Surv 2024 May;79(5):281-289. doi: 10.1097/OGX.0000000000001263. PMID: 38764205
Algwaiz G, Alharbi A, Alsehaim K, Alahmari A, El Fakih R, Aljurf M
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):316-322. doi: 10.56875/2589-0646.1031. PMID: 37363985
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
Sabella C, Goldfarb J
Am Fam Physician 1999 Oct 1;60(5):1455-60. PMID: 10524489
Heegaard ED, Hornsleth A
Acta Paediatr 1995 Feb;84(2):109-17. doi: 10.1111/j.1651-2227.1995.tb13591.x. PMID: 7756792

Diagnosis

Gigi CE, Anumba DOC
Eur J Obstet Gynecol Reprod Biol 2021 Sep;264:358-362. Epub 2021 Jul 28 doi: 10.1016/j.ejogrb.2021.07.046. PMID: 34391051
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
Abbasi N, Johnson JA, Ryan G
Ultrasound Obstet Gynecol 2017 Aug;50(2):145-153. doi: 10.1002/uog.17555. PMID: 28782230
Allmon A, Deane K, Martin KL
Am Fam Physician 2015 Aug 1;92(3):211-6. PMID: 26280141
Neu N, Duchon J, Zachariah P
Clin Perinatol 2015 Mar;42(1):77-103, viii. Epub 2014 Dec 20 doi: 10.1016/j.clp.2014.11.001. PMID: 25677998

Therapy

Kinsella PM, Yong MK, Slavin MA, Hall VG
Transpl Infect Dis 2023 Oct;25(5):e14138. Epub 2023 Aug 23 doi: 10.1111/tid.14138. PMID: 37610327
Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
Abbasi N, Johnson JA, Ryan G
Ultrasound Obstet Gynecol 2017 Aug;50(2):145-153. doi: 10.1002/uog.17555. PMID: 28782230
Allmon A, Deane K, Martin KL
Am Fam Physician 2015 Aug 1;92(3):211-6. PMID: 26280141
Neu N, Duchon J, Zachariah P
Clin Perinatol 2015 Mar;42(1):77-103, viii. Epub 2014 Dec 20 doi: 10.1016/j.clp.2014.11.001. PMID: 25677998

Prognosis

Tschöpe C, Ammirati E, Bozkurt B, Caforio ALP, Cooper LT, Felix SB, Hare JM, Heidecker B, Heymans S, Hübner N, Kelle S, Klingel K, Maatz H, Parwani AS, Spillmann F, Starling RC, Tsutsui H, Seferovic P, Van Linthout S
Nat Rev Cardiol 2021 Mar;18(3):169-193. Epub 2020 Oct 12 doi: 10.1038/s41569-020-00435-x. PMID: 33046850Free PMC Article
Admani S, Jinna S, Friedlander SF, Sloan B
Clin Dermatol 2015 Nov-Dec;33(6):657-71. Epub 2015 Sep 14 doi: 10.1016/j.clindermatol.2015.09.008. PMID: 26686017
Allmon A, Deane K, Martin KL
Am Fam Physician 2015 Aug 1;92(3):211-6. PMID: 26280141
Vafaie J, Schwartz RA
J Cutan Med Surg 2005 Aug;9(4):159-61. doi: 10.1007/s10227-005-0101-8. PMID: 16502203
Sabella C, Goldfarb J
Am Fam Physician 1999 Oct 1;60(5):1455-60. PMID: 10524489

Clinical prediction guides

Algwaiz G, Alharbi A, Alsehaim K, Alahmari A, El Fakih R, Aljurf M
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):316-322. doi: 10.56875/2589-0646.1031. PMID: 37363985
Yu Y, Wei C, Lyu J, Wu X, Wang R, Huang H, Wu J, Chen J, Peng W
Front Cell Infect Microbiol 2021;11:753970. Epub 2021 Oct 15 doi: 10.3389/fcimb.2021.753970. PMID: 34722340Free PMC Article
Crane J, Mundle W, Boucoiran I; MATERNAL FETAL MEDICINE COMMITTEE
J Obstet Gynaecol Can 2014 Dec;36(12):1107-1116. doi: 10.1016/S1701-2163(15)30390-X. PMID: 25668048
van Klink JM, Koopman HM, Oepkes D, Walther FJ, Lopriore E
Early Hum Dev 2011 Sep;87(9):589-93. Epub 2011 Aug 9 doi: 10.1016/j.earlhumdev.2011.07.003. PMID: 21831544
Waza K, Inoue K, Matsumura S
Intern Med 2007;46(24):1975-8. Epub 2007 Dec 17 doi: 10.2169/internalmedicine.46.0366. PMID: 18084119

Recent systematic reviews

Samaee S, Samaee S, Mihalca D, Fitzgerald L, Ahmed A, Hall J, Tsitsikas DA
J Clin Pathol 2023 Jul;76(7):497-500. Epub 2023 Feb 27 doi: 10.1136/jcp-2023-208763. PMID: 36849230
Monteiro VS, Baía-da-Silva DC, Silva VA, Pivoto João GA, Marinho EPM, Cubas-Vega NC, Val FFA, Perez-Gomez AS, Monte RL, Mota A, Lacerda MVG, Souza Bastos M
J Trop Pediatr 2021 Aug 27;67(4) doi: 10.1093/tropej/fmab078. PMID: 34545404
Romero Starke K, Kofahl M, Freiberg A, Schubert M, Groß ML, Schmauder S, Hegewald J, Kämpf D, Stranzinger J, Nienhaus A, Seidler A
Int J Environ Res Public Health 2019 Apr 17;16(8) doi: 10.3390/ijerph16081392. PMID: 30999694Free PMC Article
Bascietto F, Liberati M, Murgano D, Buca D, Iacovelli A, Flacco ME, Manzoli L, Familiari A, Scambia G, D'Antonio F
Ultrasound Obstet Gynecol 2018 Nov;52(5):569-576. doi: 10.1002/uog.19092. PMID: 29785793

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