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Obstructive jaundice

MedGen UID:
43988
•Concept ID:
C0022354
•
Disease or Syndrome
Synonyms: Cholestatic Jaundice; Jaundice, Cholestatic; Jaundice, Mechanical; Jaundice, Obstructive; Mechanical Jaundice; Obstructive Jaundice
SNOMED CT: Cholestatic jaundice syndrome (44018007); Cholestatic jaundice (44018007); Obstructive hyperbilirubinemia (59848001); Obstructive jaundice (59848001)
 
Monarch Initiative: MONDO:0006874

Definition

A finding indicating increased bilirubin levels in the blood and urine, due to intrahepatic or extrahepatic obstruction of the biliary system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVObstructive jaundice

Professional guidelines

PubMed

European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations.
Löhr JM, Beuers U, Vujasinovic M, Alvaro D, Frøkjær JB, Buttgereit F, Capurso G, Culver EL, de-Madaria E, Della-Torre E, Detlefsen S, Dominguez-Muñoz E, Czubkowski P, Ewald N, Frulloni L, Gubergrits N, Duman DG, Hackert T, Iglesias-Garcia J, Kartalis N, Laghi A, Lammert F, Lindgren F, Okhlobystin A, Oracz G, Parniczky A, Mucelli RMP, Rebours V, Rosendahl J, Schleinitz N, Schneider A, van Bommel EF, Verbeke CS, Vullierme MP, Witt H; UEG guideline working group
United European Gastroenterol J 2020 Jul;8(6):637-666. Epub 2020 Jun 18 doi: 10.1177/2050640620934911. PMID: 32552502Free PMC Article
Advances of recurrent risk factors and management of choledocholithiasis.
Cai JS, Qiang S, Bao-Bing Y
Scand J Gastroenterol 2017 Jan;52(1):34-43. Epub 2016 Sep 9 doi: 10.1080/00365521.2016.1224382. PMID: 27610642
Obstructive jaundice and perioperative management.
Wang L, Yu WF
Acta Anaesthesiol Taiwan 2014 Mar;52(1):22-9. Epub 2014 May 17 doi: 10.1016/j.aat.2014.03.002. PMID: 24999215

Recent clinical studies

Etiology

The pathogenesis of renal injury in obstructive jaundice: A review of underlying mechanisms, inducible agents and therapeutic strategies.
Liu J, Qu J, Chen H, Ge P, Jiang Y, Xu C, Chen H, Shang D, Zhang G
Pharmacol Res 2021 Jan;163:105311. Epub 2020 Nov 24 doi: 10.1016/j.phrs.2020.105311. PMID: 33246170
Pathophysiological consequences of obstructive jaundice and perioperative management.
Pavlidis ET, Pavlidis TE
Hepatobiliary Pancreat Dis Int 2018 Feb;17(1):17-21. Epub 2018 Jan 31 doi: 10.1016/j.hbpd.2018.01.008. PMID: 29428098
Comparison of efficacy and complications of endoscopic and percutaneous biliary drainage in malignant obstructive jaundice: a systematic review and meta-analysis.
Duan F, Cui L, Bai Y, Li X, Yan J, Liu X
Cancer Imaging 2017 Oct 16;17(1):27. doi: 10.1186/s40644-017-0129-1. PMID: 29037223Free PMC Article
Clinical Approach to Patients With Obstructive Jaundice.
Modha K
Tech Vasc Interv Radiol 2015 Dec;18(4):197-200. Epub 2015 Jul 16 doi: 10.1053/j.tvir.2015.07.002. PMID: 26615159
TRANSHEPATIC CHOLANGIOGRAPHY.
BIRCH JR, SHEA J, CURRIE DJ
Can Med Assoc J 1964 Jun 27;90(26):1442-9. PMID: 14158553Free PMC Article

Diagnosis

Clinical Approach to Patients With Obstructive Jaundice.
Modha K
Tech Vasc Interv Radiol 2015 Dec;18(4):197-200. Epub 2015 Jul 16 doi: 10.1053/j.tvir.2015.07.002. PMID: 26615159
Mirizzi syndrome.
Bower TC, Nagorney DM
HPB Surg 1988 Sep;1(1):67-74; discussion 75-6. doi: 10.1155/1988/54294. PMID: 3153777Free PMC Article
Malignant jaundice.
Huang JF, Little JM
Aust N Z J Surg 1987 Dec;57(12):905-9. doi: 10.1111/j.1445-2197.1987.tb01292.x. PMID: 2449885
PRURITUS AND JAUNDICE.
MCPHEDRAN NT, HENDERSON RD
Can Med Assoc J 1965 Jun 12;92(24):1258-60. PMID: 14296007Free PMC Article
TRANSHEPATIC CHOLANGIOGRAPHY.
BIRCH JR, SHEA J, CURRIE DJ
Can Med Assoc J 1964 Jun 27;90(26):1442-9. PMID: 14158553Free PMC Article

Therapy

A Predictive Model Based on the Gut Microbiota Improves the Diagnostic Effect in Patients With Cholangiocarcinoma.
Zhang T, Zhang S, Jin C, Lin Z, Deng T, Xie X, Deng L, Li X, Ma J, Ding X, Liu Y, Shan Y, Yu Z, Wang Y, Chen G, Li J
Front Cell Infect Microbiol 2021;11:751795. Epub 2021 Nov 23 doi: 10.3389/fcimb.2021.751795. PMID: 34888258Free PMC Article
Pathophysiological consequences of obstructive jaundice and perioperative management.
Pavlidis ET, Pavlidis TE
Hepatobiliary Pancreat Dis Int 2018 Feb;17(1):17-21. Epub 2018 Jan 31 doi: 10.1016/j.hbpd.2018.01.008. PMID: 29428098
Comparison of efficacy and complications of endoscopic and percutaneous biliary drainage in malignant obstructive jaundice: a systematic review and meta-analysis.
Duan F, Cui L, Bai Y, Li X, Yan J, Liu X
Cancer Imaging 2017 Oct 16;17(1):27. doi: 10.1186/s40644-017-0129-1. PMID: 29037223Free PMC Article
Advances of recurrent risk factors and management of choledocholithiasis.
Cai JS, Qiang S, Bao-Bing Y
Scand J Gastroenterol 2017 Jan;52(1):34-43. Epub 2016 Sep 9 doi: 10.1080/00365521.2016.1224382. PMID: 27610642
Preoperative biliary drainage for cancer of the head of the pancreas.
van der Gaag NA, Rauws EA, van Eijck CH, Bruno MJ, van der Harst E, Kubben FJ, Gerritsen JJ, Greve JW, Gerhards MF, de Hingh IH, Klinkenbijl JH, Nio CY, de Castro SM, Busch OR, van Gulik TM, Bossuyt PM, Gouma DJ
N Engl J Med 2010 Jan 14;362(2):129-37. doi: 10.1056/NEJMoa0903230. PMID: 20071702

Prognosis

Outcome of primary ERCP versus primary PTC for biliary drainage in malignant hilar biliary strictures: a systematic review and meta-analysis.
Van Eecke E, Degroote H, Vanlander A, Hindryckx P
Surg Endosc 2022 Oct;36(10):7160-7170. Epub 2022 Aug 8 doi: 10.1007/s00464-022-09413-5. PMID: 35941311
Liver fibrosis in biliary atresia.
Shen WJ, Chen G, Wang M, Zheng S
World J Pediatr 2019 Apr;15(2):117-123. Epub 2018 Nov 21 doi: 10.1007/s12519-018-0203-1. PMID: 30465125
Advances of recurrent risk factors and management of choledocholithiasis.
Cai JS, Qiang S, Bao-Bing Y
Scand J Gastroenterol 2017 Jan;52(1):34-43. Epub 2016 Sep 9 doi: 10.1080/00365521.2016.1224382. PMID: 27610642
Pancreatic cancer.
Siriwardena AK, Siriwardena AM
BMJ 2014 Oct 31;349:g6385. doi: 10.1136/bmj.g6385. PMID: 25361852
Autoimmune pancreatitis.
Pannala R, Chari ST
Curr Opin Gastroenterol 2008 Sep;24(5):591-6. doi: 10.1097/MOG.0b013e32830b10d2. PMID: 19122500

Clinical prediction guides

A Predictive Model Based on the Gut Microbiota Improves the Diagnostic Effect in Patients With Cholangiocarcinoma.
Zhang T, Zhang S, Jin C, Lin Z, Deng T, Xie X, Deng L, Li X, Ma J, Ding X, Liu Y, Shan Y, Yu Z, Wang Y, Chen G, Li J
Front Cell Infect Microbiol 2021;11:751795. Epub 2021 Nov 23 doi: 10.3389/fcimb.2021.751795. PMID: 34888258Free PMC Article
Liver fibrosis in biliary atresia.
Shen WJ, Chen G, Wang M, Zheng S
World J Pediatr 2019 Apr;15(2):117-123. Epub 2018 Nov 21 doi: 10.1007/s12519-018-0203-1. PMID: 30465125
Clinical Approach to Patients With Obstructive Jaundice.
Modha K
Tech Vasc Interv Radiol 2015 Dec;18(4):197-200. Epub 2015 Jul 16 doi: 10.1053/j.tvir.2015.07.002. PMID: 26615159
Autoimmune pancreatitis.
Sugumar A, Chari ST
J Gastroenterol Hepatol 2011 Sep;26(9):1368-73. doi: 10.1111/j.1440-1746.2011.06843.x. PMID: 21884246
Autoimmune pancreatitis.
Toomey DP, Swan N, Torreggiani W, Conlon KC
Br J Surg 2007 Sep;94(9):1067-74. doi: 10.1002/bjs.5893. PMID: 17701958

Recent systematic reviews

Outcome of primary ERCP versus primary PTC for biliary drainage in malignant hilar biliary strictures: a systematic review and meta-analysis.
Van Eecke E, Degroote H, Vanlander A, Hindryckx P
Surg Endosc 2022 Oct;36(10):7160-7170. Epub 2022 Aug 8 doi: 10.1007/s00464-022-09413-5. PMID: 35941311
How to Choose Between Percutaneous Transhepatic and Endoscopic Biliary Drainage in Malignant Obstructive Jaundice: An Updated Systematic Review and Meta-analysis.
Rizzo A, Ricci AD, Frega G, Palloni A, DE Lorenzo S, Abbati F, Mollica V, Tavolari S, DI Marco M, Brandi G
In Vivo 2020 Jul-Aug;34(4):1701-1714. doi: 10.21873/invivo.11964. PMID: 32606139Free PMC Article
Comparison of efficacy and complications of endoscopic and percutaneous biliary drainage in malignant obstructive jaundice: a systematic review and meta-analysis.
Duan F, Cui L, Bai Y, Li X, Yan J, Liu X
Cancer Imaging 2017 Oct 16;17(1):27. doi: 10.1186/s40644-017-0129-1. PMID: 29037223Free PMC Article
Efficacy of preoperative biliary drainage in malignant obstructive jaundice: a meta-analysis and systematic review.
Moole H, Bechtold M, Puli SR
World J Surg Oncol 2016 Jul 11;14(1):182. doi: 10.1186/s12957-016-0933-2. PMID: 27400651Free PMC Article
Endoscopic ultrasonography-guided biliary drainage.
Itoi T, Sofuni A, Itokawa F, Tsuchiya T, Kurihara T, Ishii K, Tsuji S, Ikeuchi N, Umeda J, Moriyasu F, Tsuchida A
J Hepatobiliary Pancreat Sci 2010 Sep;17(5):611-6. Epub 2009 Oct 6 doi: 10.1007/s00534-009-0196-1. PMID: 19806298

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