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Dry eye syndrome

MedGen UID:
4411
•Concept ID:
C0013238
•
Disease or Syndrome
Synonyms: Dry Eye Disease; Dry Eye Diseases; Dry Eye Syndrome; Dry Eye Syndromes
SNOMED CT: Dry eye syndrome (46152009)
 
Monarch Initiative: MONDO:0006733

Definition

A syndrome characterized by dryness of the cornea and conjunctiva. It is usually caused by a deficiency in tear production. Symptoms include a feeling of burning eyes and a possible foreign body presence in the eye. [from NCI]

Professional guidelines

PubMed

A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome.
Yang YJ, Lee WY, Kim YJ, Hong YP
Int J Environ Res Public Health 2021 Mar 1;18(5) doi: 10.3390/ijerph18052383. PMID: 33804439Free PMC Article
Dry Eye Syndrome Preferred Practice Pattern®.
Akpek EK, Amescua G, Farid M, Garcia-Ferrer FJ, Lin A, Rhee MK, Varu DM, Musch DC, Dunn SP, Mah FS; American Academy of Ophthalmology Preferred Practice Pattern Cornea and External Disease Panel
Ophthalmology 2019 Jan;126(1):P286-P334. Epub 2018 Oct 23 doi: 10.1016/j.ophtha.2018.10.023. PMID: 30366798
Dry Eye Disease: Prevalence, Assessment, and Management.
Rouen PA, White ML
Home Healthc Now 2018 Mar/Apr;36(2):74-83. doi: 10.1097/NHH.0000000000000652. PMID: 29498987

Recent clinical studies

Etiology

Identified risk factors for dry eye syndrome: A systematic review and meta-analysis.
Qian L, Wei W
PLoS One 2022;17(8):e0271267. Epub 2022 Aug 19 doi: 10.1371/journal.pone.0271267. PMID: 35984830Free PMC Article
Diabetes mellitus is associated with dry eye syndrome: a meta-analysis.
Yoo TK, Oh E
Int Ophthalmol 2019 Nov;39(11):2611-2620. Epub 2019 May 7 doi: 10.1007/s10792-019-01110-y. PMID: 31065905
Menopause and Dry Eye Syndrome.
Lurati AR
Nurs Womens Health 2019 Feb;23(1):71-78. Epub 2018 Dec 27 doi: 10.1016/j.nwh.2018.11.001. PMID: 30594503
Dry Eye Disease: Prevalence, Assessment, and Management.
Rouen PA, White ML
Home Healthc Now 2018 Mar/Apr;36(2):74-83. doi: 10.1097/NHH.0000000000000652. PMID: 29498987
Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause.
Sullivan SD, Sarrel PM, Nelson LM
Fertil Steril 2016 Dec;106(7):1588-1599. doi: 10.1016/j.fertnstert.2016.09.046. PMID: 27912889Free PMC Article

Diagnosis

Fibromyalgia syndrome and the eye-A review.
Zdebik N, Zdebik A, Bogusławska J, Przeździecka-Dołyk J, Turno-Kręcicka A
Surv Ophthalmol 2021 Jan-Feb;66(1):132-137. Epub 2020 Jun 5 doi: 10.1016/j.survophthal.2020.05.006. PMID: 32512032
Menopause and Dry Eye Syndrome.
Lurati AR
Nurs Womens Health 2019 Feb;23(1):71-78. Epub 2018 Dec 27 doi: 10.1016/j.nwh.2018.11.001. PMID: 30594503
Dry Eye Syndrome Preferred Practice Pattern®.
Akpek EK, Amescua G, Farid M, Garcia-Ferrer FJ, Lin A, Rhee MK, Varu DM, Musch DC, Dunn SP, Mah FS; American Academy of Ophthalmology Preferred Practice Pattern Cornea and External Disease Panel
Ophthalmology 2019 Jan;126(1):P286-P334. Epub 2018 Oct 23 doi: 10.1016/j.ophtha.2018.10.023. PMID: 30366798
Dry Eye Disease: Prevalence, Assessment, and Management.
Rouen PA, White ML
Home Healthc Now 2018 Mar/Apr;36(2):74-83. doi: 10.1097/NHH.0000000000000652. PMID: 29498987
Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause.
Sullivan SD, Sarrel PM, Nelson LM
Fertil Steril 2016 Dec;106(7):1588-1599. doi: 10.1016/j.fertnstert.2016.09.046. PMID: 27912889Free PMC Article

Therapy

Identified risk factors for dry eye syndrome: A systematic review and meta-analysis.
Qian L, Wei W
PLoS One 2022;17(8):e0271267. Epub 2022 Aug 19 doi: 10.1371/journal.pone.0271267. PMID: 35984830Free PMC Article
Can Gut Microbiota Affect Dry Eye Syndrome?
Moon J, Yoon CH, Choi SH, Kim MK
Int J Mol Sci 2020 Nov 10;21(22) doi: 10.3390/ijms21228443. PMID: 33182758Free PMC Article
Topical cyclosporine A therapy for dry eye syndrome.
de Paiva CS, Pflugfelder SC, Ng SM, Akpek EK
Cochrane Database Syst Rev 2019 Sep 13;9(9):CD010051. doi: 10.1002/14651858.CD010051.pub2. PMID: 31517988Free PMC Article
Dry Eye Syndrome Preferred Practice Pattern®.
Akpek EK, Amescua G, Farid M, Garcia-Ferrer FJ, Lin A, Rhee MK, Varu DM, Musch DC, Dunn SP, Mah FS; American Academy of Ophthalmology Preferred Practice Pattern Cornea and External Disease Panel
Ophthalmology 2019 Jan;126(1):P286-P334. Epub 2018 Oct 23 doi: 10.1016/j.ophtha.2018.10.023. PMID: 30366798
Dry Eye Disease: Prevalence, Assessment, and Management.
Rouen PA, White ML
Home Healthc Now 2018 Mar/Apr;36(2):74-83. doi: 10.1097/NHH.0000000000000652. PMID: 29498987

Prognosis

The expression of miRNA-146a-5p and its mechanism of treating dry eye syndrome.
Yin L, Zhang M, He T, Chen S
J Clin Lab Anal 2021 Jan;35(1):e23571. Epub 2020 Sep 16 doi: 10.1002/jcla.23571. PMID: 32935891Free PMC Article
Diabetes mellitus is associated with dry eye syndrome: a meta-analysis.
Yoo TK, Oh E
Int Ophthalmol 2019 Nov;39(11):2611-2620. Epub 2019 May 7 doi: 10.1007/s10792-019-01110-y. PMID: 31065905
Dry Eye Disease: Prevalence, Assessment, and Management.
Rouen PA, White ML
Home Healthc Now 2018 Mar/Apr;36(2):74-83. doi: 10.1097/NHH.0000000000000652. PMID: 29498987
Angiogenin for the Diagnosis and Grading of Dry Eye Syndrome.
Kim WS, Wee SW, Lee SH, Kim JC
Korean J Ophthalmol 2016 Jun;30(3):163-71. Epub 2016 May 18 doi: 10.3341/kjo.2016.30.3.163. PMID: 27247515Free PMC Article
Androgen deficiency and dry eye syndrome in the aging male.
Azcarate PM, Venincasa VD, Feuer W, Stanczyk F, Schally AV, Galor A
Invest Ophthalmol Vis Sci 2014 Jul 3;55(8):5046-53. doi: 10.1167/iovs.14-14689. PMID: 24994872Free PMC Article

Clinical prediction guides

A Meta-Analysis of the Efficacy of Hyaluronic Acid Eye Drops for the Treatment of Dry Eye Syndrome.
Yang YJ, Lee WY, Kim YJ, Hong YP
Int J Environ Res Public Health 2021 Mar 1;18(5) doi: 10.3390/ijerph18052383. PMID: 33804439Free PMC Article
Fibromyalgia syndrome and the eye-A review.
Zdebik N, Zdebik A, Bogusławska J, Przeździecka-Dołyk J, Turno-Kręcicka A
Surv Ophthalmol 2021 Jan-Feb;66(1):132-137. Epub 2020 Jun 5 doi: 10.1016/j.survophthal.2020.05.006. PMID: 32512032
Can Gut Microbiota Affect Dry Eye Syndrome?
Moon J, Yoon CH, Choi SH, Kim MK
Int J Mol Sci 2020 Nov 10;21(22) doi: 10.3390/ijms21228443. PMID: 33182758Free PMC Article
Topical cyclosporine A therapy for dry eye syndrome.
de Paiva CS, Pflugfelder SC, Ng SM, Akpek EK
Cochrane Database Syst Rev 2019 Sep 13;9(9):CD010051. doi: 10.1002/14651858.CD010051.pub2. PMID: 31517988Free PMC Article
Diabetes mellitus is associated with dry eye syndrome: a meta-analysis.
Yoo TK, Oh E
Int Ophthalmol 2019 Nov;39(11):2611-2620. Epub 2019 May 7 doi: 10.1007/s10792-019-01110-y. PMID: 31065905

Recent systematic reviews

Identified risk factors for dry eye syndrome: A systematic review and meta-analysis.
Qian L, Wei W
PLoS One 2022;17(8):e0271267. Epub 2022 Aug 19 doi: 10.1371/journal.pone.0271267. PMID: 35984830Free PMC Article
Vitamin D and Ocular Diseases: A Systematic Review.
Chan HN, Zhang XJ, Ling XT, Bui CH, Wang YM, Ip P, Chu WK, Chen LJ, Tham CC, Yam JC, Pang CP
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084226. PMID: 35457041Free PMC Article
Ocular Manifestations in Rheumatoid Arthritis, Connective Tissue Disease, and Vasculitis: A Systematic Review and Metaanalysis.
Turk MA, Hayworth JL, Nevskaya T, Pope JE
J Rheumatol 2021 Jan 1;48(1):25-34. Epub 2020 May 1 doi: 10.3899/jrheum.190768. PMID: 32358156
Efficacy and safety of topical and systemic medications: a systematic literature review informing the EULAR recommendations for the management of Sjögren's syndrome.
Brito-Zerón P, Retamozo S, Kostov B, Baldini C, Bootsma H, De Vita S, Dörner T, Gottenberg JE, Kruize AA, Mandl T, Ng WF, Seror R, Tzioufas AG, Vitali C, Bowman S, Mariette X, Ramos-Casals M
RMD Open 2019;5(2):e001064. Epub 2019 Oct 28 doi: 10.1136/rmdopen-2019-001064. PMID: 31749986Free PMC Article
Topical cyclosporine A therapy for dry eye syndrome.
de Paiva CS, Pflugfelder SC, Ng SM, Akpek EK
Cochrane Database Syst Rev 2019 Sep 13;9(9):CD010051. doi: 10.1002/14651858.CD010051.pub2. PMID: 31517988Free PMC Article

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