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Hyperemesis gravidarum

MedGen UID:
43776
•Concept ID:
C0020450
•
Sign or Symptom
Synonym: Hyperemesis gravidarum (disease)
SNOMED CT: Hyperemesis of pregnancy (14094001); Excessive pregnancy vomiting (14094001); Excessive vomiting in pregnancy (14094001); Hyperemesis arising during pregnancy (14094001); Hyperemesis gravidarum (14094001); Persistent AND/OR vicious vomiting arising during pregnancy (14094001); Hyperemesis in pregnancy (14094001)
 
HPO: HP:0012188
Monarch Initiative: MONDO:0006791

Definition

Excessive vomiting in early pregnancy, leading to the loss of 5% or more of body weight. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperemesis gravidarum

Professional guidelines

PubMed

Review article: Management of hyperemesis gravidarum and nausea and vomiting in pregnancy.
Lowe SA, Steinweg KE
Emerg Med Australas 2022 Feb;34(1):9-15. Epub 2021 Dec 6 doi: 10.1111/1742-6723.13909. PMID: 34872159
Nutritional consequences and management of hyperemesis gravidarum: a narrative review.
Maslin K, Dean C
Nutr Res Rev 2022 Dec;35(2):308-318. Epub 2021 Sep 16 doi: 10.1017/S0954422421000305. PMID: 34526158
Treatment options for hyperemesis gravidarum.
Abramowitz A, Miller ES, Wisner KL
Arch Womens Ment Health 2017 Jun;20(3):363-372. Epub 2017 Jan 9 doi: 10.1007/s00737-016-0707-4. PMID: 28070660Free PMC Article

Recent clinical studies

Etiology

Pregnancy-Associated Liver Diseases.
Terrault NA, Williamson C
Gastroenterology 2022 Jul;163(1):97-117.e1. Epub 2022 Mar 8 doi: 10.1053/j.gastro.2022.01.060. PMID: 35276220
Cannabis use during pregnancy and postpartum.
Badowski S, Smith G
Can Fam Physician 2020 Feb;66(2):98-103. PMID: 32060189Free PMC Article
Interventions for treating hyperemesis gravidarum: a Cochrane systematic review and meta-analysis.
Boelig RC, Barton SJ, Saccone G, Kelly AJ, Edwards SJ, Berghella V
J Matern Fetal Neonatal Med 2018 Sep;31(18):2492-2505. Epub 2017 Jul 11 doi: 10.1080/14767058.2017.1342805. PMID: 28614956
Treatment options for hyperemesis gravidarum.
Abramowitz A, Miller ES, Wisner KL
Arch Womens Ment Health 2017 Jun;20(3):363-372. Epub 2017 Jan 9 doi: 10.1007/s00737-016-0707-4. PMID: 28070660Free PMC Article
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.
McParlin C, O'Donnell A, Robson SC, Beyer F, Moloney E, Bryant A, Bradley J, Muirhead CR, Nelson-Piercy C, Newbury-Birch D, Norman J, Shaw C, Simpson E, Swallow B, Yates L, Vale L
JAMA 2016 Oct 4;316(13):1392-1401. doi: 10.1001/jama.2016.14337. PMID: 27701665

Diagnosis

Pregnancy-Associated Liver Diseases.
Terrault NA, Williamson C
Gastroenterology 2022 Jul;163(1):97-117.e1. Epub 2022 Mar 8 doi: 10.1053/j.gastro.2022.01.060. PMID: 35276220
Review article: Management of hyperemesis gravidarum and nausea and vomiting in pregnancy.
Lowe SA, Steinweg KE
Emerg Med Australas 2022 Feb;34(1):9-15. Epub 2021 Dec 6 doi: 10.1111/1742-6723.13909. PMID: 34872159
Nausea and vomiting of pregnancy and hyperemesis gravidarum.
Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes Å, Painter RC, Mullin PM
Nat Rev Dis Primers 2019 Sep 12;5(1):62. doi: 10.1038/s41572-019-0110-3. PMID: 31515515
Hyperemesis Gravidarum: A Review of Recent Literature.
London V, Grube S, Sherer DM, Abulafia O
Pharmacology 2017;100(3-4):161-171. Epub 2017 Jun 23 doi: 10.1159/000477853. PMID: 28641304
Treatment options for hyperemesis gravidarum.
Abramowitz A, Miller ES, Wisner KL
Arch Womens Ment Health 2017 Jun;20(3):363-372. Epub 2017 Jan 9 doi: 10.1007/s00737-016-0707-4. PMID: 28070660Free PMC Article

Therapy

Review article: Management of hyperemesis gravidarum and nausea and vomiting in pregnancy.
Lowe SA, Steinweg KE
Emerg Med Australas 2022 Feb;34(1):9-15. Epub 2021 Dec 6 doi: 10.1111/1742-6723.13909. PMID: 34872159
Nausea and vomiting of pregnancy and hyperemesis gravidarum.
Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes Å, Painter RC, Mullin PM
Nat Rev Dis Primers 2019 Sep 12;5(1):62. doi: 10.1038/s41572-019-0110-3. PMID: 31515515
Hyperemesis Gravidarum: A Review of Recent Literature.
London V, Grube S, Sherer DM, Abulafia O
Pharmacology 2017;100(3-4):161-171. Epub 2017 Jun 23 doi: 10.1159/000477853. PMID: 28641304
Treatment options for hyperemesis gravidarum.
Abramowitz A, Miller ES, Wisner KL
Arch Womens Ment Health 2017 Jun;20(3):363-372. Epub 2017 Jan 9 doi: 10.1007/s00737-016-0707-4. PMID: 28070660Free PMC Article
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.
McParlin C, O'Donnell A, Robson SC, Beyer F, Moloney E, Bryant A, Bradley J, Muirhead CR, Nelson-Piercy C, Newbury-Birch D, Norman J, Shaw C, Simpson E, Swallow B, Yates L, Vale L
JAMA 2016 Oct 4;316(13):1392-1401. doi: 10.1001/jama.2016.14337. PMID: 27701665

Prognosis

Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis.
Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC
Am J Obstet Gynecol 2022 Sep;227(3):414-429.e17. Epub 2022 Mar 30 doi: 10.1016/j.ajog.2022.03.052. PMID: 35367190
Hyperemesis Gravidarum: A Review of Recent Literature.
London V, Grube S, Sherer DM, Abulafia O
Pharmacology 2017;100(3-4):161-171. Epub 2017 Jun 23 doi: 10.1159/000477853. PMID: 28641304
Psychological morbidity associated with hyperemesis gravidarum: a systematic review and meta-analysis.
Mitchell-Jones N, Gallos I, Farren J, Tobias A, Bottomley C, Bourne T
BJOG 2017 Jan;124(1):20-30. Epub 2016 Jul 14 doi: 10.1111/1471-0528.14180. PMID: 27418035
Liver disease in pregnancy.
Shekhar S, Diddi G
Taiwan J Obstet Gynecol 2015 Oct;54(5):475-82. doi: 10.1016/j.tjog.2015.01.004. PMID: 26522095
Understanding hyperemesis gravidarum.
Loh KY, Sivalingam N
Med J Malaysia 2005 Aug;60(3):394-9; quiz 400. PMID: 16379204

Clinical prediction guides

Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis.
Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC
Am J Obstet Gynecol 2022 Sep;227(3):414-429.e17. Epub 2022 Mar 30 doi: 10.1016/j.ajog.2022.03.052. PMID: 35367190
Review article: Management of hyperemesis gravidarum and nausea and vomiting in pregnancy.
Lowe SA, Steinweg KE
Emerg Med Australas 2022 Feb;34(1):9-15. Epub 2021 Dec 6 doi: 10.1111/1742-6723.13909. PMID: 34872159
Interventions for treating hyperemesis gravidarum: a Cochrane systematic review and meta-analysis.
Boelig RC, Barton SJ, Saccone G, Kelly AJ, Edwards SJ, Berghella V
J Matern Fetal Neonatal Med 2018 Sep;31(18):2492-2505. Epub 2017 Jul 11 doi: 10.1080/14767058.2017.1342805. PMID: 28614956
Hyperemesis Gravidarum: A Review of Recent Literature.
London V, Grube S, Sherer DM, Abulafia O
Pharmacology 2017;100(3-4):161-171. Epub 2017 Jun 23 doi: 10.1159/000477853. PMID: 28641304
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.
McParlin C, O'Donnell A, Robson SC, Beyer F, Moloney E, Bryant A, Bradley J, Muirhead CR, Nelson-Piercy C, Newbury-Birch D, Norman J, Shaw C, Simpson E, Swallow B, Yates L, Vale L
JAMA 2016 Oct 4;316(13):1392-1401. doi: 10.1001/jama.2016.14337. PMID: 27701665

Recent systematic reviews

Long-term health outcomes of children born to mothers with hyperemesis gravidarum: a systematic review and meta-analysis.
Nijsten K, Jansen LAW, Limpens J, Finken MJJ, Koot MH, Grooten IJ, Roseboom TJ, Painter RC
Am J Obstet Gynecol 2022 Sep;227(3):414-429.e17. Epub 2022 Mar 30 doi: 10.1016/j.ajog.2022.03.052. PMID: 35367190
Interventions for treating hyperemesis gravidarum: a Cochrane systematic review and meta-analysis.
Boelig RC, Barton SJ, Saccone G, Kelly AJ, Edwards SJ, Berghella V
J Matern Fetal Neonatal Med 2018 Sep;31(18):2492-2505. Epub 2017 Jul 11 doi: 10.1080/14767058.2017.1342805. PMID: 28614956
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review.
McParlin C, O'Donnell A, Robson SC, Beyer F, Moloney E, Bryant A, Bradley J, Muirhead CR, Nelson-Piercy C, Newbury-Birch D, Norman J, Shaw C, Simpson E, Swallow B, Yates L, Vale L
JAMA 2016 Oct 4;316(13):1392-1401. doi: 10.1001/jama.2016.14337. PMID: 27701665
Interventions for nausea and vomiting in early pregnancy.
Matthews A, Haas DM, O'Mathúna DP, Dowswell T
Cochrane Database Syst Rev 2015 Sep 8;2015(9):CD007575. doi: 10.1002/14651858.CD007575.pub4. PMID: 26348534Free PMC Article
Nausea and vomiting in early pregnancy.
Festin M
BMJ Clin Evid 2014 Mar 19;2014 PMID: 24646807Free PMC Article

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