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Liposarcoma

MedGen UID:
44177
•Concept ID:
C0023827
•
Neoplastic Process
Synonym: Liposarcomas
SNOMED CT: Liposarcoma (254829001); Fibroliposarcoma (1162815008); Liposarcoma (1162815008); Malignant lipomatous tumor (1162815008); Malignant lipomatous tumor (254829001)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
HPO: HP:0012034
Monarch Initiative: MONDO:0005060
Orphanet: ORPHA69078

Definition

Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLiposarcoma
Follow this link to review classifications for Liposarcoma in Orphanet.

Professional guidelines

PubMed

Management of Synovial Sarcoma and Myxoid Liposarcoma.
Hindi N, Haas RL
Surg Oncol Clin N Am 2022 Jul;31(3):547-558. doi: 10.1016/j.soc.2022.03.012. PMID: 35715149
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Recent clinical studies

Etiology

Management of Synovial Sarcoma and Myxoid Liposarcoma.
Hindi N, Haas RL
Surg Oncol Clin N Am 2022 Jul;31(3):547-558. doi: 10.1016/j.soc.2022.03.012. PMID: 35715149
Retroperitoneal Dedifferentiated Liposarcoma.
Dehner CA, Hagemann IS, Chrisinger JSA
Am J Clin Pathol 2021 Oct 13;156(5):920-925. doi: 10.1093/ajcp/aqab051. PMID: 34125170
Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
Keung EZ, Lazar AJ, Torres KE, Wang WL, Cormier JN, Ashleigh Guadagnolo B, Bishop AJ, Lin H, Hunt KK, Bird J, Lewis VO, Patel SR, Wargo JA, Somaiah N, Roland CL
BMC Cancer 2018 Sep 24;18(1):913. doi: 10.1186/s12885-018-4829-0. PMID: 30249211Free PMC Article
Myxoid Emboli.
AbdullGaffar B, Waslewski K
Int J Surg Pathol 2018 Oct;26(7):609-616. Epub 2018 Apr 6 doi: 10.1177/1066896918768029. PMID: 29623727
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Diagnosis

Lipoma and Its Doppelganger: The Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma.
Yee EJ, Stewart CL, Clay MR, McCarter MM
Surg Clin North Am 2022 Aug;102(4):637-656. doi: 10.1016/j.suc.2022.04.006. PMID: 35952693
Management of Synovial Sarcoma and Myxoid Liposarcoma.
Hindi N, Haas RL
Surg Oncol Clin N Am 2022 Jul;31(3):547-558. doi: 10.1016/j.soc.2022.03.012. PMID: 35715149
DDIT3 Immunohistochemistry Is a Useful Tool for the Diagnosis of Myxoid Liposarcoma.
Scapa JV, Cloutier JM, Raghavan SS, Peters-Schulze G, Varma S, Charville GW
Am J Surg Pathol 2021 Feb 1;45(2):230-239. doi: 10.1097/PAS.0000000000001564. PMID: 32815829Free PMC Article
Dedifferentiated Liposarcoma: Systemic Therapy Options.
Gahvari Z, Parkes A
Curr Treat Options Oncol 2020 Feb 5;21(2):15. doi: 10.1007/s11864-020-0705-7. PMID: 32026050
Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review.
Thway K
Semin Diagn Pathol 2019 Mar;36(2):112-121. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.006. PMID: 30852045

Therapy

A review of retroperitoneal liposarcoma genomics.
Tyler R, Wanigasooriya K, Taniere P, Almond M, Ford S, Desai A, Beggs A
Cancer Treat Rev 2020 Jun;86:102013. Epub 2020 Mar 28 doi: 10.1016/j.ctrv.2020.102013. PMID: 32278233
Dedifferentiated Liposarcoma: Systemic Therapy Options.
Gahvari Z, Parkes A
Curr Treat Options Oncol 2020 Feb 5;21(2):15. doi: 10.1007/s11864-020-0705-7. PMID: 32026050
Options for treating different soft tissue sarcoma subtypes.
Ray-Coquard I, Serre D, Reichardt P, Martín-Broto J, Bauer S
Future Oncol 2018 May;14(10s):25-49. doi: 10.2217/fon-2018-0076. PMID: 29768052
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.
Demetri GD, von Mehren M, Jones RL, Hensley ML, Schuetze SM, Staddon A, Milhem M, Elias A, Ganjoo K, Tawbi H, Van Tine BA, Spira A, Dean A, Khokhar NZ, Park YC, Knoblauch RE, Parekh TV, Maki RG, Patel SR
J Clin Oncol 2016 Mar 10;34(8):786-93. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.62.4734. PMID: 26371143Free PMC Article

Prognosis

Pleomorphic liposarcoma.
Oliveira AM, Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):274-85. PMID: 11757868
Dedifferentiated liposarcoma.
Nascimento AG
Semin Diagn Pathol 2001 Nov;18(4):263-6. PMID: 11757866
Retroperitoneal sarcomas.
Eilber FC, Eilber KS, Eilber FR
Curr Treat Options Oncol 2000 Aug;1(3):274-8. doi: 10.1007/s11864-000-0040-y. PMID: 12057171
Liposarcoma.
Springfield D
Clin Orthop Relat Res 1993 Apr;(289):50-7. PMID: 8472432
Liposarcoma.
Brasfield RD, Das Gupta TK
CA Cancer J Clin 1970 Jan-Feb;20(1):3-8. PMID: 5005753

Clinical prediction guides

Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Callegaro D, Raut CP, Ajayi T, Strauss D, Bonvalot S, Ng D, Stoeckle E, Fairweather M, Rutkowski P, van Houdt WJ, Gelderblom H, Sangalli C, Hayes A, Honoré C, Gladdy RA, Fau M, Haas R, Tzanis D, Miah AB, Chung P, Baldini EH, Marreaud S, Litiere S, Swallow CJ, Gronchi A
Ann Surg 2023 Jul 1;278(1):127-134. Epub 2022 Jul 14 doi: 10.1097/SLA.0000000000005492. PMID: 35833413
Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma.
Xu C, Yan L, Guan X, Wang Z, Wu J, Lv A, Liu D, Liu F, Dong B, Zhao M, Jia L, Tian X, Hao C
Int J Biol Sci 2022;18(13):5038-5055. Epub 2022 Aug 1 doi: 10.7150/ijbs.70083. PMID: 35982904Free PMC Article
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
DDIT3 Immunohistochemistry Is a Useful Tool for the Diagnosis of Myxoid Liposarcoma.
Scapa JV, Cloutier JM, Raghavan SS, Peters-Schulze G, Varma S, Charville GW
Am J Surg Pathol 2021 Feb 1;45(2):230-239. doi: 10.1097/PAS.0000000000001564. PMID: 32815829Free PMC Article
Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas.
Dancsok AR, Gao D, Lee AF, Steigen SE, Blay JY, Thomas DM, Maki RG, Nielsen TO, Demicco EG
Oncoimmunology 2020;9(1):1747340. Epub 2020 Apr 12 doi: 10.1080/2162402X.2020.1747340. PMID: 32313727Free PMC Article

Recent systematic reviews

Soft tissue sarcomas of the buttock: A systematic review and meta-analysis.
Sacco R, Lalevée M, Pellegrino P, Ferro A, Yasmine B, André G, Matthieu G, Hamza A, Piana R, Dujardin F
Surg Oncol 2022 Dec;45:101883. Epub 2022 Nov 7 doi: 10.1016/j.suronc.2022.101883. PMID: 36371906
Immune checkpoint inhibitors in treatment of soft-tissue sarcoma: A systematic review and meta-analysis.
Saerens M, Brusselaers N, Rottey S, Decruyenaere A, Creytens D, Lapeire L
Eur J Cancer 2021 Jul;152:165-182. Epub 2021 Jun 6 doi: 10.1016/j.ejca.2021.04.034. PMID: 34107450
Esophageal Lipoma and Liposarcoma: A Systematic Review.
Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E, Bonavina L
World J Surg 2021 Jan;45(1):225-234. Epub 2020 Oct 7 doi: 10.1007/s00268-020-05789-4. PMID: 33026474Free PMC Article
Isolated Limb Perfusion and Infusion for Extremity Soft Tissue Sarcoma: A Contemporary Systematic Review and Meta-Analysis.
Neuwirth MG, Song Y, Sinnamon AJ, Fraker DL, Zager JS, Karakousis GC
Ann Surg Oncol 2017 Dec;24(13):3803-3810. Epub 2017 Oct 11 doi: 10.1245/s10434-017-6109-7. PMID: 29022281
Liposarcoma of Hypopharynx and Esophagus: a Unique Entity?
Riva G, Sensini M, Corvino A, Garzaro M, Pecorari G
J Gastrointest Cancer 2016 Jun;47(2):135-42. doi: 10.1007/s12029-016-9808-6. PMID: 26875081

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