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Breast hypertrophy

MedGen UID:
43789
Concept ID:
C0020565
Pathologic Function
Synonyms: Drug-induced gigantomastia (subtype); Gestational gigantomastia (subtype); Gigantomastia; Hypertrophy of breast; Idiopathic gigantomastia (subtype); Juvenile gigantomastia (subtype); Medication-induced gigantomastia (subtype); Pregnancy-induced gigantomastia (subtype); Puberty-induced gigantomastia (subtype)
SNOMED CT: Hypertrophy of breast (372281005)
 
HPO: HP:0010313
Monarch Initiative: MONDO:0001100

Definition

The presence of hypertrophy of the breast. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast hypertrophy

Conditions with this feature

Mammary-digital-nail syndrome
MedGen UID:
462296
Concept ID:
C3150946
Disease or Syndrome
A syndromic limb malformation characterized by congenital onychodystrophy/anonychia, brachydactyly of the fifth finger, digitalization of the thumbs, with absence or hypoplasia of the distal phalanges of the hands and feet in association with juvenile hypertrophy of the breast with gigantomastia in peripubertal females.

Professional guidelines

PubMed

Aydin D, Hansen LB, Ikander P, Drejøe JB, Lambaa S, Hölmich LR
Dan Med J 2016 Jan;63(1):A5179. PMID: 26726905
Scott-Conner CE, Schorr SJ
Am J Surg 1995 Oct;170(4):401-5. doi: 10.1016/s0002-9610(99)80313-4. PMID: 7573738
Deprettere AR, Van Acker KJ, Du Caju MV
Eur J Pediatr 1987 Mar;146(2):189-91. doi: 10.1007/BF02343232. PMID: 3569359

Recent clinical studies

Etiology

Crittenden TA, Ratcliffe J, Watson DI, Mpundu-Kaambwa C, Dean NR
Med J Aust 2022 Feb 21;216(3):147-152. Epub 2021 Nov 16 doi: 10.5694/mja2.51343. PMID: 34784653
Janik PE, Charytonowicz D, Miszczyk J, Charytonowicz M
Ann Plast Surg 2019 Jun;82(6):609-613. doi: 10.1097/SAP.0000000000001742. PMID: 30557191
Lewin R, Elander A, Lundberg J, Hansson E, Thorarinsson A, Claudelin M, Bladh H, Lidén M
J Plast Surg Hand Surg 2018 Oct;52(5):274-281. Epub 2018 Jun 13 doi: 10.1080/2000656X.2018.1476362. PMID: 29897268
Fonseca CC, Veiga DF, Garcia EDS, Cabral IV, de Carvalho MM, de Brito MJA, Ferreira LM
Aesthet Surg J 2018 Aug 16;38(9):972-979. doi: 10.1093/asj/sjx271. PMID: 29425275
Xue AS, Wolfswinkel EM, Weathers WM, Chike-Obi C, Heller L
J Pediatr Adolesc Gynecol 2013 Aug;26(4):228-33. doi: 10.1016/j.jpag.2013.03.005. PMID: 23889919

Diagnosis

Bianchi de Aguiar B, Santos Silva R, Costa C, Castro-Correia C, Fontoura M
Endokrynol Pol 2020;71(2):202-203. Epub 2020 Jan 7 doi: 10.5603/EP.a2019.0063. PMID: 31909454
Janik PE, Charytonowicz D, Miszczyk J, Charytonowicz M
Ann Plast Surg 2019 Jun;82(6):609-613. doi: 10.1097/SAP.0000000000001742. PMID: 30557191
Uebel CO, Piccinini PS, Ramos RFM, Meneguzzi K
Aesthetic Plast Surg 2019 Feb;43(1):36-45. Epub 2018 Sep 26 doi: 10.1007/s00266-018-1225-8. PMID: 30259167
Scott-Conner CE, Schorr SJ
Am J Surg 1995 Oct;170(4):401-5. doi: 10.1016/s0002-9610(99)80313-4. PMID: 7573738
Griffith JR
J Adolesc Health Care 1989 Sep;10(5):423-32. doi: 10.1016/0197-0070(89)90224-6. PMID: 2681107

Therapy

Kikuchi DS, Mustin DE, Ghanouni A, Walsh MD
J Plast Reconstr Aesthet Surg 2023 Feb;77:209-217. Epub 2022 Dec 19 doi: 10.1016/j.bjps.2022.12.003. PMID: 36587475
Nuzzi LC, Pramanick T, Massey GG, Walsh LR, McNamara CT, Firriolo JM, DiVasta AD, Labow BI
Plast Reconstr Surg 2022 Oct 1;150(4):731-738. Epub 2022 Jul 22 doi: 10.1097/PRS.0000000000009513. PMID: 35862103
Widmark-Jensen E, Bernhardsson S, Eriksson M, Hallberg H, Jepsen C, Jivegård L, Liljegren A, Petzold M, Svensson M, Wärnberg F, Hansson E
BMC Surg 2021 Sep 11;21(1):343. doi: 10.1186/s12893-021-01336-7. PMID: 34511096Free PMC Article
Bianchi de Aguiar B, Santos Silva R, Costa C, Castro-Correia C, Fontoura M
Endokrynol Pol 2020;71(2):202-203. Epub 2020 Jan 7 doi: 10.5603/EP.a2019.0063. PMID: 31909454
Xue AS, Wolfswinkel EM, Weathers WM, Chike-Obi C, Heller L
J Pediatr Adolesc Gynecol 2013 Aug;26(4):228-33. doi: 10.1016/j.jpag.2013.03.005. PMID: 23889919

Prognosis

Lessard L, Papanastasiou C, Fortin M, Ouellet JA
Plast Reconstr Surg 2023 Mar 1;151(3):498-508. Epub 2022 Nov 21 doi: 10.1097/PRS.0000000000009906. PMID: 36730482
Crittenden T, Watson DI, Ratcliffe J, Griffin PA, Dean NR; AFESA Research Group
BMJ Open 2020 Feb 17;10(2):e031804. doi: 10.1136/bmjopen-2019-031804. PMID: 32071171Free PMC Article
Crittenden TA, Watson DI, Ratcliffe J, Griffin PA, Dean NR
Plast Reconstr Surg 2019 Nov;144(5):1034-1044. doi: 10.1097/PRS.0000000000006114. PMID: 31688747
Beraldo FN, Veiga DF, Veiga-Filho J, Garcia ES, Vilas-Bôas GS, Juliano Y, Sabino-Neto M, Ferreira LM
Ann Plast Surg 2016 Apr;76(4):379-82. doi: 10.1097/SAP.0000000000000380. PMID: 25536204
Scott-Conner CE, Schorr SJ
Am J Surg 1995 Oct;170(4):401-5. doi: 10.1016/s0002-9610(99)80313-4. PMID: 7573738

Clinical prediction guides

Crittenden TA, Ratcliffe J, Watson DI, Mpundu-Kaambwa C, Dean NR
Med J Aust 2022 Feb 21;216(3):147-152. Epub 2021 Nov 16 doi: 10.5694/mja2.51343. PMID: 34784653
Crittenden TA, Watson DI, Ratcliffe J, Griffin PA, Dean NR
Plast Reconstr Surg 2019 Nov;144(5):1034-1044. doi: 10.1097/PRS.0000000000006114. PMID: 31688747
Janik PE, Charytonowicz D, Miszczyk J, Charytonowicz M
Ann Plast Surg 2019 Jun;82(6):609-613. doi: 10.1097/SAP.0000000000001742. PMID: 30557191
Fonseca CC, Veiga DF, Garcia EDS, Cabral IV, de Carvalho MM, de Brito MJA, Ferreira LM
Aesthet Surg J 2018 Aug 16;38(9):972-979. doi: 10.1093/asj/sjx271. PMID: 29425275
Samuelov R, Siplovich L
J Pediatr Surg 1988 Nov;23(11):1014-5. doi: 10.1016/s0022-3468(88)80010-1. PMID: 3244074

Recent systematic reviews

Widmark-Jensen E, Bernhardsson S, Eriksson M, Hallberg H, Jepsen C, Jivegård L, Liljegren A, Petzold M, Svensson M, Wärnberg F, Hansson E
BMC Surg 2021 Sep 11;21(1):343. doi: 10.1186/s12893-021-01336-7. PMID: 34511096Free PMC Article
Guliyeva G, Cheung JY, Avila FR, Huayllani MT, Boczar D, Broer PN, Forte AJ
Ann Plast Surg 2021 Dec 1;87(6):694-698. doi: 10.1097/SAP.0000000000002834. PMID: 33883434
Lin Y, Yang Y, Zhang X, Li W, Li H, Mu D
Ann Plast Surg 2021 Jul 1;87(1):107-112. doi: 10.1097/SAP.0000000000002609. PMID: 33346564
Tondu T, Hubens G, Tjalma WA, Thiessen FE, Vrints I, Van Thielen J, Verhoeven V
J Plast Reconstr Aesthet Surg 2020 Mar;73(3):469-485. Epub 2019 Dec 18 doi: 10.1016/j.bjps.2019.11.047. PMID: 31987776
Waltho D, Gallo L, Gallo M, Murphy J, Copeland A, Mowakket S, Moltaji S, Baxter C, Karpinski M, Thoma A
Aesthet Surg J 2020 Mar 23;40(4):383-391. doi: 10.1093/asj/sjz308. PMID: 31679031

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