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Buruli ulcer(BUD)

MedGen UID:
43206
•Concept ID:
C0085568
•
Disease or Syndrome
Synonyms: BUD; Buruli ulcer disease
SNOMED CT: Buruli ulcer (15845006); Infection due to Mycobacterium ulcerans (15845006); Searles's ulcer (15845006); Cutaneous mycobacterium ulcerans infection (15845006)
 
Monarch Initiative: MONDO:0000327

Definition

A cutaneous infection caused by Mycobacterium ulcerans. It presents with painless nodular swelling of the skin, leading to the formation of necrotizing ulcers. [from NCI]

Professional guidelines

PubMed

Challenges associated with the treatment of Buruli ulcer.
Aboagye SY, Kpeli G, Tuffour J, Yeboah-Manu D
J Leukoc Biol 2019 Feb;105(2):233-242. Epub 2018 Aug 31 doi: 10.1002/JLB.MR0318-128. PMID: 30168876
Lipid-Based Nanocarriers for Cutaneous Leishmaniais and Buruli Ulcer Management.
Simoes S, Carvalheiro M, Gaspar MM
Curr Pharm Des 2016;22(43):6577-6586. doi: 10.2174/1381612822666160701083812. PMID: 27396598
Epidemiology and management of Buruli ulcer.
Huang GK, Johnson PD
Expert Rev Anti Infect Ther 2014 Jul;12(7):855-65. doi: 10.1586/14787210.2014.910113. PMID: 24918117

Recent clinical studies

Etiology

Mycobacterial skin infection.
Gardini G, Gregori N, Matteelli A, Castelli F
Curr Opin Infect Dis 2022 Apr 1;35(2):79-87. doi: 10.1097/QCO.0000000000000820. PMID: 35067521Free PMC Article
Cutaneous Mycobacterial Infections.
Franco-Paredes C, Marcos LA, Henao-Martínez AF, Rodríguez-Morales AJ, Villamil-Gómez WE, Gotuzzo E, Bonifaz A
Clin Microbiol Rev 2018 Jan;32(1) Epub 2018 Nov 14 doi: 10.1128/CMR.00069-18. PMID: 30429139Free PMC Article
Ecohealth research in Africa: Where from-Where to?
Bergquist R, Brattig NW, Chimbari MJ, Zinsstag J, Utzinger J
Acta Trop 2017 Nov;175:1-8. Epub 2017 Jul 18 doi: 10.1016/j.actatropica.2017.07.015. PMID: 28733024
Revisiting Buruli ulcer.
Yotsu RR, Murase C, Sugawara M, Suzuki K, Nakanaga K, Ishii N, Asiedu K
J Dermatol 2015 Nov;42(11):1033-41. Epub 2015 Sep 1 doi: 10.1111/1346-8138.13049. PMID: 26332541
Mycobacterium ulcerans infection.
van der Werf TS, van der Graaf WT, Tappero JW, Asiedu K
Lancet 1999 Sep 18;354(9183):1013-8. doi: 10.1016/S0140-6736(99)01156-3. PMID: 10501380

Diagnosis

Mycobacterial skin infection.
Gardini G, Gregori N, Matteelli A, Castelli F
Curr Opin Infect Dis 2022 Apr 1;35(2):79-87. doi: 10.1097/QCO.0000000000000820. PMID: 35067521Free PMC Article
Cutaneous Mycobacterial Infections.
Franco-Paredes C, Marcos LA, Henao-Martínez AF, Rodríguez-Morales AJ, Villamil-Gómez WE, Gotuzzo E, Bonifaz A
Clin Microbiol Rev 2018 Jan;32(1) Epub 2018 Nov 14 doi: 10.1128/CMR.00069-18. PMID: 30429139Free PMC Article
Revisiting Buruli ulcer.
Yotsu RR, Murase C, Sugawara M, Suzuki K, Nakanaga K, Ishii N, Asiedu K
J Dermatol 2015 Nov;42(11):1033-41. Epub 2015 Sep 1 doi: 10.1111/1346-8138.13049. PMID: 26332541
Buruli ulcer.
Portaels F, Silva MT, Meyers WM
Clin Dermatol 2009 May-Jun;27(3):291-305. doi: 10.1016/j.clindermatol.2008.09.021. PMID: 19362692
Mycobacterium ulcerans disease.
van der Werf TS, Stienstra Y, Johnson RC, Phillips R, Adjei O, Fleischer B, Wansbrough-Jones MH, Johnson PD, Portaels F, van der Graaf WT, Asiedu K
Bull World Health Organ 2005 Oct;83(10):785-91. Epub 2005 Nov 10 PMID: 16283056Free PMC Article

Therapy

Mycobacterial skin infection.
Gardini G, Gregori N, Matteelli A, Castelli F
Curr Opin Infect Dis 2022 Apr 1;35(2):79-87. doi: 10.1097/QCO.0000000000000820. PMID: 35067521Free PMC Article
Pharmacologic management of Mycobacterium ulcerans infection.
Van Der Werf TS, Barogui YT, Converse PJ, Phillips RO, Stienstra Y
Expert Rev Clin Pharmacol 2020 Apr;13(4):391-401. Epub 2020 Apr 20 doi: 10.1080/17512433.2020.1752663. PMID: 32310683Free PMC Article
Management of BU-HIV co-infection.
O'Brien DP, Ford N, Vitoria M, Christinet V, Comte E, Calmy A, Stienstra Y, Eholie S, Asiedu K
Trop Med Int Health 2014 Sep;19(9):1040-7. Epub 2014 Jun 20 doi: 10.1111/tmi.12342. PMID: 24946829
Epidemiology and management of Buruli ulcer.
Huang GK, Johnson PD
Expert Rev Anti Infect Ther 2014 Jul;12(7):855-65. doi: 10.1586/14787210.2014.910113. PMID: 24918117
Buruli ulcer disease.
Ofori-Adjei D
Ghana Med J 2011 Mar;45(1):1. PMID: 21572816Free PMC Article

Prognosis

Mycobacterial skin infection.
Gardini G, Gregori N, Matteelli A, Castelli F
Curr Opin Infect Dis 2022 Apr 1;35(2):79-87. doi: 10.1097/QCO.0000000000000820. PMID: 35067521Free PMC Article
Methods and Approaches for Buruli Ulcer Surveillance in Africa: Lessons Learnt and Future Directions.
Timothy JWS, Pullan RL, Yotsu RR
Methods Mol Biol 2022;2387:87-102. doi: 10.1007/978-1-0716-1779-3_10. PMID: 34643905
Improving clinical and epidemiological predictors of Buruli ulcer.
Ayelo GA, Sopoh GE, Houezo JG, Fiodessihoue R, Affolabi D, Dossou AD, Barogui YT, Wadagni AAC, Agossadou DC, Hasker E, Portaels F, de Jong BC, Eddyani M
PLoS Negl Trop Dis 2018 Aug;12(8):e0006713. Epub 2018 Aug 6 doi: 10.1371/journal.pntd.0006713. PMID: 30080870Free PMC Article
The Buruli Ulcer.
Kumar S, Basu S, Bhartiya SK, Shukla VK
Int J Low Extrem Wounds 2015 Sep;14(3):217-23. Epub 2015 Aug 18 doi: 10.1177/1534734615599653. PMID: 26286931
Buruli ulcer disease.
Ofori-Adjei D
Ghana Med J 2011 Mar;45(1):1. PMID: 21572816Free PMC Article

Clinical prediction guides

Pharmacologic management of Mycobacterium ulcerans infection.
Van Der Werf TS, Barogui YT, Converse PJ, Phillips RO, Stienstra Y
Expert Rev Clin Pharmacol 2020 Apr;13(4):391-401. Epub 2020 Apr 20 doi: 10.1080/17512433.2020.1752663. PMID: 32310683Free PMC Article
Mycobacterium ulcerans mycolactones-fungi crosstalking.
Hammoudi N, Cassagne C, Armstrong N, Ranque S, Henrissat B, Drancourt M, Bouam A
Sci Rep 2019 Feb 28;9(1):3028. doi: 10.1038/s41598-019-39927-3. PMID: 30816261Free PMC Article
Human genetics of mycobacterial disease.
Dallmann-Sauer M, Correa-Macedo W, Schurr E
Mamm Genome 2018 Aug;29(7-8):523-538. Epub 2018 Aug 16 doi: 10.1007/s00335-018-9765-4. PMID: 30116885Free PMC Article
Improving clinical and epidemiological predictors of Buruli ulcer.
Ayelo GA, Sopoh GE, Houezo JG, Fiodessihoue R, Affolabi D, Dossou AD, Barogui YT, Wadagni AAC, Agossadou DC, Hasker E, Portaels F, de Jong BC, Eddyani M
PLoS Negl Trop Dis 2018 Aug;12(8):e0006713. Epub 2018 Aug 6 doi: 10.1371/journal.pntd.0006713. PMID: 30080870Free PMC Article
Buruli ulcer and mycolactone-producing mycobacteria.
Nakanaga K, Yotsu RR, Hoshino Y, Suzuki K, Makino M, Ishii N
Jpn J Infect Dis 2013;66(2):83-8. doi: 10.7883/yoken.66.83. PMID: 23514902

Recent systematic reviews

Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus.
Simpson H, Deribe K, Tabah EN, Peters A, Maman I, Frimpong M, Ampadu E, Phillips R, Saunderson P, Pullan RL, Cano J
Lancet Glob Health 2019 Jul;7(7):e912-e922. doi: 10.1016/S2214-109X(19)30171-8. PMID: 31200890Free PMC Article
Effectiveness of rifampicin-streptomycin for treatment of Buruli ulcer: a systematic review.
Tanywe A, Fernandez RS
JBI Database System Rev Implement Rep 2017 Jan;15(1):119-139. doi: 10.11124/JBISRIR-2016-003235. PMID: 28085731
Ethnopharmacological reports on anti-Buruli ulcer medicinal plants in three West African countries.
Tsouh Fokou PV, Nyarko AK, Appiah-Opong R, Tchokouaha Yamthe LR, Addo P, Asante IK, Boyom FF
J Ethnopharmacol 2015 Aug 22;172:297-311. Epub 2015 Jun 20 doi: 10.1016/j.jep.2015.06.024. PMID: 26099634
Association between footwear use and neglected tropical diseases: a systematic review and meta-analysis.
Tomczyk S, Deribe K, Brooker SJ, Clark H, Rafique K, Knopp S, Utzinger J, Davey G
PLoS Negl Trop Dis 2014;8(11):e3285. Epub 2014 Nov 13 doi: 10.1371/journal.pntd.0003285. PMID: 25393620Free PMC Article
Ecology and transmission of Buruli ulcer disease: a systematic review.
Merritt RW, Walker ED, Small PL, Wallace JR, Johnson PD, Benbow ME, Boakye DA
PLoS Negl Trop Dis 2010 Dec 14;4(12):e911. doi: 10.1371/journal.pntd.0000911. PMID: 21179505Free PMC Article

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