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Childhood acute lymphoblastic leukemia

MedGen UID:: 44122
•Concept ID:: C0023452
•: Neoplastic Process

Synonyms:	ALL, Childhood; Childhood ALL; L1 Lymphocytic Leukemia; Leukemia, L1 Lymphocytic; Leukemia, Lymphoblastic, Acute, L1; Leukemia, Lymphocytic, Acute, L1; Lymphoblastic Leukemia, Acute, Childhood; Lymphoblastic Leukemia, Acute, L1; Lymphocytic Leukemia, L1

Monarch Initiative:	MONDO:0000870

Definition

An acute lymphoblastic leukemia (current term: precursor lymphoblastic leukemia) of B-or T-cell origin which according to the FAB classification is characterized by the presence of more mature-appearing lymphoblasts. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAcute lymphoid leukemia
- CROGVChildhood acute lymphoblastic leukemia

Hematopoietic and Lymphoid System Disorder
- Hematologic disorder
  - Hematologic neoplasm
    - Leukemia
      - Acute leukemia
        Acute lymphoid leukemia
        Childhood acute lymphoblastic leukemia
        Adult L1 Acute Lymphoblastic Leukemia
        B-cell childhood acute lymphoblastic leukemia
        Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1
        Childhood L1 Acute Lymphoblastic Leukemia
        Infant Acute Lymphoblastic Leukemia
        Infant Acute Lymphoblastic Leukemia with MLL Rearrangement
        Infant Acute Lymphoblastic Leukemia without MLL Gene Rearrangement
        Infant T Acute Lymphoblastic Leukemia
        Recurrent Childhood Acute Lymphoblastic Leukemia
        Recurrent Childhood T Acute Lymphoblastic Leukemia
        Refractory Childhood Acute Lymphoblastic Leukemia
        T-cell childhood acute lymphocytic leukemia

Professional guidelines

PubMed

L-Asparaginase as the gold standard in the treatment of acute lymphoblastic leukemia: a comprehensive review.

Tosta Pérez M, Herrera Belén L, Letelier P, Calle Y, Pessoa A, Farías JG
Med Oncol 2023 Apr 15;40(5):150. doi: 10.1007/s12032-023-02014-9. PMID: 37060469

Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response.

Lee SHR, Yang W, Gocho Y, John A, Rowland L, Smart B, Williams H, Maxwell D, Hunt J, Yang W, Crews KR, Roberts KG, Jeha S, Cheng C, Karol SE, Relling MV, Rosner GL, Inaba H, Mullighan CG, Pui CH, Evans WE, Yang JJ
Nat Med 2023 Jan;29(1):170-179. Epub 2023 Jan 5 doi: 10.1038/s41591-022-02112-7. PMID: 36604538 Free PMC Article

Pharmacogenetic Predictors of Treatment-Related Toxicity Among Children With Acute Lymphoblastic Leukemia.

Maxwell RR, Cole PD
Curr Hematol Malig Rep 2017 Jun;12(3):176-186. doi: 10.1007/s11899-017-0376-z. PMID: 28317081

See all (305)

Recent clinical studies

Etiology

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.

Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325 Free PMC Article

lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review.

Illarregi U, Telleria J, Bilbao-Aldaiturriaga N, Lopez-Lopez E, Ballesteros J, Martin-Guerrero I, Gutierrez-Camino A
Int J Oncol 2022 May;60(5) Epub 2022 Apr 8 doi: 10.3892/ijo.2022.5348. PMID: 35419612

Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.

Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896 Free PMC Article

Genetic susceptibility in childhood acute lymphoblastic leukemia.

Gutierrez-Camino A, Martin-Guerrero I, García-Orad A
Med Oncol 2017 Sep 13;34(10):179. doi: 10.1007/s12032-017-1038-7. PMID: 28905228

Biology of childhood acute lymphoblastic leukemia.

Bhojwani D, Yang JJ, Pui CH
Pediatr Clin North Am 2015 Feb;62(1):47-60. doi: 10.1016/j.pcl.2014.09.004. PMID: 25435111 Free PMC Article

See all (2073)

Diagnosis

Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions.

Thastrup M, Duguid A, Mirian C, Schmiegelow K, Halsey C
Leukemia 2022 Dec;36(12):2751-2768. Epub 2022 Oct 20 doi: 10.1038/s41375-022-01714-x. PMID: 36266325 Free PMC Article

Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.

Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896 Free PMC Article

Metabolic reprogramming in childhood acute lymphoblastic leukemia.

Sbirkov Y, Burnusuzov H, Sarafian V
Pediatr Blood Cancer 2020 Jun;67(6):e28255. Epub 2020 Apr 15 doi: 10.1002/pbc.28255. PMID: 32293782

Predicting and Preventing Anthracycline-Related Cardiotoxicity.

Armenian S, Bhatia S
Am Soc Clin Oncol Educ Book 2018 May 23;38:3-12. doi: 10.1200/EDBK_100015. PMID: 30231396

Acute lymphoid leukemia.

Bleyer WA
Pediatr Ann 1983 Apr;12(4):277-92. doi: 10.3928/0090-4481-19830401-02. PMID: 6346242

See all (1619)

Therapy

Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.

Tran TH, Langlois S, Meloche C, Caron M, Saint-Onge P, Rouette A, Bataille AR, Jimenez-Cortes C, Sontag T, Bittencourt H, Laverdière C, Lavallée VP, Leclerc JM, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Michon B, Santiago R, Stevenson KE, Welch JJG, Schroeder KM, Koch V, Cellot S, Silverman LB, Sinnett D
Blood Adv 2022 Feb 22;6(4):1329-1341. doi: 10.1182/bloodadvances.2021005634. PMID: 34933343 Free PMC Article

Bone health in glucocorticoid-treated childhood acute lymphoblastic leukemia.

Velentza L, Zaman F, Sävendahl L
Crit Rev Oncol Hematol 2021 Dec;168:103492. Epub 2021 Oct 13 doi: 10.1016/j.critrevonc.2021.103492. PMID: 34655742

Pharmacogenomic and Pharmacotranscriptomic Profiling of Childhood Acute Lymphoblastic Leukemia: Paving the Way to Personalized Treatment.

Pavlovic S, Kotur N, Stankovic B, Zukic B, Gasic V, Dokmanovic L
Genes (Basel) 2019 Mar 1;10(3) doi: 10.3390/genes10030191. PMID: 30832275 Free PMC Article

Pharmacogenomics in acute lymphoblastic leukemia.

Lee SHR, Yang JJ
Best Pract Res Clin Haematol 2017 Sep;30(3):229-236. Epub 2017 Jul 27 doi: 10.1016/j.beha.2017.07.007. PMID: 29050696

Novel therapy for childhood acute lymphoblastic leukemia.

Santiago R, Vairy S, Sinnett D, Krajinovic M, Bittencourt H
Expert Opin Pharmacother 2017 Aug;18(11):1081-1099. Epub 2017 Jun 26 doi: 10.1080/14656566.2017.1340938. PMID: 28608730

See all (1427)

Prognosis

Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.

Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896 Free PMC Article

Efficacy and Toxicity of Pegaspargase and Calaspargase Pegol in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 11-001.

Vrooman LM, Blonquist TM, Stevenson KE, Supko JG, Hunt SK, Cronholm SM, Koch V, Kay-Green S, Athale UH, Clavell LA, Cole PD, Harris MH, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Place AE, Schorin MA, Welch JJG, Neuberg DS, Sallan SE, Silverman LB
J Clin Oncol 2021 Nov 1;39(31):3496-3505. Epub 2021 Jul 6 doi: 10.1200/JCO.20.03692. PMID: 34228505

TP53 alterations in relapsed childhood acute lymphoblastic leukemia.

Yu CH, Chang WT, Jou ST, Lin TK, Chang YH, Lin CY, Lin KH, Lu MY, Chen SH, Wu KH, Wang SC, Chang HH, Su YN, Hung CC, Lin DT, Chen HY, Yang YL
Cancer Sci 2020 Jan;111(1):229-238. Epub 2019 Dec 5 doi: 10.1111/cas.14238. PMID: 31729120 Free PMC Article

Improved CNS Control of Childhood Acute Lymphoblastic Leukemia Without Cranial Irradiation: St Jude Total Therapy Study 16.

Jeha S, Pei D, Choi J, Cheng C, Sandlund JT, Coustan-Smith E, Campana D, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, Khan RB, Yang JJ, Mullighan CG, Downing JR, Evans WE, Relling MV, Pui CH
J Clin Oncol 2019 Dec 10;37(35):3377-3391. Epub 2019 Oct 28 doi: 10.1200/JCO.19.01692. PMID: 31657981 Free PMC Article

Genomics of racial and ethnic disparities in childhood acute lymphoblastic leukemia.

Lim JY, Bhatia S, Robison LL, Yang JJ
Cancer 2014 Apr 1;120(7):955-62. Epub 2013 Dec 30 doi: 10.1002/cncr.28531. PMID: 24382716 Free PMC Article

See all (1490)

Clinical prediction guides

Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children.

Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896 Free PMC Article

Metabolic reprogramming in childhood acute lymphoblastic leukemia.

Sbirkov Y, Burnusuzov H, Sarafian V
Pediatr Blood Cancer 2020 Jun;67(6):e28255. Epub 2020 Apr 15 doi: 10.1002/pbc.28255. PMID: 32293782

Predicting and Preventing Anthracycline-Related Cardiotoxicity.

Armenian S, Bhatia S
Am Soc Clin Oncol Educ Book 2018 May 23;38:3-12. doi: 10.1200/EDBK_100015. PMID: 30231396

Novel therapy for childhood acute lymphoblastic leukemia.

Santiago R, Vairy S, Sinnett D, Krajinovic M, Bittencourt H
Expert Opin Pharmacother 2017 Aug;18(11):1081-1099. Epub 2017 Jun 26 doi: 10.1080/14656566.2017.1340938. PMID: 28608730

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.

Pui CH, Yang JJ, Hunger SP, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman LB, Schmiegelow K, Escherich G, Horibe K, Benoit YC, Izraeli S, Yeoh AE, Liang DC, Downing JR, Evans WE, Relling MV, Mullighan CG
J Clin Oncol 2015 Sep 20;33(27):2938-48. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.1636. PMID: 26304874 Free PMC Article

See all (1083)

Recent systematic reviews

lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review.

Maternal antibiotics exposure during pregnancy and the risk of acute lymphoblastic leukemia in childhood: a systematic review and meta-analysis.

Zhu X, Meng Y, Yang Y, Feng N
Eur J Pediatr 2022 Feb;181(2):471-478. Epub 2021 Sep 17 doi: 10.1007/s00431-021-04247-0. PMID: 34535829

Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.

Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914

miRNA deregulation in childhood acute lymphoblastic leukemia: a systematic review.

Gutierrez-Camino A, Garcia-Obregon S, Lopez-Lopez E, Astigarraga I, Garcia-Orad A
Epigenomics 2020 Jan;12(1):69-80. Epub 2019 Dec 13 doi: 10.2217/epi-2019-0154. PMID: 31833405

Minimal Residual Disease Evaluation in Childhood Acute Lymphoblastic Leukemia: An Economic Analysis.

Health Quality Ontario
Ont Health Technol Assess Ser 2016;16(8):1-83. Epub 2016 Mar 8 PMID: 27099644 Free PMC Article

See all (28)

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Childhood acute lymphoblastic leukemia

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Consumer resources

Reviews

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