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Hyperglycemic Hyperosmolar Nonketotic Coma

MedGen UID:
43778
Concept ID:
C0020457
Disease or Syndrome
Synonyms: Coma, Hyperglycemic Hyperosmolar Nonketotic; Coma, Hyperosmolar Nonketotic; Coma, Nonketotic Hyperglycemic; Coma, Nonketotic Hyperosmolar; Comas, Hyperosmolar Nonketotic; Comas, Nonketotic Hyperosmolar; Hyperglycemic Coma, Nonketotic; Hyperosmolar Coma, Nonketotic; Hyperosmolar Comas, Nonketotic; Hyperosmolar Hyperglycemic Nonketotic Coma; Hyperosmolar Nonketotic Coma; Hyperosmolar Nonketotic Comas; Nonketotic Coma, Hyperosmolar; Nonketotic Comas, Hyperosmolar; Nonketotic Hyperglycemic Coma; Nonketotic Hyperosmolar Coma; Nonketotic Hyperosmolar Comas

Definition

A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperglycemic Hyperosmolar Nonketotic Coma

Professional guidelines

Recent clinical studies

Etiology

Mustafa OG, Haq M, Dashora U, Castro E, Dhatariya KK; Joint British Diabetes Societies (JBDS) for Inpatient Care Group
Diabet Med 2023 Mar;40(3):e15005. Epub 2022 Dec 21 doi: 10.1111/dme.15005. PMID: 36370077Free PMC Article
Pasquel FJ, Tsegka K, Wang H, Cardona S, Galindo RJ, Fayfman M, Davis G, Vellanki P, Migdal A, Gujral U, Narayan KMV, Umpierrez GE
Diabetes Care 2020 Feb;43(2):349-357. Epub 2019 Nov 8 doi: 10.2337/dc19-1168. PMID: 31704689Free PMC Article
Karslioglu French E, Donihi AC, Korytkowski MT
BMJ 2019 May 29;365:l1114. doi: 10.1136/bmj.l1114. PMID: 31142480
Wolfsdorf JI, Glaser N, Agus M, Fritsch M, Hanas R, Rewers A, Sperling MA, Codner E
Pediatr Diabetes 2018 Oct;19 Suppl 27:155-177. doi: 10.1111/pedi.12701. PMID: 29900641
Sauve DO, Kessler CA
AACN Clin Issues Crit Care Nurs 1992 May;3(2):350-60. doi: 10.4037/15597768-1992-2007. PMID: 1576033

Diagnosis

Glaser N, Fritsch M, Priyambada L, Rewers A, Cherubini V, Estrada S, Wolfsdorf JI, Codner E
Pediatr Diabetes 2022 Nov;23(7):835-856. doi: 10.1111/pedi.13406. PMID: 36250645
Fayfman M, Pasquel FJ, Umpierrez GE
Med Clin North Am 2017 May;101(3):587-606. doi: 10.1016/j.mcna.2016.12.011. PMID: 28372715Free PMC Article
Dhatariya KK, Vellanki P
Curr Diab Rep 2017 May;17(5):33. doi: 10.1007/s11892-017-0857-4. PMID: 28364357Free PMC Article
Umpierrez G, Korytkowski M
Nat Rev Endocrinol 2016 Apr;12(4):222-32. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.15. PMID: 26893262
Pasquel FJ, Umpierrez GE
Diabetes Care 2014 Nov;37(11):3124-31. doi: 10.2337/dc14-0984. PMID: 25342831Free PMC Article

Therapy

Mustafa OG, Haq M, Dashora U, Castro E, Dhatariya KK; Joint British Diabetes Societies (JBDS) for Inpatient Care Group
Diabet Med 2023 Mar;40(3):e15005. Epub 2022 Dec 21 doi: 10.1111/dme.15005. PMID: 36370077Free PMC Article
Stoner GD
Am Fam Physician 2017 Dec 1;96(11):729-736. PMID: 29431405
Fayfman M, Pasquel FJ, Umpierrez GE
Med Clin North Am 2017 May;101(3):587-606. doi: 10.1016/j.mcna.2016.12.011. PMID: 28372715Free PMC Article
Umpierrez G, Korytkowski M
Nat Rev Endocrinol 2016 Apr;12(4):222-32. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.15. PMID: 26893262
Pasquel FJ, Umpierrez GE
Diabetes Care 2014 Nov;37(11):3124-31. doi: 10.2337/dc14-0984. PMID: 25342831Free PMC Article

Prognosis

Rosager EV, Heltø ALK, Fox Maule CU, Friis-Hansen L, Petersen J, Nielsen FE, Haugaard SB, Gregersen R
Diabetes Care 2024 Feb 1;47(2):272-279. doi: 10.2337/dc23-0988. PMID: 38085699
Pasquel FJ, Tsegka K, Wang H, Cardona S, Galindo RJ, Fayfman M, Davis G, Vellanki P, Migdal A, Gujral U, Narayan KMV, Umpierrez GE
Diabetes Care 2020 Feb;43(2):349-357. Epub 2019 Nov 8 doi: 10.2337/dc19-1168. PMID: 31704689Free PMC Article
Fayfman M, Pasquel FJ, Umpierrez GE
Med Clin North Am 2017 May;101(3):587-606. doi: 10.1016/j.mcna.2016.12.011. PMID: 28372715Free PMC Article
Umpierrez G, Korytkowski M
Nat Rev Endocrinol 2016 Apr;12(4):222-32. Epub 2016 Feb 19 doi: 10.1038/nrendo.2016.15. PMID: 26893262
Pasquel FJ, Umpierrez GE
Diabetes Care 2014 Nov;37(11):3124-31. doi: 10.2337/dc14-0984. PMID: 25342831Free PMC Article

Clinical prediction guides

Khor A, Mohiuddin M
Intern Med J 2023 Dec;53(12):2277-2282. Epub 2023 Jun 21 doi: 10.1111/imj.16151. PMID: 37279023
Liao WT, Lee CC, Kuo CL, Lin KC
Diabetes Res Clin Pract 2022 Oct;192:110115. Epub 2022 Oct 8 doi: 10.1016/j.diabres.2022.110115. PMID: 36220515
Pasquel FJ, Tsegka K, Wang H, Cardona S, Galindo RJ, Fayfman M, Davis G, Vellanki P, Migdal A, Gujral U, Narayan KMV, Umpierrez GE
Diabetes Care 2020 Feb;43(2):349-357. Epub 2019 Nov 8 doi: 10.2337/dc19-1168. PMID: 31704689Free PMC Article
Gershkovich B, English SW, Doyle MA, Menon K, McIntyre L
Syst Rev 2019 Sep 3;8(1):228. doi: 10.1186/s13643-019-1130-5. PMID: 31481108Free PMC Article
Bartoli E, Sainaghi PP, Bergamasco L, Castello L
Nephrology (Carlton) 2009 Apr;14(3):338-44. Epub 2009 Jan 27 doi: 10.1111/j.1440-1797.2008.01054.x. PMID: 19178646

Recent systematic reviews

Zhang W, Chen J, Bi J, Ding N, Chen X, Wang Z, Jiao Y
Front Endocrinol (Lausanne) 2022;13:1084441. Epub 2023 Jan 4 doi: 10.3389/fendo.2022.1084441. PMID: 36686495Free PMC Article
Rossi S, Romoli M, Urbinati G, Benini M, Russo M, D'Anna L, Abu-Rumeileh S, Sacco S, Querzani P, Foschi M
Neurol Sci 2022 Aug;43(8):4671-4683. Epub 2022 Apr 28 doi: 10.1007/s10072-022-06088-7. PMID: 35482160Free PMC Article
Pal R, Banerjee M, Yadav U, Bhattacharjee S
Diabetes Metab Syndr 2020 Nov-Dec;14(6):1563-1569. Epub 2020 Aug 18 doi: 10.1016/j.dsx.2020.08.015. PMID: 32853901Free PMC Article

Supplemental Content

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    Practice guidelines

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