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Low T3 Syndrome

MedGen UID:
44200
•Concept ID:
C0024043
•
Disease or Syndrome

Definition

Reduced serum concentration of tri-iodothyronine caused by a variety of non-thyroidal conditions in which there is no dysfunction in the thyroid gland or the hypothalamic-pituitary axis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow T3 Syndrome

Professional guidelines

PubMed

Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment.
Cappola AR, Desai AS, Medici M, Cooper LS, Egan D, Sopko G, Fishman GI, Goldman S, Cooper DS, Mora S, Kudenchuk PJ, Hollenberg AN, McDonald CL, Ladenson PW
Thyroid 2019 Jun;29(6):760-777. Epub 2019 May 13 doi: 10.1089/thy.2018.0416. PMID: 31081722Free PMC Article
The Management of Thyroid Abnormalities in Chronic Heart Failure.
Biondi B
Heart Fail Clin 2019 Jul;15(3):393-398. Epub 2019 Apr 5 doi: 10.1016/j.hfc.2019.02.008. PMID: 31079697

Recent clinical studies

Etiology

Low T3 syndrome predicts more adverse events in patients with hypertrophic cardiomyopathy.
He CJ, Zhu CY, Fan HY, Qian YZ, Zhai CL, Hu HL
Clin Cardiol 2023 Dec;46(12):1569-1577. Epub 2023 Sep 15 doi: 10.1002/clc.24156. PMID: 37711064Free PMC Article
Low T3 Syndrome on Admission and Response to Nutritional Support in Malnourished Medical Inpatients.
Müller NA, Kaegi-Braun N, Durmisi M, Gressies C, Tribolet P, Stanga Z, Mueller B, Schuetz P
J Clin Endocrinol Metab 2023 May 17;108(6):e240-e248. doi: 10.1210/clinem/dgac743. PMID: 36546619
Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Congestive Heart Failure and Thyroid Dysfunction: The Role of the Low T3 Syndrome and Therapeutic Aspects.
Lisco G, De Tullio A, Iacoviello M, Triggiani V
Endocr Metab Immune Disord Drug Targets 2020;20(5):646-653. doi: 10.2174/1871530319666191119112950. PMID: 31742499
Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders.
Bunevicius A, Iervasi G, Bunevicius R
Expert Rev Neurother 2015 Mar;15(3):315-26. Epub 2015 Feb 11 doi: 10.1586/14737175.2015.1013465. PMID: 25673072

Diagnosis

Low T3 syndrome predicts more adverse events in patients with hypertrophic cardiomyopathy.
He CJ, Zhu CY, Fan HY, Qian YZ, Zhai CL, Hu HL
Clin Cardiol 2023 Dec;46(12):1569-1577. Epub 2023 Sep 15 doi: 10.1002/clc.24156. PMID: 37711064Free PMC Article
An update on non-thyroidal illness syndrome.
Fliers E, Boelen A
J Endocrinol Invest 2021 Aug;44(8):1597-1607. Epub 2020 Dec 15 doi: 10.1007/s40618-020-01482-4. PMID: 33320308Free PMC Article
Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Thyroid Hormones in Critical Illness.
Maiden MJ, Torpy DJ
Crit Care Clin 2019 Apr;35(2):375-388. Epub 2019 Jan 24 doi: 10.1016/j.ccc.2018.11.012. PMID: 30784616
Thyroid hormone disorders and sepsis.
Luo B, Yu Z, Li Y
Biomed Mater Eng 2017;28(s1):S237-S241. doi: 10.3233/BME-171646. PMID: 28372300

Therapy

Low T3 Syndrome on Admission and Response to Nutritional Support in Malnourished Medical Inpatients.
Müller NA, Kaegi-Braun N, Durmisi M, Gressies C, Tribolet P, Stanga Z, Mueller B, Schuetz P
J Clin Endocrinol Metab 2023 May 17;108(6):e240-e248. doi: 10.1210/clinem/dgac743. PMID: 36546619
An update on non-thyroidal illness syndrome.
Fliers E, Boelen A
J Endocrinol Invest 2021 Aug;44(8):1597-1607. Epub 2020 Dec 15 doi: 10.1007/s40618-020-01482-4. PMID: 33320308Free PMC Article
Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Thyroid Hormones in Critical Illness.
Maiden MJ, Torpy DJ
Crit Care Clin 2019 Apr;35(2):375-388. Epub 2019 Jan 24 doi: 10.1016/j.ccc.2018.11.012. PMID: 30784616
Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders.
Bunevicius A, Iervasi G, Bunevicius R
Expert Rev Neurother 2015 Mar;15(3):315-26. Epub 2015 Feb 11 doi: 10.1586/14737175.2015.1013465. PMID: 25673072

Prognosis

Low T3 syndrome predicts more adverse events in patients with hypertrophic cardiomyopathy.
He CJ, Zhu CY, Fan HY, Qian YZ, Zhai CL, Hu HL
Clin Cardiol 2023 Dec;46(12):1569-1577. Epub 2023 Sep 15 doi: 10.1002/clc.24156. PMID: 37711064Free PMC Article
Low T3 Syndrome on Admission and Response to Nutritional Support in Malnourished Medical Inpatients.
Müller NA, Kaegi-Braun N, Durmisi M, Gressies C, Tribolet P, Stanga Z, Mueller B, Schuetz P
J Clin Endocrinol Metab 2023 May 17;108(6):e240-e248. doi: 10.1210/clinem/dgac743. PMID: 36546619
Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Low T3 syndrome as a predictor of poor prognosis in chronic lymphocytic leukemia.
Gao R, Chen RZ, Xia Y, Liang JH, Wang L, Zhu HY, Zhu Wu J, Fan L, Li JY, Yang T, Xu W
Int J Cancer 2018 Aug 1;143(3):466-477. Epub 2018 Mar 2 doi: 10.1002/ijc.31327. PMID: 29457831
Thyroid hormone disorders and sepsis.
Luo B, Yu Z, Li Y
Biomed Mater Eng 2017;28(s1):S237-S241. doi: 10.3233/BME-171646. PMID: 28372300

Clinical prediction guides

Low T3 syndrome predicts more adverse events in patients with hypertrophic cardiomyopathy.
He CJ, Zhu CY, Fan HY, Qian YZ, Zhai CL, Hu HL
Clin Cardiol 2023 Dec;46(12):1569-1577. Epub 2023 Sep 15 doi: 10.1002/clc.24156. PMID: 37711064Free PMC Article
Low T3 syndrome as a predictor of poor outcomes in patients with follicular lymphoma.
Xue LG, Shen HR, Gao R, Du KX, Xing TY, Wang WT, Wang L, Li JY, Liang JH, Xu W
Ann Hematol 2023 Apr;102(4):851-862. Epub 2023 Feb 3 doi: 10.1007/s00277-023-05117-5. PMID: 36735075Free PMC Article
Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 diabetes mellitus.
He W, Pang C, Chen L, Zeng Y, Gao L, Huang H, Zhang W, Wang X, Deng B
Muscle Nerve 2022 Dec;66(6):723-729. Epub 2022 Sep 23 doi: 10.1002/mus.27719. PMID: 36089765
Clinical characteristics and long-term prognosis of ischemic and non-ischemic cardiomyopathy.
Zhang ZH, Meng FQ, Hou XF, Qian ZY, Wang Y, Qiu YH, Jiang ZY, Du AJ, Qin CT, Zou JG
Indian Heart J 2020 Mar-Apr;72(2):93-100. Epub 2020 Apr 28 doi: 10.1016/j.ihj.2020.04.004. PMID: 32534695Free PMC Article
Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070

Recent systematic reviews

Thyroid diseases are associated with coronavirus disease 2019 infection.
Tian Y, Zhao J, Wang T, Wang H, Yao J, Wang S, Mou Y
Front Endocrinol (Lausanne) 2022;13:952049. Epub 2022 Sep 2 doi: 10.3389/fendo.2022.952049. PMID: 36120425Free PMC Article
Thyroid sequelae of COVID-19: a systematic review of reviews.
Trimboli P, Camponovo C, Scappaticcio L, Bellastella G, Piccardo A, Rotondi M
Rev Endocr Metab Disord 2021 Jun;22(2):485-491. Epub 2021 Apr 11 doi: 10.1007/s11154-021-09653-1. PMID: 33843008Free PMC Article
A prognostic role for non-thyroidal illness syndrome in chronic renal failure:a systematic review and meta-analysis.
Xiong H, Yan P, Huang Q, Shuai T, Liu J, Zhu L, Lu J, Shi X, Yang K, Liu J
Int J Surg 2019 Oct;70:44-52. Epub 2019 Aug 19 doi: 10.1016/j.ijsu.2019.08.019. PMID: 31437639
A prognostic role for Low tri-iodothyronine syndrome in acute stroke patients: A systematic review and meta-analysis.
Lamba N, Liu C, Zaidi H, Broekman MLD, Simjian T, Shi C, Doucette J, Ren S, Smith TR, Mekary RA, Bunevicius A
Clin Neurol Neurosurg 2018 Jun;169:55-63. Epub 2018 Mar 31 doi: 10.1016/j.clineuro.2018.03.025. PMID: 29627642
Low Tri-Iodothyronine Syndrome in Neurosurgical Patients: A Systematic Review of Literature.
Bunevicius A, Smith T, Laws ER
World Neurosurg 2016 Nov;95:197-207. Epub 2016 Jul 20 doi: 10.1016/j.wneu.2016.07.035. PMID: 27450974

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