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Mixed Cell Lymphoma

MedGen UID:
44225
•Concept ID:
C0024304
•
Neoplastic Process
Synonyms: Lymphocytic-Histiocytic Lymphoma, Mixed; Lymphocytic-Histiocytic Lymphomas, Mixed; Lymphoma, Mixed; Lymphoma, Mixed Cell; Lymphoma, Mixed Lymphocytic Histiocytic; Lymphoma, Mixed Lymphocytic-Histiocytic; Lymphoma, Mixed-Cell; Mixed Lymphocytic-Histiocytic Lymphoma; Mixed Lymphocytic-Histiocytic Lymphomas; Mixed Lymphoma; Mixed Lymphomas; Mixed-Cell Lymphoma; Mixed-Cell Lymphomas

Definition

An antiquated term that refers to a lymphoma composed of a mixture of small and large lymphocytes. [from NCI]

Professional guidelines

PubMed

Treatment and prognosis of orbital non-Hodgkin's lymphomas.
Platanias LC, Putterman AM, Vijayakumar S, Recant W, Weichselbaum RR, Bitran JD
Am J Clin Oncol 1992 Feb;15(1):79-83. doi: 10.1097/00000421-199202000-00015. PMID: 1372464
The non-Hodgkin's lymphomas: pathology, staging, treatment.
Hoppe RT
Curr Probl Cancer 1987 Nov-Dec;11(6):363-447. doi: 10.1016/s0147-0272(87)80006-5. PMID: 3125008

Recent clinical studies

Etiology

Detection of Epstein-Barr viral RNA in malignant lymphomas of the upper aerodigestive tract.
Chan JK, Yip TT, Tsang WY, Ng CS, Lau WH, Poon YF, Wong CC, Ma VW
Am J Surg Pathol 1994 Sep;18(9):938-46. doi: 10.1097/00000478-199409000-00009. PMID: 8067515
Non-Hodgkin's lymphoma in patients under twenty years of age. A clinicopathological study.
Ishida Y, Mukai K, Yajima S, Takayama J, Shimoyama M, Konda C, Watanabe S, Ohira M
Int J Hematol 1991 Jun;54(3):241-9. PMID: 1747459
bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma.
Yunis JJ, Mayer MG, Arnesen MA, Aeppli DP, Oken MM, Frizzera G
N Engl J Med 1989 Apr 20;320(16):1047-54. doi: 10.1056/NEJM198904203201605. PMID: 2648153
The non-Hodgkin's lymphomas: pathology, staging, treatment.
Hoppe RT
Curr Probl Cancer 1987 Nov-Dec;11(6):363-447. doi: 10.1016/s0147-0272(87)80006-5. PMID: 3125008
Malignant lymphoma, mixed cell type, diffuse.
Nathwani BN, Metter GE, Gams RA, Bartolucci AA, Hartsock RJ, Neiman RS, Byrne GE Jr, Barcos M, Kim H, Rappaport H
Blood 1983 Jul;62(1):200-8. PMID: 6602632

Diagnosis

Fine-needle aspiration cytology of lymphoproliferative lesions involving the major salivary glands.
Chhieng DC, Cangiarella JF, Cohen JM
Am J Clin Pathol 2000 Apr;113(4):563-71. doi: 10.1309/2AR0-RFGW-GTTD-G65E. PMID: 10761459
Detection of Epstein-Barr viral RNA in malignant lymphomas of the upper aerodigestive tract.
Chan JK, Yip TT, Tsang WY, Ng CS, Lau WH, Poon YF, Wong CC, Ma VW
Am J Surg Pathol 1994 Sep;18(9):938-46. doi: 10.1097/00000478-199409000-00009. PMID: 8067515
Non-Hodgkin's lymphoma in patients under twenty years of age. A clinicopathological study.
Ishida Y, Mukai K, Yajima S, Takayama J, Shimoyama M, Konda C, Watanabe S, Ohira M
Int J Hematol 1991 Jun;54(3):241-9. PMID: 1747459
Fine-needle aspiration cytology of peripheral T-cell lymphoma. A cytologic, immunologic, and cytometric study.
Katz RL, Gritsman A, Cabanillas F, Fanning CV, Dekmezian R, Ordonez NG, Barlogie B, Butler JJ
Am J Clin Pathol 1989 Feb;91(2):120-31. doi: 10.1093/ajcp/91.2.120. PMID: 2644804
The non-Hodgkin's lymphomas: pathology, staging, treatment.
Hoppe RT
Curr Probl Cancer 1987 Nov-Dec;11(6):363-447. doi: 10.1016/s0147-0272(87)80006-5. PMID: 3125008

Therapy

Central lymphatic irradiation for stage I-III follicular lymphoma: report from a single-institutional prospective study.
Ha CS, Kong JS, Tucker SL, McLaughlin P, Wilder RB, Hess MA, Cabanillas F, Cox JD
Int J Radiat Oncol Biol Phys 2003 Oct 1;57(2):316-20. doi: 10.1016/s0360-3016(03)00592-3. PMID: 12957240
High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial.
Horning SJ, Negrin RS, Hoppe RT, Rosenberg SA, Chao NJ, Long GD, Brown BW, Blume KG
Blood 2001 Jan 15;97(2):404-9. doi: 10.1182/blood.v97.2.404. PMID: 11154216
Post-liver transplantation lymphoproliferative disorders with and without infusions of donor bone marrow cells.
Restrepo A, Albrecht F, Raez LE, Fernandez HF, Nassiri M, Byrne G Jr, Cassileth PA
Crit Rev Oncog 1999;10(3):239-45. PMID: 10468183
The non-Hodgkin's lymphomas: pathology, staging, treatment.
Hoppe RT
Curr Probl Cancer 1987 Nov-Dec;11(6):363-447. doi: 10.1016/s0147-0272(87)80006-5. PMID: 3125008
A study of childhood non-Hodgkin's lymphoma.
Murphy SB, Frizzera G, Evans AE
Cancer 1975 Dec;36(6):2121-31. doi: 10.1002/cncr.2820360928. PMID: 1081906

Prognosis

Non-Hodgkin's lymphoma in patients under twenty years of age. A clinicopathological study.
Ishida Y, Mukai K, Yajima S, Takayama J, Shimoyama M, Konda C, Watanabe S, Ohira M
Int J Hematol 1991 Jun;54(3):241-9. PMID: 1747459
bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma.
Yunis JJ, Mayer MG, Arnesen MA, Aeppli DP, Oken MM, Frizzera G
N Engl J Med 1989 Apr 20;320(16):1047-54. doi: 10.1056/NEJM198904203201605. PMID: 2648153
The non-Hodgkin's lymphomas: pathology, staging, treatment.
Hoppe RT
Curr Probl Cancer 1987 Nov-Dec;11(6):363-447. doi: 10.1016/s0147-0272(87)80006-5. PMID: 3125008
Malignant lymphoma, mixed cell type, diffuse.
Nathwani BN, Metter GE, Gams RA, Bartolucci AA, Hartsock RJ, Neiman RS, Byrne GE Jr, Barcos M, Kim H, Rappaport H
Blood 1983 Jul;62(1):200-8. PMID: 6602632
A study of childhood non-Hodgkin's lymphoma.
Murphy SB, Frizzera G, Evans AE
Cancer 1975 Dec;36(6):2121-31. doi: 10.1002/cncr.2820360928. PMID: 1081906

Clinical prediction guides

Assessment of prognostic factors in follicular lymphoma patients.
Kondo E, Ogura M, Kagami Y, Taji H, Miura K, Takeuchi T, Maeda S, Asakura S, Suzuki R, Nakamura S, Morishima Y
Int J Hematol 2001 Apr;73(3):363-8. doi: 10.1007/BF02981963. PMID: 11345204
Morphologic studies of lymphocyte nuclei in follicular and diffuse mixed small- and large-cell (lymphocytic-histiocytic) lymphoma.
Dardick I, Caldwell DR, Moher D, Jabi M
Hum Pathol 1988 Aug;19(8):889-901. doi: 10.1016/s0046-8177(88)80003-0. PMID: 3042597
Peripheral T-cell lymphoma. A case report demonstrating morphologic heterogeneity and progression, and atypical immune reactions.
Winberg CD, Krance R, Sheibani K, Rappaport H
Cancer 1986 Jun 15;57(12):2329-42. doi: 10.1002/1097-0142(19860615)57:12<2329::aid-cncr2820571216>3.0.co;2-3. PMID: 3516376
Peripheral T cell lymphoma: immunologic and cell-kinetic observations associated with morphological progression.
Winberg CD, Sheibani K, Krance R, Rappaport H
Blood 1985 Oct;66(4):980-9. PMID: 3876128
Prognostic implications of karyotype and morphology in patients with non-Hodgkin's lymphoma.
Kaneko Y, Rowley JD, Variakojis D, Haren JM, Ueshima Y, Daly K, Kluskens LF
Int J Cancer 1983 Dec 15;32(6):683-92. doi: 10.1002/ijc.2910320606. PMID: 6654522

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