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Low T3 Syndrome

MedGen UID:
44200
•Concept ID:
C0024043
•
Disease or Syndrome

Definition

Reduced serum concentration of tri-iodothyronine caused by a variety of non-thyroidal conditions in which there is no dysfunction in the thyroid gland or the hypothalamic-pituitary axis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow T3 Syndrome

Professional guidelines

PubMed

Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Thyroid and Cardiovascular Disease: Research Agenda for Enhancing Knowledge, Prevention, and Treatment.
Cappola AR, Desai AS, Medici M, Cooper LS, Egan D, Sopko G, Fishman GI, Goldman S, Cooper DS, Mora S, Kudenchuk PJ, Hollenberg AN, McDonald CL, Ladenson PW
Thyroid 2019 Jun;29(6):760-777. Epub 2019 May 13 doi: 10.1089/thy.2018.0416. PMID: 31081722Free PMC Article
The Management of Thyroid Abnormalities in Chronic Heart Failure.
Biondi B
Heart Fail Clin 2019 Jul;15(3):393-398. Epub 2019 Apr 5 doi: 10.1016/j.hfc.2019.02.008. PMID: 31079697

Recent clinical studies

Etiology

Covid-19, the thyroid and the pituitary - The real state of play.
Geslot A, Chanson P, Caron P
Ann Endocrinol (Paris) 2022 Apr;83(2):103-108. Epub 2022 Jan 20 doi: 10.1016/j.ando.2021.12.004. PMID: 35065920Free PMC Article
Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Congestive Heart Failure and Thyroid Dysfunction: The Role of the Low T3 Syndrome and Therapeutic Aspects.
Lisco G, De Tullio A, Iacoviello M, Triggiani V
Endocr Metab Immune Disord Drug Targets 2020;20(5):646-653. doi: 10.2174/1871530319666191119112950. PMID: 31742499
The Role of Thyroid Hormones in Heart Failure.
Vale C, Neves JS, von Hafe M, Borges-Canha M, Leite-Moreira A
Cardiovasc Drugs Ther 2019 Apr;33(2):179-188. doi: 10.1007/s10557-019-06870-4. PMID: 30847626
Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders.
Bunevicius A, Iervasi G, Bunevicius R
Expert Rev Neurother 2015 Mar;15(3):315-26. Epub 2015 Feb 11 doi: 10.1586/14737175.2015.1013465. PMID: 25673072

Diagnosis

An update on non-thyroidal illness syndrome.
Fliers E, Boelen A
J Endocrinol Invest 2021 Aug;44(8):1597-1607. Epub 2020 Dec 15 doi: 10.1007/s40618-020-01482-4. PMID: 33320308Free PMC Article
Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Thyroid Hormones in Critical Illness.
Maiden MJ, Torpy DJ
Crit Care Clin 2019 Apr;35(2):375-388. Epub 2019 Jan 24 doi: 10.1016/j.ccc.2018.11.012. PMID: 30784616
Thyroid hormone disorders and sepsis.
Luo B, Yu Z, Li Y
Biomed Mater Eng 2017;28(s1):S237-S241. doi: 10.3233/BME-171646. PMID: 28372300
Neuroprotective actions of thyroid hormones and low-T3 syndrome as a biomarker in acute cerebrovascular disorders.
Bunevicius A, Iervasi G, Bunevicius R
Expert Rev Neurother 2015 Mar;15(3):315-26. Epub 2015 Feb 11 doi: 10.1586/14737175.2015.1013465. PMID: 25673072

Therapy

An update on non-thyroidal illness syndrome.
Fliers E, Boelen A
J Endocrinol Invest 2021 Aug;44(8):1597-1607. Epub 2020 Dec 15 doi: 10.1007/s40618-020-01482-4. PMID: 33320308Free PMC Article
Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Congestive Heart Failure and Thyroid Dysfunction: The Role of the Low T3 Syndrome and Therapeutic Aspects.
Lisco G, De Tullio A, Iacoviello M, Triggiani V
Endocr Metab Immune Disord Drug Targets 2020;20(5):646-653. doi: 10.2174/1871530319666191119112950. PMID: 31742499
The Role of Thyroid Hormones in Heart Failure.
Vale C, Neves JS, von Hafe M, Borges-Canha M, Leite-Moreira A
Cardiovasc Drugs Ther 2019 Apr;33(2):179-188. doi: 10.1007/s10557-019-06870-4. PMID: 30847626
Thyroid Hormones in Critical Illness.
Maiden MJ, Torpy DJ
Crit Care Clin 2019 Apr;35(2):375-388. Epub 2019 Jan 24 doi: 10.1016/j.ccc.2018.11.012. PMID: 30784616

Prognosis

Covid-19, the thyroid and the pituitary - The real state of play.
Geslot A, Chanson P, Caron P
Ann Endocrinol (Paris) 2022 Apr;83(2):103-108. Epub 2022 Jan 20 doi: 10.1016/j.ando.2021.12.004. PMID: 35065920Free PMC Article
Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Congestive Heart Failure and Thyroid Dysfunction: The Role of the Low T3 Syndrome and Therapeutic Aspects.
Lisco G, De Tullio A, Iacoviello M, Triggiani V
Endocr Metab Immune Disord Drug Targets 2020;20(5):646-653. doi: 10.2174/1871530319666191119112950. PMID: 31742499
The Role of Thyroid Hormones in Heart Failure.
Vale C, Neves JS, von Hafe M, Borges-Canha M, Leite-Moreira A
Cardiovasc Drugs Ther 2019 Apr;33(2):179-188. doi: 10.1007/s10557-019-06870-4. PMID: 30847626
Thyroid hormone disorders and sepsis.
Luo B, Yu Z, Li Y
Biomed Mater Eng 2017;28(s1):S237-S241. doi: 10.3233/BME-171646. PMID: 28372300

Clinical prediction guides

Low T3 syndrome is associated with peripheral neuropathy in patients with type 2 diabetes mellitus.
He W, Pang C, Chen L, Zeng Y, Gao L, Huang H, Zhang W, Wang X, Deng B
Muscle Nerve 2022 Dec;66(6):723-729. Epub 2022 Sep 23 doi: 10.1002/mus.27719. PMID: 36089765
The Association Between Low T3 Syndrome and Survival in Patients With Newly Diagnosed Multiple Myeloma: A Retrospective Study.
Pan Q, Jian Y, Zhang Y, Zhang W, Chen Z, Yang Y, Liu A, Wang G
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221094422. doi: 10.1177/15330338221094422. PMID: 35443837Free PMC Article
Covid-19, the thyroid and the pituitary - The real state of play.
Geslot A, Chanson P, Caron P
Ann Endocrinol (Paris) 2022 Apr;83(2):103-108. Epub 2022 Jan 20 doi: 10.1016/j.ando.2021.12.004. PMID: 35065920Free PMC Article
Diagnosis and treatment of low T3 syndrome in neurocritical patients.
Chen Y, Chang J, Yin R, Wen J, Ma B, Zuo W, Zhang X, Wei J
J Clin Pharm Ther 2020 Aug;45(4):759-766. Epub 2020 May 14 doi: 10.1111/jcpt.13162. PMID: 32406070
Prevalence and Clinical Significance of Low T3 Syndrome in Non-Dialysis Patients with Chronic Kidney Disease.
Fan J, Yan P, Wang Y, Shen B, Ding F, Liu Y
Med Sci Monit 2016 Apr 8;22:1171-9. doi: 10.12659/msm.895953. PMID: 27056188Free PMC Article

Recent systematic reviews

Thyroid diseases are associated with coronavirus disease 2019 infection.
Tian Y, Zhao J, Wang T, Wang H, Yao J, Wang S, Mou Y
Front Endocrinol (Lausanne) 2022;13:952049. Epub 2022 Sep 2 doi: 10.3389/fendo.2022.952049. PMID: 36120425Free PMC Article
Thyroid sequelae of COVID-19: a systematic review of reviews.
Trimboli P, Camponovo C, Scappaticcio L, Bellastella G, Piccardo A, Rotondi M
Rev Endocr Metab Disord 2021 Jun;22(2):485-491. Epub 2021 Apr 11 doi: 10.1007/s11154-021-09653-1. PMID: 33843008Free PMC Article
A prognostic role for non-thyroidal illness syndrome in chronic renal failure:a systematic review and meta-analysis.
Xiong H, Yan P, Huang Q, Shuai T, Liu J, Zhu L, Lu J, Shi X, Yang K, Liu J
Int J Surg 2019 Oct;70:44-52. Epub 2019 Aug 19 doi: 10.1016/j.ijsu.2019.08.019. PMID: 31437639
A prognostic role for Low tri-iodothyronine syndrome in acute stroke patients: A systematic review and meta-analysis.
Lamba N, Liu C, Zaidi H, Broekman MLD, Simjian T, Shi C, Doucette J, Ren S, Smith TR, Mekary RA, Bunevicius A
Clin Neurol Neurosurg 2018 Jun;169:55-63. Epub 2018 Mar 31 doi: 10.1016/j.clineuro.2018.03.025. PMID: 29627642
Low Tri-Iodothyronine Syndrome in Neurosurgical Patients: A Systematic Review of Literature.
Bunevicius A, Smith T, Laws ER
World Neurosurg 2016 Nov;95:197-207. Epub 2016 Jul 20 doi: 10.1016/j.wneu.2016.07.035. PMID: 27450974

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