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Malabsorption syndrome

MedGen UID:
44256
•Concept ID:
C0024523
•
Disease or Syndrome
Synonyms: Malabsorption Syndrome; Malabsorption Syndromes; Syndrome, Malabsorption; Syndromes, Malabsorption
SNOMED CT: Intestinal malabsorption (197476001); Malabsorption syndrome (32230006); Malabsorption (32230006)
 
Monarch Initiative: MONDO:0020598

Definition

A syndrome resulting from the inadequate absorption of nutrients in the small intestine. Symptoms include abdominal pain, bloating, and diarrhea. [from NCI]

Professional guidelines

PubMed

Incidence, Diagnosis and Management of Malabsorption Following Oesophagectomy: a Systematic Review.
Khaw RA, Nevins EJ, Phillips AW
J Gastrointest Surg 2022 Aug;26(8):1781-1790. Epub 2022 Apr 28 doi: 10.1007/s11605-022-05323-y. PMID: 35484473
Management of pancreatic exocrine insufficiency.
Dominguez-Muñoz JE
Curr Opin Gastroenterol 2019 Sep;35(5):455-459. doi: 10.1097/MOG.0000000000000562. PMID: 31219829
The medical and surgical treatment in secondary and tertiary hyperparathyroidism. Review.
Cocchiara G, Fazzotta S, Palumbo VD, Damiano G, Cajozzo M, Maione C, Buscemi S, Spinelli G, Ficarella S, Maffongelli A, Caternicchia F, Ignazio Lo Monte A, Buscemi G
Clin Ter 2017 Mar-Apr;168(2):e158-e167. doi: 10.7417/CT.2017.1999. PMID: 28383630

Recent clinical studies

Etiology

Small Intestinal Bacterial Overgrowth.
Bushyhead D, Quigley EM
Gastroenterol Clin North Am 2021 Jun;50(2):463-474. Epub 2021 Apr 23 doi: 10.1016/j.gtc.2021.02.008. PMID: 34024452
Management of pancreatic exocrine insufficiency.
Dominguez-Muñoz JE
Curr Opin Gastroenterol 2019 Sep;35(5):455-459. doi: 10.1097/MOG.0000000000000562. PMID: 31219829
The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO).
Quigley EMM
Curr Gastroenterol Rep 2019 Jan 15;21(1):3. doi: 10.1007/s11894-019-0671-z. PMID: 30645678
Small intestinal bacterial overgrowth: what it is and what it is not.
Quigley EM
Curr Opin Gastroenterol 2014 Mar;30(2):141-6. doi: 10.1097/MOG.0000000000000040. PMID: 24406476
Selected disorders of malabsorption.
Siddiqui Z, Osayande AS
Prim Care 2011 Sep;38(3):395-414; vii. doi: 10.1016/j.pop.2011.05.002. PMID: 21872088

Diagnosis

Small Intestinal Bacterial Overgrowth.
Bushyhead D, Quigley EM
Gastroenterol Clin North Am 2021 Jun;50(2):463-474. Epub 2021 Apr 23 doi: 10.1016/j.gtc.2021.02.008. PMID: 34024452
Small intestinal diverticula.
Parfenov AI, Krums LM, Pavlov MV
Ter Arkh 2019 Mar 17;91(2):4-8. doi: 10.26442/00403660.2019.02.000080. PMID: 31094166
The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO).
Quigley EMM
Curr Gastroenterol Rep 2019 Jan 15;21(1):3. doi: 10.1007/s11894-019-0671-z. PMID: 30645678
Malabsorption Syndromes.
Clark R, Johnson R
Nurs Clin North Am 2018 Sep;53(3):361-374. Epub 2018 Jul 11 doi: 10.1016/j.cnur.2018.05.001. PMID: 30100002
Fructose malabsorption syndrome.
Putkonen L, Yao CK, Gibson PR
Curr Opin Clin Nutr Metab Care 2013 Jul;16(4):473-7. doi: 10.1097/MCO.0b013e328361c556. PMID: 23739630

Therapy

Incidence, Diagnosis and Management of Malabsorption Following Oesophagectomy: a Systematic Review.
Khaw RA, Nevins EJ, Phillips AW
J Gastrointest Surg 2022 Aug;26(8):1781-1790. Epub 2022 Apr 28 doi: 10.1007/s11605-022-05323-y. PMID: 35484473
Small Intestinal Bacterial Overgrowth.
Bushyhead D, Quigley EM
Gastroenterol Clin North Am 2021 Jun;50(2):463-474. Epub 2021 Apr 23 doi: 10.1016/j.gtc.2021.02.008. PMID: 34024452
Management of pancreatic exocrine insufficiency.
Dominguez-Muñoz JE
Curr Opin Gastroenterol 2019 Sep;35(5):455-459. doi: 10.1097/MOG.0000000000000562. PMID: 31219829
Fructose malabsorption syndrome.
Putkonen L, Yao CK, Gibson PR
Curr Opin Clin Nutr Metab Care 2013 Jul;16(4):473-7. doi: 10.1097/MCO.0b013e328361c556. PMID: 23739630
Discovery of human zinc deficiency: its impact on human health and disease.
Prasad AS
Adv Nutr 2013 Mar 1;4(2):176-90. doi: 10.3945/an.112.003210. PMID: 23493534Free PMC Article

Prognosis

Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease.
Chen S, Liu X, Wang Z, Zheng D, Wang Y, Yan Y, Peng X, Ye Q, Chen Y
J Transl Med 2023 Jul 24;21(1):497. doi: 10.1186/s12967-023-04359-1. PMID: 37488584Free PMC Article
Long-term Gastrointestinal Sequelae Following COVID-19: A Prospective Follow-up Cohort Study.
Golla R, Vuyyuru S, Kante B, Kumar P, Thomas DM, Makharia G, Kedia S, Ahuja V
Clin Gastroenterol Hepatol 2023 Mar;21(3):789-796.e1. Epub 2022 Oct 21 doi: 10.1016/j.cgh.2022.10.015. PMID: 36273799Free PMC Article
Incidence, Diagnosis and Management of Malabsorption Following Oesophagectomy: a Systematic Review.
Khaw RA, Nevins EJ, Phillips AW
J Gastrointest Surg 2022 Aug;26(8):1781-1790. Epub 2022 Apr 28 doi: 10.1007/s11605-022-05323-y. PMID: 35484473
Malabsorption Syndromes.
Clark R, Johnson R
Nurs Clin North Am 2018 Sep;53(3):361-374. Epub 2018 Jul 11 doi: 10.1016/j.cnur.2018.05.001. PMID: 30100002
Malabsorption syndromes.
Salerno G, De Franco A, La Rosa S, Calistro V
Rays 2002 Jan-Mar;27(1):19-34. PMID: 12696272

Clinical prediction guides

Transcriptome profile and immune infiltrated landscape revealed a novel role of γδT cells in mediating pyroptosis in celiac disease.
Chen S, Liu X, Wang Z, Zheng D, Wang Y, Yan Y, Peng X, Ye Q, Chen Y
J Transl Med 2023 Jul 24;21(1):497. doi: 10.1186/s12967-023-04359-1. PMID: 37488584Free PMC Article
Malabsorption Spectrums in India.
ShibenduGhosh CV, Yusuf SA
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443489
Small bowel villous atrophy: celiac disease and beyond.
Elli L, Branchi F, Sidhu R, Guandalini S, Assiri A, Rinawi F, Shamir R, Das P, Makharia GK
Expert Rev Gastroenterol Hepatol 2017 Feb;11(2):125-138. Epub 2016 Dec 29 doi: 10.1080/17474124.2017.1274231. PMID: 28000520
Discovery of human zinc deficiency: its impact on human health and disease.
Prasad AS
Adv Nutr 2013 Mar 1;4(2):176-90. doi: 10.3945/an.112.003210. PMID: 23493534Free PMC Article
Malabsorption syndromes.
Salerno G, De Franco A, La Rosa S, Calistro V
Rays 2002 Jan-Mar;27(1):19-34. PMID: 12696272

Recent systematic reviews

Incidence, Diagnosis and Management of Malabsorption Following Oesophagectomy: a Systematic Review.
Khaw RA, Nevins EJ, Phillips AW
J Gastrointest Surg 2022 Aug;26(8):1781-1790. Epub 2022 Apr 28 doi: 10.1007/s11605-022-05323-y. PMID: 35484473
Prevalence of celiac disease in Iranian patients with type 1 diabetes: A systematic review and meta-analysis.
Gheshlagh RG, Rezaei H, Goli M, Ausili D, Dalvand S, Ghafouri H, Dehkordi AH
Indian J Gastroenterol 2020 Oct;39(5):419-425. Epub 2020 Dec 1 doi: 10.1007/s12664-020-01046-7. PMID: 33263176
Clinical, endoscopic, and histological differentiation between celiac disease and tropical sprue: A systematic review.
Sharma P, Baloda V, Gahlot GP, Singh A, Mehta R, Vishnubathla S, Kapoor K, Ahuja V, Gupta SD, Makharia GK, Das P
J Gastroenterol Hepatol 2019 Jan;34(1):74-83. Epub 2018 Aug 30 doi: 10.1111/jgh.14403. PMID: 30069926

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