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Aldosterone deficiency

MedGen UID:
43793
•Concept ID:
C0020595
•
Disease or Syndrome
Synonym: Hypoaldosteronism
SNOMED CT: Hypoaldosteronism (60086000); Aldosterone deficiency (60086000)

Definition

Abnormally low levels of aldosterone in the blood. [from NCI]

Professional guidelines

PubMed

Renal Tubular Acidosis and Management Strategies: A Narrative Review.
Palmer BF, Kelepouris E, Clegg DJ
Adv Ther 2021 Feb;38(2):949-968. Epub 2020 Dec 26 doi: 10.1007/s12325-020-01587-5. PMID: 33367987Free PMC Article
Association between genotype, clinical presentation, and severity of congenital adrenal hyperplasia: a review.
Al-Agha AE, Ocheltree AH, Al-Tamimi MD
Turk J Pediatr 2012 Jul-Aug;54(4):323-32. PMID: 23692712
Recent advances in diagnosis, treatment, and outcome of congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Riepe FG, Sippell WG
Rev Endocr Metab Disord 2007 Dec;8(4):349-63. doi: 10.1007/s11154-007-9053-1. PMID: 17885806

Recent clinical studies

Etiology

Adrenal Insufficiency in Peroxisomal Disorders: A Single Institution Case Series.
Gagnon C, Hurst ACE, Ashraf AP
Horm Res Paediatr 2023;96(4):439-445. Epub 2023 Jan 17 doi: 10.1159/000529126. PMID: 36649687
Aldosterone deficiency with a hormone profile mimicking pseudohypoaldosteronism.
Martín-Rivada Á, Argente J, Martos-Moreno GÁ
J Pediatr Endocrinol Metab 2020 Nov 26;33(11):1501-1505. doi: 10.1515/jpem-2020-0239. PMID: 32809961
Congenital adrenal hyperplasia--pharmacologic interventions from the prenatal phase to adulthood.
Claahsen-van der Grinten HL, Stikkelbroeck NM, Otten BJ, Hermus AR
Pharmacol Ther 2011 Oct;132(1):1-14. Epub 2011 May 18 doi: 10.1016/j.pharmthera.2011.05.004. PMID: 21635919
Fatty acids may regulate aldosterone secretion and mediate some of insulin's effects on blood pressure.
Goodfriend TL, Ball DL, Elliott ME, Chabhi A, Duong T, Raff H, Schneider EG, Brown RD, Weinbergers MH
Prostaglandins Leukot Essent Fatty Acids 1993 Jan;48(1):43-50. doi: 10.1016/0952-3278(93)90008-k. PMID: 8424122
Disorders of distal nephron function.
Sebastian A, Hulter HN, Kurtz I, Maher T, Schambelan M
Am J Med 1982 Feb;72(2):289-307. doi: 10.1016/0002-9343(82)90822-1. PMID: 6277192

Diagnosis

Renal Tubular Acidosis and Management Strategies: A Narrative Review.
Palmer BF, Kelepouris E, Clegg DJ
Adv Ther 2021 Feb;38(2):949-968. Epub 2020 Dec 26 doi: 10.1007/s12325-020-01587-5. PMID: 33367987Free PMC Article
Adrenal paracoccidioidomycosis.
Román-González A, Toro JP, Arias LF
Biomedica 2020 May 1;40(Supl. 1):20-22. doi: 10.7705/biomedica.4844. PMID: 32463603Free PMC Article
Congenital adrenal hyperplasia.
Merke DP, Bornstein SR
Lancet 2005 Jun 18-24;365(9477):2125-36. doi: 10.1016/S0140-6736(05)66736-0. PMID: 15964450
Hyper- and hypoaldosteronism.
Torpy DJ, Stratakis CA, Chrousos GP
Vitam Horm 1999;57:177-216. doi: 10.1016/s0083-6729(08)60644-5. PMID: 10232050
Adrenocortical insufficiency.
Burke CW
Clin Endocrinol Metab 1985 Nov;14(4):947-76. doi: 10.1016/s0300-595x(85)80084-0. PMID: 3002680

Therapy

MANAGEMENT OF ENDOCRINE DISEASE: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: update on the management of adult patients and prenatal treatment.
Bachelot A, Grouthier V, Courtillot C, Dulon J, Touraine P
Eur J Endocrinol 2017 Apr;176(4):R167-R181. Epub 2017 Jan 23 doi: 10.1530/EJE-16-0888. PMID: 28115464
Congenital adrenal hyperplasia--pharmacologic interventions from the prenatal phase to adulthood.
Claahsen-van der Grinten HL, Stikkelbroeck NM, Otten BJ, Hermus AR
Pharmacol Ther 2011 Oct;132(1):1-14. Epub 2011 May 18 doi: 10.1016/j.pharmthera.2011.05.004. PMID: 21635919
Recent advances in diagnosis, treatment, and outcome of congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Riepe FG, Sippell WG
Rev Endocr Metab Disord 2007 Dec;8(4):349-63. doi: 10.1007/s11154-007-9053-1. PMID: 17885806
Adrenocortical insufficiency.
Burke CW
Clin Endocrinol Metab 1985 Nov;14(4):947-76. doi: 10.1016/s0300-595x(85)80084-0. PMID: 3002680
Hyporeninemic hypoaldosteronism.
Schambelan M, Sebastian A
Adv Intern Med 1979;24:385-405. PMID: 34320

Prognosis

Aldosterone deficiency with a hormone profile mimicking pseudohypoaldosteronism.
Martín-Rivada Á, Argente J, Martos-Moreno GÁ
J Pediatr Endocrinol Metab 2020 Nov 26;33(11):1501-1505. doi: 10.1515/jpem-2020-0239. PMID: 32809961
Incidence and factors of post-adrenalectomy hyperkalemia in patients with aldosterone producing adenoma.
Chiang WF, Cheng CJ, Wu ST, Sun GH, Lin MY, Sung CC, Lin SH
Clin Chim Acta 2013 Sep 23;424:114-8. Epub 2013 May 28 doi: 10.1016/j.cca.2013.05.017. PMID: 23727469
Association between genotype, clinical presentation, and severity of congenital adrenal hyperplasia: a review.
Al-Agha AE, Ocheltree AH, Al-Tamimi MD
Turk J Pediatr 2012 Jul-Aug;54(4):323-32. PMID: 23692712
X-linked congenital adrenal hypoplasia: new mutations and long-term follow-up in three patients.
Binder G, Wollmann H, Schwarze CP, Strom TM, Peter M, Ranke MB
Clin Endocrinol (Oxf) 2000 Aug;53(2):249-55. doi: 10.1046/j.1365-2265.2000.01038.x. PMID: 10931108
Reduced urinary aldosterone excretion rates with normal plasma concentrations of aldosterone in the very elderly.
Pratt JH, Hawthorne JJ, Debono DJ
Steroids 1988 Jan-Feb;51(1-2):163-71. doi: 10.1016/0039-128x(88)90191-2. PMID: 3071880

Clinical prediction guides

Renal Tubular Acidosis and Management Strategies: A Narrative Review.
Palmer BF, Kelepouris E, Clegg DJ
Adv Ther 2021 Feb;38(2):949-968. Epub 2020 Dec 26 doi: 10.1007/s12325-020-01587-5. PMID: 33367987Free PMC Article
Association between genotype, clinical presentation, and severity of congenital adrenal hyperplasia: a review.
Al-Agha AE, Ocheltree AH, Al-Tamimi MD
Turk J Pediatr 2012 Jul-Aug;54(4):323-32. PMID: 23692712
Fatty acids may regulate aldosterone secretion and mediate some of insulin's effects on blood pressure.
Goodfriend TL, Ball DL, Elliott ME, Chabhi A, Duong T, Raff H, Schneider EG, Brown RD, Weinbergers MH
Prostaglandins Leukot Essent Fatty Acids 1993 Jan;48(1):43-50. doi: 10.1016/0952-3278(93)90008-k. PMID: 8424122
Renal tubular hyperkalaemia in childhood.
Rodríguez-Soriano J, Vallo A
Pediatr Nephrol 1988 Oct;2(4):498-509. doi: 10.1007/BF00853448. PMID: 3153064
Sodium-dependent urinary acidification in patients with aldosterone deficiency and in adrenalectomized rats: effect of furosemide.
Batlle DC
Metabolism 1986 Sep;35(9):852-60. doi: 10.1016/0026-0495(86)90228-3. PMID: 3747842

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