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Obstructive jaundice

MedGen UID:
43988
•Concept ID:
C0022354
•
Disease or Syndrome
Synonyms: Cholestatic Jaundice; Jaundice, Cholestatic; Jaundice, Mechanical; Jaundice, Obstructive; Mechanical Jaundice; Obstructive Jaundice
SNOMED CT: Cholestatic jaundice syndrome (44018007); Cholestatic jaundice (44018007); Obstructive hyperbilirubinemia (59848001); Obstructive jaundice (59848001)
 
Monarch Initiative: MONDO:0006874

Definition

A finding indicating increased bilirubin levels in the blood and urine, due to intrahepatic or extrahepatic obstruction of the biliary system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVObstructive jaundice

Professional guidelines

PubMed

Evaluation and Management of Malignant Biliary Obstruction.
Guardado NV, Llorente K, Blondeau B
Surg Oncol Clin N Am 2021 Jul;30(3):491-503. doi: 10.1016/j.soc.2021.03.001. PMID: 34053664
European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations.
Löhr JM, Beuers U, Vujasinovic M, Alvaro D, Frøkjær JB, Buttgereit F, Capurso G, Culver EL, de-Madaria E, Della-Torre E, Detlefsen S, Dominguez-Muñoz E, Czubkowski P, Ewald N, Frulloni L, Gubergrits N, Duman DG, Hackert T, Iglesias-Garcia J, Kartalis N, Laghi A, Lammert F, Lindgren F, Okhlobystin A, Oracz G, Parniczky A, Mucelli RMP, Rebours V, Rosendahl J, Schleinitz N, Schneider A, van Bommel EF, Verbeke CS, Vullierme MP, Witt H; UEG guideline working group
United European Gastroenterol J 2020 Jul;8(6):637-666. Epub 2020 Jun 18 doi: 10.1177/2050640620934911. PMID: 32552502Free PMC Article
Management of Autoimmune Pancreatitis.
Madhani K, Farrell JJ
Gastrointest Endosc Clin N Am 2018 Oct;28(4):493-519. Epub 2018 Aug 1 doi: 10.1016/j.giec.2018.05.002. PMID: 30241640

Recent clinical studies

Etiology

Endoscopic management and clinical outcomes of obstructive jaundice.
Alatise OI, Owojuyigbe AM, Omisore AD, Ndububa DA, Aburime E, Dua KS, Asombang AW
Niger Postgrad Med J 2020 Oct-Dec;27(4):302-310. doi: 10.4103/npmj.npmj_242_20. PMID: 33154282
Pathophysiological consequences of obstructive jaundice and perioperative management.
Pavlidis ET, Pavlidis TE
Hepatobiliary Pancreat Dis Int 2018 Feb;17(1):17-21. Epub 2018 Jan 31 doi: 10.1016/j.hbpd.2018.01.008. PMID: 29428098
Clinical Approach to Patients With Obstructive Jaundice.
Modha K
Tech Vasc Interv Radiol 2015 Dec;18(4):197-200. Epub 2015 Jul 16 doi: 10.1053/j.tvir.2015.07.002. PMID: 26615159
Obstructive jaundice in neonates.
Wani BN, Jajoo SN
Trop Gastroenterol 2009 Oct-Dec;30(4):195-200. PMID: 20426278
TRANSHEPATIC CHOLANGIOGRAPHY.
BIRCH JR, SHEA J, CURRIE DJ
Can Med Assoc J 1964 Jun 27;90(26):1442-9. PMID: 14158553Free PMC Article

Diagnosis

Clinical Approach to Patients With Obstructive Jaundice.
Modha K
Tech Vasc Interv Radiol 2015 Dec;18(4):197-200. Epub 2015 Jul 16 doi: 10.1053/j.tvir.2015.07.002. PMID: 26615159
Advances in the investigation of obstructive jaundice.
Addley J, Mitchell RM
Curr Gastroenterol Rep 2012 Dec;14(6):511-9. doi: 10.1007/s11894-012-0285-1. PMID: 22972453
Obstructive jaundice in neonates.
Wani BN, Jajoo SN
Trop Gastroenterol 2009 Oct-Dec;30(4):195-200. PMID: 20426278
Hepatocellular carcinoma with obstructive jaundice: diagnosis, treatment and prognosis.
Qin LX, Tang ZY
World J Gastroenterol 2003 Mar;9(3):385-91. doi: 10.3748/wjg.v9.i3.385. PMID: 12632482Free PMC Article
TRANSHEPATIC CHOLANGIOGRAPHY.
BIRCH JR, SHEA J, CURRIE DJ
Can Med Assoc J 1964 Jun 27;90(26):1442-9. PMID: 14158553Free PMC Article

Therapy

EUS-Guided Choledocho-duodenostomy Using Lumen Apposing Stent Versus ERCP With Covered Metallic Stents in Patients With Unresectable Malignant Distal Biliary Obstruction: A Multicenter Randomized Controlled Trial (DRA-MBO Trial).
Teoh AYB, Napoleon B, Kunda R, Arcidiacono PG, Kongkam P, Larghi A, Van der Merwe S, Jacques J, Legros R, Thawee RE, Saxena P, Aerts M, Archibugi L, Chan SM, Fumex F, Kaffes AJ, Ma MTW, Messaoudi N, Rizzatti G, Ng KKC, Ng EKW, Chiu PWY
Gastroenterology 2023 Aug;165(2):473-482.e2. Epub 2023 Apr 28 doi: 10.1053/j.gastro.2023.04.016. PMID: 37121331
Pathophysiological consequences of obstructive jaundice and perioperative management.
Pavlidis ET, Pavlidis TE
Hepatobiliary Pancreat Dis Int 2018 Feb;17(1):17-21. Epub 2018 Jan 31 doi: 10.1016/j.hbpd.2018.01.008. PMID: 29428098
Does endoscopic ultrasound-guided biliary drainage really have clinical impact?
Ogura T, Higuchi K
World J Gastroenterol 2015 Jan 28;21(4):1049-52. doi: 10.3748/wjg.v21.i4.1049. PMID: 25632176Free PMC Article
Hepatocellular carcinoma with obstructive jaundice: endoscopic and percutaneous biliary drainage.
Minami Y, Kudo M
Dig Dis 2012;30(6):592-7. Epub 2012 Dec 13 doi: 10.1159/000343087. PMID: 23258100
Metallic biliary endoprostheses.
Adam A
Cardiovasc Intervent Radiol 1994 May-Jun;17(3):127-32. doi: 10.1007/BF00195504. PMID: 8087827

Prognosis

Liver fibrosis in biliary atresia.
Shen WJ, Chen G, Wang M, Zheng S
World J Pediatr 2019 Apr;15(2):117-123. Epub 2018 Nov 21 doi: 10.1007/s12519-018-0203-1. PMID: 30465125
Advances of recurrent risk factors and management of choledocholithiasis.
Cai JS, Qiang S, Bao-Bing Y
Scand J Gastroenterol 2017 Jan;52(1):34-43. Epub 2016 Sep 9 doi: 10.1080/00365521.2016.1224382. PMID: 27610642
Pancreatic cancer.
Siriwardena AK, Siriwardena AM
BMJ 2014 Oct 31;349:g6385. doi: 10.1136/bmj.g6385. PMID: 25361852
Pathogenesis of cholangitis in obstructive jaundice-revisited.
Navaneethan U, Jayanthi V, Mohan P
Minerva Gastroenterol Dietol 2011 Mar;57(1):97-104. PMID: 21372774
Autoimmune pancreatitis.
Pannala R, Chari ST
Curr Opin Gastroenterol 2008 Sep;24(5):591-6. doi: 10.1097/MOG.0b013e32830b10d2. PMID: 19122500

Clinical prediction guides

Liver fibrosis in biliary atresia.
Shen WJ, Chen G, Wang M, Zheng S
World J Pediatr 2019 Apr;15(2):117-123. Epub 2018 Nov 21 doi: 10.1007/s12519-018-0203-1. PMID: 30465125
Clinical Approach to Patients With Obstructive Jaundice.
Modha K
Tech Vasc Interv Radiol 2015 Dec;18(4):197-200. Epub 2015 Jul 16 doi: 10.1053/j.tvir.2015.07.002. PMID: 26615159
Autoimmune pancreatitis.
Sugumar A, Chari ST
J Gastroenterol Hepatol 2011 Sep;26(9):1368-73. doi: 10.1111/j.1440-1746.2011.06843.x. PMID: 21884246
Autoimmune pancreatitis.
Toomey DP, Swan N, Torreggiani W, Conlon KC
Br J Surg 2007 Sep;94(9):1067-74. doi: 10.1002/bjs.5893. PMID: 17701958
Hemobilia.
Goodnight JE Jr, Blaisdell FW
Surg Clin North Am 1981 Aug;61(4):973-9. doi: 10.1016/s0039-6109(16)42493-x. PMID: 7025304

Recent systematic reviews

Comparison of Efficacy and Safety between Endoscopic Retrograde Cholangiopancreatography and Percutaneous Transhepatic Cholangial Drainage for the Treatment of Malignant Obstructive Jaundice: A Systematic Review and Meta-Analysis.
Pang L, Wu S, Kong J
Digestion 2023;104(2):85-96. Epub 2023 Jan 6 doi: 10.1159/000528020. PMID: 36617409Free PMC Article
How to Choose Between Percutaneous Transhepatic and Endoscopic Biliary Drainage in Malignant Obstructive Jaundice: An Updated Systematic Review and Meta-analysis.
Rizzo A, Ricci AD, Frega G, Palloni A, DE Lorenzo S, Abbati F, Mollica V, Tavolari S, DI Marco M, Brandi G
In Vivo 2020 Jul-Aug;34(4):1701-1714. doi: 10.21873/invivo.11964. PMID: 32606139Free PMC Article
Efficacy of preoperative biliary drainage in malignant obstructive jaundice: a meta-analysis and systematic review.
Moole H, Bechtold M, Puli SR
World J Surg Oncol 2016 Jul 11;14(1):182. doi: 10.1186/s12957-016-0933-2. PMID: 27400651Free PMC Article
Endoscopic ultrasonography-guided biliary drainage.
Itoi T, Sofuni A, Itokawa F, Tsuchiya T, Kurihara T, Ishii K, Tsuji S, Ikeuchi N, Umeda J, Moriyasu F, Tsuchida A
J Hepatobiliary Pancreat Sci 2010 Sep;17(5):611-6. Epub 2009 Oct 6 doi: 10.1007/s00534-009-0196-1. PMID: 19806298
Palliation of malignant obstructive jaundice.
Garcea G, Ong SL, Dennison AR, Berry DP, Maddern GJ
Dig Dis Sci 2009 Jun;54(6):1184-98. Epub 2008 Sep 4 doi: 10.1007/s10620-008-0479-4. PMID: 18770035

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