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Leriche syndrome

MedGen UID:: 44114
•Concept ID:: C0023370
•: Disease or Syndrome

Synonyms:	Leriche Syndrome; Leriche's Syndrome; Leriches Syndrome; Syndrome, Leriche; Syndrome, Leriche's
SNOMED CT:	Leriche syndrome (307816004); Aortic bifurcation syndrome (233972005); Saddle embolus (233972005); Aortoiliac obstruction (233972005); Saddle embolus of abdominal aorta (233972005); Aortic bifurcation embolus (233972005); Leriche's syndrome (307816004); Saddle embolus (37778000)

Monarch Initiative:	MONDO:0043683

Definition

An atherosclerotic disorder of the peripheral vascular system affecting mostly males in their later decades. It is caused by thrombotic occlusion of the abdominal aorta just above the level of the bifurcation. Clinical signs include impotence, intermittent claudication, diminished femoral pulses and cold, pallid lower extremities. Prognosis is favorable with surgical or endovascular intervention. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLeriche syndrome

Disorder by Site
- Disorder of cardiovascular system
  - Non-Neoplastic Cardiovascular Disorder
    - Non-Neoplastic Vascular Disorder
      - Arterial disorder
        Aortic disorder
        Leriche syndrome

Professional guidelines

PubMed

Endovascular management of aorto-iliac occlusive disease (Leriche syndrome).

Liang HL, Li MF, Hsiao CC, Wu CJ, Wu TH
J Formos Med Assoc 2021 Jul;120(7):1485-1492. Epub 2020 Nov 12 doi: 10.1016/j.jfma.2020.10.033. PMID: 33189506

THE LERICHE SYNDROME-PRESENT CONCEPTS OF DIAGNOSIS AND TREATMENT.

SPENCER FC
Med Rec Ann 1964 Aug;57:443-6. PMID: 14179813

VASOSPASTIC REACTION TO METHYSERGIDE MALEATE SIMULATING LERICHE SYNDROME: INEFFECTIVE TREATMENT WITH ADRENERGIC BLOCKADE.

DANIELL HW
Ann Intern Med 1964 May;60:881-5. doi: 10.7326/0003-4819-60-5-881. PMID: 14156613

See all (3)

Recent clinical studies

Etiology

Endovascular Aorto-Iliac Reconstruction vs. Aortobifemoral Bypass as First Choice for a Durable Revascularization for Aorto-Iliac Occlusive Disease.

Choudhry AJ, Shaw PM
Vasc Endovascular Surg 2023 Jan;57(1):88-92. Epub 2022 Sep 29 doi: 10.1177/15385744221130870. PMID: 36172836

Pre and Postoperative Sexual Dysfunction in Patients with Leriche Syndrome-A Prospective Pilot Study.

Tkocz M, Brzęk A, Marcinek M, Skrzypulec-Plinta V, Ziaja D
Int J Environ Res Public Health 2022 Mar 6;19(5) doi: 10.3390/ijerph19053091. PMID: 35270783 Free PMC Article

Endovascular Reconstruction for Total Aorto-Iliac Occlusion.

Piffaretti G, Fargion AT, Dorigo W, Pulli R, Ferri M, Antonello M, Bellosta R, Veraldi G, Benedetto F, Gargiulo M, Pratesi C; ILIACS Registry Group
J Endovasc Ther 2022 Aug;29(4):565-575. Epub 2021 Dec 1 doi: 10.1177/15266028211059908. PMID: 35112596

Evaluation of Therapeutic Effects on Collateral Circulation in Patients with Chronic Leriche Syndrome: a Case-Control Study of Intraluminal Stent Implantation and Surgical Bypass Grafting.

Guan J, Peng Y, Ouyang L, Li C, Fu W, Sun C, Zhou X
Cardiovasc Intervent Radiol 2021 Apr;44(4):550-557. Epub 2021 Jan 14 doi: 10.1007/s00270-020-02766-1. PMID: 33447923

Endovascular management of aorto-iliac occlusive disease (Leriche syndrome).

Liang HL, Li MF, Hsiao CC, Wu CJ, Wu TH
J Formos Med Assoc 2021 Jul;120(7):1485-1492. Epub 2020 Nov 12 doi: 10.1016/j.jfma.2020.10.033. PMID: 33189506

See all (80)

Diagnosis

Leriche syndrome.

Matsuura H, Honda H
Cleve Clin J Med 2021 Sep 1;88(9):482-483. doi: 10.3949/ccjm.88a.20179. PMID: 34470750

Evaluation of Therapeutic Effects on Collateral Circulation in Patients with Chronic Leriche Syndrome: a Case-Control Study of Intraluminal Stent Implantation and Surgical Bypass Grafting.

Guan J, Peng Y, Ouyang L, Li C, Fu W, Sun C, Zhou X
Cardiovasc Intervent Radiol 2021 Apr;44(4):550-557. Epub 2021 Jan 14 doi: 10.1007/s00270-020-02766-1. PMID: 33447923

Anatomical significance in aortoiliac occlusive disease.

Wooten C, Hayat M, du Plessis M, Cesmebasi A, Koesterer M, Daly KP, Matusz P, Tubbs RS, Loukas M
Clin Anat 2014 Nov;27(8):1264-74. Epub 2014 Jul 25 doi: 10.1002/ca.22444. PMID: 25065617

Leriche syndrome.

Liao SL, Luthra M, Rogers KM
J Am Coll Cardiol 2009 Nov 3;54(19):e11. doi: 10.1016/j.jacc.2009.06.037. PMID: 19874987

Leriche's syndrome.

Julsrud ME
J Am Podiatr Med Assoc 1992 Apr;82(4):196-201. doi: 10.7547/87507315-82-4-196. PMID: 1597828

See all (104)

Therapy

Endovascular Aorto-Iliac Reconstruction vs. Aortobifemoral Bypass as First Choice for a Durable Revascularization for Aorto-Iliac Occlusive Disease.

Choudhry AJ, Shaw PM
Vasc Endovascular Surg 2023 Jan;57(1):88-92. Epub 2022 Sep 29 doi: 10.1177/15385744221130870. PMID: 36172836

Endovascular Reconstruction for Total Aorto-Iliac Occlusion.

Leriche syndrome in a patient with acute pulmonary embolism and acute myocardial infarction: a case report and review of literature.

An X, Fu R, Zhao Z, Ni X, Xiong C, Cheng X, Liu Z
BMC Cardiovasc Disord 2020 Jan 17;20(1):26. doi: 10.1186/s12872-019-01288-0. PMID: 31952498 Free PMC Article

Surgical and endovascular treatment of occlusive aortic syndromes.

Verma H, Baliga K, George RK, Tripathi RK
J Cardiovasc Surg (Torino) 2013 Feb;54(1 Suppl 1):55-69. PMID: 23443590

Transradial approach to lower extremity interventions.

Korabathina R, Yadav SS, Coppola JT, Staniloae CS
Vasc Health Risk Manag 2010 Aug 9;6:503-9. doi: 10.2147/vhrm.s11529. PMID: 20730066 Free PMC Article

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Prognosis

Transapical transcatheter aortic valve implantation in patients with aortic diseases.

Useini D, Beluli B, Christ H, Schlömicher M, Ewais E, Patsalis P, Haldenwang P, Naraghi H, Moustafine V, Bechtel M, Strauch J
Eur J Cardiothorac Surg 2021 Jun 14;59(6):1174-1181. doi: 10.1093/ejcts/ezab050. PMID: 33709139

Midterm outcomes of endovascular treatment with bare metal stents for Leriche syndrome patients.

Zhang B, Niu G, Yan Z, Zou Y, Tong X, Yang M
Interact Cardiovasc Thorac Surg 2021 Jan 1;32(1):83-88. doi: 10.1093/icvts/ivaa223. PMID: 33221834 Free PMC Article

Accelerated Atherogenicity in Tangier Disease.

Muratsu J, Koseki M, Masuda D, Yasuga Y, Tomoyama S, Ataka K, Yagi Y, Nakagawa A, Hamada H, Fujita S, Hattori H, Ohama T, Nishida M, Hiraoka H, Matsuzawa Y, Yamashita S
J Atheroscler Thromb 2018 Oct 1;25(10):1076-1085. Epub 2018 Mar 20 doi: 10.5551/jat.43257. PMID: 29563393 Free PMC Article

The best treatment of juxtarenal aortic occlusion is and will be open surgery.

Marrocco-Trischitta MM, Bertoglio L, Tshomba Y, Kahlberg A, Marone EM, Chiesa R
J Cardiovasc Surg (Torino) 2012 Jun;53(3):307-12. PMID: 22695263

Infrarenal aortic coarctation.

Alpagut U, Ugurlucan M, Sayin OA, Tireli E, Dayioglu E
Wien Med Wochenschr 2010 Jul;160(13-14):372-5. doi: 10.1007/s10354-010-0810-5. PMID: 20694768

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Clinical prediction guides

Pre and Postoperative Sexual Dysfunction in Patients with Leriche Syndrome-A Prospective Pilot Study.

Tkocz M, Brzęk A, Marcinek M, Skrzypulec-Plinta V, Ziaja D
Int J Environ Res Public Health 2022 Mar 6;19(5) doi: 10.3390/ijerph19053091. PMID: 35270783 Free PMC Article

Endovascular Reconstruction for Total Aorto-Iliac Occlusion.

Outcome Analysis and Risk Factors for Perioperative Myocardial Ischemia After Elective Aortic Surgery.

Dovzhanskiy DI, Jäckel P, Bischoff MS, Hakimi M, Hinz U, Böckler D
Ann Vasc Surg 2022 Jan;78:209-219. Epub 2021 Jun 25 doi: 10.1016/j.avsg.2021.04.046. PMID: 34175413

Transapical transcatheter aortic valve implantation in patients with aortic diseases.

Accelerated Atherogenicity in Tangier Disease.

See all (38)