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Inflammatory bowel disease

MedGen UID:
43877
Concept ID:
C0021390
Disease or Syndrome
Synonyms: Bowel Diseases, Inflammatory; Inflammatory Bowel Disease; Inflammatory Bowel Diseases
SNOMED CT: Inflammatory bowel disease (24526004); IBD - inflammatory bowel disease (24526004)
 
Monarch Initiative: MONDO:0005265
OMIM® Phenotypic series: PS266600
Orphanet: ORPHA104012

Definition

Inflammatory bowel disease is a systemic disorder comprised of two major disorders: ulcerative colitis and Crohn disease. Crohn disease can affect any part of the digestive system while ulcerative colitis is confined to the colon. Both disorders may affect sites outside of the digestive system [from SNOMEDCT_US]

Professional guidelines

PubMed

Lacy BE, Pimentel M, Brenner DM, Chey WD, Keefer LA, Long MD, Moshiree B
Am J Gastroenterol 2021 Jan 1;116(1):17-44. doi: 10.14309/ajg.0000000000001036. PMID: 33315591
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H; IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB
Gut 2019 Dec;68(Suppl 3):s1-s106. Epub 2019 Sep 27 doi: 10.1136/gutjnl-2019-318484. PMID: 31562236Free PMC Article
Seyedian SS, Nokhostin F, Malamir MD
J Med Life 2019 Apr-Jun;12(2):113-122. doi: 10.25122/jml-2018-0075. PMID: 31406511Free PMC Article

Curated

UK NICE Clinical Guideline CG118, Colorectal cancer prevention: colonoscopic surveillance in adults with ulcerative colitis, Crohn's disease or adenomas, 2022

Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk

Recent clinical studies

Etiology

Godala M, Gaszyńska E, Zatorski H, Małecka-Wojciesko E
Nutrients 2022 Oct 12;14(20) doi: 10.3390/nu14204261. PMID: 36296945Free PMC Article
Singh N, Bernstein CN
United European Gastroenterol J 2022 Dec;10(10):1047-1053. Epub 2022 Oct 19 doi: 10.1002/ueg2.12319. PMID: 36262056Free PMC Article
Qiu P, Ishimoto T, Fu L, Zhang J, Zhang Z, Liu Y
Front Cell Infect Microbiol 2022;12:733992. Epub 2022 Feb 22 doi: 10.3389/fcimb.2022.733992. PMID: 35273921Free PMC Article
Wu F, Huang Y, Hu J, Shao Z
BMC Med 2020 Nov 10;18(1):312. doi: 10.1186/s12916-020-01778-5. PMID: 33167994Free PMC Article
Hicks CW, Wick EC, Salvatori R, Ha CY
Inflamm Bowel Dis 2015 Jan;21(1):221-8. doi: 10.1097/MIB.0000000000000185. PMID: 25208109

Diagnosis

Bruner LP, White AM, Proksell S
Prim Care 2023 Sep;50(3):411-427. Epub 2023 May 10 doi: 10.1016/j.pop.2023.03.009. PMID: 37516511
Liu D, Saikam V, Skrada KA, Merlin D, Iyer SS
Med Res Rev 2022 Sep;42(5):1856-1887. Epub 2022 May 23 doi: 10.1002/med.21893. PMID: 35603998Free PMC Article
Eraksoy H
Gastroenterol Clin North Am 2021 Jun;50(2):341-360. doi: 10.1016/j.gtc.2021.02.004. PMID: 34024445
Wu F, Huang Y, Hu J, Shao Z
BMC Med 2020 Nov 10;18(1):312. doi: 10.1186/s12916-020-01778-5. PMID: 33167994Free PMC Article
Kelsen JR, Russo P, Sullivan KE
Immunol Allergy Clin North Am 2019 Feb;39(1):63-79. doi: 10.1016/j.iac.2018.08.008. PMID: 30466773Free PMC Article

Therapy

Paik J
Drugs 2022 Aug;82(12):1303-1313. Epub 2022 Aug 22 doi: 10.1007/s40265-022-01762-8. PMID: 35994200Free PMC Article
Chandwe K, Kelly P
Nutrients 2021 Jun 7;13(6) doi: 10.3390/nu13061956. PMID: 34200282Free PMC Article
Berg DR, Colombel JF, Ungaro R
Inflamm Bowel Dis 2019 Nov 14;25(12):1896-1905. doi: 10.1093/ibd/izz059. PMID: 30934053Free PMC Article
Weingarden AR, Vaughn BP
Gut Microbes 2017 May 4;8(3):238-252. Epub 2017 Feb 10 doi: 10.1080/19490976.2017.1290757. PMID: 28609251Free PMC Article
Nelson RL, Thomas K, Morgan J, Jones A
Cochrane Database Syst Rev 2012 Feb 15;2012(2):CD003431. doi: 10.1002/14651858.CD003431.pub3. PMID: 22336789Free PMC Article

Prognosis

Agrawal M, Jess T
United European Gastroenterol J 2022 Dec;10(10):1113-1120. Epub 2022 Oct 17 doi: 10.1002/ueg2.12317. PMID: 36251359Free PMC Article
Zhao M, Gönczi L, Lakatos PL, Burisch J
J Crohns Colitis 2021 Sep 25;15(9):1573-1587. doi: 10.1093/ecco-jcc/jjab029. PMID: 33582812
Park J, Cheon JH
Yonsei Med J 2021 Feb;62(2):99-108. doi: 10.3349/ymj.2021.62.2.99. PMID: 33527789Free PMC Article
Kaplan GG, Windsor JW
Nat Rev Gastroenterol Hepatol 2021 Jan;18(1):56-66. Epub 2020 Oct 8 doi: 10.1038/s41575-020-00360-x. PMID: 33033392Free PMC Article
Windsor JW, Kaplan GG
Curr Gastroenterol Rep 2019 Jul 23;21(8):40. doi: 10.1007/s11894-019-0705-6. PMID: 31338613

Clinical prediction guides

Murthy SK, Feuerstein JD, Nguyen GC, Velayos FS
Gastroenterology 2021 Sep;161(3):1043-1051.e4. doi: 10.1053/j.gastro.2021.05.063. PMID: 34416977
Rogler G, Singh A, Kavanaugh A, Rubin DT
Gastroenterology 2021 Oct;161(4):1118-1132. Epub 2021 Aug 3 doi: 10.1053/j.gastro.2021.07.042. PMID: 34358489Free PMC Article
Jukic A, Bakiri L, Wagner EF, Tilg H, Adolph TE
Gut 2021 Oct;70(10):1978-1988. Epub 2021 Jun 18 doi: 10.1136/gutjnl-2021-324855. PMID: 34145045Free PMC Article
Skef W, Hamilton MJ, Arayssi T
World J Gastroenterol 2015 Apr 7;21(13):3801-12. doi: 10.3748/wjg.v21.i13.3801. PMID: 25852265Free PMC Article
Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM; COLORS in IBD Study Group and NEOPICS
Gastroenterology 2014 Nov;147(5):990-1007.e3. Epub 2014 Jul 21 doi: 10.1053/j.gastro.2014.07.023. PMID: 25058236Free PMC Article

Recent systematic reviews

Ahmed W, Galati J, Kumar A, Christos PJ, Longman R, Lukin DJ, Scherl E, Battat R
Clin Gastroenterol Hepatol 2022 Mar;20(3):e361-e379. Epub 2021 Mar 31 doi: 10.1016/j.cgh.2021.03.034. PMID: 33798711
Nambu R, Warner N, Mulder DJ, Kotlarz D, McGovern DPB, Cho J, Klein C, Snapper SB, Griffiths AM, Iwama I, Muise AM
Clin Gastroenterol Hepatol 2022 Apr;20(4):e653-e663. Epub 2021 Mar 18 doi: 10.1016/j.cgh.2021.03.021. PMID: 33746097Free PMC Article
Ng SC, Shi HY, Hamidi N, Underwood FE, Tang W, Benchimol EI, Panaccione R, Ghosh S, Wu JCY, Chan FKL, Sung JJY, Kaplan GG
Lancet 2017 Dec 23;390(10114):2769-2778. Epub 2017 Oct 16 doi: 10.1016/S0140-6736(17)32448-0. PMID: 29050646
Papageorgiou SN, Hagner M, Nogueira AV, Franke A, Jäger A, Deschner J
J Clin Periodontol 2017 Apr;44(4):382-393. Epub 2017 Mar 6 doi: 10.1111/jcpe.12698. PMID: 28117909
Peyrin-Biroulet L, Sandborn W, Sands BE, Reinisch W, Bemelman W, Bryant RV, D'Haens G, Dotan I, Dubinsky M, Feagan B, Fiorino G, Gearry R, Krishnareddy S, Lakatos PL, Loftus EV Jr, Marteau P, Munkholm P, Murdoch TB, Ordás I, Panaccione R, Riddell RH, Ruel J, Rubin DT, Samaan M, Siegel CA, Silverberg MS, Stoker J, Schreiber S, Travis S, Van Assche G, Danese S, Panes J, Bouguen G, O'Donnell S, Pariente B, Winer S, Hanauer S, Colombel JF
Am J Gastroenterol 2015 Sep;110(9):1324-38. Epub 2015 Aug 25 doi: 10.1038/ajg.2015.233. PMID: 26303131

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Clinical Guideline CG118, Colorectal cancer prevention: colonoscopic surveillance in adults with ulcerative colitis, Crohn's disease or adenomas, 2022
    • Nguyen et al., 2011
      Thiopurine methyltransferase (TPMT) genotyping to predict myelosuppression risk

    Consumer resources

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