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Leukemia-Lymphoma, Adult T-Cell

MedGen UID:
44128
Concept ID:
C0023493
Neoplastic Process
Synonyms: Adult T-Cell Leukemia; Adult T-Cell Leukemia-Lymphoma; Adult T-Cell Leukemia-Lymphomas; Adult T-Cell Leukemias; ATLL; HTLV Associated Leukemia Lymphoma; HTLV I Associated T Cell Leukemia Lymphoma; HTLV-Associated Leukemia-Lymphoma; HTLV-Associated Leukemia-Lymphomas; HTLV-I-Associated T-Cell Leukemia-Lymphoma; HTLV-I-Associated T-Cell Leukemia-Lymphomas; Human T Cell Leukemia Lymphoma; Human T Lymphotropic Virus Associated Leukemia Lymphoma; Human T Lymphotropic Virus-Associated Leukemia-Lymphoma; Human T-Cell Leukemia-Lymphoma; Human T-Cell Leukemia-Lymphomas; Leukemia Lymphoma, Adult T Cell; Leukemia Lymphoma, T Cell, Acute, HTLV I Associated; Leukemia, Adult T Cell; Leukemia, Adult T-Cell; Leukemia-Lymphoma, HTLV-Associated; Leukemia-Lymphoma, HTLV-I-Associated T-Cell; Leukemia-Lymphoma, Human T-Cell; Leukemia-Lymphoma, T-Cell, Acute, HTLV-I-Associated; Leukemia-Lymphomas, Adult T-Cell; Leukemia-Lymphomas, HTLV-Associated; Leukemia-Lymphomas, HTLV-I-Associated T-Cell; Leukemia-Lymphomas, Human T-Cell; Leukemias, Adult T-Cell; T Cell Leukemia Lymphoma, Adult; T Cell Leukemia Lymphoma, HTLV I Associated; T Cell Leukemia, Adult; T-Cell Leukemia, Adult; T-Cell Leukemia-Lymphoma, Adult; T-Cell Leukemia-Lymphoma, HTLV-I-Associated; T-Cell Leukemia-Lymphoma, Human; T-Cell Leukemia-Lymphomas, Adult; T-Cell Leukemia-Lymphomas, HTLV-I-Associated; T-Cell Leukemia-Lymphomas, Human; T-Cell Leukemias, Adult
SNOMED CT: Adult T-cell leukemia/lymphoma (77430005); Adult T-cell lymphoma/leukemia (77430005); Adult T-cell lymphoma (77430005); Adult T-cell leukemia (77430005); Adult T-cell leukemia/lymphoma (HTLV-1 positive) (77430005); Adult T-cell leukemia/lymphoma (110007008); Adult T-cell leukemia/lymphoma (clinical) (110007008); Adult T-cell lymphoma/leukemia (HTLV-1 +) (77430005); Adult T-cell leukemia (110007008)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
Concept ID:
C0600599
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019471
Orphanet: ORPHA86875

Definition

A rare, virus associated tumor due to human T-cell leukemia virus type 1 or human T-cell lymphotropic virus type 1 (HTLV-1) and is characterized by the presence of anti-HTLV-1 antibodies, and malignant, mature, medium-sized T cells with condensed chromatin and polylobated nuclei. The malignant cells exhibit a mature CD4+ T cells phenotype and express CD2, CD5, CD25, CD45RO, HLA-DR, and T-cell receptor αβ. Presentation is heterogeneous and is typically of aggressive leukemia or lymphoma, variable skin eruptions, and visceral organ involvement. [from ORDO]

Professional guidelines

PubMed

Watanabe K, Gomez AM, Kuramitsu S, Siurala M, Da T, Agarwal S, Song D, Scholler J, Rotolo A, Posey AD, Rook AH, Haun PL, Ruella M, Young RM, June CH
Blood Adv 2023 Jul 25;7(14):3416-3430. doi: 10.1182/bloodadvances.2022008327. PMID: 37058474Free PMC Article
Ishitsuka K
Int J Hematol 2023 Apr;117(4):473-474. Epub 2023 Mar 14 doi: 10.1007/s12185-023-03573-3. PMID: 36918503
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), T-Cell Lymphomas, 2024

Recent clinical studies

Etiology

Kameda T, Shide K, Tahira Y, Sekine M, Sato S, Ishizaki J, Takeuchi M, Akizuki K, Kamiunten A, Shimoda H, Toyama T, Maeda K, Yamashita K, Kawano N, Kawano H, Hidaka T, Yamaguchi H, Kubuki Y, Kitanaka A, Matsuoka H, Shimoda K
Viruses 2022 Mar 29;14(4) doi: 10.3390/v14040710. PMID: 35458440Free PMC Article
Miyashiro D, Sanches JA
Semin Diagn Pathol 2020 Mar;37(2):81-91. Epub 2019 Jul 30 doi: 10.1053/j.semdp.2019.07.010. PMID: 31387753
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article
Rodríguez-Zúñiga MJM, Cortez-Franco F, Qujiano-Gomero E
Actas Dermosifiliogr (Engl Ed) 2018 Jun;109(5):399-407. Epub 2018 Apr 21 doi: 10.1016/j.ad.2017.08.014. PMID: 29685460
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article

Diagnosis

Ishitsuka K
Semin Hematol 2021 Apr;58(2):114-122. Epub 2021 Mar 3 doi: 10.1053/j.seminhematol.2021.02.005. PMID: 33906721
Munakata W, Tobinai K
Cancer Treat Res 2019;176:145-161. doi: 10.1007/978-3-319-99716-2_7. PMID: 30596217
Rodríguez-Zúñiga MJM, Cortez-Franco F, Qujiano-Gomero E
Actas Dermosifiliogr (Engl Ed) 2018 Jun;109(5):399-407. Epub 2018 Apr 21 doi: 10.1016/j.ad.2017.08.014. PMID: 29685460
Oliveira PD, Farre L, Bittencourt AL
Rev Assoc Med Bras (1992) 2016 Oct;62(7):691-700. doi: 10.1590/1806-9282.62.07.691. PMID: 27925051
Qayyum S, Choi JK
Arch Pathol Lab Med 2014 Feb;138(2):282-6. doi: 10.5858/arpa.2012-0379-RS. PMID: 24476526

Therapy

Ishitsuka K
Semin Hematol 2021 Apr;58(2):114-122. Epub 2021 Mar 3 doi: 10.1053/j.seminhematol.2021.02.005. PMID: 33906721
Phillips AA, Harewood JCK
Curr Hematol Malig Rep 2018 Aug;13(4):300-307. doi: 10.1007/s11899-018-0458-6. PMID: 30047026
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article
Dittus C, Sloan JM
Hematol Oncol Clin North Am 2017 Apr;31(2):255-272. doi: 10.1016/j.hoc.2016.11.005. PMID: 28340877
Tsukasaki K
Hematology 2012 Apr;17 Suppl 1:S32-5. doi: 10.1179/102453312X13336169155330. PMID: 22507774

Prognosis

Kogure Y, Kameda T, Koya J, Yoshimitsu M, Nosaka K, Yasunaga JI, Imaizumi Y, Watanabe M, Saito Y, Ito Y, McClure MB, Tabata M, Shingaki S, Yoshifuji K, Chiba K, Okada A, Kakiuchi N, Nannya Y, Kamiunten A, Tahira Y, Akizuki K, Sekine M, Shide K, Hidaka T, Kubuki Y, Kitanaka A, Hidaka M, Nakano N, Utsunomiya A, Sica RA, Acuna-Villaorduna A, Janakiram M, Shah U, Ramos JC, Shibata T, Takeuchi K, Takaori-Kondo A, Miyazaki Y, Matsuoka M, Ishitsuka K, Shiraishi Y, Miyano S, Ogawa S, Ye BH, Shimoda K, Kataoka K
Blood 2022 Feb 17;139(7):967-982. doi: 10.1182/blood.2021013568. PMID: 34695199Free PMC Article
Munakata W, Tobinai K
Cancer Treat Res 2019;176:145-161. doi: 10.1007/978-3-319-99716-2_7. PMID: 30596217
Mehta-Shah N, Ratner L, Horwitz SM
J Oncol Pract 2017 Aug;13(8):487-492. doi: 10.1200/JOP.2017.021907. PMID: 28796966Free PMC Article
Oliveira PD, Farre L, Bittencourt AL
Rev Assoc Med Bras (1992) 2016 Oct;62(7):691-700. doi: 10.1590/1806-9282.62.07.691. PMID: 27925051
Qayyum S, Choi JK
Arch Pathol Lab Med 2014 Feb;138(2):282-6. doi: 10.5858/arpa.2012-0379-RS. PMID: 24476526

Clinical prediction guides

Wolf S, Vercruyssen M, Cook L
Curr Opin Oncol 2022 Sep 1;34(5):446-453. Epub 2022 Jul 25 doi: 10.1097/CCO.0000000000000883. PMID: 35880453
Sakamoto Y, Ishida T, Masaki A, Murase T, Takeshita M, Muto R, Iwasaki H, Ito A, Kusumoto S, Nakano N, Tokunaga M, Yonekura K, Tashiro Y, Iida S, Utsunomiya A, Ueda R, Inagaki H
Br J Haematol 2021 Nov;195(4):571-584. Epub 2021 Aug 17 doi: 10.1111/bjh.17749. PMID: 34405395Free PMC Article
Ishitsuka K
Semin Hematol 2021 Apr;58(2):114-122. Epub 2021 Mar 3 doi: 10.1053/j.seminhematol.2021.02.005. PMID: 33906721
Nosaka K, Matsuoka M
Cancer Sci 2021 May;112(5):1688-1694. Epub 2021 Mar 30 doi: 10.1111/cas.14869. PMID: 33630351Free PMC Article
Miyashiro D, Sanches JA
Semin Diagn Pathol 2020 Mar;37(2):81-91. Epub 2019 Jul 30 doi: 10.1053/j.semdp.2019.07.010. PMID: 31387753

Recent systematic reviews

Ohmoto A, Fuji S
Expert Rev Anti Infect Ther 2024 May;22(5):307-316. Epub 2024 Apr 1 doi: 10.1080/14787210.2024.2336547. PMID: 38536666
Shafiee A, Seighali N, Taherzadeh-Ghahfarokhi N, Mardi S, Shojaeian S, Shadabi S, Hasani M, Haghi S, Mozhgani SH
Virol J 2023 Jun 7;20(1):118. doi: 10.1186/s12985-023-02077-0. PMID: 37287047Free PMC Article
Nosaka K, Crawford B, Yi J, Kuan W, Matsumoto T, Takahashi T
Eur J Haematol 2022 Mar;108(3):212-222. Epub 2021 Dec 8 doi: 10.1111/ejh.13728. PMID: 34862665Free PMC Article
Henry RK, Bagg A, Wu C, Eagle RC Jr, Milman T
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3):201-211. doi: 10.1097/IOP.0000000000001695. PMID: 32427727
Oliveira PD, de Carvalho RF, Bittencourt AL
Int J STD AIDS 2017 Mar;28(3):217-228. Epub 2016 Dec 14 doi: 10.1177/0956462416684461. PMID: 28178905

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), T-Cell Lymphomas, 2024

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